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1.发明授权Fully implantable neurostimulator for autonomic nerve fiber stimulation as a therapy for urinary and bowel dysfunction 失效用于自主神经纤维刺激的完全植入式神经刺激器作为尿和肠功能障碍的治疗公开(公告)号：US08588917B2
公开(公告)日：2013-11-19
申请号：US13493753
申请日：2012-06-11
CPC分类号： A61N1/36007
摘要： An implantable stimulator(s), small enough to be located near or adjacent to an autonomic nerve(s) innervating urinary and/or gastrointestinal structures, uses a power source/storage device, such as a rechargeable battery. Periodic recharging of such a power source/storage device is accomplished, for example, by inductive coupling with an external appliance. The small stimulator provides a means of stimulating a nerve(s) or other tissue when desired, without the need for external appliances during the stimulation session. When necessary, external appliances are used for the transmission of data to and/or from the stimulator(s) and for the transmission of power, if necessary. In a preferred embodiment, the system is capable of open- and closed-loop operation. In closed-loop operation, at least one implant includes at least one sensor, and the sensed condition is used to adjust stimulation parameters.
摘要翻译： 小到足以位于支配尿和/或胃肠结构的自主神经附近或邻近的可植入刺激器使用诸如可再充电电池的电源/存储装置。 这样的电源/存储装置的定期再充电例如通过与外部电器的感应耦合来实现。 小刺激器提供了在需要时刺激神经或其他组织的手段，而不需要在刺激期间的外部器具。 必要时，如果需要，外部设备用于向刺激器传送数据和/或从刺激器传输数据。 在优选实施例中，系统能够进行开环和闭环操作。 在闭环操作中，至少一个植入物包括至少一个传感器，并且所感测到的条件用于调整刺激参数。
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2.发明授权Fully implantable microstimulator for spinal cord stimulation as a therapy for chronic pain 有权用于脊髓刺激的完全可植入的微刺激作为慢性疼痛的治疗公开(公告)号：US06871099B1
公开(公告)日：2005-03-22
申请号：US09929597
申请日：2001-08-13
CPC分类号： A61N1/36071
摘要： An implantable stimulator(s), small enough to be located near or within an area of the spine responsible for sensations in a region experiencing chronic pain uses a power source/storage device, such as a rechargeable battery. Periodic recharging of such a power source/storage device is accomplished, for example, by inductive coupling with an external appliance. The small stimulator provides a means of stimulating a nerve(s) or other tissue when desired, without the need for external appliances during the stimulation session. When necessary, external appliances are used for the transmission of data to and/or from the stimulator(s) and for the transmission of power, it necessary. In a preferred embodiment, the system is capable of open- and closed-loop operation. In closed-loop operation, at least one implant includes at least one sensor, and the sensed condition is used to adjust stimulation parameters.
摘要翻译： 小到足以位于脊柱区域内的负责在慢性疼痛区域感觉的植入式刺激器使用诸如可再充电电池的电源/存储装置。 这样的电源/存储装置的定期再充电例如通过与外部电器的感应耦合来实现。 小刺激器提供了在需要时刺激神经或其他组织的手段，而不需要在刺激期间的外部器具。 必要时，必须使用外部设备将数据传送到和/或从激励器传输，并传输电力。 在优选实施例中，系统能够进行开环和闭环操作。 在闭环操作中，至少一个植入物包括至少一个传感器，并且所感测到的条件用于调整刺激参数。
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公开(公告)号：US06941171B2
公开(公告)日：2005-09-06
申请号：US09931804
申请日：2001-08-16
申请人： Carla M. Mann , Todd K. Whitehurst , James P. McGivern , Gerald E. Loeb , Frances J. R. Richmond
发明人： Carla M. Mann , Todd K. Whitehurst , James P. McGivern , Gerald E. Loeb , Frances J. R. Richmond
CPC分类号： A61N1/36007 , A61N1/36017 , A61N1/36071 , A61N1/37205
摘要： A method and system for treatment of incontinence, urgency, frequency, and/or pelvic pain includes implantation of electrodes on a lead or the discharge portion of a catheter adjacent the perineal nerve(s) or tissue(s) to be stimulated. Stimulation pulses, either electrical or drug infusion pulses, are supplied by a stimulator implanted remotely, and through the lead or catheter, which is tunneled subcutaneously between the stimulator and stimulation site. For instance, the system and method reduce or eliminate the incidence of unintentional episodes of bladder emptying by stimulating nerve pathways that diminish involuntary bladder contractions, improve closure of the bladder outlet, and/or improve the long-term health of the urinary system by increasing bladder capacity and period between emptying. Moreover, the system and method allow a patient to be taught to receive one or more patterns of neural stimulation that can be prescribed by a physician and administered without continuous oversight by a clinical practitioner.
