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1.发明授权Surface charge modification within preformed polymer microchannels with multiple applications including modulating electroosmotic flow and creating microarrays 失效具有多种应用的预成型聚合物微通道内的表面电荷改性，包括调节电渗流和产生微阵列公开(公告)号：US06982028B2
公开(公告)日：2006-01-03
申请号：US09905566
申请日：2001-07-13
CPC分类号： B81B1/00 , G01N27/44752 , G01N27/44791
摘要： A method is described for modifying performed channels fabricated in a variety of substrate materials including PMMA. The method involves exposing a portion of a fluid flow channel to light at a fluence and wavelength which modifies the surface charge of the substrate at the exposure site. The method can be used to modulate electroosmotic flow in channels or to immobilize chemical compounds or biological species in the fluid flow channels at the modified surfaces. The method can be used to fabricate or modify microfluidic systems
摘要翻译： 描述了一种用于修改在包括PMMA的各种衬底材料中制造的所执行通道的方法。 该方法包括将流体流动通道的一部分以能量密度和波长曝光，其在曝光部位改变基底的表面电荷。 该方法可用于调节通道中的电渗流或将化学化合物或生物物质固定在改性表面的流体流动通道中。 该方法可用于制造或修饰微流体系统
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2.发明授权Chemical modification of substrates by photo-ablation under different local atmospheres and chemical environments for the fabrication of microstructures 有权在不同的局部气氛和化学环境下通过光蚀刻对基底进行化学修饰以制备微结构公开(公告)号：US06703189B2
公开(公告)日：2004-03-09
申请号：US09905567
申请日：2001-07-13
IPC分类号： G03C500
CPC分类号： B23K26/123 , B23K26/361 , B23K26/40 , B23K2103/52 , Y10S430/146
摘要： A method for simultaneously forming microstructures in substrates and altering their chemical character. The method involves exposing a surface portion of a substrate to light source, which is strong enough and of the appropriate wavelength to cause ablation of the substrate. The ablation of the substrate is controlled to form microstructures therein, such as channels. The ablation is conducted under a chemical atmosphere, which causes a change in the chemical functionality of the microstructures. The chemical atmosphere can be a gas, liquid or solid that is provided on the substrate surface. The method can be used to fabricate or modify microfluidic systems.
摘要翻译： 同时在基材中形成微结构并改变其化学特性的方法。 该方法包括将基底的表面部分暴露于足够强并且具有合适波长的光源以引起基底的烧蚀。 控制衬底的烧蚀以在其中形成诸如通道的微结构。 消融在化学气氛下进行，这导致微结构的化学官能度发生变化。 化学气氛可以是设置在基板表面上的气体，液体或固体。 该方法可用于制造或修饰微流体系统。
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公开(公告)号：US07658536B2
公开(公告)日：2010-02-09
申请号：US12106990
申请日：2008-04-21
IPC分类号： B01F5/00
CPC分类号： G05D7/0694 , Y10S366/03 , Y10T137/0318 , Y10T137/2224 , Y10T137/87652
摘要： Disclosed is an apparatus and method for the mixing of two microfluidic channels wherein several wells are oriented diagonally across the width of a mixing channel. The device effectively mixes the confluent streams with electrokinetic flow, and to a lesser degree, with pressure driven flow. The device and method may be further adapted to split a pair of confluent streams into two or more streams of equal or non-equal concentrations of reactants. Further, under electrokinetic flow, the surfaces of said wells may be specially coated so that the differing electroosmotic mobility between the surfaces of the wells and the surfaces of the channel may increase the mixing efficiency. The device and method are applicable to the steady state mixing as well as the dynamic application of mixing a plug of reagent with a confluent stream.
摘要翻译： 公开了一种用于混合两个微流体通道的装置和方法，其中若干孔沿着混合通道的宽度倾斜地定向。 该装置将汇合流与电动流有效地混合，并且在较小程度上与压力驱动流混合。 装置和方法可以进一步适于将一对汇合流分成两个或更多个相等或不相等浓度的反应物流。 此外，在电动流动下，可以特别地涂覆所述孔的表面，使得孔的表面和通道表面之间的不同的电渗流动性可以提高混合效率。 该装置和方法适用于稳态混合以及将试剂塞与汇合流混合的动态应用。
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公开(公告)号：US20080190773A1
公开(公告)日：2008-08-14
申请号：US12106990
申请日：2008-04-21
IPC分类号： G01N27/447 , B01F13/00
CPC分类号： G05D7/0694 , Y10S366/03 , Y10T137/0318 , Y10T137/2224 , Y10T137/87652
摘要： Disclosed is an apparatus and method for the mixing of two microfluidic channels wherein several wells are oriented diagonally across the width of a mixing channel. The device effectively mixes the confluent streams with electrokinetic flow, and to a lesser degree, with pressure driven flow. The device and method may be further adapted to split a pair of confluent streams into two or more streams of equal or non-equal concentrations of reactants. Further, under electrokinetic flow, the surfaces of said wells may be specially coated so that the differing electroosmotic mobility between the surfaces of the wells and the surfaces of the channel may increase the mixing efficiency. The device and method are applicable to the steady state mixing as well as the dynamic application of mixing a plug of reagent with a confluent stream.
