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36 条记录 (耗时 0.093 秒)

    Nucleic and amino acid sequences of human Rif1 and methods of use thereof
    1.
    发明申请
    Nucleic and amino acid sequences of human Rif1 and methods of use thereof 失效
    人Rif1的核酸和氨基酸序列及其使用方法

    公开(公告)号：US20060051737A1

    公开(公告)日：2006-03-09

    申请号：US11203806

    申请日：2005-08-15

    申请人： Titia Lange ,  Joshua Silverman

    发明人： Titia Lange ,  Joshua Silverman

    IPC分类号： C12Q1/00 ,  C12Q1/68

    CPC分类号： C12Q1/485 ,  G01N2500/10 ,  G01N2800/2835

    摘要： The present invention relates to human Rif1 (hRif1) nucleic acid sequences and human Rif1 amino acid sequences encoded therefrom. The invention also encompasses antibodies that are immunologically specific for human Rif1 polypeptides. Also included in the present invention are methods directed to detecting Rif1 foci formed in response to various treatments that induce DNA damage. The formation of foci comprising Rif1 in response to DNA damage serves as a positive indicator of the presence of wild type ATM kinase activity in a cell, whereas the absence of detectable Rif1 foci under such circumstances serves to identify a cell with reduced ATM kinase activity. Modulators of ATM kinase activity and/or Rif1 activity and methods for identifying such modulators are also included in the present invention.

    摘要翻译： 本发明涉及人Rif1（hRif1）核酸序列和由其编码的人Rif1氨基酸序列。 本发明还包括对人Rif1多肽具有免疫学特异性的抗体。 本发明还包括用于检测响应诱导DNA损伤的各种治疗形成的Rif1病灶的方法。 包含Rif1响应于DNA损伤的病灶的形成作为细胞中存在野生型ATM激酶活性的阳性指标，而在这种情况下不存在可检测的Rif1病灶用于鉴定具有降低的ATM激酶活性的细胞。 ATM激酶活性和/或Rif1活性的调节剂和鉴定这种调节剂的方法也包括在本发明中。

    Touch pad device
    4.
    发明授权
    Touch pad device 有权
    触摸板设备

    公开(公告)号：US08890016B2

    公开(公告)日：2014-11-18

    申请号：US13331116

    申请日：2011-12-20

    申请人： Joshua Silverman

    发明人： Joshua Silverman

    IPC分类号： H01H13/14 ,  H03M11/00

    CPC分类号： H01H13/14

    摘要： A touch pad for an operating button of an electronics device provides a contact point for tactile input through the button. The button is adhesively mounted to the button, the surface of the electronics device surrounding the button, or both button and surrounding surface. The pad preferably fully overlies the button, and may have a lower surface that conforms to the shape of the top surface of the button.

    摘要翻译： 用于电子设备的操作按钮的触摸板提供通过按钮的触觉输入的接触点。 该按钮被粘合地安装到按钮上，围绕按钮的电子设备的表面，或者按钮和周围的表面。 垫优选地完全覆盖在按钮上，并且可以具有与按钮的顶表面的形状一致的下表面。