公开(公告)号：US20060074231A1

公开(公告)日：2006-04-06

申请号：US10957220

申请日：2004-10-04

申请人： Tiberiu Siclovan ,  Faisal Syud ,  Bruce Johnson

发明人： Tiberiu Siclovan ,  Faisal Syud ,  Bruce Johnson

IPC分类号： C07K14/00 ,  C07D209/18 ,  C07H21/04 ,  C07C227/16

CPC分类号： C07H21/04

摘要： A method of labeling amino acid-containing compounds and derivatives thereof with a halide moiety comprises reacting a nucleophilic moiety on such compounds with a halogenated electrophilic compound. Radioactive halide-labeled amino acid-containing compounds can be targeted to diseased sites and provide a means to diagnose and/or treat the disease.

摘要翻译： 用卤化物部分标记含氨基酸的化合物及其衍生物的方法包括使这些化合物上的亲核部分与卤代亲电子化合物反应。 放射性卤化物标记的含氨基酸的化合物可以靶向病变部位，并提供诊断和/或治疗疾病的手段。

公开(公告)号：US20050049487A1

公开(公告)日：2005-03-03

申请号：US10647979

申请日：2003-08-26

申请人： Bruce Johnson ,  Tiberiu Siclovan

发明人： Bruce Johnson ,  Tiberiu Siclovan

IPC分类号： A61K51/04 ,  A61B6/00

CPC分类号： A61K51/04

摘要： Compounds that include a targeting moiety bound to a regioselective leaving group are useful for preparing imaging agents. The imaging agents can be isolated from by-products derived from the leaving group based on differences in the chemical attributes (e.g., net charge or polarity) of the molecules or physical attributes of the molecules through the use of a solid support. Methods of producing an imaging agent include the steps of providing a compound that includes a targeting moiety bound to a support via a linker group that contains a site for regioselective substitution of a detectable species, contacting the compound with a solution containing the detectable species, and recovering the imaging agent. Kits which include a first container having therein a solution containing a detectable species and a second container having therein a compound that includes a targeting moiety bound to a support via a leaving group that contains a site for regioselective substitution of the detectable species are also useful for preparing imaging agents.

摘要翻译： 包含与区域选择性离去基团结合的靶向部分的化合物可用于制备成像剂。 基于通过使用固体支持物的分子的化学属性（例如，净电荷或极性）或分子的物理属性的差异，可以从衍生自离去基团的副产物分离成像剂。 制备显影剂的方法包括以下步骤：提供化合物，其包括通过连接基团与支持物结合的靶向部分，所述连接基团含有可检测物质的区域选择性取代位点，使化合物与含有可检测物质的溶液接触，以及 恢复成像剂。 其中包括其中含有可检测物质的溶液的第一容器和其中具有化合物的第二容器，其中包含经由离去基团结合至载体的靶向部分的化合物，该离去基团含有可检测物质的区域选择性取代的位点也可用于 制备成像剂。

公开(公告)号：US20050089471A1

公开(公告)日：2005-04-28

申请号：US10691533

申请日：2003-10-24

申请人： Bruce Johnson ,  Frank Mondello ,  Faisal Syud ,  Andrew Torres ,  John Brogan

发明人： Bruce Johnson ,  Frank Mondello ,  Faisal Syud ,  Andrew Torres ,  John Brogan

IPC分类号： A61K49/00 ,  A61K49/14 ,  A61K49/16 ,  A61K51/10 ,  C07B59/00 ,  A61K51/00 ,  C07F5/00 ,  C07F13/00

CPC分类号： A61K49/0056 ,  A61K49/0002 ,  A61K49/0043 ,  A61K49/0058 ,  A61K49/085 ,  A61K49/14 ,  A61K49/16 ,  A61K51/10 ,  C07B59/008

摘要： Embodiments of the present invention relates to compounds labeled with imaging agents that also are capable of binding lectin-like oxidized low-density lipoprotein (LOX-1). The labeled compounds are useful for the diagnosis and monitoring of diseases in which inflammation plays a role, such as various cardiovascular diseases including but not limited to atherosclerosis, vulnerable plaque, and coronary artery disease, as well as rheumatoid arthritis.

