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公开(公告)号:US20090105229A1
公开(公告)日:2009-04-23
申请号:US12333775
申请日:2008-12-12
申请人: Thomas Albert Engler , Timothy Paul Burkholder , Joshua Ryan Clayton , Clive Gideon Diefenbacher , Kelly Wayne Furness , James Robert Henry , Yihong Li , Sushant Malhotra , Angela Lynn Marquart , Johnathan Alexander McLean , David Mendel , Jon Kevin Reel
发明人: Thomas Albert Engler , Timothy Paul Burkholder , Joshua Ryan Clayton , Clive Gideon Diefenbacher , Kelly Wayne Furness , James Robert Henry , Yihong Li , Sushant Malhotra , Angela Lynn Marquart , Johnathan Alexander McLean , David Mendel , Jon Kevin Reel
IPC分类号: A61K31/5517 , C07D487/16
CPC分类号: C07D471/06 , C07D487/06
摘要: The present invention provides kinase inhibitors of Formula I.
摘要翻译: 本发明提供式I的激酶抑制剂。
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公开(公告)号:US20110207721A1
公开(公告)日:2011-08-25
申请号:US13100618
申请日:2011-05-04
申请人: Thomas Albert Engler , Timothy Paul Burkholder , Joshua Ryan Clayton , Clive Gideon Diefenbacher , Kelly Wayne Furness , James Robert Henry , Yihong Li , Sushant Malhotra , Angela Lynn Marquart , Johnathan Alexander McLean , David Mendel , Jon Kevin Reel , Brian Raymond Berridge , Charles Edward Ruegg , John Morris Sullivan
发明人: Thomas Albert Engler , Timothy Paul Burkholder , Joshua Ryan Clayton , Clive Gideon Diefenbacher , Kelly Wayne Furness , James Robert Henry , Yihong Li , Sushant Malhotra , Angela Lynn Marquart , Johnathan Alexander McLean , David Mendel , Jon Kevin Reel , Brian Raymond Berridge , Charles Edward Ruegg , John Morris Sullivan
IPC分类号: A61K31/5517 , C07D487/04 , A61P3/10 , A61P25/28
CPC分类号: C07D471/06 , C07D487/06
摘要: The present invention provides kinase inhibitors of Formula I.
摘要翻译: 本发明提供式I的激酶抑制剂。
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公开(公告)号:US20110294792A1
公开(公告)日:2011-12-01
申请号:US13206057
申请日:2011-08-09
申请人: Thomas Albert Engler , Timothy Paul Burkholder , Joshua Ryan Clayton , Clive Gideon Diefenbacher , Kelly Wayne Furness , James Robert Henry , Yihong Li , Sushant Malhotra , Angela Lynn Marquart , Johnathan Alexander McLean , David Mendel , Jon Kevin Reel , Brian Raymond Berridge , Charles Edward Ruegg , John Morris Sullivan
发明人: Thomas Albert Engler , Timothy Paul Burkholder , Joshua Ryan Clayton , Clive Gideon Diefenbacher , Kelly Wayne Furness , James Robert Henry , Yihong Li , Sushant Malhotra , Angela Lynn Marquart , Johnathan Alexander McLean , David Mendel , Jon Kevin Reel , Brian Raymond Berridge , Charles Edward Ruegg , John Morris Sullivan
IPC分类号: A61K31/551 , A61P19/08 , C07D487/04
CPC分类号: C07D471/06 , C07D487/06
摘要: The present invention provides kinase inhibitors of Formula I.
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公开(公告)号:US08058425B2
公开(公告)日:2011-11-15
申请号:US13100618
申请日:2011-05-04
申请人: Thomas Albert Engler , Timothy Paul Burkholder , Joshua Ryan Clayton , Clive Gideon Diefenbacher , Kelly Wayne Furness , James Robert Henry , Yihong Li , Sushant Malhotra , Angela Lynn Marquart , Johnathan Alexander McLean , David Mendel , Jon Kevin Reel , Brian Raymond Berridge , Charles Edward Ruegg , John Morris Sullivan
发明人: Thomas Albert Engler , Timothy Paul Burkholder , Joshua Ryan Clayton , Clive Gideon Diefenbacher , Kelly Wayne Furness , James Robert Henry , Yihong Li , Sushant Malhotra , Angela Lynn Marquart , Johnathan Alexander McLean , David Mendel , Jon Kevin Reel , Brian Raymond Berridge , Charles Edward Ruegg , John Morris Sullivan
IPC分类号: A61P25/08 , A61K31/55 , C07D487/06
CPC分类号: C07D471/06 , C07D487/06
摘要: The present invention provides kinase inhibitors of Formula I.
