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36 条记录 (耗时 0.03 秒)

    Alkylenediamine derivatives
    3.
    发明授权
    Alkylenediamine derivatives 失效
    烷二胺衍生物

    公开(公告)号：US5310902A

    公开(公告)日：1994-05-10

    申请号：US741590

    申请日：1991-08-07

    申请人： Mitsuo Masaki ,  Masaru Satoh ,  Naoya Moritoh ,  Koichi Hashimoto ,  Toshiro Kamishiro ,  Haruhiko Shinozaki

    发明人： Mitsuo Masaki ,  Masaru Satoh ,  Naoya Moritoh ,  Koichi Hashimoto ,  Toshiro Kamishiro ,  Haruhiko Shinozaki

    IPC分类号： C07D295/13 ,  C07D223/00 ,  C07D211/26

    CPC分类号： C07D295/13

    摘要： Novel alkylenediamine derivatives effectively employable glutamate blockers have the formula (I) or (II): ##STR1## wherein each of R.sup.1 and R.sup.6 is an aliphatic hydrocarbon group, an alicyclic hydrocarbon group, an aryl group, or an aralkyl group; each of R.sup.2 and R.sup.7 is an aliphatic hydrocarbon group, an alkoxy group, an aliphatic hydrocarbon group containing an ester bonding, an aliphatic hydrocarbon group containing an ether bonding, or an aryloxy group; each of R.sup.3, R.sup.4, R.sup.5 R.sup.8, R.sup.9 and R.sup.10 is hydrogen, an alkyl group, an alkoxy group, an acyloxy group, an aryl group, an aralkyl group, hydroxyl, a hydroxylalkyl group, halogen, nitrile, nitro, amino, carbamoyl or alkoxycarbonyl; and each of m and n is an integer of 0-3 (m+n does not exceed 3); k is an integer of 1-4; each of p and i is an integer of 2-13; and each of q and j is an integer of 4-7.

    摘要翻译： 新型亚烷基二胺衍生物有效地可用的谷氨酸盐阻滞剂具有式（I）或（II）：其中R 1和R 6各自为脂族烃基，脂环族烃基，芳基 ，或芳烷基; R 2和R 7各自为脂族烃基，烷氧基，含酯键的脂族烃基，含有醚键的脂族烃基或芳氧基; R 3，R 4，R 5，R 9和R 10各自为氢，烷基，烷氧基，酰氧基，芳基，芳烷基，羟基，羟基烷基，卤素，腈，硝基，氨基，氨基甲酰基 或烷氧基羰基; 并且m和n分别为0-3的整数（m + n不超过3）; k是1-4的整数; p和i中的每一个是2-13的整数; 并且q和j中的每一个是4-7的整数。

    Amino-alcohol derivatives and processes for their preparation
    6.
    发明授权
    Amino-alcohol derivatives and processes for their preparation 失效
    氨基醇衍生物及其制备方法

    公开(公告)号：US5250546A

    公开(公告)日：1993-10-05

    申请号：US551037

    申请日：1990-07-11

    申请人： Mitsuo Masaki ,  Haruhiko Shinozaki ,  Masaru Satoh ,  Naoya Moritoh ,  Koichi Hashimoto ,  Toshiro Kamishiro

    发明人： Mitsuo Masaki ,  Haruhiko Shinozaki ,  Masaru Satoh ,  Naoya Moritoh ,  Koichi Hashimoto ,  Toshiro Kamishiro

    IPC分类号： C07D295/13 ,  A61K31/445

    CPC分类号： C07D295/13

    摘要： Amino-alcohol derivatives of the formula, ##STR1## where R.sub.1 is a straight or branched alkyl group having 3 to 8 carbon atoms, R.sub.2 and R.sub.3 are each a lower alkyl group, or R.sub.2 and R.sub.3 form a 5- to 7-membered ring together with the adjacent nitrogen atom which may have an oxygen atom attached thereto, R.sub.4 is a hydrogen atom or a lower alkyl group, R.sub.5 is a hydrogen atom or a lower alkyl group, X is a hydrogen or halogen atom or a lower alkyl or lower alkoxy group, and n is an integer of 2 or 3, and acid addition salts thereof, are effectively useful as medicines and agricultural chemicals. Processes are also disclosed for preparing such compounds.

