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公开(公告)号：US06261820B1
公开(公告)日：2001-07-17
申请号：US09411329
申请日：1999-10-01
申请人： Thomas C. Boone , Huimin Li , Michael B. Mann
发明人： Thomas C. Boone , Huimin Li , Michael B. Mann
IPC分类号： C12N948
CPC分类号： C12N9/6489 , A61K38/1703 , C12N9/6418
摘要： A fibrinolytically active metalloproteinase polypeptide (called “novel acting thrombolytic”) which is useful for blood clot lysis in vivo and methods and materials for its production by recombinant expression are described.
摘要翻译： 描述了可用于体内血液凝块溶解的纤维蛋白溶解活性金属蛋白酶多肽（称为“新型作用溶栓剂”），以及通过重组表达生产其的方法和材料。
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公开(公告)号：US07195903B2
公开(公告)日：2007-03-27
申请号：US10441667
申请日：2003-05-20
申请人： Thomas C. Boone , Huimin Li , Michael B. Mann
发明人： Thomas C. Boone , Huimin Li , Michael B. Mann
IPC分类号： C12N9/48 , C12N15/00 , C12N1/20 , C12N5/00 , C12P21/04 , A61K38/48 , C07H21/04 , C12Q1/00 , C12Q1/68 , C12N1/14 , A01N25/00
CPC分类号： C12N9/6489 , A61K38/1703 , C12N9/6418
摘要： A fibrinolytically active metalloproteinase polypeptide (called “novel acting thrombolytic”) which is useful for blood clot lysis in vivo and methods and materials for its production by recombinant expression are described.
摘要翻译： 描述了可用于体内血液凝块溶解的纤维蛋白溶解活性金属蛋白酶多肽（称为“新型作用溶栓剂”），以及通过重组表达生产其的方法和材料。
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公开(公告)号：US06617145B2
公开(公告)日：2003-09-09
申请号：US09846729
申请日：2001-05-01
申请人： Thomas C. Boone , Huimin Li , Michael B. Mann
发明人： Thomas C. Boone , Huimin Li , Michael B. Mann
IPC分类号： C12N950
CPC分类号： C12N9/6489 , A61K38/1703 , C12N9/6418
摘要： A fibrinolytically active metalloproteinase polypeptide (called “novel acting thrombolytic”) which is useful for blood clot lysis in vivo and methods and materials for its production by recombinant expression are described.
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4.发明申请公开(公告)号：US20120129771A1
公开(公告)日：2012-05-24
申请号：US13364015
申请日：2012-02-01
申请人： Thomas C. Boone , Kenneth C. Wild , Karen C. Sitney , Hosung Min , Bruce Kimmel
发明人： Thomas C. Boone , Kenneth C. Wild , Karen C. Sitney , Hosung Min , Bruce Kimmel
IPC分类号： A61K38/10 , C07H21/00 , C12N15/63 , A61P25/00 , C07K14/00 , A61K38/16 , C07K17/02 , C07K7/08 , C12N15/11
CPC分类号： C07K16/22 , A61K38/00 , C07H21/04 , C07K7/08 , C07K14/001
摘要： The present invention relates to certain biologically active peptides and polypeptides which can be used as therapeutics or prophylactics against diseases or disorders linked to NGF as the causative agent. In one aspect of the present invention, pharmacologically active polypeptides comprising peptides linked to one or more Fc domains are provided.
摘要翻译： 本发明涉及某些生物活性肽和多肽，其可以用作治疗剂或预防药物以抵抗作为致病剂与NGF相关的疾病或病症。 在本发明的一个方面，提供了包含与一个或多个Fc结构域连接的肽的药理活性多肽。
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公开(公告)号：US07994136B1
公开(公告)日：2011-08-09
申请号：US07355027
申请日：1989-05-19
CPC分类号： C07K14/8146 , A61K38/00
摘要： A novel metalloproteinase inhibitor, analogs thereof, polynucleotides encoding the same, and methods of production, are disclosed. Pharmaceutical compositions and methods of treating disorders caused by excessive amounts of metalloproteinase are also disclosed.
摘要翻译： 公开了一种新型金属蛋白酶抑制剂，其类似物，其编码的多核苷酸及其制备方法。 还公开了治疗由过量金属蛋白酶引起的疾病的药物组合物和方法。
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公开(公告)号：US07928075B2
公开(公告)日：2011-04-19
申请号：US12322977
申请日：2009-02-10
申请人： Hq Han , Hosung Min , Thomas C. Boone
发明人： Hq Han , Hosung Min , Thomas C. Boone
CPC分类号： C07K16/22 , A61K38/00 , A61K2039/505 , C07K14/00 , C07K14/475 , C07K2317/21 , C07K2317/94 , C07K2319/00 , C07K2319/30 , C07K2319/35 , C12N2710/14143 , G01N33/567 , G01N33/74 , G01N2333/475
摘要： The present invention provides binding agents comprising peptides capable of binding myostatin and inhibiting its activity. In one embodiment the binding agent comprises at least one myostatin-binding peptide attached directly or indirectly to at least one vehicle such as a polymer or an Fc domain. The binding agents of the present invention produced increased lean muscle mass when administered to animals and decreased fat to muscle ratios. Therapeutic compositions containing the binding agents of the present invention are useful for treating muscle-wasting disorders and metabolic disorders including diabetes and obesity.
