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公开(公告)号：US07176314B2
公开(公告)日：2007-02-13
申请号：US10314428
申请日：2002-12-04
申请人： Timothy D. Cushing , Xiao He , Marie-Louise Smith , Michael R. DeGraffenreid , Jay Powers , Craig S. Tomooka , David L. Clark , Xiaolin Hao , Juan C. Jaen , Marc Labelle , Nigel P. C. Walker , Adrian L. Gill , Francisco X. Talamas , Sharada Labadie
发明人： Timothy D. Cushing , Xiao He , Marie-Louise Smith , Michael R. DeGraffenreid , Jay Powers , Craig S. Tomooka , David L. Clark , Xiaolin Hao , Juan C. Jaen , Marc Labelle , Nigel P. C. Walker , Adrian L. Gill , Francisco X. Talamas , Sharada Labadie
IPC分类号： C07D215/00 , C09B25/00
CPC分类号： C07D401/04 , A61K31/4709 , C07D401/14 , C07D405/14 , A61K2300/00
摘要： Compounds, compositions and methods that are useful in the treatment of inflammatory, immunoregulatory, metabolic and cell proliferative conditions or diseases are provided herein. In particular, the invention provides compounds which modulate the expression and/or function of proteins involved in inflammation, metabolism and cell proliferation. The subject compounds contain quinoline or quinazoline rings.
摘要翻译： 本文提供了可用于治疗炎症，免疫调节，代谢和细胞增殖性病症或疾病的化合物，组合物和方法。 特别地，本发明提供调节参与炎症，代谢和细胞增殖的蛋白质的表达和/或功能的化合物。 主题化合物含有喹啉或喹唑啉环。
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公开(公告)号：US07199119B2
公开(公告)日：2007-04-03
申请号：US10666857
申请日：2003-09-19
申请人： Simon A. Burkitt , Mario G. Cardozo , Timothy D. Cushing , Michael R. DeGraffenreid , Christopher N. Farthing , Xiaolin Hao , Juan C. Jaen , XianYun Jiao , David J. Kopecky , Marc Labelle , Sarah E. Lively , Dustin L. McMinn , Sven P. Rasmussen , Youngsook Shin , Marie-Louise Smith , Andrew Smith
发明人： Simon A. Burkitt , Mario G. Cardozo , Timothy D. Cushing , Michael R. DeGraffenreid , Christopher N. Farthing , Xiaolin Hao , Juan C. Jaen , XianYun Jiao , David J. Kopecky , Marc Labelle , Sarah E. Lively , Dustin L. McMinn , Sven P. Rasmussen , Youngsook Shin , Marie-Louise Smith , Andrew Smith
IPC分类号： A61K31/5377 , A61K31/4365 , C07D413/14 , C07D471/04
CPC分类号： C07D231/56 , C07D239/74 , C07D471/04 , C07D491/04 , C07D495/04 , C07D495/14 , C07D513/04
摘要： Compounds, compositions and methods that are useful in the treatment of inflammatory, immunoregulatory, metabolic, infectious and cell proliferative diseases or conditions are provided herein. In particular, the invention provides compounds which modulate the expression and/or function of proteins involved in inflammation, metabolism, infection and cell proliferation. The subject compounds contain a fused heterobicyclic ring.
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公开(公告)号：US07635695B2
公开(公告)日：2009-12-22
申请号：US11709895
申请日：2007-02-21
申请人： Simon A. Burkitt , Mario G. Cardozo , Timothy D. Cushing , Michael R. DeGraffenreid , Christopher N. Farthing , Xiaolin Hao , Juan C. Jaen , Xian Yun Jiao , David J. Kopecky , Marc Labelle , Sarah E. Lively , Dustin L. McMinn , Sven P. Rasmussen , Youngsook Shin , Marie-Louise Smith , Andrew Smith
发明人： Simon A. Burkitt , Mario G. Cardozo , Timothy D. Cushing , Michael R. DeGraffenreid , Christopher N. Farthing , Xiaolin Hao , Juan C. Jaen , Xian Yun Jiao , David J. Kopecky , Marc Labelle , Sarah E. Lively , Dustin L. McMinn , Sven P. Rasmussen , Youngsook Shin , Marie-Louise Smith , Andrew Smith
IPC分类号： A61K31/5377 , A61K31/4365 , C07D413/14 , C07D495/04
CPC分类号： C07D231/56 , C07D239/74 , C07D471/04 , C07D491/04 , C07D495/04 , C07D495/14 , C07D513/04
摘要： Compounds, compositions and methods that are useful in the treatment of inflammatory, immunoregulatory, metabolic, infectious and cell proliferative diseases or conditions are provided herein. In particular, the invention provides compounds which modulate the expression and/or function of proteins involved in inflammation, metabolism, infection and cell proliferation. The subject compounds contain a fused heterobicyclic ring.
