公开(公告)号：US20160347855A1

公开(公告)日：2016-12-01

申请号：US15181019

申请日：2016-06-13

申请人： The Regents of the University of California ,  Agensys, Inc.

发明人： Robert E. Reiter ,  Owen N. Witte ,  Douglas C. Saffran ,  Aya Jakobovits

IPC分类号： C07K16/30 ,  G01N33/577 ,  A61K51/10 ,  A61K45/06 ,  A61K31/704 ,  G01N33/574 ,  A61K39/395

CPC分类号： C07K16/3069 ,  A01K2217/05 ,  A61K31/704 ,  A61K38/00 ,  A61K39/395 ,  A61K39/39558 ,  A61K45/06 ,  A61K47/6869 ,  A61K51/106 ,  A61K51/1072 ,  A61K2039/505 ,  C07K14/4748 ,  C07K14/705 ,  C07K16/30 ,  C07K16/3038 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/77 ,  C07K2317/92 ,  C07K2319/00 ,  G01N33/53 ,  G01N33/567 ,  G01N33/574 ,  G01N33/57407 ,  G01N33/57434 ,  G01N33/57438 ,  G01N33/577 ,  G01N2333/705 ,  A61K31/00 ,  A61K2300/00

摘要： The invention provides a novel prostate cell-surface antigen, designated Prostate Stem Cell Antigen (PSCA), which is widely over-expressed across all stages of prostate cancer, including high grade prostatic intraepithelial neoplasia (PIN), androgen-dependent and androgen-independent prostate tumors.

公开(公告)号：US20140364591A1

公开(公告)日：2014-12-11

申请号：US14297562

申请日：2014-06-05

申请人： The Regents of the University of California ,  Agensys, Inc.

发明人： Robert E. Reiter ,  Owen N. Witte ,  Douglas C. Saffran ,  Aya Jakobovits

IPC分类号： C07K16/30

CPC分类号： C07K16/3069 ,  A01K2217/05 ,  A61K31/704 ,  A61K38/00 ,  A61K39/395 ,  A61K39/39558 ,  A61K45/06 ,  A61K47/6869 ,  A61K51/106 ,  A61K51/1072 ,  A61K2039/505 ,  C07K14/4748 ,  C07K14/705 ,  C07K16/30 ,  C07K16/3038 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/77 ,  C07K2317/92 ,  C07K2319/00 ,  G01N33/53 ,  G01N33/567 ,  G01N33/574 ,  G01N33/57407 ,  G01N33/57434 ,  G01N33/57438 ,  G01N33/577 ,  G01N2333/705 ,  A61K31/00 ,  A61K2300/00

摘要： The invention provides a novel prostate cell-surface antigen, designated Prostate Stem Cell Antigen (PSCA), which is widely over-expressed across all stages of prostate cancer, including high grade prostatic intraepithelial neoplasia (PIN), androgen-dependent and androgen-independent prostate tumors.

摘要翻译： 本发明提供了一种新的前列腺细胞表面抗原，其命名为前列腺干细胞抗原（PSCA），其在前列腺癌的所有阶段中广泛过表达，包括高级前列腺上皮内瘤变（PIN），雄激素依赖性和雄激素依赖性 前列腺肿瘤。

公开(公告)号：US09962454B2

公开(公告)日：2018-05-08

申请号：US15069853

申请日：2016-03-14

申请人： AGENSYS, INC. ,  Seattle Genetics, Inc.

发明人： Daulet Satpayev ,  Robert Kendall Morrison ,  Karen Jane Meyrick Morrison ,  Jean Gudas ,  Aya Jakobovits ,  Michael Torgov ,  Zili An

IPC分类号： C07K16/18 ,  C12P21/08 ,  A61K39/395 ,  A61K47/48 ,  C07K16/30 ,  A61N5/10 ,  A61K47/68 ,  A61K39/00

CPC分类号： A61K47/6851 ,  A61K47/6801 ,  A61K47/6803 ,  A61K47/6811 ,  A61K47/6855 ,  A61K47/6857 ,  A61K47/6859 ,  A61K47/6861 ,  A61K47/6889 ,  A61K2039/505 ,  A61N5/1001 ,  C07K16/30 ,  C07K16/3015 ,  C07K16/3023 ,  C07K16/303 ,  C07K16/3038 ,  C07K2317/14 ,  C07K2317/34 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/92

摘要： Antibody drug conjugates (ADC's) that bind to 191P4D12 protein and variants thereof are described herein. 191P4D12 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, the ADC's of the invention provide a therapeutic composition for the treatment of cancer.

