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1.发明授权公开(公告)号：US07239986B2
公开(公告)日：2007-07-03
申请号：US10074789
申请日：2002-02-12
申请人： Todd R. Golub , Eric S. Lander , Jill Mesirov , Donna Slonim , Pablo Tamayo
发明人： Todd R. Golub , Eric S. Lander , Jill Mesirov , Donna Slonim , Pablo Tamayo
CPC分类号： G06F19/20
摘要： Methods and apparatus for classifying or predicting the classes for samples based on gene expression are described. Also described are methods and apparatus for ascertaining or discovering new, previously unknown classes based on gene expression.
摘要翻译： 描述了基于基因表达分类或预测样品类别的方法和装置。 还描述了基于基因表达来确定或发现新的以前未知的类的方法和装置。
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公开(公告)号：US06647341B1
公开(公告)日：2003-11-11
申请号：US09544627
申请日：2000-04-06
申请人： Todd R. Golub , Eric S. Lander , Jill Mesirov , Donna Slonim , Pablo Tamayo
发明人： Todd R. Golub , Eric S. Lander , Jill Mesirov , Donna Slonim , Pablo Tamayo
IPC分类号： G01N3348
CPC分类号： G06F19/20
摘要： Methods and apparatus for classifying or predicting the classes for samples based on gene expression are described. Also described are methods and apparatus for ascertaining or discovering new, previously unknown classes based on gene expression.
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公开(公告)号：US07324926B2
公开(公告)日：2008-01-29
申请号：US09968627
申请日：2001-10-01
申请人： Pablo Tamayo , Jane E. Staunton , Donna K. Slonim , Hilary A. Coller , Todd R. Golub , Eric S. Lander , Jill P. Mesirov
发明人： Pablo Tamayo , Jane E. Staunton , Donna K. Slonim , Hilary A. Coller , Todd R. Golub , Eric S. Lander , Jill P. Mesirov
IPC分类号： G06G7/60
CPC分类号： G01N33/5014 , C12Q1/6883 , C12Q2600/106 , C12Q2600/136 , C12Q2600/158 , G01N2800/50 , G01N2800/60 , G06F19/18 , G06F19/20 , G06F19/24
摘要： Methods and apparatus for classifying or predicting the classes for samples based on gene expression are described. Also described are methods and apparatus for ascertaining or discovering new, previously unknown classes based on gene expression. Methods, computer systems and apparatus for classifying or predicting whether a sample is treatment sensitive (e.g., chemosensitive) or treatment resistant (e.g., chemoresistant) are also provided. Classification occurs based on analysis of gene expression data from samples that have been subjected to one or more compounds.
摘要翻译： 描述了基于基因表达分类或预测样品类别的方法和装置。 还描述了基于基因表达来确定或发现新的以前未知的类的方法和装置。 还提供了用于分类或预测样品是否具有治疗敏感性（例如化学敏感性）或治疗抗性（例如化学耐药性）的方法，计算机系统和装置。 基于来自已经经受一种或多种化合物的样品的基因表达数据的分析发生分类。
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公开(公告)号：US07105293B2
公开(公告)日：2006-09-12
申请号：US09955920
申请日：2001-09-19
申请人： Sridhar Ramaswamy , Todd R. Golub , Pablo Tamayo , Michael Angelo
发明人： Sridhar Ramaswamy , Todd R. Golub , Pablo Tamayo , Michael Angelo
CPC分类号： C12Q1/6886 , C12Q2600/136 , C12Q2600/158
摘要： Sets of genetic markers for specific tumor classes are described, as well as methods of identifying a biological sample based on these markers. Also described are diagnostic, prognostic, and therapeutic screening uses for these markers, as well as oligonucleotide arrays comprising these markers.
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5.发明申请CELASTROL, GEDUNIN, AND DERIVATIVES THEREOF AS HSP90 INHIBITORS 审中-公开CELASTROL，GEDUNIN及其衍生物作为HSP90抑制剂公开(公告)号：US20110263693A1
公开(公告)日：2011-10-27
申请号：US12294507
申请日：2007-03-30
IPC分类号： A61K31/352 , A61K31/225 , A61K31/19 , A61P35/00 , C07D311/78 , C07C69/604 , C07C63/44 , A61P35/02 , C12N5/09 , C07D493/04
CPC分类号： A61K31/203
摘要： Based on the discovery that celastrol and gedunin are Hsp90 inhibitors, the present invention provides novel inhibitors of Hsp90. and pharmaceutically acceptable salts, derivatives, and compositions thereof. The invention provides two classes of compounds. One class includes celastrol and its derivatives. The other class includes gedunin and its derivatives. The present invention further provides methods for treating disorders wherein Hsρ90 inhibition is desired (e.g., proliferative diseases, cancer, inflammatory diseases, fungal infections, etc.) comprising administering a therapeutically effective amount of an inventive compound to a subject in need thereof. Celastrol, gedunin, and derivatives thereof are particularly useful in the treatment of prostate cancer, breast cancer, ovarian cancer, lung cancer, and leukemia.