摘要翻译： 本发明提供了包含能够结合肌生成抑制素并抑制其活性的肽的结合剂。 在一个实施方案中，结合剂包含至少一种与至少一种载体如聚合物或Fc结构域直接或间接连接的肌肉生长抑制素结合肽。 本发明的粘合剂在施用于动物时产生瘦肌肉质量的降低，并且脂肪与肌肉的比例降低。 含有本发明结合剂的治疗组合物可用于治疗肌肉消瘦疾病和代谢紊乱，包括糖尿病和肥胖症。
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公开(公告)号：US06946264B1
公开(公告)日：2005-09-20
申请号：US08397320
申请日：1995-03-02
IPC分类号： C12N15/09 , A61K38/00 , A61K38/55 , A61K39/395 , A61P29/00 , A61P35/00 , A61P43/00 , C07K14/00 , C07K14/81 , C07K16/00 , C07K16/38 , C12N1/11 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/99 , C12N15/02 , C12N15/15 , C12N15/70 , C12N15/81 , C12N15/85 , C12P21/00 , C12P21/02 , C12P21/08 , C12R1/19 , C12R1/865 , C12R1/91
CPC分类号： C12N15/81 , A61K38/00 , C07K14/8146 , C07K16/38 , C07K2319/02 , C12N15/70 , C12N15/85 , C12N2800/108 , C12N2840/44
摘要： A novel metalloproteinase inhibitor, analogs thereof, polynucleotides encoding the same, and methods of production, are disclosed. Pharmaceutical compositions and methods of treating disorders caused by excessive amounts of metalloproteinase are also disclosed.
摘要翻译： 公开了一种新型金属蛋白酶抑制剂，其类似物，其编码的多核苷酸及其制备方法。 还公开了治疗由过量金属蛋白酶引起的疾病的药物组合物和方法。
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公开(公告)号：US06849450B2
公开(公告)日：2005-02-01
申请号：US08803954
申请日：1997-02-21
CPC分类号： C07K16/38 , A61K38/00 , C07K14/8146 , C07K2319/02 , C12N15/70 , C12N15/81 , C12N15/85 , C12N2800/108 , C12N2830/00 , C12N2830/002 , C12N2830/702 , C12N2840/44
摘要： A novel metalloproteinase inhibitor, analogs thereof, polynucleotides encoding the same, and methods of production, are disclosed. Pharmaceutical compositions and methods of treating disorders caused by excessive amounts of metalloproteinase are also disclosed.
摘要翻译： 公开了一种新型金属蛋白酶抑制剂，其类似物，其编码的多核苷酸及其制备方法。 还公开了治疗由过量金属蛋白酶引起的疾病的药物组合物和方法。
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公开(公告)号：US09102731B2
公开(公告)日：2015-08-11
申请号：US12642711
申请日：2009-12-18
申请人： Thomas C. Boone , David W. Brankow , Colin V. Gegg, Jr. , Shaw-Fen Sylvia Hu , Chadwick T. King , Hsieng Sen Lu , Licheng Shi , Cen Xu
发明人： Thomas C. Boone , David W. Brankow , Colin V. Gegg, Jr. , Shaw-Fen Sylvia Hu , Chadwick T. King , Hsieng Sen Lu , Licheng Shi , Cen Xu
CPC分类号： C07K16/2869 , A61K39/395 , A61K39/39533 , A61K2039/505 , C07K2317/21 , C07K2317/32 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2319/30
摘要： Antigen binding proteins that bind to human CGRP receptor (CGRP R) are provided. Nucleic acids encoding the antigen binding protein, vectors, and cells encoding the same are also provided. The antigen binding proteins can inhibit binding of CGRP R to CGRP, and are useful in a number of CGRP R related disorders, including the treatment and/or prevention of migraine headaches.
摘要翻译： 提供了结合人CGRP受体（CGRP R）的抗原结合蛋白。 还提供编码抗原结合蛋白，载体和编码抗原结合蛋白的核酸的核酸。 抗原结合蛋白可以抑制CGRP R与CGRP的结合，并且可用于多种CGRP R相关疾病，包括治疗和/或预防偏头痛。
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公开(公告)号：US20120195879A1
公开(公告)日：2012-08-02
申请号：US13258668
申请日：2010-03-19
申请人： Kenneth W. Walker , Yue-Sheng Li , Thomas C. Boone , Frederick W. Jacobsen , HoSung Min , Jane Talvenheimo , Taruna Arora , George Doellgast , Janet Doellgast
发明人： Kenneth W. Walker , Yue-Sheng Li , Thomas C. Boone , Frederick W. Jacobsen , HoSung Min , Jane Talvenheimo , Taruna Arora , George Doellgast , Janet Doellgast
CPC分类号： C07K16/44 , A61K39/39591 , A61K47/6817 , A61K47/6843 , C07K14/43504 , C07K14/575 , C07K14/605 , C07K14/66 , C07K16/00 , C07K16/18 , C07K16/248 , C07K2317/21 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/92 , C07K2317/94 , C07K2319/00 , C07K2319/30 , C07K2319/55
摘要： Disclosed is an isolated antigen binding protein, such as but not limited to, an antibody or antibody fragment. Also disclosed are pharmaceutical compositions and medicaments comprising the antigen binding protein, isolated nucleic acid encoding it, vectors, host cells, and hybridomas useful in methods of making it. In some embodiments the antigen binding protein comprises one to twenty-four pharmacologically active chemical moieties conjugated thereto, such as a pharmacologically active polypeptide.
摘要翻译： 公开了分离的抗原结合蛋白，例如但不限于抗体或抗体片段。 还公开了包含抗原结合蛋白，编码它的分离的核酸，载体，宿主细胞和用于制备它的方法中的杂交瘤的药物组合物和药物。 在一些实施方案中，抗原结合蛋白包含与其结合的1-24个药理活性化学部分，例如药理学活性多肽。
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