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公开(公告)号：US20100312525A1
公开(公告)日：2010-12-09
申请号：US12703721
申请日：2010-02-10
申请人： Thomas A. Steitz , Peter B. Moore , Nenad Ban , Poul Nissen , Jeffrey Hansen , Joseph A. Ippolito
发明人： Thomas A. Steitz , Peter B. Moore , Nenad Ban , Poul Nissen , Jeffrey Hansen , Joseph A. Ippolito
IPC分类号： G06F17/50
CPC分类号： A61K31/00 , A61K31/165 , A61K31/40 , A61K31/506 , A61K31/513 , A61K31/5355 , A61K31/7048 , A61K31/7064 , A61K45/06 , C07D239/54 , C07D403/12 , C07K14/215 , C07K2299/00 , G01N33/6872 , G01N2500/00 , Y02A90/26
摘要： The invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as crystals produced by such methods. The invention also provides high resolution structures of ribosomal subunits either alone or in combination with protein synthesis inhibitors. The invention provides methods for identifying ribosome-related ligands and methods for designing ligands with specific ribosome-binding properties as well as ligands that may act as protein synthesis inhibitors. Thus, the methods and compositions of the invention may be used to produce ligands that are designed to specifically kill or inhibit the growth of any target organism.
摘要翻译： 本发明提供了生产核糖体和核糖体亚基的高分辨率晶体以及通过这些方法产生的晶体的方法。 本发明还单独或与蛋白质合成抑制剂组合提供核糖体亚基的高分辨率结构。 本发明提供了用于鉴定核糖体相关配体的方法和用于设计具有特定核糖体结合特性的配体的方法以及可用作蛋白质合成抑制剂的配体。 因此，本发明的方法和组合物可用于产生设计用于特异性杀死或抑制任何靶生物体生长的配体。
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公开(公告)号：US06952650B2
公开(公告)日：2005-10-04
申请号：US10072634
申请日：2002-02-08
申请人： Thomas A. Steitz , Peter B. Moore , Nenad Ban , Poul Nissen , Jeffrey Hansen , Joseph A. Ippolito
发明人： Thomas A. Steitz , Peter B. Moore , Nenad Ban , Poul Nissen , Jeffrey Hansen , Joseph A. Ippolito
IPC分类号： A61K31/165 , A61K31/40 , A61K31/506 , A61K31/513 , A61K31/5355 , A61K31/7048 , A61K31/7064 , A61K45/06 , C07K14/215 , G01N33/48 , G06F31/00 , G06F17/00 , C12Q1/68
CPC分类号： A61K45/06 , A61K31/165 , A61K31/40 , A61K31/506 , A61K31/513 , A61K31/5355 , A61K31/7048 , A61K31/7064 , C07K14/215 , C07K2299/00 , Y02A90/26
摘要： The invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as crystals produced by such methods. The invention also provides high resolution structures of ribosomal subunits either alone or in combination with protein synthesis inhibitors. The invention provides methods for identifying ribosome-related ligands and methods for designing ligands with specific ribosome-binding properties as well as ligands that may act as protein synthesis inhibitors. Thus, the methods and compositions of the invention may be used to produce ligands that are designed to specifically kill or inhibit the growth of any target organism.
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3.发明授权公开(公告)号：US06947845B2
公开(公告)日：2005-09-20
申请号：US10211931
申请日：2002-08-02
申请人： Thomas A. Steitz , Peter B. Moore , Joseph A. Ippolito , Nenad Ban , Poul Nissen , Jeffrey L. Hansen
发明人： Thomas A. Steitz , Peter B. Moore , Joseph A. Ippolito , Nenad Ban , Poul Nissen , Jeffrey L. Hansen
IPC分类号： C12N15/09 , A61K31/00 , A61K31/165 , A61K31/40 , A61K31/506 , A61K31/513 , A61K31/5355 , A61K31/7048 , A61K31/7064 , A61K45/06 , A61K48/00 , C07H21/04 , C07K14/215 , C12Q1/48 , C12Q1/68 , G01N33/68 , G06F17/30 , G06F17/50 , G01N33/48 , G06F31/00 , G06F17/00
CPC分类号： A61K31/00 , A61K31/165 , A61K31/40 , A61K31/506 , A61K31/513 , A61K31/5355 , A61K31/7048 , A61K31/7064 , A61K45/06 , C07D239/54 , C07D403/12 , C07K14/215 , C07K2299/00 , G01N33/6872 , G01N2500/00 , Y02A90/26
摘要： The invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as crystals produced by such methods. The invention also provides high resolution structures of ribosomal subunits either alone or in combination with protein synthesis inhibitors. The invention provides methods for identifying ribosome-related ligands and methods for designing ligands with specific ribosome-binding properties as well as ligands that may act as protein synthesis inhibitors. Thus, the methods and compositions of the invention may be used to produce ligands that are designed to specifically kill or inhibit the growth of any target organism.
