公开(公告)号：US5302708A

公开(公告)日：1994-04-12

申请号：US926589

申请日：1992-08-06

申请人： Thomas Beck ,  Werner H. Russ ,  Hartmut Springer ,  Marcus Banfer

发明人： Thomas Beck ,  Werner H. Russ ,  Hartmut Springer ,  Marcus Banfer

IPC分类号： C09B62/517 ,  D06P3/24 ,  D06P3/66 ,  C07F15/04 ,  C09B47/30

CPC分类号： C09B62/517

摘要： Phthalocyanine dyes, in particular copper phthalocyanine and nickel phthalocyanine dyes which contain one or more groups of the formula given and defined below ##STR1## or one or more carboxy groups or both groups and which furthermore can contain one or more sulfo groups, customary sulfonamide groups and/or groups of the formula given and defined below ##STR2## dye hydroxy- and/or carboxamide-containing materials, in particular fiber materials, such as cellulose fiber materials, wool and polyamide fibers, in fast, predominantly green hues of high color strength.In the formulae: R is hydrogen or a lower substituted or unsubstituted aliphatic radical, A is an aromatic carbocyclic or aromatic heterocyclic radical or an alkylene radical, which may be interrupted by 1 or 2 hetero groups, X is a direct bond or a divalent organic bridging member or together with the group --N(R)-- forms the divalent radical of a saturated heterocycle containing two N atoms, Y, in the case where A is an aromatic radical, is a direct bond or a carbamoylalkylene group or a methylene, ethylene, methylamino or .beta.-cyanoethylamino group, or Y is lower alkylene, in which case the grouping --X--A-- must be a direct bond and m is 2, Z is a fiber-reactive group of the vinylsulfonyl series and m is the number 1 or 2.

摘要翻译： 酞菁染料，特别是铜酞菁和镍酞菁染料，其含有一个或多个下式给出和定义的基团（* CHEMICAL STRUCTURE *）或一个或多个羧基或两个基团，并且还可以含有一个或多个磺基， 常规磺酰胺基团和/或下面给出和定义的式（*化学结构*）染料含羟基和/或羧酰胺的材料，特别是纤维材料，如纤维素纤维材料，羊毛和聚酰胺纤维，在快速， 主要是高色强度的绿色色调。 在下式中：R是氢或低级取代或未取代的脂族基团，A是芳族碳环或芳族杂环基或亚烷基，其可以被1或2个杂基间隔，X是直接键或二价有机 桥连成员或与基团-N（R）一起形成含有两个N原子的饱和杂环的二价基团，在A为芳族基团的情况下为直链或氨基甲酰基亚烷基或亚甲基， 乙烯，甲基氨基或（β） - 氰乙基氨基，或Y为低级亚烷基，在这种情况下，分组-XA-必须是直接键，m为2，Z为乙烯基磺酰基系列的纤维反应性基团，m为 数字1或2。