摘要翻译： 本文提供了可用于治疗炎症，免疫调节，代谢，感染和细胞增殖性疾病或病症的化合物，组合物和方法。 特别地，本发明提供调节参与炎症，代谢，感染和细胞增殖的蛋白质的表达和/或功能的化合物。 主题化合物含有稠合的杂双环。
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公开(公告)号：US07365075B2
公开(公告)日：2008-04-29
申请号：US11018401
申请日：2004-12-20
申请人： Michael R. DeGraffenreid , Xiao He , Jay P. Powers , Daqing Sun , Xuelei Yan
发明人： Michael R. DeGraffenreid , Xiao He , Jay P. Powers , Daqing Sun , Xuelei Yan
IPC分类号： A61K31/497 , A61K31/4965 , C07D403/00 , C07D295/00
CPC分类号： C07D213/38 , C07D213/61 , C07D213/81 , C07D233/54 , C07D241/04 , C07D295/26 , C07D401/06 , C07D403/06
摘要： The present invention provides Aryl Sulfonamide Compounds having the formula: and prodrugs or pharmaceutically acceptable salts or prodrugs thereof. The Aryl Sulfonamide Compounds are useful for treating diabetes, obesity, and other diseases and disorders.
摘要翻译： 本发明提供具有下式的芳基磺酰胺化合物及其前药或药学上可接受的盐或前药。 芳基磺酰胺化合物可用于治疗糖尿病，肥胖症和其他疾病和障碍。
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公开(公告)号：US07495012B2
公开(公告)日：2009-02-24
申请号：US11109871
申请日：2005-04-20
IPC分类号： A01N43/40 , A61K31/445 , C07D211/00 , C07D295/00
CPC分类号： C07D295/26 , C07D207/48 , C07D209/08 , C07D211/96 , C07D215/58 , C07D217/08 , C07D401/04 , C07D401/06 , C07D403/04
摘要： Arylsulfonamide compounds of formula I are described and have therapeutic utility, particularly in the treatment of diabetes, obesity and related conditions and disorders:
摘要翻译： 描述了式I的芳基磺酰胺化合物，并具有治疗效用，特别是在治疗糖尿病，肥胖症和相关病症和病症中：
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公开(公告)号：US20090075975A1
公开(公告)日：2009-03-19
申请号：US12276753
申请日：2008-11-24
IPC分类号： A61K31/55 , C07D209/04 , A61K31/404 , C07D403/02 , A61K31/4164 , C07D207/48 , A61K31/40 , C07D213/02 , C07D215/00 , A61P37/00 , A61P29/00 , A61P25/00 , A61P9/00 , A61P3/00 , C12N5/00 , A61K31/33 , C07D225/02 , A61K31/47 , A61K31/4545 , C07D217/22 , C07D295/00 , A61K31/5375 , C07D211/08 , A61K31/445 , C07D223/08
CPC分类号： C07D295/26 , C07D207/48 , C07D209/08 , C07D211/96 , C07D215/58 , C07D217/08 , C07D401/04 , C07D401/06 , C07D403/04
摘要： Arylsulfonamide compounds of formula I are described and have therapeutic utility, particularly in the treatment of diabetes, obesity and related conditions and disorders:
摘要翻译： 描述了式I的芳基磺酰胺化合物，并具有治疗效用，特别是在治疗糖尿病，肥胖症和相关病症和病症中：
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