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公开(公告)号：US20090105229A1
公开(公告)日：2009-04-23
申请号：US12333775
申请日：2008-12-12
申请人： Thomas Albert Engler , Timothy Paul Burkholder , Joshua Ryan Clayton , Clive Gideon Diefenbacher , Kelly Wayne Furness , James Robert Henry , Yihong Li , Sushant Malhotra , Angela Lynn Marquart , Johnathan Alexander McLean , David Mendel , Jon Kevin Reel
发明人： Thomas Albert Engler , Timothy Paul Burkholder , Joshua Ryan Clayton , Clive Gideon Diefenbacher , Kelly Wayne Furness , James Robert Henry , Yihong Li , Sushant Malhotra , Angela Lynn Marquart , Johnathan Alexander McLean , David Mendel , Jon Kevin Reel
IPC分类号： A61K31/5517 , C07D487/16
CPC分类号： C07D471/06 , C07D487/06
摘要： The present invention provides kinase inhibitors of Formula I.
摘要翻译： 本发明提供式I的激酶抑制剂。
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公开(公告)号：US20110294792A1
公开(公告)日：2011-12-01
申请号：US13206057
申请日：2011-08-09
申请人： Thomas Albert Engler , Timothy Paul Burkholder , Joshua Ryan Clayton , Clive Gideon Diefenbacher , Kelly Wayne Furness , James Robert Henry , Yihong Li , Sushant Malhotra , Angela Lynn Marquart , Johnathan Alexander McLean , David Mendel , Jon Kevin Reel , Brian Raymond Berridge , Charles Edward Ruegg , John Morris Sullivan
发明人： Thomas Albert Engler , Timothy Paul Burkholder , Joshua Ryan Clayton , Clive Gideon Diefenbacher , Kelly Wayne Furness , James Robert Henry , Yihong Li , Sushant Malhotra , Angela Lynn Marquart , Johnathan Alexander McLean , David Mendel , Jon Kevin Reel , Brian Raymond Berridge , Charles Edward Ruegg , John Morris Sullivan
IPC分类号： A61K31/551 , A61P19/08 , C07D487/04
CPC分类号： C07D471/06 , C07D487/06
摘要： The present invention provides kinase inhibitors of Formula I.
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公开(公告)号：US20110207721A1
公开(公告)日：2011-08-25
申请号：US13100618
申请日：2011-05-04
申请人： Thomas Albert Engler , Timothy Paul Burkholder , Joshua Ryan Clayton , Clive Gideon Diefenbacher , Kelly Wayne Furness , James Robert Henry , Yihong Li , Sushant Malhotra , Angela Lynn Marquart , Johnathan Alexander McLean , David Mendel , Jon Kevin Reel , Brian Raymond Berridge , Charles Edward Ruegg , John Morris Sullivan
发明人： Thomas Albert Engler , Timothy Paul Burkholder , Joshua Ryan Clayton , Clive Gideon Diefenbacher , Kelly Wayne Furness , James Robert Henry , Yihong Li , Sushant Malhotra , Angela Lynn Marquart , Johnathan Alexander McLean , David Mendel , Jon Kevin Reel , Brian Raymond Berridge , Charles Edward Ruegg , John Morris Sullivan
IPC分类号： A61K31/5517 , C07D487/04 , A61P3/10 , A61P25/28
CPC分类号： C07D471/06 , C07D487/06
摘要： The present invention provides kinase inhibitors of Formula I.
