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公开(公告)号：US20110294792A1
公开(公告)日：2011-12-01
申请号：US13206057
申请日：2011-08-09
申请人： Thomas Albert Engler , Timothy Paul Burkholder , Joshua Ryan Clayton , Clive Gideon Diefenbacher , Kelly Wayne Furness , James Robert Henry , Yihong Li , Sushant Malhotra , Angela Lynn Marquart , Johnathan Alexander McLean , David Mendel , Jon Kevin Reel , Brian Raymond Berridge , Charles Edward Ruegg , John Morris Sullivan
发明人： Thomas Albert Engler , Timothy Paul Burkholder , Joshua Ryan Clayton , Clive Gideon Diefenbacher , Kelly Wayne Furness , James Robert Henry , Yihong Li , Sushant Malhotra , Angela Lynn Marquart , Johnathan Alexander McLean , David Mendel , Jon Kevin Reel , Brian Raymond Berridge , Charles Edward Ruegg , John Morris Sullivan
IPC分类号： A61K31/551 , A61P19/08 , C07D487/04
CPC分类号： C07D471/06 , C07D487/06
摘要： The present invention provides kinase inhibitors of Formula I.
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公开(公告)号：US20090105229A1
公开(公告)日：2009-04-23
申请号：US12333775
申请日：2008-12-12
申请人： Thomas Albert Engler , Timothy Paul Burkholder , Joshua Ryan Clayton , Clive Gideon Diefenbacher , Kelly Wayne Furness , James Robert Henry , Yihong Li , Sushant Malhotra , Angela Lynn Marquart , Johnathan Alexander McLean , David Mendel , Jon Kevin Reel
发明人： Thomas Albert Engler , Timothy Paul Burkholder , Joshua Ryan Clayton , Clive Gideon Diefenbacher , Kelly Wayne Furness , James Robert Henry , Yihong Li , Sushant Malhotra , Angela Lynn Marquart , Johnathan Alexander McLean , David Mendel , Jon Kevin Reel
IPC分类号： A61K31/5517 , C07D487/16
CPC分类号： C07D471/06 , C07D487/06
摘要： The present invention provides kinase inhibitors of Formula I.
摘要翻译： 本发明提供式I的激酶抑制剂。
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公开(公告)号：US20110207721A1
公开(公告)日：2011-08-25
申请号：US13100618
申请日：2011-05-04
申请人： Thomas Albert Engler , Timothy Paul Burkholder , Joshua Ryan Clayton , Clive Gideon Diefenbacher , Kelly Wayne Furness , James Robert Henry , Yihong Li , Sushant Malhotra , Angela Lynn Marquart , Johnathan Alexander McLean , David Mendel , Jon Kevin Reel , Brian Raymond Berridge , Charles Edward Ruegg , John Morris Sullivan
发明人： Thomas Albert Engler , Timothy Paul Burkholder , Joshua Ryan Clayton , Clive Gideon Diefenbacher , Kelly Wayne Furness , James Robert Henry , Yihong Li , Sushant Malhotra , Angela Lynn Marquart , Johnathan Alexander McLean , David Mendel , Jon Kevin Reel , Brian Raymond Berridge , Charles Edward Ruegg , John Morris Sullivan
IPC分类号： A61K31/5517 , C07D487/04 , A61P3/10 , A61P25/28
CPC分类号： C07D471/06 , C07D487/06
摘要： The present invention provides kinase inhibitors of Formula I.
摘要翻译： 本发明提供式I的激酶抑制剂。
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公开(公告)号：US08058425B2
公开(公告)日：2011-11-15
申请号：US13100618
申请日：2011-05-04
申请人： Thomas Albert Engler , Timothy Paul Burkholder , Joshua Ryan Clayton , Clive Gideon Diefenbacher , Kelly Wayne Furness , James Robert Henry , Yihong Li , Sushant Malhotra , Angela Lynn Marquart , Johnathan Alexander McLean , David Mendel , Jon Kevin Reel , Brian Raymond Berridge , Charles Edward Ruegg , John Morris Sullivan
发明人： Thomas Albert Engler , Timothy Paul Burkholder , Joshua Ryan Clayton , Clive Gideon Diefenbacher , Kelly Wayne Furness , James Robert Henry , Yihong Li , Sushant Malhotra , Angela Lynn Marquart , Johnathan Alexander McLean , David Mendel , Jon Kevin Reel , Brian Raymond Berridge , Charles Edward Ruegg , John Morris Sullivan
IPC分类号： A61P25/08 , A61K31/55 , C07D487/06
CPC分类号： C07D471/06 , C07D487/06
摘要： The present invention provides kinase inhibitors of Formula I.
