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公开(公告)号：US6024866A
公开(公告)日：2000-02-15
申请号：US139893
申请日：1993-10-19
Applicant: Jerry J. Weers , Timothy J. O'Brien
Inventor： Jerry J. Weers , Timothy J. O'Brien
CPC classification number: C10L1/2222 , C10L1/221 , C10L1/238 , E21B43/34
Abstract: Hydrocarbons, gas mixtures of hydrocarbons, and the like containing hydrogen sulfide are brought into intimate contact with a hydrogen sulfide scavenger prepared by reacting an alkylenepolyamine with formaldehyde, whereby the amount of hydrogen sulfide in the hydrocarbon is significantly reduced.
Abstract translation: 含有硫化氢的碳氢化合物，烃类气体混合物等与通过使亚烷基多胺与甲醛反应制备的硫化氢清除剂紧密接触，由此烃中硫化氢的量显着降低。
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公开(公告)号：US08679203B2
公开(公告)日：2014-03-25
申请号：US12951849
申请日：2010-11-22
Applicant: Timothy J. O'Brien , Jerry J. Weers
Inventor： Timothy J. O'Brien , Jerry J. Weers
IPC: C10L1/22
CPC classification number: C10G19/02 , C10G27/10 , C10G29/06 , C10L1/04 , C10L2290/54 , C10L2290/544
Abstract: Hydrogen sulfide and mercaptans in hydrocarbons, gas mixtures of hydrocarbons and the like may be scavenged therefrom by being brought into intimate contact with a mercaptan scavenger formulation of quaternary ammonium alkoxide or hydroxide in the presence of a high oxidative state metal such as cobalt, iron, chromium and/or nickel. The high oxidative state metal, being an oxidizer, acts as a catalyst when combined with the quaternary ethoxide or hydroxide for improved mercaptan scavenging performance.
Abstract translation: 烃类中的硫化氢和硫醇，碳氢化合物的气体混合物等可以通过在高氧化态金属如钴，铁等的存在下与硫醇季铵盐或氢氧化物的硫醇清除剂配方紧密接触而被清除， 铬和/或镍。 作为氧化剂的高氧化态金属与季戊四醇或氢氧化物结合时用作催化剂，以改善硫醇清除性能。
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3.发明授权
公开(公告)号：US5266185A
公开(公告)日：1993-11-30
申请号：US580020
申请日：1990-09-10
Applicant: Jerry J. Weers , Timothy J. O'Brien , Catherine E. Thomasson
Inventor： Jerry J. Weers , Timothy J. O'Brien , Catherine E. Thomasson
IPC: C07D307/14 , C07D307/52 , C07D333/20 , C09K8/54 , C10G29/20 , C10L1/228 , C10L1/232 , C10L1/24 , C10G9/16
CPC classification number: C10L1/2283 , C09K8/54 , C10G29/20 , C10L1/232 , C10L1/245
Abstract: Hydrogen sulfide evolution in a heavy hydrocarbon (such as a residual fuel oil) derived from a heavy crude oil (such as a API 8 gravity crude) is suppressed by contacting the hydrocarbon with a compound corresponding to the reaction product of a heterocyclic aldehyde (such as furfural) and an organic primary amine.
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公开(公告)号：US20110113680A1
公开(公告)日：2011-05-19
申请号：US12951849
申请日：2010-11-22
Applicant: Timothy J. O'Brien , Jerry J. Weers
Inventor： Timothy J. O'Brien , Jerry J. Weers
CPC classification number: C10G19/02 , C10G27/10 , C10G29/06 , C10L1/04 , C10L2290/54 , C10L2290/544
Abstract: Hydrogen sulfide and mercaptans in hydrocarbons, gas mixtures of hydrocarbons and the like may be scavenged therefrom by being brought into intimate contact with a mercaptan scavenger formulation of quaternary ammonium alkoxide or hydroxide in the presence of a high oxidative state metal such as cobalt, iron, chromium and/or nickel. The high oxidative state metal, being an oxidizer, acts as a catalyst when combined with the quaternary ethoxide or hydroxide for improved mercaptan scavenging performance.
