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公开(公告)号：US11845778B2
公开(公告)日：2023-12-19
申请号：US17378587
申请日：2021-07-16
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services , Institute for Research in Biomedicine
发明人： Baoshan Zhang , Guillaume Stewart-Jones , John Mascola , Kai Xu , Gwo-Yu Chuang , Li Ou , Peter Kwong , Yaroslav Tsybovsky , Wing-Pui Kong , Aliaksandr Druz , Davide Corti , Antonio Lanzavecchia
IPC分类号： A61K39/155 , C07K14/005 , A61P31/14 , C12N7/00
CPC分类号： C07K14/005 , A61K39/155 , A61P31/14 , C12N7/00 , C07K2319/50 , C12N2760/18634 , C12N2760/18734
摘要： Embodiments of a recombinant human Parainfluenza Virus (hPIV) F ectodomain trimer stabilized in a prefusion conformation are provided. Also disclosed are nucleic acids encoding the hPIV F ectodomain trimer and methods of producing the hPIV F ectodomain trimer. Methods for inducing an immune response in a subject are also disclosed. In some embodiments, the method can be a method for treating or inhibiting a hPIV infection in a subject by administering a effective amount of the recombinant hPIV F ectodomain trimer to the subject.
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公开(公告)号：US11602559B2
公开(公告)日：2023-03-14
申请号：US16338964
申请日：2017-10-03
发明人： Peter Kwong , Rui Kong , Tongqing Zhou , John Mascola , Kai Xu , Cheng Cheng , Gwo-Yu Chuang , Kevin Liu , Baoshan Zhang , Li Ou , Wing-Pui Kong
摘要： Embodiments of immunogens based on the HIV-1 Env fusion peptide and methods of their use and production are disclosed. Nucleic acid molecules encoding the immunogens are also provided. In several embodiments, the immunogens can be used to generate an immune response to HIV-1 Env in a subject, for example, to treat or prevent an HIV-1 infection in the subject.
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公开(公告)号：US11174292B2
公开(公告)日：2021-11-16
申请号：US16089993
申请日：2017-03-29
发明人： Peter Kwong , Barney Graham , John Mascola , Li Ou , Aliaksandr Druz , Man Chen , Wing-Pui Kong , Ivelin Stefanov Georgiev , Emily Rundlet , Michael Gordon Joyce , Yaroslav Tsybovsky , Paul Thomas , Marie Pancera , Mallika Sastry , Cinque Soto , Joseph Van Galen , Guillaume Stewart-Jones , Yongping Yang , Baoshan Zhang , Ulrich Baxa
IPC分类号： C07K14/005 , A61K39/12 , A61P37/04 , A61P31/14 , A61K39/00
摘要： Embodiments of a recombinant Respiratory Syncytial Virus (RSV) F ectodomain trimer stabilized in a prefusion conformation are provided. Also disclosed are nucleic acids encoding the RSV F ectodomain trimer and methods of producing the RSV F ectodomain trimer. Methods for inducing an immune response in a subject are also disclosed. In some embodiments, the method can be a method for treating or preventing a RSV infection in a subject by administering a therapeutically effective amount of the recombinant RSV F ectodomain trimer to the subject.
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公开(公告)号：US12053519B2
公开(公告)日：2024-08-06
申请号：US17277694
申请日：2019-09-23
发明人： Peter Kwong , Li Ou , John Mascola , Baoshan Zhang , Kai Xu , Wing-Pui Kong , Yaroslav Tsybovsky , Cara W. Chao , Jeffrey Boyington , Yiran Wang
CPC分类号： A61K39/21 , A61K9/1658 , A61K47/64 , A61K47/644 , A61K47/646 , A61K47/6925 , A61P31/18 , A61K2039/6031 , A61K2039/6037 , A61K2039/6068 , A61K2039/6075 , A61K2039/6081 , A61K2039/645
摘要： Embodiments of immunogenic conjugates including the HIV-1 Env fusion peptide and methods of their use and production are disclosed. In several embodiments, the immunogenic conjugates can be used to generate an immune response to HIV-1 Env in a subject, for example, to treat or prevent an HIV-1 infection in the subject.
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5.发明公开公开(公告)号：US20240299510A1
公开(公告)日：2024-09-12
申请号：US18270436
申请日：2021-12-31
申请人： The United States of America,as represented by the Secretary,Department of Health and Human Services
发明人： Peter D. Kwong , Gwo-Yu Chuang , Baoshan Zhang , Wing-Pui Kong , Yiran Wang , Cara Chao , John R. Mascola , Li Ou , Tongqing Zhou , Yongping Yang , Bohan Liu , Cheng Cheng , Daniel W. Biner , Reda Rawi
CPC分类号： A61K39/0005 , A61K45/06 , A61P3/06 , C12N9/6454 , C12Y304/21061
摘要： The present disclosure describes the grafting of epitope residues from human PCSK9 to non-human PCSK9 or PCSK9 structural homologs and elimination of 9-mers oligopeptides that are found in human protein to reduce self-targeting response. Anti-genicity of the epitope-scaffold constructs was demonstrated toward anti-human PCSK9 antibodies. similar to wild type human PCSK9. It was shown that disclosed PCSK9 immunogens could significantly reduce LDL and cholesterol levels in immunized mice.
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公开(公告)号：US11878998B2
公开(公告)日：2024-01-23
申请号：US17524380
申请日：2021-11-11
发明人： Peter Kwong , Barney Graham , John Mascola , Li Ou , Aliaksandr Druz , Man Chen , Wing-Pui Kong , Ivelin Stefanov Georgiev , Emily Rundlet , Michael Gordon Joyce , Yaroslav Tsybovsky , Paul Thomas , Marie Pancera , Mallika Sastry , Cinque Soto , Joseph Van Galen , Guillaume Stewart-Jones , Yongping Yang , Baoshan Zhang , Ulrich Baxa
IPC分类号： C07K14/005 , A61K39/12 , A61P37/04 , A61P31/14 , A61K39/00
CPC分类号： C07K14/005 , A61K39/12 , A61P31/14 , A61P37/04 , A61K39/00 , A61K2039/5252 , A61K2039/5254 , A61K2039/53 , A61K2039/543 , A61K2039/55505 , A61K2039/55561 , A61K2039/55566 , C07K2319/21 , C07K2319/22 , C07K2319/50 , C07K2319/70 , C07K2319/735 , C12N2710/10343 , C12N2760/18522 , C12N2760/18523 , C12N2760/18534
摘要： Embodiments of a recombinant Respiratory Syncytial Virus (RSV) F ectodomain trimer stabilized in a prefusion conformation are provided. Also disclosed are nucleic acids encoding the RSV F ectodomain trimer and methods of producing the RSV F ectodomain trimer. Methods for inducing an immune response in a subject are also disclosed. In some embodiments, the method can be a method for treating or preventing a RSV infection in a subject by administering a therapeutically effective amount of the recombinant RSV F ectodomain trimer to the subject.
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