摘要翻译： 本发明的实施方案涉及还能够结合凝集素样氧化低密度脂蛋白（LOX-1）的成像剂标记的化合物。 标记的化合物可用于诊断和监测炎症起作用的疾病，例如各种心血管疾病，包括但不限于动脉粥样硬化，易损斑块和冠状动脉疾病以及类风湿性关节炎。

公开(公告)号：US20050089470A1

公开(公告)日：2005-04-28

申请号：US10691532

申请日：2003-10-24

申请人： Bruce Johnson ,  Faisal Syud

发明人： Bruce Johnson ,  Faisal Syud

IPC分类号： A61K49/00 ,  C07B59/00 ,  A61K51/00 ,  C07F5/00

CPC分类号： A61K49/0002 ,  C07B59/008

摘要： The present invention relates to compounds labeled with imaging agents that also are capable of binding lectin-like oxidized low-density lipoprotein (LOX-1). The labeled compounds are useful for the diagnosis and monitoring of diseases in which inflammation plays a role, such as various cardiovascular diseases including but not limited to atherosclerosis, vulnerable plaque and coronary artery disease, as well as rheumatoid arthritis.

摘要翻译： 本发明涉及也能够结合凝集素样氧化低密度脂蛋白（LOX-1）的成像剂标记的化合物。 标记的化合物可用于诊断和监测炎症起作用的疾病，例如各种心血管疾病，包括但不限于动脉粥样硬化，易损斑块和冠状动脉疾病以及类风湿性关节炎。

公开(公告)号：USD1022049S1

公开(公告)日：2024-04-09

申请号：US29831471

申请日：2022-03-21

申请人： Bruce Johnson

设计人： Bruce Johnson

摘要： FIG. 1 is a front perspective view of the box lid stand in an assembled state, showing my design;
FIG. 2 is a front view thereof;
FIG. 3 is a rear view thereof;
FIG. 4 is a top view thereof;
FIG. 5 is bottom view thereof;
FIG. 6 is a left-side view thereof;
FIG. 7 is a right-side view thereof;
FIG. 8 is a front view thereof in a disassembled state; and,
FIG. 9 is a front perspective view thereof, in an environment of use.
The dash-dash broken lines showing a box lid in FIG. 9 depict environmental subject matter and form no part of the claimed design. The appearance of any portion of the box lid stand shown between break lines forms no part of the claimed design. The dot-dash-dot broken lines depicting the boundary of the box lid stand form no part of the claimed design. All other dash-dash broken lines show portions of the box lid stand that form no part of the claimed design.

公开(公告)号：US20230049174A1

公开(公告)日：2023-02-16

申请号：US17889150

申请日：2022-08-16

申请人： Bruce Johnson

发明人： Bruce Johnson

IPC分类号： A61B10/00

摘要： A method for sample encapsulation. A first sampling swab is provided that includes an absorbent portion and a fluid control portion that extends from the absorbent portion. The absorbent portion is proximate a proximal end of the first sampling swab. The fluid control portion is proximate a distal end of the first sampling swab. A sample is collected with the absorbent portion. At least a portion of the sample is liquid. An encapsulation material is provided that includes a first web and a second web. The first sampling swab is positioned between the first web and the second web. The first web is urged into contact with the second web proximate the absorbent portion. The urging of the first web into contact with the second web proximate the absorbent portion causes liquid to move from the absorbent portion towards the fluid control portion. The urging of the first web into contact with the second web proximate the absorbent portion is discontinued which causes the liquid to be drawn into the absorbent portion. The first web is urged into contact with the second web proximate the distal end of the first sampling swab to encapsulate the liquid in the encapsulation material.

公开(公告)号：USD938823S1

公开(公告)日：2021-12-21

申请号：US29762887

申请日：2020-12-18

申请人： Bruce Johnson

设计人： Bruce Johnson

公开(公告)号：US20190262167A1

公开(公告)日：2019-08-29

申请号：US16407898

申请日：2019-05-09

申请人： Liney Guidry ,  Theresa Johnson ,  Reed Johnson ,  Bruce Johnson

发明人： Liney Guidry ,  Theresa Johnson ,  Reed Johnson ,  Bruce Johnson

IPC分类号： A61F5/44 ,  A61F5/445

摘要： An ostomy pouch replacement device allows ostomates with a surgically created stoma to collect, contain and dispose of bodily fluids during hygienic maintenance. The device is customizable to each ostomate's unique stoma diameter and provides a disposable waste receptacle having a hollow absorbent section and a solid absorbent section for sanitary, discreet and odorless disposal of both urine and excrement. The disposable waste receptacle may include a super absorbent polymer powder that becomes a gel in the presence of liquid. The device preferably consists of a disposable waste receptacle that may be positioned over the stoma and includes an absorbent inner material for capturing waste, a cap or plug for scaling the device after use, and a collar stand for pressing an adhesive wafer to the skin and for holding the assembled device in an upright position.

