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公开(公告)号：US20060136146A1
公开(公告)日：2006-06-22
申请号：US11239699
申请日：2005-09-29
申请人： Thomas Steitz , Peter Moore , Nenad Ban , Poul Nissen , Jeffrey Hansen
发明人： Thomas Steitz , Peter Moore , Nenad Ban , Poul Nissen , Jeffrey Hansen
IPC分类号： G06F19/00
CPC分类号： A61K31/00 , A61K31/165 , A61K31/40 , A61K31/506 , A61K31/513 , A61K31/5355 , A61K31/7048 , A61K31/7064 , A61K45/06 , C07D239/54 , C07D403/12 , C07K14/215 , C07K2299/00 , G01N33/6872 , G01N2500/00 , Y02A90/26
摘要： The invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as crystals produced by such methods. The invention also provides high resolution structures of ribosomal subunits either alone or in combination with protein synthesis inhibitors. The invention provides methods for identifying ribosome-related ligands and methods for designing ligands with specific ribosome-binding properties as well as ligands that may act as protein synthesis inhibitors. Thus, the methods and compositions of the invention may be used to produce ligands that are designed to specifically kill or inhibit the growth of any target organism.
摘要翻译： 本发明提供了生产核糖体和核糖体亚基的高分辨率晶体以及通过这些方法产生的晶体的方法。 本发明还单独或与蛋白质合成抑制剂组合提供核糖体亚基的高分辨率结构。 本发明提供了用于鉴定核糖体相关配体的方法和用于设计具有特定核糖体结合特性的配体的方法以及可用作蛋白质合成抑制剂的配体。 因此，本发明的方法和组合物可用于产生设计用于特异性杀死或抑制任何靶生物体生长的配体。
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公开(公告)号：US20050234227A1
公开(公告)日：2005-10-20
申请号：US10914680
申请日：2004-08-09
申请人： Thomas Steitz , Peter Moore , Nenad Ban , Poul Nissen , Jeffrey Hansen
发明人： Thomas Steitz , Peter Moore , Nenad Ban , Poul Nissen , Jeffrey Hansen
IPC分类号： G01N33/50 , A61K31/165 , A61K31/40 , A61K31/506 , A61K31/513 , A61K31/5355 , A61K31/7048 , A61K45/06 , C07K1/14 , C07K14/195 , C07K14/215 , G01N33/15 , G06F19/00 , C07H21/02 , C12N9/22 , G01N33/48
CPC分类号： A61K31/40 , A61K31/165 , A61K31/506 , A61K31/513 , A61K31/5355 , A61K31/7048 , A61K45/06 , C07K14/215 , C07K2299/00
摘要： The invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as crystals produced by such methods. The invention also provides high resolution structures of ribosomal subunits either alone or in combination with protein synthesis inhibitors. The invention provides methods for identifying ribosome-related ligands and methods for designing ligands with specific ribosome-binding properties as well as ligands that may act as protein synthesis inhibitors. Thus, the methods and compositions of the invention may be used to produce ligands that are designed to specifically kill or inhibit the growth of any target organism.
摘要翻译： 本发明提供了生产核糖体和核糖体亚基的高分辨率晶体以及通过这些方法产生的晶体的方法。 本发明还单独或与蛋白质合成抑制剂组合提供核糖体亚基的高分辨率结构。 本发明提供了用于鉴定核糖体相关配体的方法和用于设计具有特定核糖体结合特性的配体的方法以及可用作蛋白质合成抑制剂的配体。 因此，本发明的方法和组合物可用于产生设计用于特异性杀死或抑制任何靶生物体生长的配体。
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公开(公告)号：US20050036997A1
公开(公告)日：2005-02-17
申请号：US10211931
申请日：2002-08-02
IPC分类号： C12N15/09 , A61K31/00 , A61K31/165 , A61K31/40 , A61K31/506 , A61K31/513 , A61K31/5355 , A61K31/7048 , A61K31/7064 , A61K45/06 , A61K48/00 , C07H21/04 , C07K14/215 , C12Q1/48 , C12Q1/68 , G01N33/68 , G06F17/30 , G06F17/50 , G01N33/48 , A61K38/43 , C12N9/99
CPC分类号： A61K31/00 , A61K31/165 , A61K31/40 , A61K31/506 , A61K31/513 , A61K31/5355 , A61K31/7048 , A61K31/7064 , A61K45/06 , C07D239/54 , C07D403/12 , C07K14/215 , C07K2299/00 , G01N33/6872 , G01N2500/00 , Y02A90/26
摘要： The invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as crystals produced by such methods. The invention also provides high resolution structures of ribosomal subunits either alone or in combination with protein synthesis inhibitors. The invention provides methods for identifying ribosome-related ligands and methods for designing ligands with specific ribosome-binding properties as well as ligands that may act as protein synthesis inhibitors. Thus, the methods and compositions of the invention may be used to produce ligands that are designed to specifically kill or inhibit the growth of any target organism.
