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    Microneedles for minimally invasive drug delivery
    3.
    发明授权
    Microneedles for minimally invasive drug delivery 失效
    用于微创药物递送的微针

    公开(公告)号：US06980855B2

    公开(公告)日：2005-12-27

    申请号：US10767485

    申请日：2004-01-29

    申请人： Steve T. Cho

    发明人： Steve T. Cho

    IPC分类号： B81B1/00 ,  A61B5/15 ,  A61M5/32 ,  A61M37/00 ,  B81C1/00 ,  A61N1/30

    CPC分类号： B81C1/00111 ,  A61B5/14514 ,  A61B5/150022 ,  A61B5/150221 ,  A61B5/150282 ,  A61B5/150748 ,  A61B5/15087 ,  A61B5/150969 ,  A61B5/150984 ,  A61B5/157 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2037/003 ,  A61M2037/0038 ,  A61M2037/0053 ,  B81B2201/055

    摘要： The present invention provides a microneedle incorporating a base that is broad relative to a height of the microneedle, to minimize breakage. The microneedle further includes a fluid channel and a beveled non-coring tip. Preferably arrays of such microneedles are fabricated utilizing conventional semiconductor derived micro-scale fabrication techniques. A dot pattern mask is formed on an upper surface of a silicon substrate, with each orifice of the dot pattern mask corresponding to a desired location of a microneedle. Orifices are formed that pass completely through the substrate by etching. A nitride pattern mask is formed to mask all areas in which a nitride layer is not desired. A nitride layer is then deposited on the bottom of the silicon substrate, on the walls of the orifice, and on the top of the silicon substrate around the periphery of the orifice. The nitride layer around the periphery of the orifice is offset somewhat, such that one side of the orifice has a larger nitride layer. Anisotropic etching is used to remove a substantial portion of the substrate, creating a plurality of angular, blunt, and generally pyramidal-shaped microneedles. A subsequent removal of the nitride layer, followed by an isotropic etching step, softens and rounds out the blunt angular microneedles, providing generally conical-shaped microneedles. The uneven nitride layer adjacent the orifice ensures that the microneedles will include a beveled tip. Such microneedle arrays are preferably incorporated into handheld diagnostic and drug delivery systems.

    摘要翻译： 本发明提供了一种结合了相对于微针的高度宽的基底的微针，以使破损最小化。 微针还包括流体通道和倾斜的非取心尖端。 优选地，使用常规的半导体衍生的微尺度制造技术制造这种微针的阵列。 在硅基板的上表面上形成点阵图案掩模，点图案掩模的每个孔口对应于微针的期望位置。 形成通过蚀刻完全通过基板的孔。 形成氮化物图案掩模以掩盖不需要氮化物层的所有区域。 然后将氮化物层沉积在硅衬底的底部，孔的壁上，以及围绕孔的周边的硅衬底的顶部上。 围绕孔的周边的氮化物层稍微偏移，使得孔的一侧具有较大的氮化物层。 使用各向异性蚀刻去除基本部分的大部分，产生多个角，钝，通常为锥形的微针。 随后去除氮化物层，随后进行各向同性的蚀刻步骤，软化和圆化钝角微针，提供大致锥形的微针。 邻近孔口的不均匀氮化物层确保了微针将包括一个倾斜尖端。 这种微针阵列优选并入手持诊断和药物输送系统中。

    Closed-loop IV fluid flow control
    4.
    发明授权
    Closed-loop IV fluid flow control 有权
    闭环IV流体流量控制

    公开(公告)号：US06685668B1

    公开(公告)日：2004-02-03

    申请号：US09628846

    申请日：2000-07-31

    申请人： Steve T. Cho ,  Gene E. Clark

    发明人： Steve T. Cho ,  Gene E. Clark

    IPC分类号： A61M3100

    CPC分类号： A61M5/16881 ,  A61M5/16804 ,  A61M5/172

    摘要： In a closed-loop process, a controller uses a flow sensor to monitor the flow of a medicinal fluid being infused into a patient, to achieve a desired rate of flow. A relatively inexpensive peristaltic pump or electronically controlled valve can be used to vary the flow of the medicinal fluid through a fluid line. A Y site within the fluid line includes an integral flow sensor having an orifice. The flow sensor includes proximal and distal pressure sensors disposed on opposite sides of the orifice to monitor the distal and proximal pressure, producing a signal indicative of the rate of flow of the medicinal fluid through the fluid line. A signal produced by the controller is input to a motor driving the pump or to the valve to vary the rate of flow as required to achieve the desired infusion rate of the medicinal fluid.

