公开(公告)号：US11331280B2

公开(公告)日：2022-05-17

申请号：US16675267

申请日：2019-11-06

申请人： The Procter & Gamble Company ,  The Cleveland Clinic Foundation

发明人： Stanley Leon Hazen ,  Jose Carlos Garcia-Garcia ,  Jodie Michelle Reed ,  Lori Ann Reinsalu ,  Vincent Peter Sica ,  Timothy R Baker

IPC分类号： A61K31/10 ,  A61K36/28 ,  A61P9/10 ,  A61P7/12 ,  A61P25/28

摘要： A method of inhibiting the conversion of choline to trimethylamine (TMA) and lowering TMAO in an individual by providing a composition comprising (2-hydroxyethyl) dimethylsulfonium with a counterion wherein the counterion is selected from chloride, bromide or iodide.

公开(公告)号：US10780072B2

公开(公告)日：2020-09-22

申请号：US15366819

申请日：2016-12-01

申请人： The Procter & Gamble Company ,  The Cleveland Clinic Foundation

发明人： Stanley Leon Hazen ,  Jose Carlos Garcia-Garcia ,  George Franklin Gerberick ,  John August Wos ,  David Thomas Stanton ,  Thomas Alfred Inglin ,  Michael Reilly ,  Angela Jane Deutsch ,  Jodie Michele Reed ,  David Blair Cody

IPC分类号： A61K31/26 ,  A61K31/166 ,  A61K31/216 ,  A61K31/22 ,  A61K31/325 ,  A61K31/351 ,  A61K45/06 ,  C07D213/04 ,  C07D295/13

摘要： The invention provides one or more methods of inhibiting the conversion of choline to trimethylamine (TMA) and lowering TMAO in an individual comprising administering to the individual one or more compositions comprising a compound set forth in Formula (I): wherein the compound is administered in an amount effective to inhibit formation of trimethylamine (TMA) from choline in the individual.

公开(公告)号：US11246844B2

公开(公告)日：2022-02-15

申请号：US15609791

申请日：2017-05-31

申请人： The Procter & Gamble Company ,  The Cleveland Clinic Foundation

发明人： Stanley Leon Hazen ,  Jose Carlos Garcia-Garcia ,  George Franklin Gerberick ,  John August Wos ,  Xiaodong Gu ,  Michael Reilly ,  Mark Robert Sivik ,  Jodie Michelle Reed ,  David Blair Cody

IPC分类号： A61K31/14 ,  C07D303/36 ,  A61K31/275 ,  C07C237/06 ,  A61K31/04 ,  C07C229/30 ,  C07C217/40 ,  C07D211/46 ,  C07C215/40 ,  C07C229/12 ,  C07C219/08 ,  C07D451/02 ,  A61K31/205 ,  C07C255/24 ,  C07C211/63 ,  C07C229/22 ,  C07C11/02 ,  C07C11/22 ,  C07C13/04 ,  C07C69/003 ,  C07C69/01 ,  C07C211/62 ,  C07C233/02 ,  C07C255/07 ,  C07D303/04

摘要： A method of inhibiting the conversion of choline to trimethylamine (TMA) and lowering TMAO by providing a composition comprising a compound set forth in Formula (I):

公开(公告)号：US10786479B2

公开(公告)日：2020-09-29

申请号：US15366877

申请日：2016-12-01

申请人： The Procter & Gamble Company ,  The Cleveland Clinic Foundation

发明人： Stanley Leon Hazen ,  Jose Carlos Garcia-Garcia ,  George Franklin Gerberick ,  John August Wos ,  David Thomas Stanton ,  Thomas Alfred Inglin ,  Michael Reilly ,  Angela Jane Deutsch ,  Jodie Michele Reed ,  David Blair Cody

IPC分类号： A61K31/26 ,  A61K31/166 ,  A61K31/216 ,  A61K31/22 ,  A61K31/325 ,  A61K31/351 ,  A61K45/06 ,  C07D213/04 ,  C07D295/13

摘要： The invention provides a method of inhibiting the conversion of carnitine to trimethylamine (TMA) and lowering TMAO in an individual comprising administering to the individual one or more compositions comprising a compound set forth in Formula (I): Wherein the compound is administered in an amount effective to inhibit conversion of carnitine to TMA in the individual.

公开(公告)号：US10751301B2

公开(公告)日：2020-08-25

申请号：US16149882

申请日：2018-10-02

申请人： The Procter & Gamble Company ,  The Cleveland Clinic Foundation

发明人： Jose Carlos Garcia-Garcia ,  George Franklin Gerberick ,  Michael Reilly ,  Stanley Leon Hazen ,  Xiaodong Gu

IPC分类号： A61K31/095 ,  A61K45/06 ,  A61K31/39 ,  A61K31/10 ,  A61P3/00 ,  A61K31/275 ,  A61K31/19 ,  A61P43/00

摘要： A method of inhibiting the conversion of choline to trimethylamine (TMA) and lowering TMAO in an individual by providing a composition comprising a compound set forth in Formula (I):