摘要翻译: 本发明提供式的激酶抑制剂。
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公开(公告)号:US20050090483A1
公开(公告)日:2005-04-28
申请号:US10506459
申请日:2003-03-04
申请人: Thomas Engler , Timothy Burkholder , Joshua Clayton , Clive Diefenbacher , Kelly Furness , James Henry , Yihong Li , Sushant Malhotra , Angela Marquart , Johnathan McLean , David Mendel , Jon Reel
发明人: Thomas Engler , Timothy Burkholder , Joshua Clayton , Clive Diefenbacher , Kelly Furness , James Henry , Yihong Li , Sushant Malhotra , Angela Marquart , Johnathan McLean , David Mendel , Jon Reel
IPC分类号: A61K31/407 , A61K31/4355 , A61K31/4745 , A61K31/55 , A61K31/5513 , A61P3/10 , A61P25/08 , A61P25/28 , A61P43/00 , C07D471/06 , C07D487/06 , C07D498/06 , C07D519/00 , A61K31/551 , C07D487/14
CPC分类号: C07D471/06 , C07D487/06
摘要: The present invention provides kinase inhibitors of Formula I.
摘要翻译: 本发明提供式I的激酶抑制剂。
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6.Heterocyclic Compounds As Modulators Of Peroxisome Proliferator Activated Receptors, Useful For The Treatment And/Or Prevention Of Disorders Modulated By A Ppar 审中-公开
标题翻译: 杂环化合物作为过氧化物酶体增殖物激活受体的调节剂,可用于治疗和/或预防由Ppar调节的疾病公开(公告)号:US20080207685A1
公开(公告)日:2008-08-28
申请号:US10577828
申请日:2004-11-16
IPC分类号: A61K31/4709 , C07D217/24 , A61P3/10 , A61P9/10 , A61P3/04
CPC分类号: C07D413/12 , C07D217/06 , C07D413/14 , C07D417/12 , C07D417/14
摘要: The present invention is directed to a compound of formula (I), or a pharmaceutically acceptable salt, solvate, hydrate or stereoisomer thereof, which is useful in treating or preventing disorders mediated by a peroxisome proliferator activated receptor (PPAR) such as syndrome X, type II diabetes, hyperglycemia, hyperlipidemia, obesity, coagaulopathy, hypertension, arteriosclerosis, and other disorders related to syndrome X and cardiovascular diseases.
摘要翻译: 本发明涉及式(I)化合物或其药学上可接受的盐,溶剂合物,水合物或立体异构体,其可用于治疗或预防由过氧化物酶体增殖物激活受体(PPAR)介导的病症,例如综合征X, II型糖尿病,高血糖症,高脂血症,肥胖症,凝血病,高血压,动脉硬化以及与综合症X和心血管疾病相关的其它疾病。
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7.3-Pyridyloxymethyl heterocyclic ether compounds useful in controlling chemical synaptic transmission 失效
标题翻译: 用于控制化学突触传递的3-吡啶氧基甲基杂环醚化合物公开(公告)号:US6127386A
公开(公告)日:2000-10-03
申请号:US844540
申请日:1997-04-18
申请人: Nan-Horng Lin , Yun He , Mark W. Holladay , Keith B. Ryther , Yihong Li , Hao Bai
发明人: Nan-Horng Lin , Yun He , Mark W. Holladay , Keith B. Ryther , Yihong Li , Hao Bai
IPC分类号: A61K31/44 , A61K31/4427 , A61K31/4436 , A61K31/4439 , A61K31/445 , A61K31/4545 , A61K31/465 , A61K31/4709 , A61K31/497 , A61K31/501 , A61K31/505 , A61K31/506 , A61P25/00 , A61P43/00 , C07D401/12 , C07D401/14 , C07D405/14 , C07D407/14 , C07D409/14 , C07D213/30 , C07D471/02
CPC分类号: C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14
摘要: Novel 3-pyridyloxymethyl heterocyclic ether compounds of the formula: ##STR1## or the pharmaceutically-acceptable salts or prodrugs thereof are selective and potent ligands at neuronal nicotinic cholinergic channel receptors, and are effective in controlling synaptic transmission. Key intermediates and processes using this key intermediates to produce compounds of formula I with the variables defined in the specification are also described.
