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公开(公告)号：US11235056B2
公开(公告)日：2022-02-01
申请号：US16496912
申请日：2018-03-26
IPC分类号： A61K39/21 , C07K14/005 , C12N7/00 , C07K14/16 , A61K39/00
摘要： Embodiments of immunogens based on the outer domain of HIV-1 gp120 and methods of their use and production are disclosed. Nucleic acid molecules encoding the immunogens are also provided. In several embodiments, the immunogens can be used to prime an immune response to gp120 in a subject, for example, to treat or prevent an HIV-1 infection in the subject.
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公开(公告)号：US11969466B2
公开(公告)日：2024-04-30
申请号：US18314052
申请日：2023-05-08
发明人： John R. Mascola , Jeffrey C. Boyington , Hadi M. Yassine , Peter D. Kwong , Barney S. Graham , Masaru Kanekiyo
IPC分类号： A61K39/145 , A61K39/12 , C07K14/005 , C07K14/47 , C12N7/00 , A61K39/00
CPC分类号： A61K39/145 , A61K39/12 , C07K14/005 , C07K14/47 , C12N7/00 , A61K2039/55555 , A61K2039/55566 , A61K2039/6031 , C07K2319/00 , C12N2760/16122 , C12N2760/16134
摘要： Vaccines that elicit broadly protective anti-influenza antibodies. Some vaccines comprise nanoparticles that display HA trimers from influenza virus on their surface. The nanoparticles are fusion proteins comprising a monomeric subunit (e.g., ferritin) joined to the stem region of an influenza HA protein. The fusion proteins self-assemble to form the HA-displaying nanoparticles. The vaccines comprise only the stem region of an influenza HA protein joined to a trimerization domain. Also provided are fusion proteins, and nucleic acid molecules encoding such proteins, and assays using nanoparticles of the invention to detect anti-influenza antibodies.
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公开(公告)号：US10363301B2
公开(公告)日：2019-07-30
申请号：US15313265
申请日：2015-05-27
发明人： John R. Mascola , Jeffrey C. Boyington , Hadi M. Yassine , Peter D. Kwong , Barney S. Graham , Masaru Kanekiyo
IPC分类号： A61K39/145 , C12N7/00 , A61K39/12 , C07K14/005 , C07K14/47 , A61K39/00
摘要： Vaccines that elicit broadly protective anti-influenza antibodies. Some vaccines comprise nanoparticles that display HA trimers from influenza virus on their surface. The nanoparticles are fusion proteins comprising a monomeric subunit (e.g., ferritin) joined to the stem region of an influenza HA protein. The fusion proteins self-assemble to form the HA-displaying nanoparticles. The vaccines comprise only the stem region of an influenza HA protein joined to a trimerization domain. Also provided are fusion proteins, and nucleic acid molecules encoding such proteins, and assays using nanoparticles of the invention to detect anti-influenza antibodies.
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公开(公告)号：US09783595B2
公开(公告)日：2017-10-10
申请号：US15226744
申请日：2016-08-02
发明人： Mark Connors , Jinghe Huang , Leo B. Laub , Peter Kwong , Gary Nabel , John R. Mascola , Baoshan Zhang , Rebecca S. Rudicell , Ivelin Georgiev , Yongping Yang , Jiang Zhu , Gilad Ofek
CPC分类号： C07K16/1063 , A61K39/42 , A61K45/06 , A61K49/0004 , A61K2039/505 , C07K16/00 , C07K16/1045 , C07K2317/14 , C07K2317/21 , C07K2317/31 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , G01N33/56972 , G01N33/56983 , G01N33/56988 , G01N2333/161
摘要： Monoclonal neutralizing antibodies are disclosed that specifically bind to the HIV-1 gp41 membrane-proximal external region (MPER). Also disclosed are compositions including the disclosed antibodies that specifically bind gp41, nucleic acids encoding these antibodies, expression vectors including the nucleic acids, and isolated host cells that express the nucleic acids. The antibodies and compositions disclosed herein can be used for detecting the presence of HIV-1 in a biological sample, or detecting an HIV-1 infection or diagnosing AIDS in a subject. In additional, the broad neutralization breadth of the disclosed antibodies makes them ideal for treating a subject with an HIV infection. Thus, disclosed are methods of treating and/or preventing HIV infection.
