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公开(公告)号：US06596752B1
公开(公告)日：2003-07-22
申请号：US10193137
申请日：2002-07-12
申请人： Thomas J. Lobl , Bradley R. Teegarden , Alexander Polinsky , Gilbert M. Rishton , Masafumi Yamagishi , Steven Tanis , Jed F. Fisher , Edward W. Thomas , Robert A. Chrusciel
发明人： Thomas J. Lobl , Bradley R. Teegarden , Alexander Polinsky , Gilbert M. Rishton , Masafumi Yamagishi , Steven Tanis , Jed F. Fisher , Edward W. Thomas , Robert A. Chrusciel
IPC分类号： A61K31415
CPC分类号： C07D213/81 , C07C229/46 , C07C233/60 , C07C233/63 , C07C233/83 , C07C233/87 , C07C235/40 , C07C235/64 , C07C235/84 , C07C237/22 , C07C237/40 , C07C237/42 , C07C255/29 , C07C255/46 , C07C259/08 , C07C271/22 , C07C271/28 , C07C275/26 , C07C275/42 , C07C311/21 , C07C311/64 , C07D207/16 , C07D209/20 , C07D213/64 , C07D213/82 , C07D217/26 , C07D233/64 , C07D295/185 , C07D295/192 , C07D307/68 , C07D333/24
摘要： The present invention relates to small molecules according to the formula [I]: which are potent inhibitors of &agr;4&bgr;1 mediated adhesion to either VCAM or CS-1 and which can be used for treating or preventing &agr;4&bgr;1 adhesion mediated conditions in a mammal such as a human.
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公开(公告)号：US06482849B1
公开(公告)日：2002-11-19
申请号：US09102584
申请日：1998-06-23
申请人： Thomas J. Lobl , Bradley R. Teegarden , Alexander Polinsky , Gilbert M. Rishton , Masafumi Yamagishi , Steven Tanis , Jed F. Fisher , Edward W. Thomas , Robert A. Chrusciel
发明人： Thomas J. Lobl , Bradley R. Teegarden , Alexander Polinsky , Gilbert M. Rishton , Masafumi Yamagishi , Steven Tanis , Jed F. Fisher , Edward W. Thomas , Robert A. Chrusciel
IPC分类号： A61K3127
CPC分类号： C07D213/81 , C07C229/46 , C07C233/60 , C07C233/63 , C07C233/83 , C07C233/87 , C07C235/40 , C07C235/64 , C07C235/84 , C07C237/22 , C07C237/40 , C07C237/42 , C07C255/29 , C07C255/46 , C07C259/08 , C07C271/22 , C07C271/28 , C07C275/26 , C07C275/42 , C07C311/21 , C07C311/64 , C07D207/16 , C07D209/20 , C07D213/64 , C07D213/82 , C07D217/26 , C07D233/64 , C07D295/185 , C07D295/192 , C07D307/68 , C07D333/24
摘要： The present invention relates to small molecules according to the formula [I]: which are potent inhibitors of &agr;4&bgr;1 mediated adhesion to either VCAM or CS-1 and which can be used for treating or preventing &agr;4&bgr;1 adhesion mediated conditions in a mammal such as a human.
摘要翻译： 本发明涉及根据式[I]的小分子：其是α4β1介导的对VCAM或CS-1的粘附的有效抑制剂，其可用于治疗或预防哺乳动物如人的α4β1粘附介导的病症 。
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公开(公告)号：US08765816B2
公开(公告)日：2014-07-01
申请号：US13263162
申请日：2010-04-06
申请人： Gilbert M. Rishton , Susan Catalano
发明人： Gilbert M. Rishton , Susan Catalano
CPC分类号： C07C217/62 , C07C211/27 , C07D207/08 , C07D211/22
摘要： Compounds that are central nervous system drug candidates for the treatment of cognitive decline and, more particularly, Alzheimer's disease are provided. Methods of treating, inhibiting, and/or abatement of cognitive decline and/or Alzheimer's disease with a compound or pharmaceutically acceptable salt of the invention are also provided. Also provided are methods of preparing the compounds/compositions of the invention.