摘要翻译： 基于发现celastrol和gedunin是Hsp90抑制剂，本发明提供了新型的Hsp90抑制剂。 及其药学上可接受的盐，衍生物和组合物。 本发明提供了两类化合物。 一类包括celastrol及其衍生物。 另一类包括gedunin及其衍生物。 本发明进一步提供了治疗其中需要抑制Hs＆gt; 90抑制（例如增殖性疾病，癌症，炎性疾病，真菌感染等）的疾病的方法，包括向有需要的受试者施用治疗有效量的本发明化合物。 Celastrol，gedunin及其衍生物特别可用于治疗前列腺癌，乳腺癌，卵巢癌，肺癌和白血病。
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公开(公告)号：US20230075965A1
公开(公告)日：2023-03-09
申请号：US17793581
申请日：2021-01-22
申请人： Constantine S. Mitsiades , Michal Sheffer , Jennifer Roth , Chris C. Mader , Channing Yu , Todd R. Golub , Lotte Wieten , Dana-Farber Cancer Institute, Inc. , The Broad Institute, Inc. , Maastricht University Medical Center
发明人： Constantine S. Mitsiades , Michal Sheffer , Jennifer Roth , Chris C. Mader , Channing Yu , Todd R. Golub , Lotte Wieten
IPC分类号： G01N33/574 , A61K35/17 , A61P35/00 , A61P37/04 , C12N15/10 , A61K31/713 , A61K31/4045 , A61K45/06
摘要： The present invention relates, in part, to methods for selecting subjects for and treating subjects with a type of immunotherapy based on certain biomarkers from the subjects.
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7.发明申请COMPOSITIONS, KITS, AND METHODS FOR IDENTIFICATION, ASSESSMENT, PREVENTION, AND THERAPY OF HEPATIC DISORDERS 审中-公开组合物，用途及方法，用于鉴别，评估，预防和治疗HEPATIC DISORDERS公开(公告)号：US20110263441A1
公开(公告)日：2011-10-27
申请号：US13124487
申请日：2009-10-15
申请人： Todd R. Golub , Yujin Hoshida , Bryan C. Fuchs , Kenneth K. Tanabe , Josep M. Llovet Bayer , Augusto Villanueva
发明人： Todd R. Golub , Yujin Hoshida , Bryan C. Fuchs , Kenneth K. Tanabe , Josep M. Llovet Bayer , Augusto Villanueva
CPC分类号： G01N33/57438 , G01N2800/08 , G01N2800/50
摘要： The invention relates to compositions, kits, and methods for detecting, characterizing, preventing, and treating hepatic disorders such as hepatocellular carcinoma and/or cirrhosis. A variety of informative biomarkers corresponding thereto, are provided, wherein alterations in expression relative to a control is correlated with the presence of a hepatic disorder, likelihood of survival from a hepatic disorder, and likelihood of recurrence of a hepatic disorder.
摘要翻译： 本发明涉及用于检测，表征，预防和治疗肝脏疾病如肝细胞癌和/或肝硬化的组合物，试剂盒和方法。 提供了与其对应的各种信息性生物标志物，其中相对于对照的表达的改变与肝脏疾病的存在，肝脏疾病的存活可能性和肝脏疾病的复发的可能性相关。
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8.发明授权公开(公告)号：US07011947B2
公开(公告)日：2006-03-14
申请号：US10198064
申请日：2002-07-17
CPC分类号： G01N33/57426 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/136 , C12Q2600/158 , G01N2333/475 , G01N2800/52
摘要： The present invention relates to the diagnosis of mixed lineage leukemia (MLL), acute lymphoblastic leukemia (ALL), and acute myelogenous leukemia (AML) according to the gene expression profile of a sample from an individual, as well as to methods of therapy and screening that utilize the genes identified herein as targets.
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公开(公告)号：US20110015080A1
公开(公告)日：2011-01-20
申请号：US12870126
申请日：2010-08-27
申请人： Todd R. Golub , Justin Lamb , David Peck , Jun Lu , Eric Alexander Miska
发明人： Todd R. Golub , Justin Lamb , David Peck , Jun Lu , Eric Alexander Miska
CPC分类号： C12N15/1072 , C12Q1/6834 , C12Q1/6886 , C12Q2563/149 , C12Q2533/107 , C12Q2525/155
摘要： The present invention is directed to novel high-throughput, low-cost, and flexible solution-based methods for RNA expression profiling, including expression of microRNAs and mRNAs.
摘要翻译： 本发明涉及用于RNA表达谱的新型高通量，低成本和灵活的基于溶液的方法，包括microRNA和mRNA的表达。
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10.发明授权公开(公告)号：US07501248B2
公开(公告)日：2009-03-10
申请号：US11236702
申请日：2005-09-26
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158 , G01N2800/52 , G06F19/00
摘要： Methods identifying prostate cancer, methods for prognosing and diagnosing prostate cancer, methods for identifying a compound that modulates prostate cancer development, methods for determining the efficacy of a prostate cancer therapy, and oligonucleotide microarrays containing probes for genes involved in prostate cancer development are described.
摘要翻译： 描述前列腺癌的方法，前列腺癌的预测和诊断方法，用于鉴定调节前列腺癌发展的化合物的方法，用于确定前列腺癌疗法的功效的方法，以及含有涉及前列腺癌发展的基因的探针的寡核苷酸微阵列。
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