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    Fixed dried red blood cells and method of use
    5.
    发明授权
    Fixed dried red blood cells and method of use 失效
    固定干红细胞和使用方法

    公开(公告)号：US06884573B2

    公开(公告)日：2005-04-26

    申请号：US10231635

    申请日：2002-08-30

    申请人： Thomas H. Fischer ,  Marjorie S. Read ,  Arthur P. Bode ,  Timothy C. Nichols

    发明人： Thomas H. Fischer ,  Marjorie S. Read ,  Arthur P. Bode ,  Timothy C. Nichols

    IPC分类号： A01N1/02 ,  A61K35/18 ,  A01N63/00

    CPC分类号： A01N1/0226 ,  A01N1/02 ,  A01N1/0284 ,  A01N1/0289 ,  A61K35/18

    摘要： Fixed-dried red blood cells (RBCs), and processes for preparing the same are disclosed. The red blood cells, upon reconstitution with distilled water or appropriate buffer: bind oxygen with native affinities, have partial deformability, present minimal thrombogenicity to platelets, and have oblated blood group antigens. The RBCs are preferably fixed by means of cross-linkers with aldehyde functions such as paraformaldehyde or glutaraldehyde either alone or in combination. Native oxygen kinetics are achieved by preparing the red blood cells with 1,6-diphosphofructose. Blood group antigens and chemical functions that render the lyophilized RBCs thrombogenic are occluded by chemically attaching polyoxyethylene glycol polymers to the surface membrane of the red blood cells. The cross-linked red blood cells are preferably died by lyophilization.

    摘要翻译： 公开了固定干红细胞（RBC）及其制备方法。 红细胞在用蒸馏水或适当的缓冲液重构后，与氧化天然亲和力结合，具有部分变形能力，对血小板具有最小的血栓形成，并且具有扁平的血型抗原。 RBCs优选通过具有醛官能团的交联剂例如多聚甲醛或戊二醛单独或组合固定。 通过制备具有1,6-二磷酸果糖的红细胞来实现天然氧动力学。 通过将聚氧乙烯二醇聚合物化学连接到红细胞的表面膜上，使冻干的RBC血栓形成的血型抗原和化学功能被阻断。 交联的红细胞优选通过冻干死亡。

    Fixed-dried red blood cells
    6.
    发明授权
    Fixed-dried red blood cells 失效
    固定干红细胞

    公开(公告)号：US07358039B2

    公开(公告)日：2008-04-15

    申请号：US11041560

    申请日：2005-01-24

    申请人： Thomas H. Fischer ,  Marjorie S. Read ,  Arthur P. Bode ,  Timothy C. Nichols

    发明人： Thomas H. Fischer ,  Marjorie S. Read ,  Arthur P. Bode ,  Timothy C. Nichols

    IPC分类号： A01N1/02 ,  A01N63/00

    CPC分类号： A01N1/0226 ,  A01N1/02 ,  A01N1/0284 ,  A01N1/0289 ,  A61K35/18

    摘要： Fixed-dried red blood cells (RBCs), and processes for preparing the same are disclosed. The red blood cells, upon reconstitution with distilled water or appropriate buffer: bind oxygen with native affinities, have partial deformability, present minimal thrombogenicity to platelets, and have oblated blood group antigens. The RBCs are preferably fixed by means of cross-linkers with aldehyde functions such as paraformaldehyde or glutaraldehyde either alone or in combination. Native oxygen kinetics are achieved by preparing the red blood cells with 1,6-diphosphofructose. Blood group antigens and chemical functions that render the lyophilized RBCs thrombogenic are occluded by chemically attaching polyoxyethylene glycol polymers to the surface membrane of the red blood cells. The cross-linked red blood cells are preferably died by lyophilization.

    摘要翻译： 公开了固定干红细胞（RBC）及其制备方法。 红细胞在用蒸馏水或适当的缓冲液重构后，与氧化天然亲和力结合，具有部分变形能力，对血小板具有最小的血栓形成，并且具有扁平的血型抗原。 RBCs优选通过具有醛官能团的交联剂例如多聚甲醛或戊二醛单独或组合固定。 通过制备具有1,6-二磷酸果糖的红细胞来实现天然氧动力学。 通过将聚氧乙烯二醇聚合物化学连接到红细胞的表面膜上，使冻干的RBC血栓形成的血型抗原和化学功能被阻断。 交联的红细胞优选通过冻干死亡。

    Reagents for screening tests and bioassay of von Willebrand's factor (platelet aggregating factor) in blood plasmas
    10.
    发明授权
    Reagents for screening tests and bioassay of von Willebrand's factor (platelet aggregating factor) in blood plasmas 失效
    血液血浆中von Willebrand {3 s因子（血小板聚集因子）的筛选试验和生物测定试剂

    公开(公告)号：US4145185A

    公开(公告)日：1979-03-20

    申请号：US772228

    申请日：1977-02-25

    申请人： Kenneth M. Brinkhous ,  Marjorie S. Read

    发明人： Kenneth M. Brinkhous ,  Marjorie S. Read

    IPC分类号： G01N33/50 ,  G01N33/16 ,  A61K35/38 ,  C09K3/00

    CPC分类号： G01N33/5005

    摘要： Screening tests and bioassay of von Willebrand's factor (platelet aggregating factor) in human and animal blood plasma are effected using a reagent of blood platelets and snake venom having a positive platelet aggregating cofactor effect. The reagent and tests may also suitably employ dried blood platelets. The reagent may comprise dried platelets and either ristocetin or active snake venom as the platelet aggregating cofactor.

    摘要翻译： 使用血小板试剂和具有积极的血小板聚集辅因子作用的蛇毒进行人和动物血浆中von Willebrand因子（血小板聚集因子）的筛选试验和生物测定。 试剂和试验也可适当地使用干血小板。 试剂可以包含干血小板和瑞斯托菌素或活性蛇毒作为血小板聚集辅因子。