摘要翻译： 提供了用于治疗认知衰退的中枢神经系统药物候选物的化合物，更具体地说是阿尔茨海默氏病。 还提供了用本发明的化合物或药学上可接受的盐治疗，抑制和/或减轻认知衰退和/或阿尔茨海默病的方法。 还提供了制备本发明的化合物/组合物的方法。
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公开(公告)号：US20120129945A1
公开(公告)日：2012-05-24
申请号：US13388128
申请日：2010-08-02
申请人： Gilbert M. Rishton , Susan Catalano
发明人： Gilbert M. Rishton , Susan Catalano
IPC分类号： A61K31/137 , C07C33/30 , A61K31/045 , A61P25/28 , C07C211/25 , C07C209/22 , C07C29/143 , A61K31/13 , C07C211/27 , C07C33/14
CPC分类号： C07C211/27 , A61K31/015 , C07B2200/07 , C07C33/14 , C07C33/30 , C07C211/25 , C07C403/08 , C07C403/18 , C07C2601/16
摘要： Compounds that are central nervous system drug candidates for the treatment of cognitive decline and, more particularly, Alzheimer's disease are provided. Methods of treating, inhibiting, and/or abatement of cognitive decline and/or Alzheimer's disease with a compound or pharmaceutically acceptable salt of the invention are also provided. Also provided are methods of preparing the compounds/compositions of the invention.
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公开(公告)号：US06921762B2
公开(公告)日：2005-07-26
申请号：US10298205
申请日：2002-11-15
申请人： Guolin Cai , Jennifer N. Chau , Celia Dominguez , Yuelie Lu , Gilbert M. Rishton
发明人： Guolin Cai , Jennifer N. Chau , Celia Dominguez , Yuelie Lu , Gilbert M. Rishton
IPC分类号： A61K31/4545 , A61K31/4709 , A61K31/506 , A61K31/519 , A61P1/04 , A61P1/18 , A61P3/10 , A61P7/00 , A61P9/10 , A61P11/00 , A61P11/02 , A61P11/06 , A61P17/00 , A61P17/06 , A61P19/02 , A61P19/06 , A61P19/10 , A61P21/00 , A61P25/00 , A61P25/28 , A61P27/00 , A61P29/00 , A61P31/04 , A61P31/16 , A61P31/18 , A61P31/20 , A61P31/22 , A61P33/06 , A61P35/00 , A61P35/02 , C07D401/04 , C07D471/04 , C07D487/04 , C07D487/08 , C07D519/00 , A61K31/4188
CPC分类号： C07D401/04 , C07D471/04 , C07D487/04
摘要： Selected novel substituted indolizine-like compounds are effective for treatment of diseases, such as TNF-α, IL-1β, IL-6 and/or IL-8 mediated diseases, and other maladies, such as cancer, pain and diabetes. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for treatment of diseases and other maladies or conditions involving inflammation, cancer, pain, diabetes and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译： 所选择的新型取代的吲哚嗪类化合物对于治疗诸如TNF-α，IL-1β，IL-6和/或IL-8介导的疾病以及其它疾病如癌症，疼痛和糖尿病等疾病是有效的。 本发明包括新型化合物，类似物，前药和药学上可接受的盐，用于治疗疾病和其它疾病或涉及炎症，癌症，疼痛，糖尿病等的疾病的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。
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6.发明授权Naphthyl-, quinolyl- and isoquinolyl- sulfonamide derivatives as cell adhesion modulators 失效萘基，喹啉基和异喹啉基磺酰胺衍生物作为细胞粘附调节剂
公开(公告)号：US5707985A
公开(公告)日：1998-01-13
申请号：US472645
申请日：1995-06-07
IPC分类号： C07C311/16 , C07C311/18 , C07C311/20 , C07C311/21 , C07C335/26 , C07D215/36 , C07D221/22 , C07D221/24 , C07D241/24 , C07D295/26 , C07D311/00 , C07D401/04 , C07D401/12 , C07D403/12 , C07D407/12 , C07D413/12 , C07D453/02 , C07D471/08 , C07D487/08 , C07D495/04 , C07D495/08 , A61K31/395 , A61K31/55 , C07D471/02
CPC分类号： C07D241/24 , C07C311/16 , C07C311/18 , C07C311/20 , C07C311/21 , C07C335/26 , C07D215/36 , C07D221/22 , C07D221/24 , C07D295/26 , C07D311/00 , C07D401/04 , C07D401/12 , C07D403/12 , C07D407/12 , C07D413/12 , C07D453/02 , C07D471/08 , C07D487/08 , C07D495/04 , C07D495/08 , C07C2101/14 , C07C2102/42 , C07C2103/66 , C07C2103/74
摘要： There are disclosed novel substituted naphthyl-, quinolyl- and isoquinolyl- sulfonamide derivatives that are useful in a method of treating immuno-inflammatory diseases in a mammalian patient suffering therefrom. Pharmaceutical compositions containing the sulfonamide compounds are also provided.
