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    Method for identifying protein synthesis inhibitors by ribosome structure
    3.
    发明申请
    Method for identifying protein synthesis inhibitors by ribosome structure 审中-公开
    通过核糖体结构鉴定蛋白质合成抑制剂的方法

    公开(公告)号：US20100131258A1

    公开(公告)日：2010-05-27

    申请号：US12220342

    申请日：2008-07-22

    申请人： Thomas A. Steitz ,  Peter B. Moore ,  Nenad Ban ,  Poul Nissen ,  Jeffrey Hansen

    发明人： Thomas A. Steitz ,  Peter B. Moore ,  Nenad Ban ,  Poul Nissen ,  Jeffrey Hansen

    IPC分类号： G06G7/48

    CPC分类号： A61K31/40 ,  A61K31/165 ,  A61K31/506 ,  A61K31/513 ,  A61K31/5355 ,  A61K31/7048 ,  A61K45/06 ,  C07K14/215 ,  C07K2299/00

    摘要： The invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as crystals produced by such methods. The invention also provides high resolution structures of ribosomal subunits either alone or in combination with protein synthesis inhibitors. The invention provides methods for identifying ribosome-related ligands and methods for designing ligands with specific ribosome-binding properties as well as ligands that may act as protein synthesis inhibitors. Thus, the methods and compositions of the invention may be used to produce ligands that are designed to specifically kill or inhibit the growth of any target organism.

    摘要翻译： 本发明提供了生产核糖体和核糖体亚基的高分辨率晶体以及通过这些方法产生的晶体的方法。 本发明还单独或与蛋白质合成抑制剂组合提供核糖体亚基的高分辨率结构。 本发明提供了用于鉴定核糖体相关配体的方法和用于设计具有特定核糖体结合特性的配体的方法以及可用作蛋白质合成抑制剂的配体。 因此，本发明的方法和组合物可用于产生设计用于特异性杀死或抑制任何靶生物体生长的配体。

    Crystals of the large ribosomal subunit
    4.
    发明授权
    Crystals of the large ribosomal subunit 有权
    大核糖体亚基的晶体

    公开(公告)号：US06638908B1

    公开(公告)日：2003-10-28

    申请号：US09635708

    申请日：2000-08-09

    申请人： Thomas A. Steitz ,  Peter B. Moore ,  Nenad Ban ,  Poul Nissen ,  Jeffrey Hansen

    发明人： Thomas A. Steitz ,  Peter B. Moore ,  Nenad Ban ,  Poul Nissen ,  Jeffrey Hansen

    IPC分类号： A61K3800

    CPC分类号： C07K14/215 ,  C07K2299/00

    摘要： The present invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as the crystals produced by such methods. The x-ray diffraction patterns of the crystals provided by the present invention are of sufficiently high resolution for determining the three-dimensional structure of ribosomes and ribosomal subunits, for identifying ligand binding sites on ribosomes and ribosomal subunits, and for molecular modeling of ligands which interact with ribosomes and ribosomal subunits. The present invention provides methods for identifying ribosome-related ligands and methods for designing ligands with specific ribosome-binding properties. Thus, the methods of the present invention may be used to produce ligands which are designed to kill or inhibit any specific target organism(s).

    摘要翻译： 本发明提供了生产核糖体和核糖体亚基的高分辨率晶体的方法以及通过这些方法制备的晶体。 由本发明提供的晶体的x射线衍射图具有足够高的分辨率，用于确定核糖体和核糖体亚基的三维结构，用于鉴定核糖体和核糖体亚基上的配体结合位点，以及用于配体的分子模拟 与核糖体和核糖体亚基相互作用。 本发明提供鉴定核糖体相关配体的方法和用于设计具有特定核糖体结合特性的配体的方法。 因此，本发明的方法可用于产生设计用于杀死或抑制任何特定靶生物的配体。

    Determination and uses of the atomic structures of ribosomes and ribosomal subunits and their ligand complexes
    5.
    发明授权
    Determination and uses of the atomic structures of ribosomes and ribosomal subunits and their ligand complexes 有权
    确定和使用核糖体和核糖体亚基及其配体配合物的原子结构

    公开(公告)号：US07504486B2

    公开(公告)日：2009-03-17

    申请号：US10391289

    申请日：2003-03-17

    申请人： Thomas A. Steitz ,  Peter B. Moore ,  Nenad Ban ,  Poul Nissen ,  Jeffrey Hansen

    发明人： Thomas A. Steitz ,  Peter B. Moore ,  Nenad Ban ,  Poul Nissen ,  Jeffrey Hansen

    IPC分类号： C07K1/14 ,  G01N31/00

    CPC分类号： C07K14/215 ,  C07K2299/00

    摘要： The present invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as the crystals produced by such methods. The x-ray diffraction patterns of the crystals provided by the present invention are of sufficiently high resolution for determining the three-dimensional structure of ribosomes and ribosomal subunits, for identifying ligand binding sites on ribosomes and ribosomal subunits, and for molecular modeling of ligands which interact with ribosomes and ribosomal subunits. The present invention provides methods for identifying ribosome-related ligands and methods for designing ligands with specific ribosome-binding properties. Thus, the methods of the present invention may be used to produce ligands which are designed to kill or inhibit any specific target organism(s).

