-
公开(公告)号：US11845778B2
公开(公告)日：2023-12-19
申请号：US17378587
申请日：2021-07-16
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services , Institute for Research in Biomedicine
发明人： Baoshan Zhang , Guillaume Stewart-Jones , John Mascola , Kai Xu , Gwo-Yu Chuang , Li Ou , Peter Kwong , Yaroslav Tsybovsky , Wing-Pui Kong , Aliaksandr Druz , Davide Corti , Antonio Lanzavecchia
IPC分类号： A61K39/155 , C07K14/005 , A61P31/14 , C12N7/00
CPC分类号： C07K14/005 , A61K39/155 , A61P31/14 , C12N7/00 , C07K2319/50 , C12N2760/18634 , C12N2760/18734
摘要： Embodiments of a recombinant human Parainfluenza Virus (hPIV) F ectodomain trimer stabilized in a prefusion conformation are provided. Also disclosed are nucleic acids encoding the hPIV F ectodomain trimer and methods of producing the hPIV F ectodomain trimer. Methods for inducing an immune response in a subject are also disclosed. In some embodiments, the method can be a method for treating or inhibiting a hPIV infection in a subject by administering a effective amount of the recombinant hPIV F ectodomain trimer to the subject.
-
公开(公告)号：US12053519B2
公开(公告)日：2024-08-06
申请号：US17277694
申请日：2019-09-23
发明人： Peter Kwong , Li Ou , John Mascola , Baoshan Zhang , Kai Xu , Wing-Pui Kong , Yaroslav Tsybovsky , Cara W. Chao , Jeffrey Boyington , Yiran Wang
CPC分类号： A61K39/21 , A61K9/1658 , A61K47/64 , A61K47/644 , A61K47/646 , A61K47/6925 , A61P31/18 , A61K2039/6031 , A61K2039/6037 , A61K2039/6068 , A61K2039/6075 , A61K2039/6081 , A61K2039/645
摘要： Embodiments of immunogenic conjugates including the HIV-1 Env fusion peptide and methods of their use and production are disclosed. In several embodiments, the immunogenic conjugates can be used to generate an immune response to HIV-1 Env in a subject, for example, to treat or prevent an HIV-1 infection in the subject.
-
3.发明授权公开(公告)号：US10961283B2
公开(公告)日：2021-03-30
申请号：US16312166
申请日：2017-06-27
发明人： Peter Kwong , Ivelin Georgiev , Michael Gordon Joyce , Masaru Kanekiyo , Aliaksandr Druz , Ulrich Baxa , Joseph Van Galen , Cheng Cheng , John Mascola , Yaroslav Tsybovsky , Yongping Yang , Barney Graham , Syed Mohammad Moin , Jeffrey Boyington
IPC分类号： C07K14/11 , A61K39/21 , C12N7/00 , C07K14/08 , C07K14/16 , C07K14/165 , C07K14/435 , A61K39/00
摘要： Disclosed are recombinant insect ferritin nanoparticles that can be used to display two different trimeric antigens at an equal ratio. Also disclosed are nucleic acids encoding the recombinant insect ferritin nanoparticles and methods of producing the recombinant insect ferritin nanoparticles. Methods for eliciting an immune response in a subject are also provided.
-
公开(公告)号：US11939356B2
公开(公告)日：2024-03-26
申请号：US17202231
申请日：2021-03-15
发明人： Peter Kwong , Ivelin Georgiev , Michael Gordon Joyce , Masaru Kanekiyo , Aliaksandr Druz , Ulrich Baxa , Joseph Van Galen , Cheng Cheng , John Mascola , Yaroslav Tsybovsky , Yongping Yang , Barney Graham , Syed Mohammad Moin , Jeffrey Boyington
IPC分类号： C07K14/11 , A61K39/21 , C07K14/08 , C07K14/16 , C07K14/165 , C07K14/435 , C12N7/00 , A61K39/00
CPC分类号： C07K14/11 , A61K39/21 , C07K14/082 , C07K14/162 , C07K14/165 , C07K14/43563 , C12N7/00 , A61K2039/55555 , C07K2319/735 , C12N2740/16134 , C12N2760/16134 , C12N2770/20034
摘要： Disclosed are recombinant insect ferritin nanoparticles that can be used to display two different trimeric antigens at an equal ratio. Also disclosed are nucleic acids encoding the recombinant insect ferritin nanoparticles and methods of producing the recombinant insect ferritin nanoparticles. Methods for eliciting an immune response in a subject are also provided.
-
公开(公告)号：US11174292B2
公开(公告)日：2021-11-16
申请号：US16089993
申请日：2017-03-29
发明人： Peter Kwong , Barney Graham , John Mascola , Li Ou , Aliaksandr Druz , Man Chen , Wing-Pui Kong , Ivelin Stefanov Georgiev , Emily Rundlet , Michael Gordon Joyce , Yaroslav Tsybovsky , Paul Thomas , Marie Pancera , Mallika Sastry , Cinque Soto , Joseph Van Galen , Guillaume Stewart-Jones , Yongping Yang , Baoshan Zhang , Ulrich Baxa
IPC分类号： C07K14/005 , A61K39/12 , A61P37/04 , A61P31/14 , A61K39/00
摘要： Embodiments of a recombinant Respiratory Syncytial Virus (RSV) F ectodomain trimer stabilized in a prefusion conformation are provided. Also disclosed are nucleic acids encoding the RSV F ectodomain trimer and methods of producing the RSV F ectodomain trimer. Methods for inducing an immune response in a subject are also disclosed. In some embodiments, the method can be a method for treating or preventing a RSV infection in a subject by administering a therapeutically effective amount of the recombinant RSV F ectodomain trimer to the subject.
-
公开(公告)号：US11878998B2
公开(公告)日：2024-01-23
申请号：US17524380
申请日：2021-11-11
发明人： Peter Kwong , Barney Graham , John Mascola , Li Ou , Aliaksandr Druz , Man Chen , Wing-Pui Kong , Ivelin Stefanov Georgiev , Emily Rundlet , Michael Gordon Joyce , Yaroslav Tsybovsky , Paul Thomas , Marie Pancera , Mallika Sastry , Cinque Soto , Joseph Van Galen , Guillaume Stewart-Jones , Yongping Yang , Baoshan Zhang , Ulrich Baxa
IPC分类号： C07K14/005 , A61K39/12 , A61P37/04 , A61P31/14 , A61K39/00
CPC分类号： C07K14/005 , A61K39/12 , A61P31/14 , A61P37/04 , A61K39/00 , A61K2039/5252 , A61K2039/5254 , A61K2039/53 , A61K2039/543 , A61K2039/55505 , A61K2039/55561 , A61K2039/55566 , C07K2319/21 , C07K2319/22 , C07K2319/50 , C07K2319/70 , C07K2319/735 , C12N2710/10343 , C12N2760/18522 , C12N2760/18523 , C12N2760/18534
摘要： Embodiments of a recombinant Respiratory Syncytial Virus (RSV) F ectodomain trimer stabilized in a prefusion conformation are provided. Also disclosed are nucleic acids encoding the RSV F ectodomain trimer and methods of producing the RSV F ectodomain trimer. Methods for inducing an immune response in a subject are also disclosed. In some embodiments, the method can be a method for treating or preventing a RSV infection in a subject by administering a therapeutically effective amount of the recombinant RSV F ectodomain trimer to the subject.
-
-
-
-
-
搜索结果
6 条记录 (耗时 0.025 秒)