公开(公告)号：US5256776A

公开(公告)日：1993-10-26

申请号：US936138

申请日：1992-08-27

申请人： Thomas Beck ,  Werner H. Russ ,  Hartmut Springer ,  Marcus Banfer

发明人： Thomas Beck ,  Werner H. Russ ,  Hartmut Springer ,  Marcus Banfer

IPC分类号： C07D487/22 ,  C09B62/44 ,  C09B62/517 ,  C09B62/016 ,  D06P1/38 ,  D06P3/10 ,  D06P3/66

CPC分类号： C09B62/517 ,  C09B62/4418

摘要： Water-soluble phthalocyanine dyestuffs, processes for their preparation and their use Phthalocyanine dyestuffs, in particular copper phthalocyanine and nickel phthalocyanine dyestuffs, which contain one or more groups of the formula define below ##STR1## or one or more carboxy groups, or both groups, and which furthermore can have one or more sulfo groups, customary sulfonamide groups and/or groups of the general formula defined below ##STR2## dye materials containing hydroxy and/or carboxamide groups, in particular fiber materials, such as, for example, cellulose fiber materials, wool and polyamide fibers, in deep-colored, fast, mainly green shades. In the formulae:R.sup.1 and R.sup.2 are both, independently of one another, hydrogen or a lower optionally substituted aliphatic radical, G is lower alkylene, or is phenylene, which can be substituted by lower alkyl, lower alkoxy, halogen, sulfo, carboxy and/or nitro, or the grouping --N(R.sup.1)--G--N(R.sup.2)-- forms the bivalent radical of a saturated heterocyclic ring, W is halogen, lower alkoxy, aryloxy, sulfo, phenylsulfonyl, lower alkylsulfonyl or an optionally substituted amino group, or is a radical of the formula --N(R.sup.3)--A--(Y--Z).sub.m, where R.sup.3, A, Y, Z and m have the meaning given below, A is an aromatic carbocyclic or aromatic heterocyclic radical or an alkylene radical, which can be interrupted by 1 or 2 hetero groups, or is an alkylenephenylene radical or the bivalent radical of a saturated heterocyclic ring containing two N atoms, Y, in the case where A is an aromatic radical, is a direct bond or a carbamoyl-alkylene group or a methylene, ethylene, methylamino or .beta.-cyanoethyl-amino group, or Y is lower alkylene, and in this case A necessarily is a direct bond and m is 2, Z is a fiber-reactive group of the vinylsulfone series, m is the number 1 or 2 and R.sup.3 is hydrogen or lower alkyl.

公开(公告)号：US5231172A

公开(公告)日：1993-07-27

申请号：US964516

申请日：1992-10-21

申请人： Thomas Beck ,  Werner H. Russ ,  Wilhelm Muhlig

发明人： Thomas Beck ,  Werner H. Russ ,  Wilhelm Muhlig

IPC分类号： C09B62/503 ,  C09B62/505 ,  C09B62/51 ,  C09B62/513 ,  C09B62/515 ,  C09B62/517 ,  D06P3/14 ,  D06P3/24 ,  D06P3/66

CPC分类号： C09B62/503

摘要： There are described water-soluble fiber-reactive dye-stuffs which possess a triazinylamino radical to which is bonded as second substituent an amino group or an N-containing heterocyclic group which, bonded via an arylene, alkylene or aralkyl radical, possesses a fiber-reactive grouping of the vinyl sulfone series, and to which is bonded as third substituent a sulfonamide group, wherein the sulfone radical is substituted by optionally substituted aryl, alkylenearyl or arylenealkyl or optionally substituted amino groups.The dyestuffs are used for dyeing hydroxy - and/or carboxamido-containing material, in particular fiber material, such as cellulose fibers, wool and synthetic polyamide.

摘要翻译： 描述了具有作为第二取代基键合的三嗪基氨基的水溶性纤维反应性染料，氨基或含氮杂环基，其通过亚芳基，亚烷基或芳烷基键合，具有纤维 - 乙烯基砜系列的反应性分组，并且作为第三取代基与磺酰胺基团键合，其中砜基被任选取代的芳基，亚烷基硬脂基或亚芳基烷基或任选取代的氨基取代。 染料用于染色含羟基和/或羧酰胺的材料，特别是纤维材料，如纤维素纤维，羊毛和合成聚酰胺。