摘要翻译： 本发明提供式I的激酶抑制剂。
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公开(公告)号：US08058425B2
公开(公告)日：2011-11-15
申请号：US13100618
申请日：2011-05-04
申请人： Thomas Albert Engler , Timothy Paul Burkholder , Joshua Ryan Clayton , Clive Gideon Diefenbacher , Kelly Wayne Furness , James Robert Henry , Yihong Li , Sushant Malhotra , Angela Lynn Marquart , Johnathan Alexander McLean , David Mendel , Jon Kevin Reel , Brian Raymond Berridge , Charles Edward Ruegg , John Morris Sullivan
发明人： Thomas Albert Engler , Timothy Paul Burkholder , Joshua Ryan Clayton , Clive Gideon Diefenbacher , Kelly Wayne Furness , James Robert Henry , Yihong Li , Sushant Malhotra , Angela Lynn Marquart , Johnathan Alexander McLean , David Mendel , Jon Kevin Reel , Brian Raymond Berridge , Charles Edward Ruegg , John Morris Sullivan
IPC分类号： A61P25/08 , A61K31/55 , C07D487/06
CPC分类号： C07D471/06 , C07D487/06
摘要： The present invention provides kinase inhibitors of Formula I.
摘要翻译： 本发明提供式的激酶抑制剂。
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公开(公告)号：US07405305B2
公开(公告)日：2008-07-29
申请号：US10506029
申请日：2003-03-05
申请人： Pamela Ann Albaugh , Jochen Ammenn , Timothy Paul Burkholder , Joshua Ryan Clayton , Scott Eugene Conner , Brian Eugene Cunningham , Thomas Albert Engler , Kelly Wayne Furness , James Robert Henry , Sushant Malhotra , Mark Joseph Tebbe , Guoxin Zhu , YiHong Li , Brian Raymond Berridge , Charles Edward Ruegg , John Morris Sullivan
发明人： Pamela Ann Albaugh , Jochen Ammenn , Timothy Paul Burkholder , Joshua Ryan Clayton , Scott Eugene Conner , Brian Eugene Cunningham , Thomas Albert Engler , Kelly Wayne Furness , James Robert Henry , Sushant Malhotra , Mark Joseph Tebbe , Guoxin Zhu , YiHong Li , Brian Raymond Berridge , Charles Edward Ruegg , John Morris Sullivan
IPC分类号： C07D209/12 , C07D207/24 , C07D211/06
CPC分类号： C07D451/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D471/04 , C07D491/04
摘要： The present invention provides kinase inhibitors of Formula (I)
摘要翻译： 本发明提供式（I）的激酶抑制剂，
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![Imidazo[1,2-A]pyridine compounds as VEGF-R2 inhibitors](/abs-image/US/2010/02/23/US07666879B2/abs.jpg.150x150.jpg)
公开(公告)号：US07666879B2
公开(公告)日：2010-02-23
申请号：US11816416
申请日：2006-02-23
申请人： David Anthony Barda , Timothy Paul Burkholder , Joshua Ryan Clayton , Yan Hao , James Robert Henry , John Monte Knobeloch , Johnathan Alexander McLean , David Mendel , Mark Edward Rempala , Zhao-Qing Wang , Yvonne Yee Mai Yip , Boyu Zhong
发明人： David Anthony Barda , Timothy Paul Burkholder , Joshua Ryan Clayton , Yan Hao , James Robert Henry , John Monte Knobeloch , Johnathan Alexander McLean , David Mendel , Mark Edward Rempala , Zhao-Qing Wang , Yvonne Yee Mai Yip , Boyu Zhong
IPC分类号： A01N43/42 , A61K31/44 , C07D471/02 , C07D491/02 , C07D498/02 , C07D513/02 , C07D515/02 , C07D401/00
CPC分类号： C07D471/04
摘要： The present invention provides compounds that are inhibitors of VEGF-R2 of the formula: (I) and methods of using these compounds.
摘要翻译： 本发明提供了下式所示的VEGF-R2抑制剂的化合物：（I）和使用这些化合物的方法。
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![IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AS VEGF-R2 INHIBITORS](/abs-image/US/2009/09/10/US20090227622A1/abs.jpg.150x150.jpg)
公开(公告)号：US20090227622A1
公开(公告)日：2009-09-10
申请号：US11816416
申请日：2006-02-23
申请人： David Anthony Barda , Timothy Paul Burkholder , Joshua Ryan Clayton , Yan Hao , James Robert Henry , John Monte Knobeloch , Johnathan Alexander Mclean , David Mendel , Mark Edward Rempala , Zhao-Qing Wang , Yvonne Yee Yip , Boyu Zhong
发明人： David Anthony Barda , Timothy Paul Burkholder , Joshua Ryan Clayton , Yan Hao , James Robert Henry , John Monte Knobeloch , Johnathan Alexander Mclean , David Mendel , Mark Edward Rempala , Zhao-Qing Wang , Yvonne Yee Yip , Boyu Zhong
IPC分类号： A61K31/437 , C07D471/04
CPC分类号： C07D471/04
摘要： The present invention provides compounds that are inhibitors of VEGF-R2 of the formula: (I) and methods of using these compounds.
