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    ENZYMATIC AMINATION
    1.
    发明申请
    ENZYMATIC AMINATION 审中-公开
    酶联系

    公开(公告)号：US20160244790A1

    公开(公告)日：2016-08-25

    申请号：US15073105

    申请日：2016-03-17

    申请人： Thomas HAAS ,  Jan Christoph Pfeffer ,  Kurt Faber ,  Michael Fuchs

    发明人： Thomas HAAS ,  Jan Christoph Pfeffer ,  Kurt Faber ,  Michael Fuchs

    IPC分类号： C12P13/00 ,  C12P17/04 ,  C12P7/22 ,  C12P17/12

    CPC分类号： C12P13/001 ,  C12P7/22 ,  C12P17/04 ,  C12P17/12

    摘要： A method comprising the steps (a) contacting a hydrocarbon comprising a hydroxyl group with a biological agent having oxygen-dependent and cofactor-dependent carbohydrate oxidase activity in the presence of oxygen and carbohydrate oxidase cofactor, and (b) contacting the hydrocarbon produced in step a) with a biological agent having transaminase activity and a biological agent having cofactor-dependent amino acid dehydrogenase activity in the presence of amino acid dehydrogenase cofactor and the substrate amino acid of the amino acid dehydrogenase.

    摘要翻译： 一种方法，包括以下步骤：（a）在氧和碳水化合物氧化酶辅因子的存在下使包含羟基的烃与具有氧依赖性和辅因子依赖性碳水化合物氧化酶活性的生物试剂接触，和（b）使步骤 a）具有转氨酶活性的生物制剂和在氨基酸脱氢酶辅因子和氨基酸脱氢酶的底物氨基酸存在下具有辅因子依赖性氨基酸脱氢酶活性的生物试剂。

    PROCESS FOR PREPARING AN ALPHA, OMEGA-ALKANEDIOL
    3.
    发明申请
    PROCESS FOR PREPARING AN ALPHA, OMEGA-ALKANEDIOL 审中-公开
    制备ALPHA，OMEGA-ALKANEDIOL的方法

    公开(公告)号：US20150353963A1

    公开(公告)日：2015-12-10

    申请号：US14763378

    申请日：2014-01-10

    申请人： Thomas HAAS ,  Philip ENGEL ,  Jan Christoph PFEFFER ,  Oliver THUM ,  Christian GEHRING

    发明人： Thomas HAAS ,  Phillip ENGEL ,  Jan Christoph PFEFFER ,  Oliver THUM ,  Christian GEHRING

    IPC分类号： C12P7/18 ,  C07C29/136 ,  C07C67/08

    CPC分类号： C12P7/18 ,  C07C29/136 ,  C07C67/08 ,  C12P7/62 ,  C12Y114/15003

    摘要： The invention relates to a process for preparing an α,ω-alkanediol comprising the steps of a) reacting an alkanoic acid with an alkanol to give an ester, b) oxidizing at least one terminal carbon atom of the ester by contacting with a whole-cell catalyst, which expresses an alkane hydroxylase, in aqueous solution and in the presence of molecular oxygen, to give an oxidized ester, c) hydrogenating the oxidized ester to form the alkanediol and alkanol, and d) removing the alkanol by distillation, forming a reaction mixture depleted with respect to the alkanol, and recycling the alkanol in step b).

    摘要翻译： 本发明涉及一种制备α，ω-链烷二醇的方法，包括以下步骤：a）使链烷酸与链烷醇反应得到酯，b）通过与全烷基酯接触来氧化酯的至少一个末端碳原子， 在水溶液中和在分子氧存在下表达烷烃羟化酶的细胞催化剂，得到氧化的酯，c）氢化氧化的酯以形成链烷二醇和链烷醇，和d）通过蒸馏除去烷醇，形成 反应混合物相对于烷醇消耗，并在步骤b）中回收链烷醇。

    METHOD FOR STORING EXCESS ENERGY
    4.
    发明申请
    METHOD FOR STORING EXCESS ENERGY 审中-公开
    储存能量的方法

    公开(公告)号：US20160137969A1

    公开(公告)日：2016-05-19

    申请号：US14898679

    申请日：2014-06-17

    申请人： Thomas HAAS ,  EVONIK DEGUSSA GMBH

    发明人： Thomas HAAS

    IPC分类号： C12M1/00 ,  F01K11/02 ,  C12P7/54 ,  F02C6/14 ,  C12P7/42 ,  C12P7/06

    CPC分类号： C12M43/04 ,  C10K3/00 ,  C12M29/00 ,  C12M43/08 ,  C12P7/065 ,  C12P7/42 ,  C12P7/54 ,  F01K11/02 ,  F02C6/14 ,  Y02E50/17

    摘要： The invention relates to a method for utilizing gases containing CO and/or CO2, which method comprises the following steps: A) providing a gas flow of the gas containing CO and/or CO2, B) converting at least a portion of the gas flow into electrical energy, C) transforming at least a portion of the gas flow into at least one organic substance using a biotechnological fermentation process, and possibly D) repeating method steps B) and C).