公开(公告)号：US08945570B2

公开(公告)日：2015-02-03

申请号：US13662318

申请日：2012-10-26

申请人： Agensys, Inc.

发明人： Aya Jakobovits ,  Robert Kendall Morrison ,  Arthur B. Raitano ,  Pia M. Challita-Eid ,  Juan J. Perez-Villar ,  Karen Jane Meyrick Morrison ,  Mary Faris ,  Wangmao Ge ,  Jean Gudas ,  Steven B. Kanner

IPC分类号： A61K31/00 ,  A61K35/14 ,  A61K38/00 ,  A61K38/16 ,  A61K39/00 ,  A61K39/395 ,  A61K49/00 ,  A61B5/055 ,  A01N61/00 ,  C07K1/00 ,  C07K14/00 ,  C07K16/00 ,  C07K16/30 ,  C07K14/47 ,  A61K47/48 ,  A61K51/10

CPC分类号： C07K16/18 ,  A61K38/00 ,  A61K47/646 ,  A61K47/6813 ,  A61K51/1093 ,  C07K14/47 ,  C07K16/30 ,  C07K16/3038 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/622 ,  G01N33/57484 ,  Y10T436/25

摘要： The invention described herein relates to novel nucleic acid sequences and their encoded proteins, referred to as 158P1D7 and variants thereof, and to diagnostic and therapeutic methods and compositions useful in the management of various cancers that express 158P1D7 and variants thereof.

摘要翻译： 本文描述的本发明涉及新颖的核酸序列及其编码的蛋白质，被称为158P1D7及其变体，以及可用于治疗表达158P1D7及其变体的各种癌症的诊断和治疗方法和组合物。

公开(公告)号：US10894090B2

公开(公告)日：2021-01-19

申请号：US15943527

申请日：2018-04-02

申请人： AGENSYS, INC. ,  SEAGEN INC.

发明人： Daulet Satpayev ,  Robert Kendall Morrison ,  Karen Jane Meyrick Morrison ,  Jean Gudas ,  Aya Jakobovits ,  Michael Torgov ,  Zili An

IPC分类号： A61K39/395 ,  A61K47/68 ,  C07K16/30 ,  A61K39/00

摘要： Antibody drug conjugates (ADC's) that bind to 191P4D12 protein and variants thereof are described herein. 191P4D12 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, the ADC's of the invention provide a therapeutic composition for the treatment of cancer.

公开(公告)号：US10597463B2

公开(公告)日：2020-03-24

申请号：US15448430

申请日：2017-03-02

申请人： AGENSYS, INC.

发明人： Aya Jakobovits ,  Soudabeh Etessami ,  Pia M. Challita-Eid ,  Juan J. Perez-Villar ,  Karen J. Morrison ,  Xiao-Chi Jia ,  Mary Faris ,  Jean Gudas ,  Arthur B. Raitano

IPC分类号： A61K48/00 ,  C07K16/40 ,  C07H21/04 ,  A61K39/395 ,  A61K45/06 ,  A61K51/10 ,  C07K16/30 ,  A61K47/68 ,  G01N33/68 ,  A61K39/00

摘要： Antibodies and molecules derived therefrom that bind to novel STEAP-1 protein, and variants thereof, are described wherein STEAP-1 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, STEAP-1 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The STEAP-1 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with STEAP-1 can be used in active or passive immunization.

公开(公告)号：US08846043B2

公开(公告)日：2014-09-30

申请号：US14059374

申请日：2013-10-21

申请人： Agensys, Inc.

发明人： Aya Jakobovits ,  Arthur B. Raitano ,  Mary Faris ,  Rene S. Hubert ,  Wangmao Ge ,  Karen Jane Meyrick Morrison ,  Robert Kendall Morrison ,  Pia M. Challita-Eid

IPC分类号： A61K39/395 ,  A61K39/00

CPC分类号： C07K16/30 ,  A61K31/7088 ,  A61K39/00 ,  A61K51/1045 ,  A61K2039/505 ,  C07K14/47 ,  C07K16/18 ,  C07K16/3023 ,  C07K16/303 ,  C07K16/3038 ,  C07K16/3046 ,  C07K16/3061 ,  C07K16/3069 ,  C07K16/40 ,  C07K2317/20 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2319/30 ,  C12N9/16 ,  C12Q1/6886 ,  C12Q2600/158 ,  G01N33/57492 ,  Y02A50/466

摘要： A novel gene 0161P2F10B (also designated 161P2F10B) and its encoded protein, and variants thereof, are described wherein 161P2F10B exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 161P2F10B provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 161P2F10B gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 161P2F10B can be used in active or passive immunization.

