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    Urea linker derivatives for use as PPAR modulators
    10.
    发明授权
    Urea linker derivatives for use as PPAR modulators 失效
    用作PPAR调节剂的尿素接头衍生物

    公开(公告)号：US06984661B2

    公开(公告)日：2006-01-10

    申请号：US10500489

    申请日：2003-01-21

    申请人： James Robert Henry ,  YiHong Li

    发明人： James Robert Henry ,  YiHong Li

    IPC分类号： A61K31/36 ,  A61K31/195 ,  C07D317/44 ,  C07C323/63 ,  C07C275/28

    CPC分类号： C07C275/36 ,  C07C275/10 ,  C07C275/24 ,  C07C275/28 ,  C07C275/30 ,  C07C275/34 ,  C07C275/38 ,  C07C2601/14 ,  C07C2602/08 ,  C07D317/66

    摘要： The present invention is directed to compounds of the structural formula (I), and pharmaceutically acceptable salts, solvates and hydrates thereof: Formula I (a) R1, R2 and R6 are each independently selected from the group consisting of hydrogen, C1-C8 alkyl substituted C1-C8 alkyl, aryl-C0-4-alkyl, substituted aryl-C0-4-alkyl, heteroaryl-C0-4-alkyl, substituted heteroaryl-C0-4-alkyl, C3-C6 cycloalkylaryl-C0-2-alkyl, and substituted C3-C6 cycloalkylaryl-C0-2-alkyl; (b) X is an optionally substituted C1-C5 alkylene linker wherein one carbon atom of the linker may be replaced with O, NH or S; (c) Y is C, O, S, NH or a single bond; and (d) E is selected from the group consisting of hydrogen, C(R3)(R4)A, A, (CH2)n COOR19 and substituted (CH2)n COOR19.

    摘要翻译： 本发明涉及结构式（I）的化合物及其药学上可接受的盐，溶剂合物和水合物：式I（a）R 1，R 2和R 6各自独立地选自氢，C 1 -C 6烷基， 1个C 1 -C 8烷基取代的C 1 -C 8烷基，芳基-C 0-4