摘要翻译： 本发明提供了生产核糖体和核糖体亚基的高分辨率晶体以及通过这些方法产生的晶体的方法。 本发明还单独或与蛋白质合成抑制剂组合提供核糖体亚基的高分辨率结构。 本发明提供了用于鉴定核糖体相关配体的方法和用于设计具有特定核糖体结合特性的配体的方法以及可用作蛋白质合成抑制剂的配体。 因此，本发明的方法和组合物可用于产生设计用于特异性杀死或抑制任何靶生物体生长的配体。
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公开(公告)号：US20050272681A1
公开(公告)日：2005-12-08
申请号：US11067522
申请日：2005-02-25
IPC分类号： C12N15/09 , A61K31/00 , A61K31/165 , A61K31/40 , A61K31/506 , A61K31/513 , A61K31/5355 , A61K31/7048 , A61K31/7064 , A61K45/06 , A61K48/00 , C07H21/04 , C07K14/215 , C12Q1/48 , C12Q1/68 , G01N33/68 , G06F17/30 , G06F17/50
CPC分类号： A61K31/00 , A61K31/165 , A61K31/40 , A61K31/506 , A61K31/513 , A61K31/5355 , A61K31/7048 , A61K31/7064 , A61K45/06 , C07D239/54 , C07D403/12 , C07K14/215 , C07K2299/00 , G01N33/6872 , G01N2500/00 , Y02A90/26
摘要： The invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as crystals produced by such methods. The invention also provides high resolution structures of ribosomal subunits either alone or in combination with protein synthesis inhibitors. The invention provides methods for identifying ribosome-related ligands and methods for designing ligands with specific ribosome-binding properties as well as ligands that may act as protein synthesis inhibitors. Thus, the methods and compositions of the invention may be used to produce ligands that are designed to specifically kill or inhibit the growth of any target organism.
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公开(公告)号：US20100204253A1
公开(公告)日：2010-08-12
申请号：US12645877
申请日：2009-12-23
申请人： Thomas Steitz , Peter B. Moore , Joyce A. Sutcliffe , Adegboyega K. Oyelere , Joseph A. Ippolito
发明人： Thomas Steitz , Peter B. Moore , Joyce A. Sutcliffe , Adegboyega K. Oyelere , Joseph A. Ippolito
IPC分类号： A61K31/505 , A61P31/04
CPC分类号： A61K31/00 , A61K31/165 , A61K31/40 , A61K31/506 , A61K31/513 , A61K31/5355 , A61K31/7048 , A61K31/7064 , A61K45/06 , C07D239/54 , C07D403/12 , C07K14/215 , C07K2299/00 , G01N33/6872 , G01N2500/00 , Y02A90/26
摘要： The invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as crystals produced by such methods. The invention also provides high resolution structures of ribosomal subunits either alone or in combination with protein synthesis inhibitors. The invention provides methods for identifying ribosome-related ligands and methods for designing ligands with specific ribosome-binding properties as well as ligands that may act as protein synthesis inhibitors. Thus, the methods and compositions of the invention may be used to produce ligands that are designed to specifically kill or inhibit the growth of any target organism.
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