Abstract translation: 烃类中的硫化氢和硫醇，碳氢化合物的气体混合物等可以通过在高氧化态金属如钴，铁等的存在下与硫醇季铵盐或氢氧化物的硫醇清除剂配方紧密接触而被清除， 铬和/或镍。 作为氧化剂的高氧化态金属与季戊四醇或氢氧化物结合时用作催化剂，以改善硫醇清除性能。
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公开(公告)号：US20080230445A1
公开(公告)日：2008-09-25
申请号：US12042536
申请日：2008-03-05
Applicant: Timothy J. O'Brien , Jerry J. Weers
Inventor： Timothy J. O'Brien , Jerry J. Weers
IPC: C10G29/20
CPC classification number: C10G19/02 , C10G27/10 , C10G29/06 , C10G2300/1033 , C10G2300/1037 , C10G2300/202 , C10G2300/207 , C10G2300/80
Abstract: Hydrogen sulfide and mercaptans in hydrocarbons, gas mixtures of hydrocarbons and the like may be scavenged therefrom by being brought into intimate contact with a mercaptan scavenger formulation of quaternary ammonium alkoxide or hydroxide in the presence of a high oxidative state metal such as cobalt, iron, chromium and/or nickel. The high oxidative state metal, being an oxidizer, acts as a catalyst when combined with the quaternary ethoxide or hydroxide for improved mercaptan scavenging performance.
Abstract translation: 烃类中的硫化氢和硫醇，碳氢化合物的气体混合物等可以通过在高氧化态金属如钴，铁等的存在下与硫醇季铵盐或氢氧化物的硫醇清除剂配方紧密接触而被清除， 铬和/或镍。 作为氧化剂的高氧化态金属与季戊四醇或氢氧化物结合时用作催化剂，以改善硫醇清除性能。
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Patent Agency Ranking
公开(公告)号：US5284576A
公开(公告)日：1994-02-08
申请号：US031062
申请日：1993-03-12
Applicant: Jerry J. Weers , Timothy J. O'Brien
Inventor： Jerry J. Weers , Timothy J. O'Brien
CPC classification number: C10L1/2222 , C10L1/221 , C10L1/238 , E21B43/34
Abstract: Hydrocarbons, gas mixtures of hydrocarbons, and the like containing hydrogen sulfide are brought into intimate contact with a hydrogen sulfide scavenger prepared by reacting an alkylenepolyamine with formaldehyde, whereby the amount of hydrogen sulfide in the hydrocarbon is significantly reduced.
Abstract translation: 含有硫化氢的碳氢化合物，烃类气体混合物等与通过使亚烷基多胺与甲醛反应制备的硫化氢清除剂紧密接触，由此烃中硫化氢的量显着降低。
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公开(公告)号：US09783795B2
公开(公告)日：2017-10-10
申请号：US12913174
申请日：2010-10-27
Applicant: Martin J. Cannon , Kristina L. Bondurant , Timothy J. O'Brien
Inventor： Martin J. Cannon , Kristina L. Bondurant , Timothy J. O'Brien
CPC classification number: C12N9/6445 , A61K38/00 , C12N9/6424
Abstract: Peptides of from about 7 to about 50 amino acid residues in length that have epitopes that bind to more than one HLA class II protein and stimulate CD4+ T cells for treatment of cancer from one of three serine proteases overexpressed in ovarian cancer and other cancers—stratum corneum chymotryptic enzyme, matriptase, and hepsin—are described. Since the peptides bind to more than one HLA class II protein variant, they can be used to treat cancer in most patients of a population having a variety of HLA class II alleles. The peptides can be loaded onto autologous dendritic cells of a cancer patient and infused into the patient to activate a CD4+ and CD8+ T cell response that recognizes tumor cells expressing the peptide antigen.