    摘要翻译： 在闭环过程中，控制器使用流量传感器来监测注入患者体内的药液的流量，以达到所需的流速。 可以使用相对便宜的蠕动泵或电子控制阀来改变药液通过流体管线的流动。 流体管线内的Y位置包括具有孔口的一体式流量传感器。 流量传感器包括设置在孔的相对侧上的近端和远端压力传感器，以监测远端和近端压力，产生指示药液通过流体管线的流速的信号。 由控制器产生的信号被输入到驱动泵或阀的马达，以根据需要改变流速以实现药液的所需输液速率。

    Fluid flow measurement device
    5.
    发明授权
    Fluid flow measurement device 失效

    公开(公告)号：US07082843B2

    公开(公告)日：2006-08-01

    申请号：US11205929

    申请日：2005-08-17

    申请人： Gene E. Clark ,  Steve T. Cho ,  Harlow B. Christianson ,  John M. Sperinde

    发明人： Gene E. Clark ,  Steve T. Cho ,  Harlow B. Christianson ,  John M. Sperinde

    IPC分类号： G01F1/22

    CPC分类号： G01F1/383 ,  A61M5/16813 ,  A61M5/16854 ,  A61M5/16886 ,  G01F1/363 ,  G01F1/40

    摘要： The invention is directed to a device for obtaining flow rate measurements including a sensor assembly and a housing. The sensor assembly includes a body defining a first fluid flow passage having an inlet, an outlet, a flow restricting element in the first fluid flow passage between the inlet and the outlet, an upstream fluid pressure sensor, a downstream fluid pressure sensor, an upstream signal contact connected to the upstream fluid pressure sensor, and a downstream signal contact connected to the downstream fluid pressure sensor. The housing has an upstream portion defining an upstream port, a downstream portion defining a downstream port, and a probe access port configured to provide access of a probe to at least one of the upstream signal contact and downstream signal contact. The housing can also define a second fluid flow passage in parallel with the first fluid flow passage. The device can be disposable.

    Microneedles for minimally invasive drug delivery
    6.
    发明授权
    Microneedles for minimally invasive drug delivery 有权

    公开(公告)号：US06767341B2

    公开(公告)日：2004-07-27

    申请号：US09880377

    申请日：2001-06-13

    申请人： Steve T. Cho

    发明人： Steve T. Cho

    IPC分类号： A61M532

    CPC分类号： B81C1/00111 ,  A61B5/14514 ,  A61B5/150022 ,  A61B5/150221 ,  A61B5/150282 ,  A61B5/150748 ,  A61B5/15087 ,  A61B5/150969 ,  A61B5/150984 ,  A61B5/157 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2037/003 ,  A61M2037/0038 ,  A61M2037/0053 ,  B81B2201/055

    摘要： The present invention provides a microneedle incorporating a base that is broad relative to a height of the microneedle, to minimize breakage. The microneedle further includes a fluid channel and a beveled non-coring tip. Preferably arrays of such microneedles are fabricated utilizing conventional semiconductor derived micro-scale fabrication techniques. A dot pattern mask is formed on an upper surface of a silicon substrate, with each orifice of the dot pattern mask corresponding to a desired location of a microneedle. Orifices are formed that pass completely through the substrate by etching. A nitride pattern mask is formed to mask all areas in which a nitride layer is not desired. A nitride layer is then deposited on the bottom of the silicon substrate, on the walls of the orifice, and on the top of the silicon substrate around the periphery of the orifice. The nitride layer around the periphery of the orifice is offset somewhat, such that one side of the orifice has a larger nitride layer. Anisotropic etching is used to remove a substantial portion of the substrate, creating a plurality of angular, blunt, and generally pyramidal-shaped microneedles. A subsequent removal of the nitride layer, followed by an isotropic etching step, softens and rounds out the blunt angular microneedles, providing generally conical-shaped microneedles. The uneven nitride layer adjacent the orifice ensures that the microneedles will include a beveled tip. Such microneedle arrays are preferably incorporated into handheld diagnostic and drug delivery systems.

