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11 条记录 (耗时 0.045 秒)

    Crystals of the large ribosomal subunit
    1.
    发明授权
    Crystals of the large ribosomal subunit 有权
    大核糖体亚基的晶体

    公开(公告)号：US06638908B1

    公开(公告)日：2003-10-28

    申请号：US09635708

    申请日：2000-08-09

    申请人： Thomas A. Steitz ,  Peter B. Moore ,  Nenad Ban ,  Poul Nissen ,  Jeffrey Hansen

    发明人： Thomas A. Steitz ,  Peter B. Moore ,  Nenad Ban ,  Poul Nissen ,  Jeffrey Hansen

    IPC分类号： A61K3800

    CPC分类号： C07K14/215 ,  C07K2299/00

    摘要： The present invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as the crystals produced by such methods. The x-ray diffraction patterns of the crystals provided by the present invention are of sufficiently high resolution for determining the three-dimensional structure of ribosomes and ribosomal subunits, for identifying ligand binding sites on ribosomes and ribosomal subunits, and for molecular modeling of ligands which interact with ribosomes and ribosomal subunits. The present invention provides methods for identifying ribosome-related ligands and methods for designing ligands with specific ribosome-binding properties. Thus, the methods of the present invention may be used to produce ligands which are designed to kill or inhibit any specific target organism(s).

    摘要翻译： 本发明提供了生产核糖体和核糖体亚基的高分辨率晶体的方法以及通过这些方法制备的晶体。 由本发明提供的晶体的x射线衍射图具有足够高的分辨率，用于确定核糖体和核糖体亚基的三维结构，用于鉴定核糖体和核糖体亚基上的配体结合位点，以及用于配体的分子模拟 与核糖体和核糖体亚基相互作用。 本发明提供鉴定核糖体相关配体的方法和用于设计具有特定核糖体结合特性的配体的方法。 因此，本发明的方法可用于产生设计用于杀死或抑制任何特定靶生物的配体。

    Use of the crystal structure of Staphylococcus aureus isoleucyl-tRNA synthetase in antibiotic design
    4.
    发明授权
    Use of the crystal structure of Staphylococcus aureus isoleucyl-tRNA synthetase in antibiotic design 失效
    在抗生素设计中使用金黄色葡萄球菌异亮氨酰-tRNA合成酶的晶体结构

    公开(公告)号：US06631329B1

    公开(公告)日：2003-10-07

    申请号：US09629732

    申请日：2000-07-31

    申请人： Jimin Wang ,  Laura F. Silvian ,  Thomas A. Steitz

    发明人： Jimin Wang ,  Laura F. Silvian ,  Thomas A. Steitz

    IPC分类号： G06F1900

    CPC分类号： C12N9/93

    摘要： The present invention provides the atomic coordinates derived from high resolution x-ray diffraction of the cocrystal complex comprising mupirocin with its target enzyme, isoleucyl-tRNA synthetase from Staphylococcus aureus, and the cognate tRNAile from Escherichia coli. The present invention further provides methods of using the atomic coordinates to identify and design new agents which modulate protein synthesis as well as the agents themselves.

    摘要翻译： 本发明提供衍生自包含莫匹罗星与其目标酶的共晶体络合物的高分辨率x射线衍射的原子坐标，来自金黄色葡萄球菌的异亮氨酰-tRNA合成酶和来自大肠杆菌的同源tRNA。 本发明还提供使用原子坐标来鉴定和设计调节蛋白质合成的新试剂以及试剂本身的方法。

    Method for identifying protein synthesis inhibitors by ribosome structure
    5.
    发明申请
    Method for identifying protein synthesis inhibitors by ribosome structure 审中-公开
    通过核糖体结构鉴定蛋白质合成抑制剂的方法

    公开(公告)号：US20100131258A1

    公开(公告)日：2010-05-27

    申请号：US12220342

    申请日：2008-07-22

    申请人： Thomas A. Steitz ,  Peter B. Moore ,  Nenad Ban ,  Poul Nissen ,  Jeffrey Hansen

    发明人： Thomas A. Steitz ,  Peter B. Moore ,  Nenad Ban ,  Poul Nissen ,  Jeffrey Hansen

    IPC分类号： G06G7/48

    CPC分类号： A61K31/40 ,  A61K31/165 ,  A61K31/506 ,  A61K31/513 ,  A61K31/5355 ,  A61K31/7048 ,  A61K45/06 ,  C07K14/215 ,  C07K2299/00

    摘要： The invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as crystals produced by such methods. The invention also provides high resolution structures of ribosomal subunits either alone or in combination with protein synthesis inhibitors. The invention provides methods for identifying ribosome-related ligands and methods for designing ligands with specific ribosome-binding properties as well as ligands that may act as protein synthesis inhibitors. Thus, the methods and compositions of the invention may be used to produce ligands that are designed to specifically kill or inhibit the growth of any target organism.

    摘要翻译： 本发明提供了生产核糖体和核糖体亚基的高分辨率晶体以及通过这些方法产生的晶体的方法。 本发明还单独或与蛋白质合成抑制剂组合提供核糖体亚基的高分辨率结构。 本发明提供了用于鉴定核糖体相关配体的方法和用于设计具有特定核糖体结合特性的配体的方法以及可用作蛋白质合成抑制剂的配体。 因此，本发明的方法和组合物可用于产生设计用于特异性杀死或抑制任何靶生物体生长的配体。

    Determination and uses of the atomic structures of ribosomes and ribosomal subunits and their ligand complexes
    8.
    发明授权
    Determination and uses of the atomic structures of ribosomes and ribosomal subunits and their ligand complexes 有权
    确定和使用核糖体和核糖体亚基及其配体配合物的原子结构

    公开(公告)号：US07504486B2

    公开(公告)日：2009-03-17

    申请号：US10391289

    申请日：2003-03-17

    申请人： Thomas A. Steitz ,  Peter B. Moore ,  Nenad Ban ,  Poul Nissen ,  Jeffrey Hansen

    发明人： Thomas A. Steitz ,  Peter B. Moore ,  Nenad Ban ,  Poul Nissen ,  Jeffrey Hansen

    IPC分类号： C07K1/14 ,  G01N31/00

    CPC分类号： C07K14/215 ,  C07K2299/00

    摘要： The present invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as the crystals produced by such methods. The x-ray diffraction patterns of the crystals provided by the present invention are of sufficiently high resolution for determining the three-dimensional structure of ribosomes and ribosomal subunits, for identifying ligand binding sites on ribosomes and ribosomal subunits, and for molecular modeling of ligands which interact with ribosomes and ribosomal subunits. The present invention provides methods for identifying ribosome-related ligands and methods for designing ligands with specific ribosome-binding properties. Thus, the methods of the present invention may be used to produce ligands which are designed to kill or inhibit any specific target organism(s).

    摘要翻译： 本发明提供了生产核糖体和核糖体亚基的高分辨率晶体的方法以及通过这些方法制备的晶体。 由本发明提供的晶体的x射线衍射图具有足够高的分辨率，用于确定核糖体和核糖体亚基的三维结构，用于鉴定核糖体和核糖体亚基上的配体结合位点，以及用于配体的分子模拟 与核糖体和核糖体亚基相互作用。 本发明提供鉴定核糖体相关配体的方法和用于设计具有特定核糖体结合特性的配体的方法。 因此，本发明的方法可用于产生设计用于杀死或抑制任何特定靶生物的配体。