摘要翻译： 用于治疗失禁，紧迫性，频率和/或骨盆疼痛的方法和系统包括将电极植入导联或导管的排出部分，邻近会阴神经或要刺激的组织。 刺激脉冲（电或药物输注脉冲）由远程植入的刺激器和通过刺激器和刺激部位之间皮下隧道穿过的导联或导管提供。 例如，该系统和方法通过刺激神经通路降低或消除膀胱排空的无意发作，从而减少无意识的膀胱收缩，改善膀胱出口的闭合，和/或通过增加泌尿系统的长期健康来改善 膀胱容量和排空期间。 此外，该系统和方法允许患者接受一种或多种神经刺激模式，其可由医师处方并由临床医师进行无持续监督。
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4.发明授权Implantable stimulator system and method for treatment of incontinence and pain 有权植入式刺激器系统和治疗失禁和疼痛的方法公开(公告)号：US06735474B1
公开(公告)日：2004-05-11
申请号：US09642979
申请日：2000-08-18
申请人： Gerald E. Loeb , Francis J. R. Richmond , Carla M. Mann , Michael A. Faltys , Todd K. Whitehurst , James P. McGivern
发明人： Gerald E. Loeb , Francis J. R. Richmond , Carla M. Mann , Michael A. Faltys , Todd K. Whitehurst , James P. McGivern
IPC分类号： A61N136
CPC分类号： A61N1/36007 , A61N1/36071 , A61N1/37205
摘要： A method and system for treatment of incontinence and/or pelvic pain includes the injection or laparoscopic implantation of one or more battery- or radio frequency-powered microstimulators (10) beneath the skin of the perineum and/or adjacent the tibial nerve. The devices are programmed using radio-frequency control via an external controller (20, 30)) that can be used by a physician to produce patterns of output stimulation pulses judged to be efficacious by appropriate clinical testing to diminish symptoms. The stimulation program is retained in the microstimulator device (10) or external controller (20) and is transmitted when commanded to start and stop by a signal from the patient or caregiver. The system and method reduce the incidence of unintentional episodes of bladder emptying by stimulating nerve pathways (8) that diminish involuntary bladder contractions, improve closure of the bladder outlet, and/or improve the long-term health of the urinary system by increasing bladder capacity and period between emptying. The incidence of fecal incontinence is similarly reduced or eliminated. Furthermore, the system and method reduce or eliminate the incidence of pelvic pain by chronically stimulating nerve pathways that derive from the sacral roots using a miniature implantable neurostimulator that can be implanted with a minimal surgical procedure. Moreover, the system and method allow a patient to be taught to receive one or more patterns of neural stimulation that can be prescribed by a physician and administered without continuous oversight by a clinical practitioner.
摘要翻译： 用于治疗失禁和/或骨盆疼痛的方法和系统包括在会阴皮肤和/或邻近胫神经之下的一个或多个电池或射频激励微刺激器（10）的注射或腹腔镜植入。 所述装置通过外部控制器（20,30）使用射频控制进行编程，所述外部控制器（20,30））可由医生用来产生通过适当的临床测试判断为有效的输出刺激脉冲的模式以减少症状。 刺激程序被保留在微型刺激器装置（10）或外部控制器（20）中，并且在命令通过来自患者或看护者的信号启动和停止时被传送。 该系统和方法通过刺激神经通路（8）减少膀胱排空的无意发作的发生率（8），通过增加膀胱容量来减少非自愿膀胱收缩，改善膀胱出口闭合和/或改善泌尿系统的长期健康 和排空之间的时期。 大便失禁的发生率同样减少或消除。 此外，该系统和方法通过使用可以以最小外科手术植入的微型可植入神经刺激器来减少或消除由骶根引起的长期刺激神经通路的盆腔疼痛的发生。 此外，该系统和方法允许患者接受一种或多种神经刺激模式，其可由医师处方并由临床医师进行无持续监督。
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5.发明授权Fully implantable neurostimulator for autonomic nerve fiber stimulation as a therapy for urinary and bowel dysfunction 有权用于自主神经纤维刺激的完全植入式神经刺激器作为尿和肠功能障碍的治疗公开(公告)号：US08214048B1
公开(公告)日：2012-07-03
申请号：US11373756
申请日：2006-03-10
CPC分类号： A61N1/36007
摘要： An implantable stimulator(s), small enough to be located near or adjacent to an autonomic nerve(s) innervating urinary and/or gastrointestinal structures, uses a power source/storage device, such as a rechargeable battery. Periodic recharging of such a power source/storage device is accomplished, for example, by inductive coupling with an external appliance. The small stimulator provides a means of stimulating a nerve(s) or other tissue when desired, without the need for external appliances during the stimulation session. When necessary, external appliances are used for the transmission of data to and/or from the stimulator(s) and for the transmission of power, if necessary. In a preferred embodiment, the system is capable of open- and closed-loop operation. In closed-loop operation, at least one implant includes at least one sensor, and the sensed condition is used to adjust stimulation parameters.
