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    Polypeptides having affinity for HER2
    6.
    发明授权
    Polypeptides having affinity for HER2 有权
    对HER2具有亲和力的多肽

    公开(公告)号：US08501909B2

    公开(公告)日：2013-08-06

    申请号：US12735068

    申请日：2008-12-22

    申请人： Lars Abrahmsén ,  Nina Herne ,  Joachim Feldwisch ,  Christofer Lendel ,  Vladimir Tolmachev

    发明人： Lars Abrahmsén ,  Nina Herne ,  Joachim Feldwisch ,  Christofer Lendel ,  Vladimir Tolmachev

    IPC分类号： A61K38/00 ,  A61K51/08 ,  A61K49/00

    CPC分类号： A61K51/08 ,  A61K38/00 ,  A61K51/088 ,  C07K16/32

    摘要： HER2 binding polypeptides comprising the amino acid sequence EX1 RNAYWEIA LLPNLTNQQK RAFIRKLYDD PSQSSELLX2E AKKLNDSQ wherein X1 in position 2 is M, I or L, and X2 in position 39 is S or C (SEQ ID NO: 1) are disclosed. Moreover, such peptides comprising a chelating environment are disclosed. Also radiolabeled polypeptides formed by the peptides comprising a chelating environment and radionuclides are disclosed. Furthermore, methods of in vivo imaging of the body of a mammalian subject having or suspected of having a cancer characterized by overexpression of HER2 comprising administration of such a radiolabeled polypeptide followed by obtainment of an image of the body using a medical imaging instrument and also methods of treating such cancer are disclosed. Furthermore, the use of such a radiolabeled polypeptide in diagnosis and treatment of cancer characterized by overexpression of HER2. Nucleic acids encoding the polypeptides, expression vectors comprising the nucleic acids and host cells comprising the expression vectors are also disclosed.

    摘要翻译： HER2结合多肽包含氨基酸序列EX1 RNAYWEIA LLPNLTNQQK RAFIRKLYDD PSQSSELLX2E AKKLNDSQ，其中位置2中的X1是M，I或L，而位置39的X2是S或C（SEQ ID NO：1）。 此外，公开了包含螯合环境的这些肽。 还公开了由包含螯合环境和放射性核素的肽形成的放射性标记的多肽。 此外，具有或怀疑具有HER2过表达的哺乳动物受试者的身体的体内成像方法包括施用这种放射性标记的多肽，然后使用医学成像仪获得身体的图像，以及方法 公开了治疗这种癌症的方法。 此外，这种放射性标记的多肽在诊断和治疗HER2过表达的癌症中的应用。 还公开了编码多肽的核酸，包含核酸的表达载体和包含表达载体的宿主细胞。

    Polypeptide derived from protein A and able to bind PDGF
    7.
    发明授权
    Polypeptide derived from protein A and able to bind PDGF 有权
    衍生自蛋白A​​并能够结合PDGF的多肽

    公开(公告)号：US09187535B2

    公开(公告)日：2015-11-17

    申请号：US12735070

    申请日：2008-12-17

    申请人： Malin Lindborg ,  Elin Gunneriusson ,  Christofer Lendel

    发明人： Malin Lindborg ,  Elin Gunneriusson ,  Christofer Lendel

    IPC分类号： C07K14/31

    CPC分类号： C07K14/31 ,  C07K2318/20 ,  C07K2319/00

    摘要： The invention provides a platelet derived growth factor receptor beta (PDGF-Rβ) binding polypeptide, comprising a platelet derived growth factor receptor beta binding motif, PBM, which motif consists of an amino acid sequence as defined herein, wherein the PDGF-Rβ-binding polypeptide binds to PDGF-Rβ such that the KD value of the interaction is at most 1×10−6 M. Also provided are methods and uses of said polypeptide in treatment and diagnosis of PDGF-Rβ-related conditions.

    摘要翻译： 本发明提供了一种血小板衍生生长因子受体β（PDGF-R＆bgr）结合多肽，其包含血小板衍生生长因子受体β结合基序，PBM，该基序由本文定义的氨基酸序列组成，其中PDGF-R＆bgr; 结合多肽结合PDGF-R＆bgr; 使得相互作用的KD值至多为1×10 -6 M。还提供了所述多肽在治疗和诊断PDGF-R＆bgr相关病症中的方法和用途。

    POLYPEPTIDES HAVING AFFINITY FOR HER2
    9.
    发明申请
    POLYPEPTIDES HAVING AFFINITY FOR HER2 有权
    具有HER2的亲和力的多肽

    公开(公告)号：US20110020223A1

    公开(公告)日：2011-01-27

    申请号：US12735068

    申请日：2008-12-22

    申请人： Lars Abrahmsén ,  Nina Herne ,  Joachim Feldwisch ,  Christofer Lendel ,  Vladimir Tolmachew