摘要翻译： 本发明提供了下式所示的VEGF-R2抑制剂的化合物：（I）和使用这些化合物的方法。
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公开(公告)号：US07897600B2
公开(公告)日：2011-03-01
申请号：US12632879
申请日：2009-12-08
IPC分类号： A61K31/5377 , C07D413/14
CPC分类号： C07D487/04
摘要： The present invention provides amino pyrazole compounds useful in the treatment of chronic myeloproliferative disorders and various cancers, e.g., glioblastoma, breast cancer, multiple myeloma, prostate cancer, and leukemias.
摘要翻译： 本发明提供可用于治疗慢性骨髓增生性疾病和各种癌症的氨基吡唑化合物，例如成胶质细胞瘤，乳腺癌，多发性骨髓瘤，前列腺癌和白血病。
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公开(公告)号：US20120149684A1
公开(公告)日：2012-06-14
申请号：US13391895
申请日：2010-10-20
申请人： Douglas Wade Beight , Timothy Paul Burkholder , Joshua Ryan Clayton , MariJean Eggen , Kenneth James Henry, JR. , Deidre Michelle Johns , Saravanan Parthasarathy , Huaxing Pei , Mark Edward Rempala , Jason Scott Sawyer
发明人： Douglas Wade Beight , Timothy Paul Burkholder , Joshua Ryan Clayton , MariJean Eggen , Kenneth James Henry, JR. , Deidre Michelle Johns , Saravanan Parthasarathy , Huaxing Pei , Mark Edward Rempala , Jason Scott Sawyer
IPC分类号： A61K31/519 , C07D487/04 , A61P35/00 , C07D471/04
CPC分类号： C07D471/04 , A61K31/519 , C07D487/04
摘要： The present invention provides AKT inhibitors of the formula: Formula I The present invention also provides pharmaceutical compositions comprising compounds of Formula I, uses of compounds of Formula I and method of using compounds of Formula I.
摘要翻译： 本发明提供下式的AKT抑制剂：式I本发明还提供包含式I化合物的药物组合物，式I化合物的用途和使用式I化合物的方法。
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公开(公告)号：US08436002B2
公开(公告)日：2013-05-07
申请号：US13391895
申请日：2010-10-20
申请人： Douglas Wade Beight , Timothy Paul Burkholder , Joshua Ryan Clayton , MariJean Eggen , Kenneth James Henry, Jr. , Deidre Michelle Johns , Saravanan Parthasarathy , Huaxing Pei , Mark Edward Rempala , Jason Scott Sawyer
发明人： Douglas Wade Beight , Timothy Paul Burkholder , Joshua Ryan Clayton , MariJean Eggen , Kenneth James Henry, Jr. , Deidre Michelle Johns , Saravanan Parthasarathy , Huaxing Pei , Mark Edward Rempala , Jason Scott Sawyer
IPC分类号： A01N43/54 , A01N43/90 , A01N43/42 , A01N43/40 , A61K31/517 , A61K31/519 , A61K31/44 , A61K31/445
CPC分类号： C07D471/04 , A61K31/519 , C07D487/04
摘要： The present invention provides AKT inhibitors of the formula: Formula I The present invention also provides pharmaceutical compositions comprising compounds of Formula I, uses of compounds of Formula I and method of using compounds of Formula I.
摘要翻译： 本发明提供下式的AKT抑制剂：式I本发明还提供包含式I化合物的药物组合物，式I化合物的用途和使用式I化合物的方法。
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