公开(公告)号：US10675256B2

公开(公告)日：2020-06-09

申请号：US16149913

申请日：2018-10-02

申请人： The Procter & Gamble Company ,  The Cleveland Clinic Foundation

发明人： Jose Carlos Garcia-Garcia ,  George Franklin Gerberick ,  John August Wos ,  Stanley Leon Hazen ,  Xiaodong Gu

IPC分类号： A61K31/14 ,  A61K31/215 ,  A61K45/06 ,  A61K31/16 ,  A61K31/5375 ,  A61K31/277 ,  A61P3/00 ,  A61K31/198 ,  A61P43/00 ,  A61K31/196

摘要： A method of inhibiting the conversion of choline to trimethylamine (TMA) and lowering TMAO in an individual by providing a composition comprising a compound set forth in Formula (I):

公开(公告)号：US10213407B2

公开(公告)日：2019-02-26

申请号：US15366940

申请日：2016-12-01

申请人： The Procter & Gamble Company ,  THE CLEVELAND CLINIC FOUNDATION

发明人： Jose Carlos Garcia-Garcia ,  Stanley Leon Hazen ,  John August Wos

IPC分类号： C12N9/00 ,  A61K31/26 ,  A61K31/145 ,  A61K31/166 ,  A61K31/216 ,  A61K31/22 ,  A61K31/325 ,  A61K31/351 ,  A61K31/5375 ,  A61K31/27 ,  A61K31/4453 ,  A61K45/06 ,  A61K31/336 ,  A61K31/439 ,  A61K31/4425 ,  A61K31/452 ,  C07C331/20 ,  C07D211/46 ,  C07D213/04 ,  C07D213/30 ,  C07D213/65 ,  C07D295/13 ,  C07D303/36 ,  C07D453/02 ,  A61K31/04 ,  A61K31/095 ,  A61K31/275

摘要： The invention provides a method of inhibiting the conversion of choline or carnitine to trimethylamine (TMA) and lowering TMAO in an individual comprising administering to the individual a composition comprising a compound set forth in FORMULA (I): The invention also provides for a method of inhibiting the production of TMA by bacteria comprising administering to the individual a composition comprising a compound set forth in FORMULA (I) wherein the compound is administered in an amount effective to inhibit formation of trimethylamine (TMA) from choline or carnitine in the individual.

公开(公告)号：US20170058270A1

公开(公告)日：2017-03-02

申请号：US15247997

申请日：2016-08-26

申请人： The Procter & Gamble Company ,  Alimentary Health Ltd.

发明人： Jose Carlos Garcia-Garcia ,  Michael John Janusz ,  Barry Kiely ,  Eileen Frances Murphy ,  Liam O'Mahony

IPC分类号： C12N9/12 ,  A23L33/135 ,  A23C9/12 ,  A61K35/745

CPC分类号： C12N9/12 ,  A23C9/1203 ,  A23L33/135 ,  A23V2002/00 ,  A23Y2300/55 ,  A61K35/74 ,  A61K35/745 ,  C12Y207/10002

摘要： A formulation comprising an ingestible carrier and an isolated strain of Bifidobacterium longum.

摘要翻译： 包含可摄入载体和长双歧杆菌的分离菌株的制剂。

公开(公告)号：US20160317432A1

公开(公告)日：2016-11-03

申请号：US15140523

申请日：2016-04-28

申请人： The Procter & Gamble Company

发明人： Jose Carlos Garcia-Garcia ,  Jeffrey Alan Henry ,  Brian W. Howard ,  Nicholas William Geary ,  Raul Victorino Nunes ,  Freddy Arthur Barnabas ,  Safa Motlagh ,  Yiping Sun

IPC分类号： A61K8/99 ,  C12N1/20 ,  A61K35/74

CPC分类号： A61K8/99 ,  A61K35/74 ,  A61K2800/40 ,  A61K2800/805 ,  A61K2800/81 ,  A61Q7/00 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/007 ,  A61Q19/02 ,  A61Q19/04 ,  A61Q19/06 ,  A61Q19/08 ,  C12N1/20

摘要： The disclosure relates to topical compositions and methods comprising whole, non-viable Micrococcaceae cells, wherein the cells have been processed to kill the cells while minimizing lysis. The topical compositions and methods are useful for decreasing skin inflammation and improving skin barrier function.

摘要翻译： 本公开涉及包含完整的，不可行的微球菌细胞的局部组合物和方法，其中已经处理细胞以杀死细胞同时使裂解最小化。 局部组合物和方法可用于减少皮肤炎症和改善皮肤屏障功能。

公开(公告)号：US11649336B2

公开(公告)日：2023-05-16

申请号：US17341476

申请日：2021-06-08

申请人： The Procter & Gamble Company

发明人： Dimitris Ioannis Collias ,  John Andrew McDaniel ,  Gary Wayne Gilbertson ,  Martin Ian James ,  Arsen Arsenov Simonyan ,  Jose Carlos Garcia-Garcia

IPC分类号： C08J11/16 ,  C08J11/10

CPC分类号： C08J11/105 ,  C08J11/16 ,  C08J2333/08

摘要： Poly(acrylic acid)-based superabsorbent polymer (SAP) in a feed stream is converted into poly(acrylic acid) (PAA) in an extensional flow device. The total energy used to degrade the SAP into PAA is less than about 50 MJ/kg SAP.