摘要翻译： 本发明提供了生产核糖体和核糖体亚基的高分辨率晶体以及通过这些方法产生的晶体的方法。 本发明还单独或与蛋白质合成抑制剂组合提供核糖体亚基的高分辨率结构。 本发明提供了用于鉴定核糖体相关配体的方法和用于设计具有特定核糖体结合特性的配体的方法以及可用作蛋白质合成抑制剂的配体。 因此，本发明的方法和组合物可用于产生设计用于特异性杀死或抑制任何靶生物体生长的配体。
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公开(公告)号：US08470990B2
公开(公告)日：2013-06-25
申请号：US12645877
申请日：2009-12-23
申请人： Thomas A. Steitz , Peter B. Moore , Joyce A. Sutcliffe , Adegboyega K. Oyelere , Joseph A. Ippolito
发明人： Thomas A. Steitz , Peter B. Moore , Joyce A. Sutcliffe , Adegboyega K. Oyelere , Joseph A. Ippolito
CPC分类号： A61K31/00 , A61K31/165 , A61K31/40 , A61K31/506 , A61K31/513 , A61K31/5355 , A61K31/7048 , A61K31/7064 , A61K45/06 , C07D239/54 , C07D403/12 , C07K14/215 , C07K2299/00 , G01N33/6872 , G01N2500/00 , Y02A90/26
摘要： The invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as crystals produced by such methods. The invention also provides high resolution structures of ribosomal subunits either alone or in combination with protein synthesis inhibitors. The invention provides methods for identifying ribosome-related ligands and methods for designing ligands with specific ribosome-binding properties as well as ligands that may act as protein synthesis inhibitors. Thus, the methods and compositions of the invention may be used to produce ligands that are designed to specifically kill or inhibit the growth of any target organism.
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公开(公告)号：US07666849B2
公开(公告)日：2010-02-23
申请号：US11067522
申请日：2005-02-25
申请人： Thomas A. Steitz , Peter B. Moore , Joyce A. Sutcliffe , Adegboyega K. Oyelere , Joseph A. Ippolito
发明人： Thomas A. Steitz , Peter B. Moore , Joyce A. Sutcliffe , Adegboyega K. Oyelere , Joseph A. Ippolito
IPC分类号： A61K38/00
CPC分类号： A61K31/00 , A61K31/165 , A61K31/40 , A61K31/506 , A61K31/513 , A61K31/5355 , A61K31/7048 , A61K31/7064 , A61K45/06 , C07D239/54 , C07D403/12 , C07K14/215 , C07K2299/00 , G01N33/6872 , G01N2500/00 , Y02A90/26
摘要： The invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as crystals produced by such methods. The invention also provides high resolution structures of ribosomal subunits either alone or in combination with protein synthesis inhibitors. The invention provides methods for identifying ribosome-related ligands and methods for designing ligands with specific ribosome-binding properties as well as ligands that may act as protein synthesis inhibitors. Thus, the methods and compositions of the invention may be used to produce ligands that are designed to specifically kill or inhibit the growth of any target organism.
