专利检索 ap:("The United States of America, as represented by the Secretary, Department of Health AND Human Services") AND inv:"George W. Wright" 第 1 页

1.

发明授权
Evaluation of mantle cell lymphoma and methods related thereto 有权

公开(公告)号：US11725248B2

公开(公告)日：2023-08-15

申请号：US16094965

申请日：2017-04-20

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services , British Columbia Cancer Agency Branch , Julius-Maximilians—University of Würzburg , Oregon Health & Science University , Hospital Clinic de Barcelona , Universitat de Barcelona , Oslo University Hospital HF , Board of Regents of the University of Nebraska , The Cleveland Clinic Foundation , Mayo Foundation for Medical Education and Research

发明人： Louis M. Staudt , David William Scott , George W. Wright , Andreas Rosenwald , Pau Abrisqueta , Rita Braziel , Elias Campo Guerri , Wing C. Chan , Joseph M. Connors , Jan Delabie , Diego Villa , Kai Fu , Randy D. Gascoyne , Timothy Greiner , Elaine S. Jaffe , Pedro Jares , Anja Mottok , German Ott , Lisa M. Rimsza , Graham Slack , Dennis Weisenburger , Erlend B. Smeland , James Robert Cook

IPC分类号： C12Q1/6886

CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/158

摘要： The present invention provides methods of determining a survival predictor score of a subject having mantle cell lymphoma (MCL). The present invention also provides methods of predicting the survival outcome of a subject having MCL and provides methods of selecting a treatment for a subject having MCL.

2.

发明授权
Method for determining lymphoma type and providing treatment 有权

公开(公告)号：US11646099B2

公开(公告)日：2023-05-09

申请号：US16713528

申请日：2019-12-13

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services , British Columbia Cancer Agency Branch , Mayo Foundation for Medical Education and Research , Julius-Maximilians-University of Würzburg , Board of Regents of the University of Nebraska , Oslo University Hospital HF , Hospital Clinic de Barcelona , Universitat de Barcelona , Institut D'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS) , Robert Bosch Gesellschaft fuer medizinische Forschung mbH , Oregon Health & Science University , City of Hope , The Cleveland Clinic Foundation

发明人： Louis M. Staudt , Christian Steidl , Anja Mottok , George W. Wright , David William Scott , Lisa M. Rimsza , Andreas Rosenwald , Randy Gascoyne , Timothy Greiner , Dennis Weisenburger , Erlend B. Smeland , Jan Delabie , Elias Campo Guerri , German Ott , Rita Braziel , Elaine S. Jaffe , Kai Fu , Wing C. Chan , Joo Song , James R. Cook

IPC分类号： G01N33/48 , G16B5/00 , G16B25/10 , C12Q1/6886

CPC分类号： G16B5/00 , C12Q1/6886 , G16B25/10 , C12Q2600/112 , C12Q2600/158

摘要： In embodiments of the invention, the invention provides a method for distinguishing between lymphoma types based on gene expression measurements. In embodiments, the invention distinguishes between PMBCL and DLBCL based on gene expression signatures, and can further distinguish between DLBCL subtypes. In embodiments of the invention, the distinctions are used in methods of treatment.

3.

发明授权
Method for subtyping lymphoma types by means of expression profiling 有权

公开(公告)号：US10607717B2

公开(公告)日：2020-03-31

申请号：US15035101

申请日：2014-11-05

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services , British Columbia Cancer Agency Branch , Arizona Board of Regents on Behalf of the University of Arizona , Universitat de Barcelona , Hospital Clinic de Barcelona , The Cleveland Clinic Foundation , The Board of Regents of the University of Nebraska , Oregon Health and Science University , Julius-Maximilians-University of Würzburg , Oslo University Hospital HF

发明人： Louis M. Staudt , George W. Wright , David William Scott , Joseph M. Connors , Randy D. Gascoyne , Lisa Rimsza , Elias Campo Guerri , Raymond Tubbs , Timothy C. Greiner , James Robert Cook , Kai Fu , Paul Michael Williams , Chih-Jian Lih , Elaine S. Jaffe , Rita M. Braziel , Andreas Rosenwald , Erlend B. Smeland , Wing C. Chan , German Ott , Jan Delabie , Dennis Weisenburger

IPC分类号： G01N33/48 , G16B25/00 , G16B5/00 , C12Q1/6886

摘要： The invention is directed to methods for selecting a treatment option for an activated B cell-like diffuse large B cell lymphoma (ABC DLBCL) subject, a germinal center B cell-like diffuse large B cell lymphoma (GCB DLBCL) subject, a primary mediastinal B cell lymphoma (PMBL) subject, a Burkitt lymphoma (BL) subject, or a mantle cell lymphoma (MCL) subject by analyzing digital gene expression data obtained from the subject, e.g., from a biopsy sample.

4.

发明授权
Methods for identifying, diagnosing, and predicting survival of lymphomas 有权

公开(公告)号：US10370715B2

公开(公告)日：2019-08-06

申请号：US14570316

申请日：2014-12-15

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services

发明人： Louis M. Staudt , George W. Wright , Sandeep Dave , Bruce K. Tan

IPC分类号： G01N33/48 , G01N33/00 , C12Q1/6883 , C12Q1/6886 , G01N33/574

摘要： The invention provides methods for identifying, diagnosing, and predicting survival in a lymphoma or lymphoproliferative disorder on the basis of gene expression patterns. The invention provides a microarray for obtaining gene expression data from a lymphoma sample. The invention also provides a variety of methods for utilizing lymphoma gene expression data to determine the identity of a particular lymphoma and to predict survival in a subject diagnosed with a particular lymphoma, which is useful in developing an appropriate therapeutic approach.