公开(公告)号：US20230165509A1

公开(公告)日：2023-06-01

申请号：US18060439

申请日：2022-11-30

Applicant: The Regents of the University of California

Inventor： Duygu Kuzum ,  Xin Liu ,  Takaki Komiyama ,  Chi Ren

IPC: A61B5/37 ,  A61B5/384 ,  G16H50/50

CPC classification number: A61B5/37 ,  A61B5/384 ,  G16H50/50

Abstract: Methods and devices for computationally constructing brain potentials across whole brain using electrocorticography signals recorded from a small region on the brain surface are disclosed. In some embodiments of the disclosed technology, a method includes obtaining a plurality of locally recorded surface potentials from a plurality of first cortical areas of a brain surface; and performing a virtual reconstruction of an average brain activity for individual cortical areas and a pixel-level cortex-wide brain activity for a plurality of cortical areas of the brain surface including the plurality of first cortical areas based on the plurality of locally recorded surface potentials.

公开(公告)号：US20230172513A1

公开(公告)日：2023-06-08

申请号：US18063040

申请日：2022-12-07

Applicant: The Regents of the University of California

Inventor： Duygu Kuzum ,  Yichen Lu ,  Xin Liu ,  Jeong-hoon Kim

IPC: A61B5/293 ,  B81B1/00 ,  B81C1/00 ,  A61B5/00

CPC classification number: A61B5/293 ,  A61B5/0084 ,  B81B1/008 ,  B81C1/00111 ,  A61B2562/04 ,  A61B2562/028 ,  A61B2562/125 ,  A61B2562/164 ,  A61B2562/0209 ,  B81B2201/12 ,  B81B2203/04 ,  B81B2203/0361

Abstract: Flexible, insertable, transparent microelectrode arrays that allow integration of electrophysiological recordings with any optical imaging or stimulation technology are disclosed. In some embodiments of the disclosed technology, a microelectrode array includes a flexible substrate layer including a shank member extending in a first direction and a tapered tip at an end of the shank member, and a plurality of electrode wires arranged in the first direction on the flexible substrate layer, wherein the plurality of electrode wires includes adjacent electrode wires having different lengths from each other such that an electrode wire arranged closer to a centerline of the flexible substrate layer is longer than an adjacent electrode arranged further away from the centerline of the flexible substrate.