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公开(公告)号：US07365075B2
公开(公告)日：2008-04-29
申请号：US11018401
申请日：2004-12-20
申请人： Michael R. DeGraffenreid , Xiao He , Jay P. Powers , Daqing Sun , Xuelei Yan
发明人： Michael R. DeGraffenreid , Xiao He , Jay P. Powers , Daqing Sun , Xuelei Yan
IPC分类号： A61K31/497 , A61K31/4965 , C07D403/00 , C07D295/00
CPC分类号： C07D213/38 , C07D213/61 , C07D213/81 , C07D233/54 , C07D241/04 , C07D295/26 , C07D401/06 , C07D403/06
摘要： The present invention provides Aryl Sulfonamide Compounds having the formula: and prodrugs or pharmaceutically acceptable salts or prodrugs thereof. The Aryl Sulfonamide Compounds are useful for treating diabetes, obesity, and other diseases and disorders.
摘要翻译： 本发明提供具有下式的芳基磺酰胺化合物及其前药或药学上可接受的盐或前药。 芳基磺酰胺化合物可用于治疗糖尿病，肥胖症和其他疾病和障碍。
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公开(公告)号：US08637576B2
公开(公告)日：2014-01-28
申请号：US12582535
申请日：2009-10-20
申请人： Jay P. Powers , Michael R. Degraffenreid , Xiao He , Lisa D. Julian , Dustin L. McMinn , Daqing Sun , Yosup Rew , Xuelei Yan
发明人： Jay P. Powers , Michael R. Degraffenreid , Xiao He , Lisa D. Julian , Dustin L. McMinn , Daqing Sun , Yosup Rew , Xuelei Yan
IPC分类号： A61K31/165 , A61K31/44
CPC分类号： C07D277/28 , C07C235/42 , C07C235/54 , C07C237/42 , C07C255/29 , C07C255/31 , C07C255/44 , C07C255/46 , C07C255/60 , C07C317/36 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2602/42 , C07D211/16 , C07D211/18 , C07D211/22 , C07D211/34 , C07D211/38 , C07D211/52 , C07D211/60 , C07D211/64 , C07D213/40 , C07D213/61 , C07D213/74 , C07D213/81 , C07D213/84 , C07D213/89 , C07D233/64 , C07D295/192 , C07D307/22 , C07D309/14 , C07D333/20
摘要： Benzamide derivatives of formulae I and II, and pharmaceutically acceptable salts, solvates, stereoisomers, and prodrugs thereof, and pharmaceutical compositions comprising the same, are described and have therapeutic utility, particularly in the treatment of diabetes, obesity, and related conditions and disorders: wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, and R12 are defined as provided herein.
摘要翻译： 描述了式I和II的苯甲酰胺衍生物及其药学上可接受的盐，溶剂化物，立体异构体和前药，以及包含其的药物组合物，并具有治疗用途，特别是治疗糖尿病，肥胖症和相关病症和病症： 其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8，R 9，R 10，R 11和R 12如本文所提供。
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公开(公告)号：US07495012B2
公开(公告)日：2009-02-24
申请号：US11109871
申请日：2005-04-20
IPC分类号： A01N43/40 , A61K31/445 , C07D211/00 , C07D295/00
CPC分类号： C07D295/26 , C07D207/48 , C07D209/08 , C07D211/96 , C07D215/58 , C07D217/08 , C07D401/04 , C07D401/06 , C07D403/04
摘要： Arylsulfonamide compounds of formula I are described and have therapeutic utility, particularly in the treatment of diabetes, obesity and related conditions and disorders:
摘要翻译： 描述了式I的芳基磺酰胺化合物，并具有治疗效用，特别是在治疗糖尿病，肥胖症和相关病症和病症中：
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公开(公告)号：US07834047B2
公开(公告)日：2010-11-16
申请号：US12276753
申请日：2008-11-24
IPC分类号： A01N43/36 , A61K31/40 , C07D207/00 , C07D295/00
CPC分类号： C07D295/26 , C07D207/48 , C07D209/08 , C07D211/96 , C07D215/58 , C07D217/08 , C07D401/04 , C07D401/06 , C07D403/04
摘要： Arylsulfonamide compounds of formula I are described and have therapeutic utility, particularly in the treatment of diabetes, obesity and related conditions and disorders:
摘要翻译： 描述了式I的芳基磺酰胺化合物，并具有治疗效用，特别是在治疗糖尿病，肥胖症和相关病症和病症中：