摘要翻译： 描述了新颖的基因0161P2F10B（也称为161P2F10B）及其编码的蛋白质及其变体，其中161P2F10B在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，161P2F10B提供了诊断， 癌症的预后，预防和/或治疗靶标。 161P2F10B基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与161P2F10B反应的抗体或T细胞可用于主动或被动免疫。

公开(公告)号：US09617346B2

公开(公告)日：2017-04-11

申请号：US14604658

申请日：2015-01-23

申请人： AGENSYS, INC.

发明人： Aya Jakobovits ,  Soudabeh Etessami ,  Pia M. Challita-Eid ,  Juan J. Perez-Villar ,  Karen J. Morrison ,  Xiao-Chi Jia ,  Mary Faris ,  Jean Gudas ,  Arthur B. Raitano

IPC分类号： C07H21/04 ,  C07K16/40 ,  A61K39/395 ,  A61K45/06 ,  A61K47/48 ,  A61K51/10 ,  C07K16/30 ,  G01N33/68 ,  A61K39/00

CPC分类号： C07K16/40 ,  A61K39/39533 ,  A61K45/06 ,  A61K47/48607 ,  A61K47/6861 ,  A61K51/106 ,  A61K51/1075 ,  A61K2039/505 ,  C07H21/04 ,  C07K16/3069 ,  C07K2317/24 ,  C07K2317/565 ,  G01N33/6887 ,  A61K2300/00

摘要： Antibodies and molecules derived therefrom that bind to novel STEAP-1 protein, and variants thereof, are described wherein STEAP-1 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, STEAP-1 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The STEAP-1 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with STEAP-1 can be used in active or passive immunization.

公开(公告)号：US20130189286A1

公开(公告)日：2013-07-25

申请号：US13830899

申请日：2013-03-14

申请人： AGENSYS, INC. ,  Seattle Genetics

发明人： Daulet SATPAEV ,  Robert Kendall Morrison ,  Karen Jane Meyrick Morrison ,  Jean Gudas ,  Aya Jakobovits ,  Michael Torgov ,  Zili An

IPC分类号： A61K47/48

CPC分类号： A61K47/6851 ,  A61K47/6801 ,  A61K47/6803 ,  A61K47/6811 ,  A61K47/6855 ,  A61K47/6857 ,  A61K47/6859 ,  A61K47/6861 ,  A61K47/6889 ,  A61K2039/505 ,  A61N5/1001 ,  C07K16/30 ,  C07K16/3015 ,  C07K16/3023 ,  C07K16/303 ,  C07K16/3038 ,  C07K2317/14 ,  C07K2317/34 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/92

摘要： Antibody drug conjugates (ADC's) that bind to 191P4D12 protein and variants thereof are described herein. 191P4D12 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, the ADC's of the invention provide a therapeutic composition for the treatment of cancer.

公开(公告)号：US09314538B2

公开(公告)日：2016-04-19

申请号：US14798302

申请日：2015-07-13

申请人： AGENSYS, INC. ,  Seattle Genetics, Inc.

发明人： Daulet Satpayev ,  Robert Kendall Morrison ,  Karen Jane Meyrick Morrison ,  Jean Gudas ,  Aya Jakobovits ,  Michael Torgov ,  Zili An

IPC分类号： C07K16/18 ,  C12P21/08 ,  A61K47/48 ,  C07K16/30 ,  A61N5/10 ,  A61K39/00

CPC分类号： A61K47/6851 ,  A61K47/6801 ,  A61K47/6803 ,  A61K47/6811 ,  A61K47/6855 ,  A61K47/6857 ,  A61K47/6859 ,  A61K47/6861 ,  A61K47/6889 ,  A61K2039/505 ,  A61N5/1001 ,  C07K16/30 ,  C07K16/3015 ,  C07K16/3023 ,  C07K16/303 ,  C07K16/3038 ,  C07K2317/14 ,  C07K2317/34 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/92

摘要： Antibody drug conjugates (ADC's) that bind to 191P4D12 protein and variants thereof are described herein. 191P4D12 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, the ADC's of the invention provide a therapeutic composition for the treatment of cancer.

摘要翻译： 本文描述了结合191P4D12蛋白及其变体的抗体药物偶联物（ADC）。 191P4D12在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，本发明的ADC提供了用于治疗癌症的治疗组合物。