摘要翻译： 公开了一种用于混合两个微流体通道的装置和方法，其中若干孔沿着混合通道的宽度倾斜地定向。 该装置将汇合流与电动流有效地混合，并且在较小程度上与压力驱动流混合。 装置和方法可以进一步适于将一对汇合流分成两个或更多个相等或不相等浓度的反应物流。 此外，在电动流动下，可以特别地涂覆所述孔的表面，使得孔的表面和通道表面之间的不同的电渗流动性可以提高混合效率。 该装置和方法适用于稳态混合以及将试剂塞与汇合流混合的动态应用。
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公开(公告)号：US06907895B2
公开(公告)日：2005-06-21
申请号：US10188664
申请日：2002-07-01
CPC分类号： G05D7/0694 , Y10S366/03 , Y10T137/0318 , Y10T137/2224 , Y10T137/87652
摘要： Disclosed is an apparatus and method for the mixing of two microfluidic channels wherein several wells are oriented diagonally across the width of a mixing channel. The device effectively mixes the confluent streams with electrokinetic flow, and to a lesser degree, with pressure driven flow. The device and method may be further adapted to split a pair of confluent streams into two or more streams of equal or non-equal concentrations of reactants. Further, under electrokinetic flow, the surfaces of said wells may be specially coated so that the differing electroosmotic mobility between the surfaces of the wells and the surfaces of the channel may increase the mixing efficiency. The device and method are applicable to the steady state mixing as well as the dynamic application of mixing a plug of reagent with a confluent stream.
摘要翻译： 公开了一种用于混合两个微流体通道的装置和方法，其中若干孔沿着混合通道的宽度倾斜地定向。 该装置将汇合流与电动流有效地混合，并且在较小程度上与压力驱动流混合。 装置和方法可以进一步适于将一对汇合流分成两个或更多个相等或不相等浓度的反应物流。 此外，在电动流动下，可以特别地涂覆所述孔的表面，使得孔的表面和通道表面之间的不同的电渗流动性可以提高混合效率。 该装置和方法适用于稳态混合以及将试剂塞与汇合流混合的动态应用。
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公开(公告)号：US08417352B2
公开(公告)日：2013-04-09
申请号：US12769382
申请日：2010-04-28
CPC分类号： A61N1/0456 , A61N1/0452 , A61N1/0476 , A61N1/0492 , A61N1/0502 , A61N1/0551 , A61N1/36014 , A61N1/36017 , A61N1/36021
摘要： An electrotherapy system for stimulating sensory nerves within skin tissue includes a electrode carrier, a pulse generator, an array of skin-penetrating electrodes and surface skin electrodes, a pulse conditioning circuit, and a power source. The system administers biphasic pulsed current at the surface skin electrodes and monophasic pulsed current at each skin-penetrating electrode. The skin-penetrating surfaces and skin contact surfaces of the electrotherapy system may be sterilized or may be replaceable for outpatient reusability.
摘要翻译： 用于刺激皮肤组织内的感觉神经的电疗系统包括电极载体，脉冲发生器，皮肤穿透电极阵列和表面皮肤电极，脉冲调节电路和电源。 该系统在每个皮肤穿透电极处施加表面电极处的双相脉冲电流和单相脉冲电流。 电疗系统的皮肤穿透表面和皮肤接触表面可以被灭菌或可以替换为门诊可重用性。
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公开(公告)号：US20120153155A1
公开(公告)日：2012-06-21
申请号：US11974856
申请日：2007-10-15
申请人： Timothy J. Johnson
发明人： Timothy J. Johnson
IPC分类号： G01N21/59
CPC分类号： G01J3/108 , G01N21/3504
摘要： Novel systems and methods for remotely detecting at least one constituent of a gas via infrared detection are provided. A system includes at least one extended source of broadband infrared radiation and a spectrally sensitive receiver positioned remotely from the source. The source and the receiver are oriented such that a surface of the source is in the field of view of the receiver. The source includes a heating component thermally coupled to the surface, and the heating component is configured to heat the surface to a temperature above ambient temperature. The receiver is operable to collect spectral infrared absorption data representative of a gas present between the source and the receiver. The invention advantageously overcomes significant difficulties associated with active infrared detection techniques known in the art, and provides an infrared detection technique with a much greater sensitivity than passive infrared detection techniques known in the art.