公开(公告)号：US09416034B2

公开(公告)日：2016-08-16

申请号：US12320526

申请日：2009-01-28

申请人： Bruce Johnson ,  Kevin Doyle ,  Keith Schulte

发明人： Bruce Johnson ,  Kevin Doyle ,  Keith Schulte

IPC分类号： C02F1/66 ,  C02F1/00 ,  C02F1/76 ,  C02F103/42

CPC分类号： C02F1/66 ,  C02F1/008 ,  C02F1/4674 ,  C02F1/76 ,  C02F2103/42 ,  C02F2209/06

摘要： A method and an apparatus for dispensing a pH balancing solution are provided. The apparatus includes a system having a chlorine generator with a power supply coupled to the chlorine generator, the chlorine generator servicing a body of water and chlorinating it. A pH monitoring and balancing unit is provided. The pH monitoring and balancing unit monitors and measures when power is supplied from the power supply to the chlorine generator to produce chlorine and thereby calculates an operational time for the chlorine generator. A pH monitoring and balancing unit controller is also provided, the pH monitoring and balancing unit controller computing an estimated pH level based on the production of the chlorine generator from the operational time measured and then determining if the estimated pH is outside of a desired range, and, if it is outside of the desired range, metering a discrete amount of pH balancing solution based on this estimated pH level to return the pH of the body of water to within the desired range.

摘要翻译： 提供了一种用于分配pH平衡溶液的方法和装置。 该装置包括具有氯发生器的系统，其具有耦合到氯发生器的电源，氯发生器服务于水体并对其进行氯化。 提供pH监测和平衡单元。 pH监测和平衡单元监测和测量从电源向氯气发生器供电以产生氯气，从而计算氯气发生器的运行时间。 还提供pH监测和平衡单元控制器，pH监测和平衡单元控制器根据测量的操作时间计算基于氯发生器的产生的估计的pH水平，然后确定估计的pH是否在期望的范围之外， 并且如果超出所需范围，则基于该估计的pH值计量离散量的pH平衡溶液，以将水体的pH值返回到所需范围内。

公开(公告)号：US09004881B2

公开(公告)日：2015-04-14

申请号：US13452077

申请日：2012-04-20

申请人： Tom M. Simmons ,  John M. Simmons ,  David M. Simmons ,  Bruce Johnson

发明人： Tom M. Simmons ,  John M. Simmons ,  David M. Simmons ,  Bruce Johnson

IPC分类号： F04B45/00 ,  F04B47/08 ,  F04B23/04 ,  F04B7/04 ,  F04B43/12 ,  F04B43/073

CPC分类号： F04B43/1136 ,  F04B43/0736 ,  F04B43/113 ,  F04B45/043 ,  F04B45/0536 ,  F04B45/0736 ,  F04B49/22 ,  F04B53/22 ,  Y10T29/49236

摘要： A fluid pump includes a pump body enclosing a first cavity and a second cavity, a first flexible member disposed within the first cavity, a second flexible member disposed within the second cavity, and a drive shaft extending between and attached to each of the first flexible member and the second flexible member. The drive shaft is configured to slide back and forth within the pump body. The pump also includes a first shift valve and a second shift valve disposed between the first flexible member and the second flexible member, operatively coupled to deliver a drive fluid to drive fluid chambers in alternating sequence. Some fluid pumps disclosed herein include a housing defining a modular-receiving cavity and a modular insert secured within the modular-receiving cavity by an interference fit. Methods of manufacturing and using fluid pumps are also disclosed.

摘要翻译： 流体泵包括：泵体，其包围第一空腔和第二空腔;布置在第一空腔内的第一柔性构件，设置在第二空腔内的第二柔性构件;以及驱动轴，其在第一弹性体 会员和第二个灵活会员。 驱动轴构造成在泵体内前后滑动。 泵还包括设置在第一柔性构件和第二柔性构件之间的第一换档阀和第二换档阀，其可操作地联接以传递驱动流体以交替的顺序驱动流体室。 本文公开的一些流体泵包括限定模块化容纳腔的壳体和通过过盈配合固定在模块化接收腔内的模块化插入件。 还公开了制造和使用流体泵的方法。