公开(公告)号：US5321134A

公开(公告)日：1994-06-14

申请号：US972139

申请日：1992-11-05

申请人： Thomas Beck ,  Werner H. Russ ,  Wilhelm Muhlig

发明人： Thomas Beck ,  Werner H. Russ ,  Wilhelm Muhlig

IPC分类号： C07D487/22 ,  C09B47/20 ,  C09B62/10 ,  C09B62/44 ,  C09B62/517 ,  C09B47/24

CPC分类号： C09B62/517 ,  C09B62/4418

摘要： There are described water-soluble phthalocyanine dyes, in particular copper phthalocyanine and nickel phthalocyanine dyes, which have the formula (1) defined hereinafter and can be used for the dyeing and printing of hydroxy and/or carboxyamido-containing fiber material, such as cotton, wool and synthetic polyamide, by the techniques customary in the art for fiber-reactive dyes. ##STR1## in which Pc is a phthalocyanine radical, R.sup.1 and R.sup.2 are both hydrogen or alkyl, A is an aromatic carboxylic or heterocyclic radical, which may be substituted by substituents customary in dyes, or is an alkylene radical, which may be substituted by 1 or 2 hetero groups, X is a direct bond or a divalent organic binding link, such as an alkylene radical or an alkyleneamino group, Y is a direct bond or a group of the formula --CO--NH--alkylene-- or a methylamino or .beta.-cyanoethylamino group, Z is a fiber-reactive radical from the vinylsulfonyl series or is .beta.-hydroxyethylsulfonyl, m is the number 1 or 2, W is halogen, sulfo, phenylsulfonyl, alkylsulfonyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms or substituted or unsubstituted aryloxy or W is an amino group of the formula (2) or (3) ##STR2## in which R.sup.2, X, A, Y, Z and m have one of the above-mentioned meanings, and R.sup.3 is hydrogen or substituted or unsubstituted alkyl or cycloalkyl and R.sup.4 is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted phenyl or cyano, or R.sup.3 and R.sup.4, together with the nitrogen atom, form a heterocyclic ring, a is a number from 1 to 4 and b is a number from zero to 3, and the sum of (a+b) is a number from 1 to 4, and M is a hydrogen atom or an alkali metal or another salt-forming metal.

摘要翻译： 描述了具有下文定义的式（1）的水溶性酞菁染料，特别是铜酞菁和镍酞菁染料，可用于染色和印刷含有羟基和/或羧酰氨基的纤维材料如棉花 ，羊毛和合成聚酰胺，通过本领域中用于纤维活性染料的技术。 （1）其中Pc是酞菁基团，R 1和R 2都是氢或烷基，A是芳族羧酸或杂环基，其可以被染料中常规的取代基取代，或者是亚烷基，其可以是 被1或2个杂基团取代，X是直接键或二价有机结合键，例如亚烷基或亚烷基氨基，Y是直接键或式-CO-NH-亚烷基 - 或 甲基氨基或β-氰基乙基氨基，Z为乙烯基磺酰基系列的纤维反应性基团或为β-羟基乙基磺酰基，m为数1或2，W为卤素，磺基，苯磺酰基，1至4个碳原子的烷基磺酰基，烷氧基 具有1至4个碳原子或取代或未取代的芳氧基或W是式（2）或（3）的氨基。其中R2，X，A，Y，Z 并且m具有上述含义之一，且R 3为氢或取代或未取代的烷基或环烷基，且R 4为氢， 取代或未取代的烷基，取代或未取代的苯基或氰基，或R 3和R 4与氮原子一起形成杂环，a为1至4的数，b为0至3的数， （a + b）为1〜4的数，M为氢原子或碱金属或其他成盐金属。

公开(公告)号：US09791531B2

公开(公告)日：2017-10-17

申请号：US14231118

申请日：2014-03-31

申请人： Thomas Beck ,  Rainer Schneider

发明人： Thomas Beck ,  Rainer Schneider

IPC分类号： G01R33/24 ,  G01R33/54 ,  G01R33/58

CPC分类号： G01R33/543 ,  G01R33/243 ,  G01R33/246 ,  G01R33/583

摘要： A method for establishing a magnetic resonance system actuation sequence is described. A first number of field distribution maps are acquired for slices of the measurement region, and a radiofrequency pulse train is established on the basis thereof for the magnetic resonance system actuation sequence. This acquisition of the first number of field distribution maps may be brought about on the basis of an acquisition scheme. A reduced number of field distribution representation maps are established on the basis of the acquired field distribution maps, which field distribution representation maps represent the first number of acquired field distribution maps in accordance with a predetermined optimization criterion, and the radiofrequency pulse train is established on the basis of the field distribution representation maps.