    摘要翻译： 本发明提供了生产核糖体和核糖体亚基的高分辨率晶体的方法以及通过这些方法制备的晶体。 由本发明提供的晶体的x射线衍射图具有足够高的分辨率，用于确定核糖体和核糖体亚基的三维结构，用于鉴定核糖体和核糖体亚基上的配体结合位点，以及用于配体的分子模拟 与核糖体和核糖体亚基相互作用。 本发明提供鉴定核糖体相关配体的方法和用于设计具有特定核糖体结合特性的配体的方法。 因此，本发明的方法可用于产生设计用于杀死或抑制任何特定靶生物的配体。

    Crystals of the large ribosomal subunit
    7.
    发明授权
    Crystals of the large ribosomal subunit 有权
    大核糖体亚基的晶体

    公开(公告)号：US06939848B2

    公开(公告)日：2005-09-06

    申请号：US10391491

    申请日：2003-03-17

    申请人： Thomas A. Steitz ,  Peter B. Moore ,  Nenad Ban ,  Poul Nissen ,  Jeffrey Hansen

    发明人： Thomas A. Steitz ,  Peter B. Moore ,  Nenad Ban ,  Poul Nissen ,  Jeffrey Hansen

    IPC分类号： C07K14/215 ,  A61K38/00 ,  G01N33/48 ,  G06F17/00 ,  G06F19/00

    CPC分类号： C07K14/215 ,  C07K2299/00

    摘要： The present invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as the crystals produced by such methods. The x-ray diffraction patterns of the crystals provided by the present invention are of sufficiently high resolution for determining the three-dimensional structure of ribosomes and ribosomal subunits, for identifying ligand binding sites on ribosomes and ribosomal subunits, and for molecular modeling of ligands which interact with ribosomes and ribosomal subunits. The present invention provides methods for identifying ribosome-related ligands and methods for designing ligands with specific ribosome-binding properties. Thus, the methods of the present invention may be used to produce ligands which are designed to kill or inhibit any specific target organism(s).

    摘要翻译： 本发明提供了生产核糖体和核糖体亚基的高分辨率晶体的方法以及通过这些方法制备的晶体。 由本发明提供的晶体的x射线衍射图具有足够高的分辨率，用于确定核糖体和核糖体亚基的三维结构，用于鉴定核糖体和核糖体亚基上的配体结合位点，以及用于配体的分子模拟 与核糖体和核糖体亚基相互作用。 本发明提供鉴定核糖体相关配体的方法和用于设计具有特定核糖体结合特性的配体的方法。 因此，本发明的方法可用于产生设计用于杀死或抑制任何特定靶生物的配体。

    Watercraft attachment device
    10.
    发明授权
    Watercraft attachment device 有权
    船舶附件装置

    公开(公告)号：US08074593B2

    公开(公告)日：2011-12-13

    申请号：US12434788

    申请日：2009-05-04

    申请人： Jeffrey Hansen ,  Todd Kaminski

    发明人： Jeffrey Hansen ,  Todd Kaminski

    IPC分类号： B63B17/00

    CPC分类号： B63B1/121

    摘要： The present invention relates to a watercraft attachment device for joining two watercrafts comprising: a pair of parallel tubes, where said parallel tubes are substantially parallel to the watercrafts; a pair of perpendicular tubes, where said perpendicular tubes are substantially perpendicular to the two parallel tubes and adjoin the parallel tubes; four abutting corners, where the four abutting corners are formed by the intersecting tubes; a plurality of hook attachments extending from the each corner, where said hook attachments extend over a lip of each cockpit within the watercrafts to connect the watercrafts to the watercraft attachment device; and at least one tension cord extending from each corner, where said tensioning cords tighten the hook attachments to secure the watercraft attachment device in place.

    摘要翻译： 本发明涉及一种用于连接两个船舶的船舶附着装置，包括：一对平行管，其中所述平行管基本上平行于船只; 一对垂直管，其中所述垂直管基本上垂直于两个平行管并与平行管相邻; 四个邻接的角部，其中四个邻接的角由相交的管形成; 从所述每个角落延伸的多个钩附件，其中所述钩附件在所述船只内的每个驾驶舱的唇缘上延伸以将所述船舶连接到所述船只附着装置; 以及从每个角落延伸的至少一个张紧绳，其中所述张紧绳紧固所述钩附件以将所述船只附接装置固定就位。