摘要翻译: 下式的新型3-吡啶氧基甲基杂环醚化合物或其药学上可接受的盐或前药是神经元烟碱胆碱能通道受体的选择性和有效配体,并且有效地控制突触传递。 还描述了使用该关键中间体产生具有本说明书中定义的变量的式I化合物的关键中间体和方法。
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8.3-pyridyloxymethyl heterocyclic ether compounds useful in controlling chemical synaptic transmission 失效
标题翻译: 可用于控制化学突触传播的3-吡啶氧基甲基杂环醚化合物公开(公告)号:US5629325A
公开(公告)日:1997-05-13
申请号:US660044
申请日:1996-06-06
申请人: Nan-Horng Lin , Yun He , Mark W. Holladay , Keith Ryther , Yihong Li
发明人: Nan-Horng Lin , Yun He , Mark W. Holladay , Keith Ryther , Yihong Li
IPC分类号: A61K31/44 , A61K31/4427 , A61K31/4436 , A61K31/4439 , A61K31/445 , A61K31/4545 , A61K31/465 , A61K31/4709 , A61K31/497 , A61K31/501 , A61K31/505 , A61K31/506 , A61P25/00 , A61P43/00 , C07D401/12 , C07D401/14 , C07D405/14 , C07D407/14 , C07D409/14 , C07D401/02
CPC分类号: C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14
摘要: Novel 3-pyridyloxymethyl heterocyclic ether compounds of the formula: ##STR1## or the pharmaceutically-acceptable salts or prodrugs thereof are selective and potent ligands at neuronal nicotinic cholinergic channel receptors, and are effective in controlling synaptic transmission.
摘要翻译: 具有下式的新颖的3-吡啶氧基甲基杂环醚化合物或其药学上可接受的盐或前药是神经元烟碱胆碱能通道受体的选择性和有效的配体,并且有效地控制突触传递。
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9.Methods and species-specific primers for detection and quantification of Streptococcus mutans and Streptococcus sanguinis in mixed bacterial samples 审中-公开
标题翻译: 在混合细菌样品中检测和定量变异链球菌和血链球菌的方法和物种特异性引物公开(公告)号:US20090305252A1
公开(公告)日:2009-12-10
申请号:US12156955
申请日:2008-06-04
申请人: Yihong Li , Page W. Caufield , Deepak Saxena , Zhou Chen
发明人: Yihong Li , Page W. Caufield , Deepak Saxena , Zhou Chen
CPC分类号: C12Q1/689 , C12Q2600/16
摘要: Dental caries is a polymicrobial infectious disease. Of the hundreds of bacteria present in the biofilms coating teeth, the Streptococcus mutans (S. mutans) remain strongly linked to caries and dental disease. Streptococcus sanguinis (S. sanguinis) may serve a protective or antagonistic role against the cariogenic bacterium S. mutans. In the present invention, exemplary sets of species-specific PCR primers are provided for the identification and quantification of S. mutans and of S. sanguinis in clinical samples, including the simultaneous and sensitive analysis of both bacterial species. Assays, kits and methods for determining the presence and amount of S. mutans and/or S. sanguinis are provided. Oligonucleotide probes and primers for use in the assays, kits and methods are described. Assays and methods for determining and evaluating an individual's oral bacteria, risk for caries, and effects of prevention and treatment modalities, are provided.
摘要翻译: 牙龋是一种多微生物感染性疾病。 在生物膜涂覆牙齿中存在的数百种细菌中,变形链球菌(变形链球菌)与龋齿和牙齿疾病密切相关。 血清链球菌(S.sanguinis)可能对致龋菌细菌变形链球菌起保护作用或拮抗作用。 在本发明中,提供了典型的物种特异性PCR引物组用于在临床样品中鉴定和定量变形链球菌和血清芽孢杆菌,包括对这两种细菌物种的同时和敏感的分析。 提供了用于确定变形链球菌和/或血清血友病的存在和量的测定,试剂盒和方法。 描述了用于测定,试剂盒和方法的寡核苷酸探针和引物。 提供了确定和评估个人口腔细菌,龋风险和预防和治疗方式的影响的方法和方法。
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10.
公开(公告)号:US06627767B2
公开(公告)日:2003-09-30
申请号:US09934765
申请日:2001-08-22
申请人: Gang Liu , Yihong Li , David A. Janowick , Zhonghua Pei
发明人: Gang Liu , Yihong Li , David A. Janowick , Zhonghua Pei
IPC分类号: C07C22900
CPC分类号: C07D207/26 , C07C233/56 , C07C235/24 , C07C237/22 , C07C259/06 , C07C311/51 , C07C2601/14 , C07D209/48 , C07D211/26 , C07D213/74 , C07D215/12 , C07D215/14 , C07D277/74 , C07D295/13 , C07D295/185 , C07D307/68 , C07D307/91 , C07D319/18 , C07D333/20 , C07D333/28 , C07D405/12
摘要: or therapeutically acceptable salts thereof, are protein tyrosine kinase PTP1B inhibitors. Preparation of the compounds, compositions containing the compounds, and treatment of diseases using the compounds are disclosed.
摘要翻译: 或其可治疗可接受的盐是蛋白酪氨酸激酶PTP1B抑制剂。 公开了化合物的制备,含有该化合物的组合物以及使用该化合物治疗疾病。
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