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公开(公告)号：US12053520B2
公开(公告)日：2024-08-06
申请号：US17587817
申请日：2022-01-28
IPC分类号： A61K39/21 , C07K14/005 , C07K14/16 , C12N7/00 , A61K39/00
CPC分类号： A61K39/21 , C07K14/005 , C07K14/162 , C12N7/00 , C12Y205/01078 , A61K2039/5258 , A61K2039/55555 , C07K2319/00 , C12N2740/16023 , C12N2740/16043 , C12N2740/16111 , C12N2740/16122 , C12N2740/16134 , C12N2740/16171
摘要： Embodiments of immunogens based on the outer domain of HIV-1 gp120 and methods of their use and production are disclosed. Nucleic acid molecules encoding the immunogens are also provided. In several embodiments, the immunogens can be used to prime an immune response to gp120 in a subject, for example, to treat or prevent an HIV-1 infection in the subject.
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6.发明授权公开(公告)号：US11149082B2
公开(公告)日：2021-10-19
申请号：US16342962
申请日：2017-10-17
申请人： UNIVERSITY OF MARYLAND, COLLEGE PARK , THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , INTERNATIONAL AIDS VACCINE INITIATIVE
发明人： Javier Guenaga , Yuxing Li , James Steinhardt , John R. Mascola
摘要： The present disclosure relates to multispecific antibodies targeting the human immunodeficiency virus-1 (HIV-1) envelope, methods for their production, pharmaceutical compositions containing said antibodies and uses thereof in treatment and prevention of HIV infection.
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公开(公告)号：US10047148B2
公开(公告)日：2018-08-14
申请号：US15699902
申请日：2017-09-08
发明人： Mark Connors , Jinghe Huang , Leo B. Laub , Peter Kwong , Gary Nabel , John R. Mascola , Baoshan Zhang , Rebecca S. Rudicell , Ivelin Georgiev , Yongping Yang , Jiang Zhu , Gilad Ofek
IPC分类号： A61K39/395 , C07K16/00 , A61K39/42 , C07K16/10 , A61K39/00 , G01N33/569 , A61K45/06 , A61K49/00
摘要： Monoclonal neutralizing antibodies are disclosed that specifically bind to the HIV-1 gp41 membrane-proximal external region (MPER). Also disclosed are compositions including the disclosed antibodies that specifically bind gp41, nucleic acids encoding these antibodies, expression vectors including the nucleic acids, and isolated host cells that express the nucleic acids. The antibodies and compositions disclosed herein can be used for detecting the presence of HIV-1 in a biological sample, or detecting an HIV-1 infection or diagnosing AIDS in a subject. In additional, the broad neutralization breadth of the disclosed antibodies makes them ideal for treating a subject with an HIV infection. Thus, disclosed are methods of treating and/or preventing HIV infection.
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公开(公告)号：US11793871B2
公开(公告)日：2023-10-24
申请号：US17742201
申请日：2022-05-11
发明人： Jeffrey C. Boyington , Barney S. Graham , John R. Mascola , Hadi M. Yassine , Kizzmekia S. Corbett , Syed M. Moin , Lingshu Wang , Masaru Kanekiyo
IPC分类号： A61K39/145 , C07K14/005 , C07K14/195 , A61K39/12 , A61P31/16 , A61K39/00
CPC分类号： A61K39/145 , A61K39/12 , A61P31/16 , C07K14/005 , C07K14/195 , A61K2039/55555 , C07K2319/00 , C12N2760/16122 , C12N2760/16134
摘要： Vaccines that elicit broadly protective anti-influenza antibodies. The vaccines comprise nanoparticles that display HA trimers from Group 2 influenza virus on their surface. The nanoparticles are fusion proteins comprising a monomeric subunit (e.g., ferritin) joined to stabilized stem regions of Group 2 influenza virus HA proteins. The fusion proteins self-assemble to form the HA-displaying nanoparticles. Also provided are fusion proteins, and nucleic acid molecules encoding such proteins, and assays using nanoparticles of the invention to detect anti-influenza antibodies.