公开(公告)号：US09109391B2

公开(公告)日：2015-08-18

申请号：US12693556

申请日：2010-01-26

申请人： Thomas Beck ,  Christina Biermann

发明人： Thomas Beck ,  Christina Biermann

IPC分类号： G06K9/00 ,  E06B5/16 ,  E06B3/56 ,  E06B3/263 ,  E06B3/70

CPC分类号： E06B5/161 ,  A61B6/00 ,  E06B3/56 ,  E06B2003/2631 ,  E06B2003/7078 ,  G06K9/4638 ,  G06K9/62 ,  G06K2209/055 ,  G06T7/11 ,  G06T7/12 ,  G06T7/136 ,  G06T7/187 ,  G06T7/33 ,  G06T2207/30101

摘要： A method is disclosed for determining a branching point within a hollow organ in image data representing the spatial structure thereof. In at least one embodiment, the method includes setting a start point within the hollow organ; determining at least one local threshold which corresponds to the presence of a wall of the hollow organ; carrying out a region growing method using the threshold; analyzing the connectivity of a number of outer growth layers; and localizing a branching on the basis of the connectivity analysis. Moreover, at least one embodiment of the invention relates to a correspondingly designed branching determination unit.

摘要翻译： 公开了一种用于在表示其空间结构的图像数据中确定中空器官内的分支点的方法。 在至少一个实施例中，该方法包括设置中空器官内的起始点; 确定对应于所述中空器官的壁的存在的至少一个局部阈值; 使用阈值进行区域增长方法; 分析多个外生长层的连通性; 并在连通性分析的基础上本地化分支。 此外，本发明的至少一个实施例涉及相应设计的分支确定单元。

公开(公告)号：US08618439B2

公开(公告)日：2013-12-31

申请号：US13397057

申请日：2012-02-15

申请人： Thomas Beck ,  Nigel-Philip Cox ,  Silke Settegast

发明人： Thomas Beck ,  Nigel-Philip Cox ,  Silke Settegast

IPC分类号： B23K26/38 ,  B23K15/08

CPC分类号： B23K15/085 ,  B23K26/384 ,  B23K26/389 ,  B23K2101/001 ,  F01D5/186 ,  F05D2230/13 ,  Y02T50/67 ,  Y02T50/676 ,  Y10T29/49341

摘要： There are a multiplicity of methods of making through-holes. In particular in the production of a multiplicity of film-cooling holes, as in gas turbine blades or combustion chamber elements, small time advantages are also important when making a hole. The method according to the invention, to make the hole close to the final contour in each case in sections in a top and a bottom region in order to then produce the final contour with other laser parameters, achieves time advantages.

摘要翻译： 有多种形成通孔的方法。 特别是在制造多个薄膜冷却孔时，如在燃气轮机叶片或燃烧室元件中，小的时间优点在制造孔时也是重要的。 根据本发明的方法，为了使其在顶部和底部区域中的每一种情况下，使得孔接近于最终轮廓，以便随后用其他激光参数产生最终轮廓，这实现了时间优点。

公开(公告)号：US20130012438A1

公开(公告)日：2013-01-10

申请号：US13458086

申请日：2012-04-27

申请人： Henry Blair ,  Thomas Beck ,  Robert Charles Ladner

发明人： Henry Blair ,  Thomas Beck ,  Robert Charles Ladner

IPC分类号： A61K38/17 ,  A61P29/00 ,  A61P9/10 ,  A61K38/11

CPC分类号： A61K38/55 ,  A61K31/195 ,  A61K38/57 ,  A61K45/06 ,  A61K2300/00

摘要： Methods, kits and compositions are described that include a non-naturally occurring kallikrein inhibitor and an anti-thrombolytic agent, e.g., an anti-fibrinolytic agent, for preventing or reducing blood loss and/or ischemia, e.g., ischemia associated with perioperative blood loss and cerebral ischemia, the onset of systemic inflammatory response, and/or reperfusion injury, e.g., reperfusion injury associated with cerebral ischemia or a focal brain ischemia, e.g., in patients subjected to invasive surgical procedures, especially procedures requiring cardiopulmonary bypass.