    发明人： Lars Abrahmsén ,  Nina Herne ,  Joachim Feldwisch ,  Christofer Lendel ,  Vladimir Tolmachew

    IPC分类号： A61K51/08 ,  C07K14/00 ,  A61P35/00 ,  C12N15/12 ,  C12N15/63 ,  C12N5/00

    CPC分类号： A61K51/08 ,  A61K38/00 ,  A61K51/088 ,  C07K16/32

    摘要： HER2 binding polypeptides comprising the amino acid sequence EX1 RNAYWEIA LLPNLTNQQK RAFIRKLYDD PSQSSELLX2E AKKLNDSQ wherein X1 in position 2 is M, I or L, and X2 in position 39 is S or C (SEQ ID NO:1) are disclosed. Moreover, such peptides comprising a chelating environment are disclosed. Also radiolabeled polypeptides formed by the peptides comprising a chelating environment and radionuclides are disclosed. Furthermore, methods of in vivo imaging of the body of a mammalian subject having or suspected of having a cancer characterized by overexpression of HER2 comprising administration of such a radiolabeled polypeptide followed by obtainment of an image of the body using a medical imaging instrument and also methods of treating such cancer are disclosed. Furthermore, the use of such a radiolabeled polypeptide in diagnosis and treatment of cancer characterized by overexpression of HER2. Nucleic acids encoding the polypeptides, expression vectors comprising the nucleic acids and host cells comprising the expression vectors are also disclosed.

    摘要翻译： HER2结合多肽包含氨基酸序列EX1 RNAYWEIA LLPNLTNQQK RAFIRKLYDD PSQSSELLX2E AKKLNDSQ，其中位置2中的X1是M，I或L，而位置39的X2是S或C（SEQ ID NO：1）。 此外，公开了包含螯合环境的这些肽。 还公开了由包含螯合环境和放射性核素的肽形成的放射性标记的多肽。 此外，具有或怀疑具有HER2过表达的哺乳动物受试者的身体的体内成像方法包括施用这种放射性标记的多肽，然后使用医学成像仪获得身体的图像，以及方法 公开了治疗这种癌症的方法。 此外，这种放射性标记的多肽在诊断和治疗HER2过表达的癌症中的应用。 还公开了编码多肽的核酸，包含核酸的表达载体和包含表达载体的宿主细胞。

    Polypeptide libraries with a predetermined scaffold
    10.
    发明授权
    Polypeptide libraries with a predetermined scaffold 有权
    具有预定支架的多肽文库

    公开(公告)号：US09469670B2

    公开(公告)日：2016-10-18

    申请号：US12735069

    申请日：2008-12-22

    申请人： Lars Abrahmsén ,  Nina Herne ,  Christofer Lendel ,  Joachim Feldwisch

    发明人： Lars Abrahmsén ,  Nina Herne ,  Christofer Lendel ,  Joachim Feldwisch

    IPC分类号： C40B40/10 ,  C07K1/04 ,  C12N15/10 ,  C07K14/31

    CPC分类号： C07K14/31 ,  C07K1/047 ,  C12N15/1037 ,  C12N15/1041 ,  C12N15/1044 ,  C12N15/1075 ,  C40B40/10 ,  G01N33/6845 ,  G01N2333/31

    摘要： Populations of polypeptide variants based on a common scaffold, each polypeptide in the population comprising the scaffold amino acid sequence EXXXAXXEIX XLPNLTXXQX XAFIXKLXDD PSQSSELLSE AKKLNDSQ (SEQ ID NO: 1) or AKYAKEXXXAXX EIXXLPNLTX XQXXAFIXKL XDDPSQSSEL LSEAKKLNDS Q (SEQ ID NO:2), wherein each X individually corresponds to an amino acid residue which is varied in the population are disclosed. Also populations of polynucleotides, wherein each member encodes a member of a polypeptide population are disclosed. Furthermore, combinations of such polypeptide populations and such polynucleotide populations are disclosed, wherein each member of polypeptide population is physically or spatially associated with the polynucleotide encoding that member via means for genotype-phenotype coupling.

    摘要翻译： 基于共同支架的多肽变体群体，群体中的每个多肽包含支架氨基酸序列EXXXAXXEIX XLPNLTXXQX XAFIXKLXDD PSQSSELLSE AKKLNDSQ（SEQ ID NO：1）或AKYAKEXXXAXX EIXXLPNLTX XQXXAFIXKL XDDPSQSSEL LSEAKKLNDS Q（SEQ ID NO：2），其中每个 X分别对应于在群体中变化的氨基酸残基。 还公开了多核苷酸的种群，其中每个成员编码多肽群体的成员。 此外，公开了这种多肽群体和这种多核苷酸群体的组合，其中多肽群体的每个成员通过用于基因型 - 表型偶联的方式与编码该成员的多核苷酸物理或空间相关联。