Method of Identifying Cosmetic Agents For Treating Periorbital Dyschromia and Systems Therefor
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    发明申请
    Method of Identifying Cosmetic Agents For Treating Periorbital Dyschromia and Systems Therefor 审中-公开
    鉴定化妆品用于治疗眶周性色素变色的方法及其系统

    公开(公告)号:US20150125559A1

    公开(公告)日:2015-05-07

    申请号:US14472716

    申请日:2014-08-29

    IPC分类号: C12Q1/68 G06F19/20 G06F19/18

    摘要: A method of constructing a data architecture for use in identifying connections between perturbagens and genes associated with a type of periorbital dyschromia. The method includes providing a gene expression profile for a keratinocyte, fibroblast, melanocyte or melanoma cell, which has been exposed to at least one perturbagen, and comparing the gene expression profile to a control cell from the same cell line. Genes that are differentially expressed in response to the perturbagen are identified by comparing the gene expression profiles of the control cell and the test cell. An ordered list of identifiers representing the differentially expressed genes is created according to the differential expression of the genes. The ordered list is stored as an instance on a computer readable medium. The steps are then repeated to construct a data architecture of stored instances.

    摘要翻译: 构建数据架构的方法,用于识别扰动与与一种类型的眶周致昏着色相关的基因之间的连接。 该方法包括提供暴露于至少一种扰动剂的角质形成细胞,成纤维细胞,黑素细胞或黑素瘤细胞的基因表达谱,并将基因表达谱与来自相同细胞系的对照细胞进行比较。 通过比较对照细胞和测试细胞的基因表达谱来鉴定响应于扰动剂差异表达的基因。 根据基因的差异表达产生代表差异表达基因的标识符的有序列表。 有序列表作为实例存储在计算机可读介质上。 然后重复这些步骤以构建存储实例的数据架构。