    Method of making a micromechanical silicon-on-glass tuning fork gyroscope
    8.
    发明授权
    Method of making a micromechanical silicon-on-glass tuning fork gyroscope 失效
    制造微机电硅玻璃音叉陀螺仪的方法

    公开(公告)号：US5492596A

    公开(公告)日：1996-02-20

    申请号：US191979

    申请日：1994-02-04

    申请人： Steve T. Cho

    发明人： Steve T. Cho

    IPC分类号： G01C19/5719 ,  H01L21/306 ,  G01P9/04

    CPC分类号： G01C19/5719 ,  Y10S438/924

    摘要： A micromechanical tuning fork gyroscope fabricated by a dissolved silicon wafer process whereby electrostatic bonding forms a hermetic seal between an etched glass substrate, metal electrodes deposited thereon, and a silicon comb-drive tuning fork gyroscope. The dissolved silicon wafer process involves single sided processing of a silicon substrate, including the steps of etching recesses, diffusing an etch resistant dopant into the silicon substrate, and releasing various components of the silicon gyroscope by etching through the diffusion layer in desired locations. The glass substrate also undergoes single sided processing, including the steps of etching recesses, depositing a multi-metal system in the recesses, and selectively etching portions of the multi-metal system. One substrate is inverted over the other and aligned before anodic bonding of the two substrates is performed.

    摘要翻译： 通过溶解的硅晶片工艺制造的微机械音叉陀螺仪，其中静电接合在蚀刻的玻璃基板，沉积在其上的金属电极和硅梳驱动音叉陀螺仪之间形成气密密封。 溶解的硅晶片工艺涉及硅衬底的单面处理，包括蚀刻凹槽，将耐蚀刻掺杂剂扩散到硅衬底中的步骤，以及通过在期望的位置蚀刻通过扩散层来释放硅陀螺仪的各种组件。 玻璃基板也进行单面加工，包括蚀刻凹槽，在凹槽中沉积多金属系统以及选择性蚀刻多金属系统的部分的步骤。 一个基板在两个基板的阳极接合之前被反转并对齐。

    Closed-loop IV fluid flow control
    9.
    发明授权
    Closed-loop IV fluid flow control 有权
    闭环IV流体流量控制

    公开(公告)号：US06981960B2

    公开(公告)日：2006-01-03

    申请号：US10727702

    申请日：2003-12-04

    申请人： Steve T. Cho ,  Gene E. Clark

    发明人： Steve T. Cho ,  Gene E. Clark

    IPC分类号： A61M31/00

    CPC分类号： A61M5/16881 ,  A61M5/16804 ,  A61M5/172

    摘要： In a cosed-loop process, a controller uses a flow sensor to monitor the flow of a medicinal fluid being infused into a patient, to achieve a desired rate of flow. A relatively inexpensive peristaltic pump or electronically controlled valve can be used to vary the flow of the medicinal fluid through a fluid line. A Y site within the fluid line includes an integral flow sensor having an orifice. The flow sensor includes proximal and distal pressure sensors disposed on opposite sides of the orifice to monitor the distal and proximal pressure, producing a signal indicative of the rate of flow of the medicinal fluid through the fluid line. A signal produced by the controller is input to a motor driving the pump or to the valve to vary the rate of flow as required to achieve the desired infusion rate of the medicinal fluid.

    摘要翻译： 在旋转环路过程中，控制器使用流量传感器来监测被输入到患者体内的药液的流动，以达到所需的流速。 可以使用相对便宜的蠕动泵或电子控制阀来改变药液通过流体管线的流动。 流体管线内的Y位置包括具有孔口的一体式流量传感器。 流量传感器包括设置在孔的相对侧上的近端和远端压力传感器，以监测远端和近端压力，产生指示药液通过流体管线的流速的信号。 由控制器产生的信号被输入到驱动泵或阀的马达，以根据需要改变流速以实现药液的所需输液速率。