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公开(公告)号：US20090075975A1
公开(公告)日：2009-03-19
申请号：US12276753
申请日：2008-11-24
IPC分类号： A61K31/55 , C07D209/04 , A61K31/404 , C07D403/02 , A61K31/4164 , C07D207/48 , A61K31/40 , C07D213/02 , C07D215/00 , A61P37/00 , A61P29/00 , A61P25/00 , A61P9/00 , A61P3/00 , C12N5/00 , A61K31/33 , C07D225/02 , A61K31/47 , A61K31/4545 , C07D217/22 , C07D295/00 , A61K31/5375 , C07D211/08 , A61K31/445 , C07D223/08
CPC分类号： C07D295/26 , C07D207/48 , C07D209/08 , C07D211/96 , C07D215/58 , C07D217/08 , C07D401/04 , C07D401/06 , C07D403/04
摘要： Arylsulfonamide compounds of formula I are described and have therapeutic utility, particularly in the treatment of diabetes, obesity and related conditions and disorders:
摘要翻译： 描述了式I的芳基磺酰胺化合物，并具有治疗效用，特别是在治疗糖尿病，肥胖症和相关病症和病症中：
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公开(公告)号：US20100069447A1
公开(公告)日：2010-03-18
申请号：US12582535
申请日：2009-10-20
申请人： Jay P. POWERS , Michael Degraffenreid , Xiao He , Lisa Julian , Dustin L. McMinn , Daqing Sun , Yosup Rew , Xuelei Yan
发明人： Jay P. POWERS , Michael Degraffenreid , Xiao He , Lisa Julian , Dustin L. McMinn , Daqing Sun , Yosup Rew , Xuelei Yan
IPC分类号： A61K31/44 , C07C233/00 , C07D213/02 , A61K31/166 , A61P37/06
CPC分类号： C07D277/28 , C07C235/42 , C07C235/54 , C07C237/42 , C07C255/29 , C07C255/31 , C07C255/44 , C07C255/46 , C07C255/60 , C07C317/36 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2602/42 , C07D211/16 , C07D211/18 , C07D211/22 , C07D211/34 , C07D211/38 , C07D211/52 , C07D211/60 , C07D211/64 , C07D213/40 , C07D213/61 , C07D213/74 , C07D213/81 , C07D213/84 , C07D213/89 , C07D233/64 , C07D295/192 , C07D307/22 , C07D309/14 , C07D333/20
摘要： Benzamide derivatives of formulae I and II, and pharmaceutically acceptable salts, solvates, stereoisomers, and prodrugs thereof, and pharmaceutical compositions comprising the same, are described and have therapeutic utility, particularly in the treatment of diabetes, obesity, and related conditions and disorders: wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, and R12 are defined as provided herein.
摘要翻译： 描述了式I和II的苯甲酰胺衍生物及其药学上可接受的盐，溶剂化物，立体异构体和前药，以及包含其的药物组合物，并具有治疗用途，特别是治疗糖尿病，肥胖症和相关病症和病症： 其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8，R 9，R 10，R 11和R 12如本文所提供。
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公开(公告)号：US20080269283A1
公开(公告)日：2008-10-30
申请号：US12163088
申请日：2008-06-27
申请人： Pingchen Fan , Hiroyuki Goto , Xiao He , Makoto Kukutani , Marc Labelle , Dustin L. McMinn , Jay P. Powers , Yosup Rew , Daqing Sun , Xuelei Yan
发明人： Pingchen Fan , Hiroyuki Goto , Xiao He , Makoto Kukutani , Marc Labelle , Dustin L. McMinn , Jay P. Powers , Yosup Rew , Daqing Sun , Xuelei Yan
IPC分类号： A61K31/47 , A61K31/40 , A61K31/277 , A61K31/165 , A61K31/10 , C07C317/26 , C07D215/12 , C07D207/06 , C07C255/00 , C07C381/00 , C07C317/14 , C07D233/56 , A61K31/4164 , C07D277/02 , C07D409/00 , A61K31/4439 , A61K31/426 , A61K31/427 , A61P3/04 , A61P3/10 , C12N5/00
CPC分类号： C07C317/44 , C07C317/14 , C07C317/22 , C07C2601/02 , C07D215/36 , C07D233/54 , C07D277/36 , C07D277/54 , C07D277/56 , C07D295/096 , C07D295/112 , C07D417/04
摘要： Aryl sulfone compounds of formula I and II are described and have therapeutic utility, particularly in the treatment of diabetes, obesity and related conditions and disorders:
摘要翻译： 描述了式I和II的芳基砜化合物，并具有治疗效用，特别是在治疗糖尿病，肥胖症和相关病症和病症中：
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公开(公告)号：US07754890B2
公开(公告)日：2010-07-13
申请号：US12163088
申请日：2008-06-27
申请人： Pingchen Fan , Hiroyuki Goto , Xiao He , Makoto Kakutani , Marc Labelle , Dustin L. McMinn , Jay P. Powers , Yosup Rew , Daqing Sun , Xuelei Yan
发明人： Pingchen Fan , Hiroyuki Goto , Xiao He , Makoto Kakutani , Marc Labelle , Dustin L. McMinn , Jay P. Powers , Yosup Rew , Daqing Sun , Xuelei Yan
IPC分类号： C07D277/26 , A61K31/425
CPC分类号： C07C317/44 , C07C317/14 , C07C317/22 , C07C2601/02 , C07D215/36 , C07D233/54 , C07D277/36 , C07D277/54 , C07D277/56 , C07D295/096 , C07D295/112 , C07D417/04
摘要： Aryl sulfone compounds of formula I and II are described and have therapeutic utility, particularly in the treatment of diabetes, obesity and related conditions and disorders:
摘要翻译： 描述了式I和II的芳基砜化合物，并具有治疗效用，特别是在治疗糖尿病，肥胖症和相关病症和病症中：
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公开(公告)号：US07605289B2
公开(公告)日：2009-10-20
申请号：US11448986
申请日：2006-06-08
申请人： Jay P. Powers , Michael Degraffenreid , Xiao He , Lisa Julian , Dustin L. McMinn , Daqing Sun , Yosup Rew , Xuelei Yan
发明人： Jay P. Powers , Michael Degraffenreid , Xiao He , Lisa Julian , Dustin L. McMinn , Daqing Sun , Yosup Rew , Xuelei Yan
IPC分类号： C07C233/65 , A61K31/165
CPC分类号： C07D277/28 , C07C235/42 , C07C235/54 , C07C237/42 , C07C255/29 , C07C255/31 , C07C255/44 , C07C255/46 , C07C255/60 , C07C317/36 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2602/42 , C07D211/16 , C07D211/18 , C07D211/22 , C07D211/34 , C07D211/38 , C07D211/52 , C07D211/60 , C07D211/64 , C07D213/40 , C07D213/61 , C07D213/74 , C07D213/81 , C07D213/84 , C07D213/89 , C07D233/64 , C07D295/192 , C07D307/22 , C07D309/14 , C07D333/20
摘要： Benzamide derivatives of formula I and II, and pharmaceutically acceptable salts, solvates, stereoisomers, and prodrugs thereof, and pharmaceutical compositions comprising the same, are described and have therapeutic utility, particularly in the treatment of diabetes, obesity, and related conditions and disorders: wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, and R12 are defined as provided herein.
摘要翻译： 描述了式I和II的苯甲酰胺衍生物及其药学上可接受的盐，溶剂合物，立体异构体和前药，以及包含其的药物组合物，具有治疗用途，特别是治疗糖尿病，肥胖症和相关病症和病症： 其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8，R 9，R 10，R 11和R 12如本文所提供。
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公开(公告)号：US07402704B2
公开(公告)日：2008-07-22
申请号：US11105583
申请日：2005-04-14
申请人： Pingchen Fan , Hiroyuki Goto , Xiao He , Makoto Kakutani , Marc Labelle , Dustin L. McMinn , Jay P. Powers , Yosup Rew , Daqing Sun , Xuelei Yan
发明人： Pingchen Fan , Hiroyuki Goto , Xiao He , Makoto Kakutani , Marc Labelle , Dustin L. McMinn , Jay P. Powers , Yosup Rew , Daqing Sun , Xuelei Yan
IPC分类号： C07C317/14 , A61K31/255 , A61K31/275
CPC分类号： C07C317/44 , C07C317/14 , C07C317/22 , C07C2601/02 , C07D215/36 , C07D233/54 , C07D277/36 , C07D277/54 , C07D277/56 , C07D295/096 , C07D295/112 , C07D417/04
摘要： Aryl sulfone compounds of formula I and II are described and have therapeutic utility, particularly in the treatment of diabetes, obesity and related conditions and disorders:
摘要翻译： 描述了式I和II的芳基砜化合物，并具有治疗效用，特别是在治疗糖尿病，肥胖症和相关病症和病症中：
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