摘要翻译： 本发明提供式的激酶抑制剂。
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公开(公告)号：US07405305B2
公开(公告)日：2008-07-29
申请号：US10506029
申请日：2003-03-05
申请人： Pamela Ann Albaugh , Jochen Ammenn , Timothy Paul Burkholder , Joshua Ryan Clayton , Scott Eugene Conner , Brian Eugene Cunningham , Thomas Albert Engler , Kelly Wayne Furness , James Robert Henry , Sushant Malhotra , Mark Joseph Tebbe , Guoxin Zhu , YiHong Li , Brian Raymond Berridge , Charles Edward Ruegg , John Morris Sullivan
发明人： Pamela Ann Albaugh , Jochen Ammenn , Timothy Paul Burkholder , Joshua Ryan Clayton , Scott Eugene Conner , Brian Eugene Cunningham , Thomas Albert Engler , Kelly Wayne Furness , James Robert Henry , Sushant Malhotra , Mark Joseph Tebbe , Guoxin Zhu , YiHong Li , Brian Raymond Berridge , Charles Edward Ruegg , John Morris Sullivan
IPC分类号： C07D209/12 , C07D207/24 , C07D211/06
CPC分类号： C07D451/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D471/04 , C07D491/04
摘要： The present invention provides kinase inhibitors of Formula (I)
摘要翻译： 本发明提供式（I）的激酶抑制剂，
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公开(公告)号：US07405299B2
公开(公告)日：2008-07-29
申请号：US10535381
申请日：2003-11-24
申请人： Douglas Wade Beight , Timothy Paul Burkholder , Todd Vincent Decollo , Alexander Glenn Godfrey , Charles Raymond Heap , Chi-Hsin Richard King , Hong-Yu Li , William Thomas McMillen , Jason Scott Sawyer , Yan Wang , Clive Gideon Diefenbacher , Thomas Albert Engler , Sushant Malhotra , Sreenivasa Reedy Mundla
发明人： Douglas Wade Beight , Timothy Paul Burkholder , Todd Vincent Decollo , Alexander Glenn Godfrey , Charles Raymond Heap , Chi-Hsin Richard King , Hong-Yu Li , William Thomas McMillen , Jason Scott Sawyer , Yan Wang , Clive Gideon Diefenbacher , Thomas Albert Engler , Sushant Malhotra , Sreenivasa Reedy Mundla
IPC分类号： C07D241/36 , C07D217/00 , C07D401/00
CPC分类号： C07D487/04
摘要： The current invention relates to compounds of the formula: (Ia) and the pharmaceutically acceptable salts thereof and their use as TGF-beta signal transduction inhibitors for treating cancer and other diseases in a patient in need thereof by administration of said compounds.
摘要翻译： 本发明涉及式（Ia）化合物及其药学上可接受的盐及其作为TGF-β信号转导抑制剂的用途，其用于通过施用所述化合物治疗有需要的患者中的癌症和其它疾病。
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公开(公告)号：US08022065B2
公开(公告)日：2011-09-20
申请号：US12333775
申请日：2008-12-12
IPC分类号： A61P25/28 , A61K31/55 , C07D487/06
CPC分类号： C07D471/06 , C07D487/06
摘要： The present invention provides kinase inhibitors of Formula I.
摘要翻译： 本发明提供式I的激酶抑制剂。
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公开(公告)号：US20080262004A1
公开(公告)日：2008-10-23
申请号：US11577094
申请日：2005-11-02
申请人： Clive Gideon Diefenbacher , Thomas Albert Engler , Hong-Yu Li , Sushant Malhotra , Jason Scott Sawyer , Yan Wang
发明人： Clive Gideon Diefenbacher , Thomas Albert Engler , Hong-Yu Li , Sushant Malhotra , Jason Scott Sawyer , Yan Wang
IPC分类号： A61K31/519 , C07D471/04 , A61K31/437 , A61P25/28 , A61P35/00 , C07D487/04
CPC分类号： C07D487/04 , C07D471/04 , C07D519/00
摘要： The present invention is directed to inhibitors of TGF-β of Formula I:
摘要翻译： 本发明涉及式I的TGF-β抑制剂：
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公开(公告)号：US07511056B2
公开(公告)日：2009-03-31
申请号：US11577094
申请日：2005-11-02
申请人： Clive Gideon Diefenbacher , Thomas Albert Engler , Hong-Yu Li , Sushant Malhotra , Jason Scott Sawyer , Yan Wang
发明人： Clive Gideon Diefenbacher , Thomas Albert Engler , Hong-Yu Li , Sushant Malhotra , Jason Scott Sawyer , Yan Wang
IPC分类号： A01N43/42 , A61K31/44 , C07D491/02 , C07D498/02 , C07D401/00
CPC分类号： C07D487/04 , C07D471/04 , C07D519/00
摘要： The present invention is directed to inhibitors of TGF-β of Formula I:
摘要翻译： 本发明涉及式I的TGF-β抑制剂：
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公开(公告)号：US07109229B2
公开(公告)日：2006-09-19
申请号：US10344245
申请日：2001-09-24
申请人： Thomas Albert Engler , Kelly Wayne Furness , Sushant Malhotra , Stephen Lyle Briggs , Harold Burns Brooks , David K yes Clawson , Concepcion Sanchez-Martinez , Faming Zhang , Guoxin Zhu
发明人： Thomas Albert Engler , Kelly Wayne Furness , Sushant Malhotra , Stephen Lyle Briggs , Harold Burns Brooks , David K yes Clawson , Concepcion Sanchez-Martinez , Faming Zhang , Guoxin Zhu
IPC分类号： A61K31/40 , C07D481/00
CPC分类号： C07D403/14 , C07D487/14
摘要： The compounds disclosed herein are indolocarbazoles of Formula (I), which are potent CDK4 inhibitors, and are useful in the treatment of cell proliferative disorders, including cancer. Formula (I).
摘要翻译： 本文公开的化合物是式（I）的吲哚并唑，其是有效的CDK4抑制剂，并且可用于治疗包括癌症的细胞增殖性疾病。 式（I）。
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