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8.发明申请APPARATUS AND METHOD FOR CONTROLLING MOISTURE IN THE MANUFACTURE OF GLASS FIBER INSULATION 审中-公开用于控制玻璃纤维绝缘制造中的水分的装置和方法公开(公告)号：US20120144870A1
公开(公告)日：2012-06-14
申请号：US13313109
申请日：2011-12-07
申请人： Timothy J. Johnson , David R. Mirth , Michael Timothy Pellegrin , Frank Bruce Inglis , Terry Burn
发明人： Timothy J. Johnson , David R. Mirth , Michael Timothy Pellegrin , Frank Bruce Inglis , Terry Burn
CPC分类号： D04H13/008 , B05B7/0892 , C03B37/0206 , C03B37/10 , C03C25/26 , D04H1/4226 , D04H1/642 , D04H1/655 , D10B2101/06
摘要： Apparatus, systems and methods for monitoring and controlling the amount of moisture introduced into the forming hood area in the manufacture of mineral fiber insulation products. Moisture from coolant liquids, binder dispersions and binder diluents are all introduced deliberately into a forming hood; ambient moisture and water from combustion are additional sources. A series of global variable control valves, one for each fluid system; as well as individual variable control valves for each fiberizing unit are provided with associated meters. Sensors monitor fibrous pack conditions and ambient conditions and provide inputs to the valve control system. A specific 3-ring liquid dispensing system is also disclosed.
摘要翻译： 用于监测和控制在矿物纤维绝缘产品的制造中引入成形罩区域的水分量的装置，系统和方法。 来自冷却剂液体，粘合剂分散体和粘合剂稀释剂的水分都故意引入成型罩; 来自燃烧的环境水分和水分是额外的来源。 一系列全球变量控制阀，每个流体系统一个; 以及每个纤维化单元的单个可变控制阀都配有相关的仪表。 传感器监测纤维包装条件和环境条件，并为阀门控制系统提供输入。 还公开了具体的3环液体分配系统。
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公开(公告)号：US5621355A
公开(公告)日：1997-04-15
申请号：US537051
申请日：1995-09-29
CPC分类号： H03H11/04
摘要： Process-dependent characteristics of a continuous time circuit, e.g., particular the sensitivity of the corner frequency of a continuous time filter to variations in absolute capacitance, is obviated by modifying a resistance-based transconductance tuning circuit, so that the tuning resistor is replaced with a switched capacitor circuit. The effect of this switched sampled data resistor replacement is such that, if each of the resistor-simulating switched capacitor of the transconductance stage and one or more load capacitors of the filter is established in the same processing sequence, what would otherwise be process-sensitive terms in the corner frequency-establishing ratio (g.sub.m /C) effectively cancel each other, so that the corner frequency fhi becomes proportional to a readily controlled frequency parameter for the sampled data resistor.
摘要翻译： 连续时间电路的过程相关特性，特别是连续时间滤波器的转角频率对绝对电容变化的敏感度，通过修改基于电阻的跨导调谐电路来消除，从而将调谐电阻替换为 开关电容电路。 这种切换采样数据电阻器替换的效果是这样的，如果跨导级的电阻模拟开关电容器和滤波器的一个或多个负载电容器中的每一个以相同的处理顺序建立，否则将是过程敏感的 角频率建立比（gm / C）中的术语有效地相互抵消，从而转角频率fhi与采样数据电阻器的容易控制的频率参数成比例。
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公开(公告)号：US20120221830A1
公开(公告)日：2012-08-30
申请号：US13409033
申请日：2012-02-29
申请人： Gregory J. Faanes , Eric P. Lundberg , Abdulla Bataineh , Timothy J. Johnson , Michael Parker , James Robert Kohn , Steven L. Scott , Robert Alverson
发明人： Gregory J. Faanes , Eric P. Lundberg , Abdulla Bataineh , Timothy J. Johnson , Michael Parker , James Robert Kohn , Steven L. Scott , Robert Alverson
IPC分类号： G06F15/76
CPC分类号： G06F15/8053
摘要： A processor core, comprises one or more vector units operable to change between a fine-grained vector mode having a shorter maximum vector length and a coarse-grained vector mode having a longer maximum vector length. Changing vector modes comprises halting all instruction stream execution in the core, flushing one or more registers in a register space, reconfiguring one or more vector registers in the register space, and restarting instruction execution in the core.
摘要翻译： 处理器核心包括一个或多个向量单元，其可操作以在具有较短最大向量长度的细粒子矢量模式和具有较长最大向量长度的粗粒矢量模式之间进行切换。 更改向量模式包括停止核心中的所有指令流执行，刷新寄存器空间中的一个或多个寄存器，重新配置寄存器空间中的一个或多个向量寄存器，以及重新启动核心中的指令执行。
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