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8.发明授权公开(公告)号：US08430936B2
公开(公告)日：2013-04-30
申请号：US12270071
申请日：2008-11-13
Applicant: Timothy J. O'Brien , Brian R. Munson
Inventor： Timothy J. O'Brien , Brian R. Munson
IPC: C10L1/18
CPC classification number: C10L1/2225 , C10L1/222 , C10L1/223 , C10L10/00 , Y02E50/13
Abstract: Biodiesel fuels, renewable diesel fuels and feedstocks to these fuels (derived from plant seed oils or animal fats) are viewed as more environmentally friendly, renewable alternative fuels or supplemental fuels with petroleum-based diesel. Alkyl phenol amine aldehyde condensates improve the stability of biofuels by inhibiting the degradation processes. Alkyl phenylene diamines employed together with alkyl phenol amine aldehyde condensates in the biofuels give synergistically improved stability of the fuels.
Abstract translation: 这些燃料（来自植物种子油或动物脂肪）的生物柴油燃料，可再生柴油燃料和原料被视为更环保的可再生替代燃料或具有石油基柴油的补充燃料。 烷基酚胺醛缩合物通过抑制降解过程改善了生物燃料的稳定性。 与生物燃料中的烷基酚胺醛缩合物一起使用的烷基亚苯基二胺可协同地提高燃料的稳定性。
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公开(公告)号：US07785841B2
公开(公告)日：2010-08-31
申请号：US11012787
申请日：2004-12-15
Applicant: Timothy J. O'Brien
Inventor： Timothy J. O'Brien
IPC: C12P19/34 , C12Q1/00 , C12Q1/68 , C12P19/26 , C12P19/28 , C12P19/36 , C12P19/38 , C12P19/40 , G01N1/00 , G01N21/00
CPC classification number: C12N9/6424 , A61K39/00 , A61K48/00 , A61K2039/53 , C12N9/6472 , C12N9/6489 , C12Q1/37 , C12Q1/6886 , C12Q2600/112 , C12Q2600/136 , C12Q2600/158 , G01N33/573 , G01N33/574 , G01N33/57449 , G01N2333/96486 , Y10T436/25
Abstract: The disclosed nucleic acid primer sets, used in combination with quantitative amplification (PCR) of tissue cDNA, can indicate the presence of specific proteases in a tissue sample. Specifically, the present invention relates to expression of PUMP-1 protease (matrix metalloprotease 7). The detected proteases are themselves specifically over-expressed in certain cancers, and their presence may serve for early detection of associated ovarian and other malignancies, and for the design of interactive therapies for cancer treatment.
Abstract translation: 所公开的与组织cDNA的定量扩增（PCR）组合使用的核酸引物组可以指示组织样品中特异性蛋白酶的存在。 具体地说，本发明涉及PUMP-1蛋白酶（基质金属蛋白酶7）的表达。 检测到的蛋白酶本身在某些癌症中特异性过度表达，并且它们的存在可用于早期检测相关的卵巢癌和其他恶性肿瘤，并且用于设计用于癌症治疗的交互式治疗。
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10.发明授权Transmembrane serine protease overexpressed in ovarian carcinoma and uses thereof 有权卵巢癌中过表达的跨膜丝氨酸蛋白酶及其用途公开(公告)号：US07638277B2
公开(公告)日：2009-12-29
申请号：US11400825
申请日：2006-04-07
Applicant: Timothy J. O'Brien , Lowell J. Underwood
Inventor： Timothy J. O'Brien , Lowell J. Underwood
IPC: C12Q1/68
CPC classification number: C12N9/6424 , A61K38/00 , A61K39/00 , A61K48/00 , C07K14/4748 , C07K14/705 , C07K16/3069 , C07K2317/34 , C12N9/6472 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158 , C12Q2600/16 , G01N33/574
Abstract: The present invention provides a TADG-12 protein and a DNA fragment encoding such protein. Also provided is a vector/host cell capable of expressing the DNA. The present invention further provides various methods of early detection of associated ovarian and other malignancies, and of interactive therapies for cancer treatment by utilizing the DNA and/or protein disclosed herein.
Abstract translation: 本发明提供了TADG-12蛋白质和编码这种蛋白质的DNA片段。 还提供能够表达DNA的载体/宿主细胞。 本发明进一步提供各种早期检测相关卵巢癌和其他恶性肿瘤的方法，以及利用本文公开的DNA和/或蛋白质进行癌症治疗的相互作用治疗。
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