    摘要翻译： 本发明涉及一种利用含有CO和/或CO 2的气体的方法，该方法包括以下步骤：A）提供含有CO和/或CO 2的气体的气流，B）将至少一部分气流 C）使用生物技术发酵方法将至少一部分气流转化成至少一种有机物质，以及可能的D）重复方法步骤B）和C）。

    METHOD OF PRODUCING HIGHER ALCOHOLS
    5.
    发明申请
    METHOD OF PRODUCING HIGHER ALCOHOLS 审中-公开
    生产高级醇的方法

    公开(公告)号：US20160215302A1

    公开(公告)日：2016-07-28

    申请号：US15009425

    申请日：2016-01-28

    申请人： Thomas HAAS ,  Thomas BUELTER ,  Martin DEMLER

    发明人： Thomas HAAS ,  Thomas BUELTER ,  Martin DEMLER

    IPC分类号： C12P7/04 ,  C12N1/20

    摘要： The present invention relates to a reaction mixture and a method of producing at least one higher alcohol comprising a reaction mixture comprising a mixed culture of a first and a second microorganism in an aqueous medium comprising carbon monoxide gas, wherein the first microorganism is an acetogenic microorganism capable of converting a carbon source to acetate and/or ethanol; and the second microorganism is selected from the group consisting of Clostridium kluyveri, and C. Carboxidivorans capable of converting the acetate and/or ethanol to form an acid; wherein the first microorganism is further capable of converting the acid to the corresponding higher alcohol and the higher alcohol comprises at least 6 carbon atoms.

    摘要翻译： 本发明涉及一种反应混合物和一种生产至少一种高级醇的方法，所述高级醇包括在包含一氧化碳气体的水性介质中包含第​​一和第二微生物的混合培养物的反应混合物，其中第一微生物是产乙酸微生物 能够将碳源转化成乙酸酯和/或乙醇; 并且第二微生物选自克氏梭菌（Clostridium kluyveri）和C.能够转化乙酸盐和/或乙醇以形成酸的羧酰替葡萄糖; 其中第一微生物还能够将酸转化成相应的高级醇，高级醇包含至少6个碳原子。

    FATTY ACID AND DERIVATIVES PRODUCTION
    7.
    发明申请
    FATTY ACID AND DERIVATIVES PRODUCTION 审中-公开
    脂肪酸和衍生物生产

    公开(公告)号：US20160138061A1

    公开(公告)日：2016-05-19

    申请号：US14943333

    申请日：2015-11-17

    申请人： Thomas HAAS ,  Markus Poetter ,  Steffen Schaffer

    发明人： Thomas HAAS ,  Markus Poetter ,  Steffen Schaffer

    IPC分类号： C12P7/64

    CPC分类号： C12P7/6409 ,  Y02P20/59

    摘要： At least one fatty acid and/or derivative thereof is produced from a gas containing H2, CO2, and O2 by providing a genetically modified hydrogen oxidizing bacterium in an aqueous medium; and contacting the aqueous medium with the gas containing H2, CO2 and O2 in a weight ratio of 20 to 70 (H2): 10 to 45 (CO2): 5 to 35 (O2); wherein the fatty acid contains at least 5 carbon atoms and wherein the hydrogen oxidizing bacterium is genetically modified relative to the wild type bacterium to increase the expression of enzyme E1 that is capable of catalyzing the conversion of acetyl CoA to acyl ACP via malonyl coA and to increase the expression of enzyme E2 that is capable of catalyzing the conversion of Acyl ACP to the fatty acid.

