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公开(公告)号：US11504305B2
公开(公告)日：2022-11-22
申请号：US15609564
申请日：2017-05-31
摘要： The present invention relates to compositions and methods for mineralizing a dental surface or subsurface including providing a composition including stabilized ACP and a source of fluoride ions.
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公开(公告)号：US10695370B2
公开(公告)日：2020-06-30
申请号：US14906395
申请日：2014-07-23
摘要： The present invention relates to compositions for mineralizing a dental surface, in particular tooth enamel. Methods of mineralizing hypomineralized lesions (including subsurface lesions) in the tooth enamel caused by dental caries, dental corrosion and fluorosis are also provided. In particular, the invention relates to a method of mineralizing a dental surface or subsurface comprising contacting the dental surface or subsurface with a compound that is capable of increasing or maintaining the pH of a solution and a mineralizing agent.
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公开(公告)号：US09814662B2
公开(公告)日：2017-11-14
申请号：US15059878
申请日：2016-03-03
摘要： The present invention relates to a phosphopeptide-stabilized amorphous calcium phosphate and/or amorphous calcium fluoride phosphate complex, wherein the complex is formed at a pH of below 7.0. Methods of making such complexes are also provided. The complexes are useful in dental applications, in particular in dental remineralization.
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公开(公告)号：US20170333296A1
公开(公告)日：2017-11-23
申请号：US15609564
申请日：2017-05-31
摘要： The present invention relates to compositions and methods for mineralizing a dental surface or subsurface including providing a composition including stabilized ACP and a source of fluoride ions.
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5.发明申请SYNTHETIC PEPTIDE CONSTRUCTS FOR THE DIAGNOSIS AND TREATMENT OF PERIODONTIS ASSOCIATED WITH PORPHYROMONAS GINGIVALIS 有权用于诊断和治疗与PORPHYROMONAS GINGIVALIS相关的PERIODONTIS的合成肽结构公开(公告)号：US20130309179A1
公开(公告)日：2013-11-21
申请号：US13852272
申请日：2013-03-28
IPC分类号： C07K14/195
CPC分类号： C07K14/195 , A61K38/00 , A61K39/00 , A61K39/0216 , A61K2039/55544 , A61K2039/55566 , A61K2039/6037 , C12N9/52
摘要： The present invention relates to an oral composition and an immunogenic composition for the suppression of the pathogenic effects of the intra-oral bacterium Porphyromonas gingivalis associated with periodontal disease.
摘要翻译： 本发明涉及用于抑制口腔内细菌与牙周病相关的牙龈卟啉单胞菌的致病作用的口腔组合物和免疫原性组合物。
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公开(公告)号：US12128068B2
公开(公告)日：2024-10-29
申请号：US18214964
申请日：2023-06-27
CPC分类号： A61K33/42 , A61K8/21 , A61K8/24 , A61K8/64 , A61K9/0058 , A61K47/42 , A61Q11/00 , A61K2800/28 , A61K2800/592
摘要： The present invention relates to compositions for mineralizing a dental surface, in particular tooth enamel. Methods of mineralizing hypomineralized lesions (including subsurface lesions) in the tooth enamel caused by dental caries, dental corrosion and fluorosis are also provided. In particular, the invention relates to a method of mineralizing a dental surface or subsurface comprising contacting the dental surface or subsurface with a compound that is capable of increasing or maintaining the pH of a solution and a mineralizing agent.
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公开(公告)号：US20240016836A1
公开(公告)日：2024-01-18
申请号：US18210381
申请日：2023-06-15
CPC分类号： A61K33/42 , A61K9/0058 , A61K38/1709
摘要： The present invention relates to compositions and their use for oral care. In particular, the compositions and methods are for maintaining oral health and/or treating various oral conditions such as gingivitis. The present invention relates to methods and uses of stabilized amorphous calcium phosphate (ACP) and/or stabilized amorphous calcium fluoride phosphate (ACFP) in the preparation of a medicament for reducing pathogenic oral bacteria at an oral site in an individual; increasing commensal oral bacteria at an oral site in an individual; decreasing the proportion of pathogenic oral bacteria at an oral site in an individual; inhibiting oral dysbiosis; reducing gingival inflammation in an individual in need thereof; treating gingivitis in an individual in need thereof; and treating chronic gingivitis in an individual in need thereof.
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公开(公告)号：US20240000671A1
公开(公告)日：2024-01-04
申请号：US18052390
申请日：2022-11-03
摘要： The present invention relates to compositions and methods for mineralizing a dental surface or subsurface including providing a composition including stabilized ACP and a source of fluoride ions.
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公开(公告)号：US11564873B2
公开(公告)日：2023-01-31
申请号：US17169012
申请日：2021-02-05
IPC分类号： A61K8/19 , A61K8/24 , A61Q11/00 , A61K33/42 , A61K33/24 , A61K9/00 , A61K9/68 , A61K6/20 , A61K6/74
摘要： The present invention relates to improved complexes of amorphous calcium phosphate and/or amorphous calcium fluoride phosphate stabilised by phosphopeptides/phosphoproteins by addition of stannous ions. These complexes have anticariogenic properties useful to protect tooth structures as they remineralize (repair) early stages of dental caries and have other dental/medical applications (including anti-calculus, anti-erosion/corrosion and anti-dentinal hypersensitivity). Methods of making the complexes of the invention and of treatment or prevention of various dental conditions including dental caries, dental calculus, dental erosion/corrosion and dental hypersensitivity are also provided.
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公开(公告)号：US20220401473A1
公开(公告)日：2022-12-22
申请号：US17832556
申请日：2022-06-03
摘要： The present invention relates to compositions for mineralizing a dental surface, in particular tooth enamel. Methods of mineralizing hypomineralized lesions (including subsurface lesions) in the tooth enamel caused by dental caries, dental corrosion and fluorosis are also provided. In particular, the invention relates to a method of mineralizing a dental surface or subsurface comprising contacting the dental surface or subsurface with a compound that is capable of increasing or maintaining the pH of a solution and a mineralizing agent.
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