    摘要翻译： 其中R1是具有3至8个碳原子的直链或支链烷基，R2和R3各自为低级烷基，或R2和R3形成5-至7-元环的下式的氨基醇衍生物， 与可能具有氧原子的相邻氮原子一起，R4是氢原子或低级烷基，R5是氢原子或低级烷基，X是氢或卤素原子或低级烷基或低级烷基 烷氧基，n为2或3的整数，其酸加成盐可有效用作药物和农药。 还公开了制备这些化合物的方法。

    Glycerol derivative and anti-hypertensive agent
    7.
    发明授权
    Glycerol derivative and anti-hypertensive agent 失效
    甘油衍生物和抗高血压药

    公开(公告)号：US5183811A

    公开(公告)日：1993-02-02

    申请号：US554343

    申请日：1990-07-19

    申请人： Mitsuo Masaki ,  Hiromitsu Takeda ,  Toshiro Kamishiro ,  Masao Yamamoto

    发明人： Mitsuo Masaki ,  Hiromitsu Takeda ,  Toshiro Kamishiro ,  Masao Yamamoto

    IPC分类号： C07F9/10 ,  C07F9/572 ,  C07F9/576 ,  C07F9/58 ,  C07F9/59 ,  C07F9/60 ,  C07F9/62 ,  C07F9/6539

    CPC分类号： C07F9/582 ,  C07F9/10 ,  C07F9/5722 ,  C07F9/5725 ,  C07F9/5765 ,  C07F9/592 ,  C07F9/595 ,  C07F9/60 ,  C07F9/62 ,  C07F9/6539

    摘要： A novel glycerol derivative which is effective to reduce blood pressure has the formula: ##STR1## wherein R.sup.1 is an alkyl group having 10-22 carbon atoms, R.sup.2 is lower acyl, benzoyl, aryl, mono-, di- or triarylalkyl, alkyl, cycloalkyl, or cycloalkylalkyl; Q is substituted or unsubstituted alkylene containing 1-4 carbon atoms, l is 0 or 1; Y is a nitrogen-containing heterocyclic group or a nitrogen-containing bridged heterocyclic group (--(Q).sub.l -- is attached to a carbon atom contained in a hetero-ring of the heterocyclic group) in which Y is the bridged heterocyclic group where l is 0; and each of R.sup.5, R.sup.6 and R.sup.7 is hydrogen, lower alkyl, aryl or aralkyl.

    摘要翻译： 有效降低血压的新型甘油衍生物具有下式：其中R1是具有10-22个碳原子的烷基，R2是低级酰基，苯甲酰基，芳基，单 - ，三 - 芳基烷基，烷基， 环烷基或环烷基烷基; Q是取代或未取代的含有1-4个碳原子的亚烷基，l是0或1; Y是含氮杂环基或含氮桥接杂环基（ - （Q）1-连接到杂环基杂环中含有的杂原子上的碳原子），其中Y是桥连杂环基，其中l 是0; R 5，R 6和R 7各自为氢，低级烷基，芳基或芳烷基。

    Method of reducing blood pressure
    9.
    发明授权
    Method of reducing blood pressure 失效
    降低血压的方法