    摘要翻译： 通过在水性介质中提供遗传修饰的氢氧化细菌，从含有H 2，CO 2和O 2的气体产生至少一种脂肪酸和/或其衍生物; 并使含水介质与含有H 2，CO 2和O 2的气体以20至70（H 2）：10至45（CO 2）：5至35（O 2）的重量比接触; 其中所述脂肪酸含有至少5个碳原子，并且其中所述氢氧化细菌相对于野生型细菌被遗传修饰以增加能够通过丙二酰辅酶A催化乙酰辅酶A转化为酰基ACP的酶E1的表达， 增加能够催化酰基ACP向脂肪酸转化的酶E2的表达。

    METHOD FOR PRODUCING ACYL AMINO ACIDS
    8.
    发明申请
    METHOD FOR PRODUCING ACYL AMINO ACIDS 审中-公开
    制备ACYA氨基酸的方法

    公开(公告)号：US20160272950A1

    公开(公告)日：2016-09-22

    申请号：US14915012

    申请日：2014-08-25

    申请人： Jasmin CORTHALS ,  Katrin GRAMMANN ,  Thomas HAAS ,  Maik OLFERT ,  Nicole POTGRAVE ,  Liv REINECKE ,  Steffen SCHAFFER ,  Jan WOLTER

    发明人： Jasmin CORTHALS ,  Katrin GRAMMANN ,  Thomas HAAS ,  Maik OLFERT ,  Nicole POTGRAVE ,  Liv REINECKE ,  Steffen SCHAFFER ,  Jan WOLTER

    IPC分类号： C12N9/10 ,  C12P13/04

    CPC分类号： C12N9/1029 ,  C12N9/00 ,  C12N9/10 ,  C12N9/93 ,  C12P7/64 ,  C12P13/02 ,  C12P13/04 ,  C12Y203/01065 ,  C12Y203/01086

    摘要： The present invention relates to a cell expressing an amino acid-N-acyl-transferase, which is preferably recombinant, and an acyl-CoA synthetase, which is preferably recombinant, wherein the cell has a reduced fatty acid degradation capacity, a method for producing acyl amino acids, comprising the step contacting an amino acid and an acyl CoA in the presence of an amino acid-N-acyl-transferase, which is preferably isolated and/or recombinant, wherein the amino acid-N-acyl-transferase is preferably a human amino acid-N-acyl-transferase, or culturing the cell and a reaction mixture comprising an amino acid-N-acyl-transferase, which is preferably isolated and/or recombinant, an acyl-CoA synthetase, which is preferably isolated and/or recombinant, an amino acid and either a fatty acid-CoA or a fatty acid and an acyl-CoA-synthase.

    摘要翻译： 本发明涉及优选重组的表达氨基酸-N-酰基转移酶的细胞和优选重组的酰基辅酶A合成酶，其中所述细胞具有降低的脂肪酸降解能力，生产方法 酰基氨基酸，其包含在优选分离和/或重组的氨基酸-N-酰基转移酶存在下使氨基酸和酰基辅酶A接触的步骤，其中氨基酸-N-酰基转移酶优选为 人氨基酸-N-酰基转移酶或培养细胞，以及包含优选分离和/或重组的氨基酸-N-酰基转移酶的反应混合物，其优选分离和 /或重组体，氨基酸和脂肪酸-CoA或脂肪酸和酰基辅酶A合成酶。

    RHAMNOLIPID SYNTHESIS
    9.
    发明申请
    RHAMNOLIPID SYNTHESIS 审中-公开

    公开(公告)号：US20180066297A1

    公开(公告)日：2018-03-08

    申请号：US15551904

    申请日：2016-02-16

    申请人： Thomas Haas ,  Thomas Bülter ,  Stefan Buchholz ,  Simon Beck

    发明人： Thomas HAAS ,  Thomaas BÜLTER ,  Stefan BUCHHOLZ ,  Simon BECK

    IPC分类号： C12P19/44 ,  C12N9/10 ,  C12N9/14

    CPC分类号： C12P19/44 ,  C12N9/1051 ,  C12N9/14

    摘要： There is provided a method of producing at least one rhamnolipid comprising: (a) contacting a recombinant cell with a medium containing a carbon source; wherein the recombinant cell has been genetically modified such that, compared to the wild-type of the cell, the cell has an increased activity of at least one of the enzymes E1, E2 and E3, wherein the enzyme E1 is an α/β hydrolase (RHIA), the enzyme E2 is a rhamnosyltransferase I (RHIB) and the enzyme E3 is a rhamnosyltransferase II (RHIC), and wherein the carbon source is an alkane and/or alkanoic acid comprising 6 to 10 carbon atoms.