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9.发明公开公开(公告)号：US20240299510A1
公开(公告)日：2024-09-12
申请号：US18270436
申请日：2021-12-31
申请人： The United States of America,as represented by the Secretary,Department of Health and Human Services
发明人： Peter D. Kwong , Gwo-Yu Chuang , Baoshan Zhang , Wing-Pui Kong , Yiran Wang , Cara Chao , John R. Mascola , Li Ou , Tongqing Zhou , Yongping Yang , Bohan Liu , Cheng Cheng , Daniel W. Biner , Reda Rawi
CPC分类号： A61K39/0005 , A61K45/06 , A61P3/06 , C12N9/6454 , C12Y304/21061
摘要： The present disclosure describes the grafting of epitope residues from human PCSK9 to non-human PCSK9 or PCSK9 structural homologs and elimination of 9-mers oligopeptides that are found in human protein to reduce self-targeting response. Anti-genicity of the epitope-scaffold constructs was demonstrated toward anti-human PCSK9 antibodies. similar to wild type human PCSK9. It was shown that disclosed PCSK9 immunogens could significantly reduce LDL and cholesterol levels in immunized mice.
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公开(公告)号：US09475862B2
公开(公告)日：2016-10-25
申请号：US14356557
申请日：2012-11-07
发明人： Mark Connors , Jinghe Huang , Leo B. Laub , Peter Kwong , Gary Nabel , John R. Mascola , Baoshan Zhang , Rebecca S. Rudicell , Ivelin Georgiev , Yongping Yang , Jiang Zhu , Gilad Ofek
IPC分类号： A61K45/06 , C07K16/10 , G01N33/569 , A61K39/21 , A61K39/395 , C07K16/00 , A61K39/42 , A61K49/00
CPC分类号： C07K16/1063 , A61K39/42 , A61K45/06 , A61K49/0004 , A61K2039/505 , C07K16/00 , C07K16/1045 , C07K2317/14 , C07K2317/21 , C07K2317/31 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , G01N33/56972 , G01N33/56983 , G01N33/56988 , G01N2333/161
摘要： Monoclonal neutralizing antibodies are disclosed that specifically bind to the HIV-1 gp41 membrane-proximal external region (MPER). Also disclosed are compositions including the disclosed antibodies that specifically bind gp41, nucleic acids encoding these antibodies, expression vectors including the nucleic acids, and isolated host cells that express the nucleic acids. The antibodies and compositions disclosed herein can be used for detecting the presence of HIV-1 in a biological sample, or detecting an HIV-1 infection or diagnosing AIDS in a subject. In additional, the broad neutralization breadth of the disclosed antibodies makes them ideal for treating a subject with an HIV infection. Thus, disclosed are methods of treating and/or preventing HIV infection.
摘要翻译： 公开了特异性结合HIV-1 gp41膜近端外部区域（MPER）的单克隆中和抗体。 还公开了包括所公开的特异性结合gp41的抗体，编码这些抗体的核酸，包括核酸的表达载体和表达核酸的分离的宿主细胞的组合物。 本文公开的抗体和组合物可用于检测生物样品中HIV-1的存在，或检测受试者中的HIV-1感染或AIDS的诊断。 此外，所公开的抗体的广泛中和宽度使其成为治疗HIV感染的受试者的理想选择。 因此，公开了治疗和/或预防HIV感染的方法。
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