摘要翻译： 本发明提供了生产核糖体和核糖体亚基的高分辨率晶体以及通过这些方法产生的晶体的方法。 本发明还单独或与蛋白质合成抑制剂组合提供核糖体亚基的高分辨率结构。 本发明提供了用于鉴定核糖体相关配体的方法和用于设计具有特定核糖体结合特性的配体的方法以及可用作蛋白质合成抑制剂的配体。 因此，本发明的方法和组合物可用于产生设计用于特异性杀死或抑制任何靶生物体生长的配体。
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公开(公告)号：US20100204253A1
公开(公告)日：2010-08-12
申请号：US12645877
申请日：2009-12-23
申请人： Thomas Steitz , Peter B. Moore , Joyce A. Sutcliffe , Adegboyega K. Oyelere , Joseph A. Ippolito
发明人： Thomas Steitz , Peter B. Moore , Joyce A. Sutcliffe , Adegboyega K. Oyelere , Joseph A. Ippolito
IPC分类号： A61K31/505 , A61P31/04
CPC分类号： A61K31/00 , A61K31/165 , A61K31/40 , A61K31/506 , A61K31/513 , A61K31/5355 , A61K31/7048 , A61K31/7064 , A61K45/06 , C07D239/54 , C07D403/12 , C07K14/215 , C07K2299/00 , G01N33/6872 , G01N2500/00 , Y02A90/26
摘要： The invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as crystals produced by such methods. The invention also provides high resolution structures of ribosomal subunits either alone or in combination with protein synthesis inhibitors. The invention provides methods for identifying ribosome-related ligands and methods for designing ligands with specific ribosome-binding properties as well as ligands that may act as protein synthesis inhibitors. Thus, the methods and compositions of the invention may be used to produce ligands that are designed to specifically kill or inhibit the growth of any target organism.
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公开(公告)号：US08841263B2
公开(公告)日：2014-09-23
申请号：US13525900
申请日：2012-06-18
申请人： Jay J. Farmer , Ashoke Bhattacharjee , Yi Chen , Joel A. Goldberg , Joseph A. Ippolito , Zoltan F. Kanyo , Rongliang Lou , Adegboyega K. Oyelere , Edward C. Sherer , Joyce A. Sutcliffe , Deping Wang , Yusheng Wu , Yanming Du
发明人： Jay J. Farmer , Ashoke Bhattacharjee , Yi Chen , Joel A. Goldberg , Joseph A. Ippolito , Zoltan F. Kanyo , Rongliang Lou , Adegboyega K. Oyelere , Edward C. Sherer , Joyce A. Sutcliffe , Deping Wang , Yusheng Wu , Yanming Du
摘要： The present invention provides macrocyclic compounds useful as therapeutic agents of the formula: or a pharmaceutically acceptable salt, ester, N-oxide, or prodrug thereof, wherein T, R1, R2, R3, D, E, F, and G are as defined herein. More particularly, these compounds are useful as anti-infective, antiproliferative, anti-inflammatory and prokinetic agents.
摘要翻译： 本发明提供可用作下式的治疗剂的大环化合物：或其药学上可接受的盐，酯，N-氧化物或前药，其中T，R 1，R 2，R 3，D，E，F和G如上所定义 这里。 更具体地，这些化合物可用作抗感染，抗增殖，抗炎和促动力剂。
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公开(公告)号：US20120252747A1
公开(公告)日：2012-10-04
申请号：US13525900
申请日：2012-06-18
申请人： Jay J. Farmer , Ashoke Bhattacharjee , Yi Chen , Joel A. Goldberg , Joseph A. Ippolito , Zoltan F. Kanyo , Rongliang Lou , Adegboyega K. Oyelere , Edward C. Sherer , Joyce A. Sutcliffe , Deping Wang , Yusheng Wu , Yanming Du
发明人： Jay J. Farmer , Ashoke Bhattacharjee , Yi Chen , Joel A. Goldberg , Joseph A. Ippolito , Zoltan F. Kanyo , Rongliang Lou , Adegboyega K. Oyelere , Edward C. Sherer , Joyce A. Sutcliffe , Deping Wang , Yusheng Wu , Yanming Du
IPC分类号： A61K31/7056 , C07H17/08 , A61P1/14 , A61P31/00 , A61P29/00 , A61P35/00 , C07H17/00 , A61K31/706
摘要： The present invention provides macrocyclic compounds useful as therapeutic agents of the formula: or a pharmaceutically acceptable salt, ester, N-oxide, or prodrug thereof, wherein T, R1, R2, R3, D, E, F, and G are as defined herein. More particularly, these compounds are useful as anti-infective, antiproliferative, anti-inflammatory and prokinetic agents.