摘要翻译： 公开了新的取代的萘基，喹啉基和异喹啉基磺酰胺衍生物，其可用于在患有其的哺乳动物患者中治疗免疫炎性疾病的方法。 还提供了含有磺酰胺化合物的药物组合物。
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公开(公告)号：US09499462B2
公开(公告)日：2016-11-22
申请号：US13983430
申请日：2012-02-01
申请人： Gilbert M. Rishton , Susan Catalano
发明人： Gilbert M. Rishton , Susan Catalano
IPC分类号： C07C211/00 , C07C33/20 , C07C33/14 , C07C33/26 , C07C33/30 , C07C215/26 , C07C215/28 , C07C211/27
CPC分类号： C07C33/20 , C07B2200/07 , C07C33/14 , C07C33/26 , C07C33/30 , C07C211/27 , C07C215/26 , C07C215/28 , C07C2601/16
摘要： Compounds that are central nervous system drug candidates for the treatment of cognitive decline and, more particularly, Alzheimer's disease are provided. Methods for treatment, inhibition, and/or abatement of cognitive decline and/or Alzheimer's disease with a compound or pharmaceutically acceptable salt of the invention are also provided. Also provided are methods of preparing the compounds/compositions of the invention.
摘要翻译： 提供了用于治疗认知衰退的中枢神经系统药物候选物的化合物，更具体地说是阿尔茨海默氏病。 还提供了用本发明的化合物或药学上可接受的盐治疗，抑制和/或减轻认知衰退和/或阿尔茨海默病的方法。 还提供了制备本发明的化合物/组合物的方法。
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公开(公告)号：US20140080916A1
公开(公告)日：2014-03-20
申请号：US13983430
申请日：2012-02-01
申请人： Gilbert M. Rishton , Susan Catalano
发明人： Gilbert M. Rishton , Susan Catalano
IPC分类号： C07C33/20 , C07C211/27
CPC分类号： C07C33/20 , C07B2200/07 , C07C33/14 , C07C33/26 , C07C33/30 , C07C211/27 , C07C215/26 , C07C215/28 , C07C2601/16
摘要： Compounds that are central nervous system drug candidates for the treatment of cognitive decline and, more particularly, Alzheimer's disease are provided. Methods for treatment, inhibition, and/or abatement of cognitive decline and/or Alzheimer's disease with a compound or pharmaceutically acceptable salt of the invention are also provided. Also provided are methods of preparing the compounds/compositions of the invention.
摘要翻译： 提供了用于治疗认知衰退的中枢神经系统药物候选物的化合物，更具体地说是阿尔茨海默氏病。 还提供了用本发明的化合物或药学上可接受的盐治疗，抑制和/或消除认知衰退和/或阿尔茨海默病的方法。 还提供了制备本发明的化合物/组合物的方法。
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公开(公告)号：US20120095105A1
公开(公告)日：2012-04-19
申请号：US13263162
申请日：2010-04-06
申请人： Gilbert M. Rishton , Susan Catalano
发明人： Gilbert M. Rishton , Susan Catalano
IPC分类号： A61K31/137 , A61P25/28 , C07C211/27
CPC分类号： C07C217/62 , C07C211/27 , C07D207/08 , C07D211/22
摘要： Compounds that are central nervous system drug candidates for the treatment of cognitive decline and, more particularly, Alzheimer's disease are provided. Methods of treating, inhibiting, and/or abatement of cognitive decline and/or Alzheimer's disease with a compound or pharmaceutically acceptable salt of the invention are also provided. Also provided are methods of preparing the compounds/compositions of the invention.
摘要翻译： 提供了用于治疗认知衰退的中枢神经系统药物候选物的化合物，更具体地说是阿尔茨海默氏病。 还提供了用本发明的化合物或药学上可接受的盐治疗，抑制和/或减轻认知衰退和/或阿尔茨海默病的方法。 还提供了制备本发明的化合物/组合物的方法。
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公开(公告)号：US20110111068A1
公开(公告)日：2011-05-12
申请号：US12800500
申请日：2010-05-17
IPC分类号： A61K36/906 , C40B50/00 , A61K31/40 , A61K31/135 , C07D207/04 , C07D295/02 , C07C211/00 , A61P25/00 , A61P25/28
CPC分类号： C07C217/64 , C07D207/04 , C07D207/08
摘要： Compounds that are central nervous system drug candidates for the treatment of cognitive decline and, more particularly, Alzheimer's disease are provided. Methods of treating, inhibiting, and/or abatement of cognitive decline and Alzheimer's disease with a derivative of ginger oil are also provided. Also provided is a method of conditioning biological extracts, such as a medicinal plant extract, by a reductive amination process to give nitrogen-containing derivatives.
摘要翻译： 提供了用于治疗认知衰退的中枢神经系统药物候选物的化合物，更具体地说是阿尔茨海默氏病。 还提供了用姜油衍生物治疗，抑制和/或减轻认知衰退和阿尔茨海默氏病的方法。 还提供了通过还原胺化法调节生物提取物如药用植物提取物以得到含氮衍生物的方法。
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