摘要翻译： 小到足以位于支配尿和/或胃肠结构的自主神经附近或邻近的可植入刺激器使用诸如可再充电电池的电源/存储装置。 这样的电源/存储装置的定期再充电例如通过与外部电器的感应耦合来实现。 小刺激器提供了在需要时刺激神经或其他组织的手段，而不需要在刺激期间的外部器具。 必要时，如果需要，外部设备用于向刺激器传送数据和/或从刺激器传输数据。 在优选实施例中，系统能够进行开环和闭环操作。 在闭环操作中，至少一个植入物包括至少一个传感器，并且所感测到的条件用于调整刺激参数。
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公开(公告)号：US08934968B2
公开(公告)日：2015-01-13
申请号：US11779769
申请日：2007-07-18
CPC分类号： A61N1/36114 , A61M5/14276 , A61M2205/054 , A61M2205/3523 , A61M2205/8206 , A61M2230/06
摘要： A method for treating a patient may include treating coronary artery disease in combination with angina pectoris and/or the control of angina pain by delivering chemical and/or electrical stimulation pulses to the cardiac and/or nervous tissue of the patient in a coordinated manner. A system for treating a patient suffering from coronary artery disease and angina may include a stimulator that generates at least one pulse in accordance with prescribed parameters, a catheter, a lead, and/or a sensor.
摘要翻译： 用于治疗患者的方法可以包括通过以协调的方式将化学和/或电刺激脉冲递送到患者的心脏和/或神经组织来治疗与心绞痛联合的冠状动脉疾病和/或控制心绞痛。 用于治疗患有冠状动脉疾病和心绞痛的患者的系统可以包括根据规定参数产生至少一个脉冲的刺激器，导管，引线和/或传感器。
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7.发明授权Cavernous nerve stimulation via unidirectional propagation of action potentials 有权通过动作电位的单向传播进行海绵体神经刺激公开(公告)号：US08712547B2
公开(公告)日：2014-04-29
申请号：US13036278
申请日：2011-02-28
申请人： Todd K. Whitehurst , James P. McGivern , Rafael Carbunaru , Matthew I. Haller , Tom Xiaohai He , Kerry Bradley
发明人： Todd K. Whitehurst , James P. McGivern , Rafael Carbunaru , Matthew I. Haller , Tom Xiaohai He , Kerry Bradley
CPC分类号： A61N1/0556 , A61N1/0551 , A61N1/36071 , A61N1/37205
摘要： An implantable stimulation device includes a device body; at least one set of partitioned electrodes disposed on a portion of the device body and configured and arranged for application of electrical stimulation to adjacent tissue; and insulating material separating the partitioned electrodes from each other. Each set of partitioned electrodes includes a plurality of partitioned electrodes disposed around a circumference of the device body. The implantable stimulation device can be configured and arranged so that each of the partitioned electrodes is independently programmable.