摘要翻译： 本发明提供可用作下式的治疗剂的大环化合物：或其药学上可接受的盐，酯，N-氧化物或前药，其中T，R 1，R 2，R 3，D，E，F和G如上所定义 这里。 更具体地，这些化合物可用作抗感染，抗增殖，抗炎和促动力剂。
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公开(公告)号：US08202843B2
公开(公告)日：2012-06-19
申请号：US10590782
申请日：2005-02-25
申请人： Jay J. Farmer , Ashoke Bhattacharjee , Yi Chen , Joel A. Goldberg , Joseph A. Ippolito , Zoltan F. Kanyo , Rongliang Lou , Adegboyega K. Oyelere , Edward C. Sherer , Joyce A. Sutcliffe , Deping Wang , Yusheng Wu , Yanming Du
发明人： Jay J. Farmer , Ashoke Bhattacharjee , Yi Chen , Joel A. Goldberg , Joseph A. Ippolito , Zoltan F. Kanyo , Rongliang Lou , Adegboyega K. Oyelere , Edward C. Sherer , Joyce A. Sutcliffe , Deping Wang , Yusheng Wu , Yanming Du
摘要： The present invention provides macrocyclic compounds useful as therapeutic agents of the formula: or a pharmaceutically acceptable salt, ester, N-oxide, or prodrug thereof, wherein T, R1, R2, R3, D, E, F, and G are as defined herein. More particularly, these compounds are useful as anti-infective, antiproliferative, anti-inflammatory and prokinetic agents.
摘要翻译： 本发明提供可用作下式的治疗剂的大环化合物：或其药学上可接受的盐，酯，N-氧化物或前药，其中T，R 1，R 2，R 3，D，E，F和G如上所定义 这里。 更具体地，这些化合物可用作抗感染，抗增殖，抗炎和促动力剂。
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10.发明授权公开(公告)号：US07335753B2
公开(公告)日：2008-02-26
申请号：US11359820
申请日：2006-02-21
申请人： Deping Wang , Joyce A. Sutcliffe , Adegboyega K. Oyelere , Timothy S. McConnell , Joseph A. Ippolito , John N. Abelson , Dane M. Springer , Joseph M. Salvino , Rongliang Lou , Joel A. Goldberg , Jay J. Farmer , Erin M. Duffy , Ashoke Bhattacharjee
发明人： Deping Wang , Joyce A. Sutcliffe , Adegboyega K. Oyelere , Timothy S. McConnell , Joseph A. Ippolito , John N. Abelson , Dane M. Springer , Joseph M. Salvino , Rongliang Lou , Joel A. Goldberg , Jay J. Farmer , Erin M. Duffy , Ashoke Bhattacharjee
IPC分类号： A61K31/7052 , A61K31/7048 , A61K31/4709 , A61K31/4176 , A61K31/4192 , A61K31/422 , C07H17/08 , C07D249/04 , C07D261/04 , C07D403/04 , C07D215/06
CPC分类号： A61K31/42 , A61K31/44 , A61K31/497 , A61K31/5375 , A61K31/7048 , C07H17/00
摘要： The invention provides a family of bifunctional heterocyclic compounds useful as anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. The invention also provides methods of making the bifunctional heterocyclic compounds, and methods of using such compounds as anti-infective, anti-proliferative agents, anti-inflammatory, and/or prokinetic agents.
摘要翻译： 本发明提供了一种可用作抗感染，抗增殖，抗炎和促动力的双功能杂环化合物。 本发明还提供了制备双官能杂环化合物的方法，以及使用这些化合物作为抗感染剂，抗增殖剂，抗炎剂和/或促动力剂的方法。
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