摘要翻译： 描述了包括非天然存在的激肽释放酶抑制剂和抗血栓溶解剂（例如抗纤维蛋白溶解剂）的方法，试剂盒和组合物，用于预防或减少失血和/或缺血，例如与围手术期失血相关的缺血 脑缺血，全身炎症反应发作和/或再灌注损伤，例如与脑缺血或局灶性脑缺血相关的再灌注损伤，例如在经历侵入性外科手术的患者中，特别是需要体外循环的手术。

公开(公告)号：US08237082B2

公开(公告)日：2012-08-07

申请号：US12223204

申请日：2007-01-05

申请人： Thomas Beck ,  Silke Settegast

发明人： Thomas Beck ,  Silke Settegast

IPC分类号： B23K26/38

CPC分类号： B23K26/0648 ,  B23K26/0622 ,  B23K26/064 ,  B23K26/0665 ,  B23K26/389

摘要： There is described a method for producing a hole using e.g. a lasers, wherein short laser pulse durations are used. The laser pulse durations are varied, short laser pulse durations being utilized only in the area to be removed in which an influence on the penetration behavior and discharge behavior is noticeable while longer pulse durations of >0.4 ms are used. This is the case for the inner surface of a diffuser of a hole, for example, which can be produced very accurately by means of short laser pulse durations.

摘要翻译： 描述了使用例如制造孔的方法。 激光器，其中使用短激光脉冲持续时间。 激光脉冲持续时间是变化的，短激光脉冲持续时间仅在要去除的区域中被使用，其中在使用> 0.4ms的较长脉冲持续时间时，对穿透行为和放电行为的影响是显着的。 这是例如孔的扩散器的内表面的情况，例如，可以通过短的激光脉冲持续时间非常精确地制造。

公开(公告)号：US08188045B2

公开(公告)日：2012-05-29

申请号：US11804388

申请日：2007-05-18

申请人： Henry Blair ,  Thomas Beck ,  Robert C. Ladner

发明人： Henry Blair ,  Thomas Beck ,  Robert C. Ladner

IPC分类号： A61K38/16 ,  A61P7/02 ,  C07K14/00

CPC分类号： A61K38/55 ,  A61K31/195 ,  A61K38/57 ,  A61K45/06 ,  A61K2300/00

摘要： Methods, kits and compositions are described that include a non-naturally occurring kallikrein inhibitor and an anti-thrombolytic agent, e.g., an anti-fibrinolytic agent, for preventing or reducing blood loss and/or ischemia, e.g., ischemia associated with perioperative blood loss and cerebral ischemia, the onset of systemic inflammatory response, and/or reperfusion injury, e.g., reperfusion injury associated with cerebral ischemia or a focal brain ischemia, e.g., in patients subjected to invasive surgical procedures, especially procedures requiring cardiopulmonary bypass.

摘要翻译： 描述了包括非天然存在的激肽释放酶抑制剂和抗血栓溶解剂（例如抗纤维蛋白溶解剂）的方法，试剂盒和组合物，用于预防或减少失血和/或缺血，例如与围手术期失血相关的缺血 脑缺血，全身炎症反应发作和/或再灌注损伤，例如与脑缺血或局灶性脑缺血相关的再灌注损伤，例如在经历侵入性外科手术的患者中，特别是需要体外循环的手术。