摘要翻译： 可植入刺激装置包括装置主体; 至少一组分隔电极，其设置在所述装置主体的一部分上，并被配置和布置成用于对相邻组织施加电刺激; 以及将分隔电极彼此分离的绝缘材料。 每组分隔电极包括围绕装置主体的圆周设置的多个分隔电极。 可植入式刺激装置可以被配置和布置成使得每个分隔电极可独立编程。
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公开(公告)号：US08364278B2
公开(公告)日：2013-01-29
申请号：US10503281
申请日：2003-01-29
IPC分类号： A61N1/05
CPC分类号： H01R43/16 , A61N1/05 , H01R13/5224 , Y10T29/49204
摘要： A lead assembly for a small implantable medical device connects a remote electrode to a microdevice and inhibits fluid ingress into the connection. Microdevices may provide either or both tissue stimulation and sensing. Known microdevices include spaced apart electrodes on the outer surface of the microdevice. The lead assembly includes an insulated lead including a proximal end and a distal end, with at least one conductor therebetween; at least one electrode at the distal end of the lead and electrically connected to the at least one conductor, and a connector attached to the proximal end of the lead and adapted to be removably connectable to the microdevice. The connector includes at least one contact to electrically connect at least one device electrode on the microdevice to the at least one conductor. The lead assembly is configured to inhibit fluid ingress into the connector.
摘要翻译： 用于小型可植入医疗装置的引导组件将远程电极连接到微型装置并且阻止流体进入连接。 微器件可以提供组织刺激和感测之一或两者。 已知的微器件在微器件的外表面上包括间隔开的电极。 引线组件包括绝缘引线，其包括近端和远端，其间具有至少一个导体; 在所述引线的远端处的至少一个电极并且电连接到所述至少一个导体，以及连接到所述引线的近端并适于可移除地连接到所述微器件的连接器。 所述连接器包括至少一个接触件，以将所述微器件上的至少一个器件电极电连接到所述至少一个导体。 引线组件被配置为抑制流体进入连接器。
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9.发明授权Methods and systems for direct electrical current stimulation as a therapy for cancer and other neoplastic diseases 有权直接电流刺激作为癌症和其他肿瘤疾病治疗的方法和系统公开(公告)号：US06901296B1
公开(公告)日：2005-05-31
申请号：US10133768
申请日：2002-04-26
CPC分类号： A61N1/205 , A61N1/08 , A61N1/37205
摘要： A small implantable stimulator(s) includes at least two electrodes for delivering electrical stimulation to surrounding tissue. The small stimulator provides means of stimulating a neoplasm with direct electrical current, such as relatively low-level direct current, without the need for external appliances during the stimulation session. The stimulator may be configured to be small enough to be implanted entirely within a neoplasm. Open- and closed-loop systems are disclosed.
摘要翻译： 一个小的植入式刺激器包括至少两个用于向周围组织传递电刺激的电极。 小的刺激器提供了用直接电流刺激肿瘤的手段，例如相对低的直流电流，而不需要在刺激期间的外部器具。 刺激器可以被配置为足够小以完全植入肿瘤内。 公开了开环和闭环系统。
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10.发明授权Fully implantable neurostimulator for cavernous nerve stimulation as a therapy for erectile dysfunction and other sexual dysfunction 有权用于海绵神经刺激的完全植入式神经刺激器作为勃起功能障碍和其他性功能障碍的治疗方法公开(公告)号：US06650943B1
公开(公告)日：2003-11-18
申请号：US09799988
申请日：2001-03-06
IPC分类号： A61N136
CPC分类号： A61N1/372 , A61N1/36007 , A61N1/37205
摘要： An implantable stimulator(s) with at least two electrodes, which is small enough to have the electrodes located adjacent to a cavernous nerve(s) or other nerve(s) innervating the reproductive organs, uses a power source/storage device, such as a rechargeable battery. Periodic recharging of such a battery is accomplished, for example, by inductive coupling with an external appliance. The small stimulator provides means of stimulating a nerve(s) when desired, without the need for external appliances during the stimulation session. When necessary, external appliances are used for the transmission of data to and/or from the stimulator(s) and for the transmission of power. In a preferred embodiment, the system is capable of open-and closed-loop operation. In closed-loop operation, at least one implant includes a sensor, and the sensed condition is used to adjust stimulation parameters.
摘要翻译： 具有至少两个电极的可植入刺激器，其足够小以使电极位于邻近海绵状神经或支配生殖器官的其他神经，使用电源/存储装置，例如 可充电电池 这种电池的定期再充电例如通过与外部电器的感应耦合来实现。 小刺激器提供在需要时刺激神经的手段，而不需要在刺激期间的外部器具。 必要时，外部设备用于传送和/或从刺激器传输数据和传输电力。 在优选实施例中，系统能够进行开环和闭环操作。 在闭环操作中，至少一个植入物包括传感器，并且所使用的感测条件用于调节刺激参数。
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