    公开(公告)号：US5523317A

    公开(公告)日：1996-06-04

    申请号：US188446

    申请日：1994-01-26

    申请人： Mitsuo Masaki ,  Fumiyo Hara ,  Toshiro Kamishiro

    发明人： Mitsuo Masaki ,  Fumiyo Hara ,  Toshiro Kamishiro

    IPC分类号： A61K31/415 ,  A61K31/47 ,  A01N43/50

    CPC分类号： A61K31/47 ,  A61K31/415

    摘要： Disclosed is a method of reducing blood pressure which comprises administering to a patient an imidazole derivative of the formula: ##STR1## wherein: each of R.sup.1 and R.sup.2 is hydrogen, substituted or unsubstituted alkyl, alkoxyalkyl, cycloalkyl, aryl, aralkyl, or R.sup.1 and R.sup.2 are combined to form hetero ring; each of R.sup.3, R.sup.4, R.sup.5 and R.sup.6 is hydrogen, halogen, substituted or unsubstituted alkoxy, substituted or unsubstituted alkyl, aryl, aryloxy, alkoxycarbonyl, nitro, amino, acyl, or R.sup.3 is combined with R.sup.2 to form heteroring; R.sup.7 is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted aryl, substituted or unsubstituted arylcarbonyl, or S-containing heteroring; each of R.sup.8 and R.sup.9 is hydrogen, halogen, substituted or unsubstituted alkoxy, unsubstituted or substituted alkyl, alkoxycarbonyl, aralkyl, nitro, amino, acyl, substituted or unsubstituted aryl, or R.sup.8 and R.sup.9 are combined to from alkylene; and n is 0 or 1.

    摘要翻译： 公开了降低血压的方法，其包括向患者施用下式的咪唑衍生物：其中：R 1和R 2各自为氢，取代或未取代的烷基，烷氧基烷基，环烷基，芳基，芳烷基， 或R 1和R 2结合形成杂环; R 3，R 4，R 5和R 6中的每一个为氢，卤素，取代或未取代的烷氧基，取代或未取代的烷基，芳基，芳氧基，烷氧基羰基，硝基，氨基，酰基或R3与R 2结合形成杂环; R 7是氢，取代或未取代的烷基，取代或未取代的芳基，取代或未取代的芳基羰基或含S的杂环; R8和R9各自为氢，卤素，取代或未取代的烷氧基，未取代或取代的烷基，烷氧基羰基，芳烷基，硝基，氨基，酰基，取代或未取代的芳基，或R8和R9与亚烷基结合; n为0或1。

    Alkylenediamine derivatives
    10.
    发明授权
    Alkylenediamine derivatives 失效
    烷二胺衍生物

    公开(公告)号：US5070196A

    公开(公告)日：1991-12-03

    申请号：US562422

    申请日：1990-08-01

    申请人： Mitsuo Masaki ,  Masaru Satoh ,  Naoya Moritoh ,  Koichi Hashimoto ,  Toshiro Kamishiro ,  Haruhiko Shinozaki

    发明人： Mitsuo Masaki ,  Masaru Satoh ,  Naoya Moritoh ,  Koichi Hashimoto ,  Toshiro Kamishiro ,  Haruhiko Shinozaki

    IPC分类号： C07D295/13

    CPC分类号： C07D295/13

    摘要： Novel alkylenediamine derivatives effectively employable as glutamate blockers have the formula (I) or (II): ##STR1## wherein each of R.sup.1 and R.sup.6 is an aliphatic hydrocarbon group, an alicyclic hydrocarbon group, an aryl group, or an aralkyl group; each of R.sup.2 and R.sup.7 is an aliphatic hydrocarbon group, an alkoxy group, an aliphatic hydrocarbon group containing an ester bonding, an aliphatic hydrocarbon group containing an ether bonding, or an aryloxy group; each of R.sup.3, R.sup.4, R.sup.5, R.sup.8, R.sup.9 and R.sup.10 is hydrogen, an alkyl group, an alkoxy group, an acyloxy group, an aryl group, an aralkyl group, hydroxyl, a hydroxylalkyl group, halogen, nitrile, nitro, amino, carbamoyl or alkoxycarbonyl; and each of m and n is an integer of 0-3 (m+n does not exceed 3); k is an integer of 1-4; each of p and i is an integer of 2-13; and each of q and j is an integer of 4-7.

    摘要翻译： 作为谷氨酸盐阻滞剂有效利用的新型亚烷基二胺衍生物具有式（I）或（II）：其中R 1和R 6各自为脂族烃基，脂环族烃基，芳基 基团或芳烷基; R 2和R 7各自为脂族烃基，烷氧基，含酯键的脂族烃基，含有醚键的脂族烃基或芳氧基; R 3，R 4，R 5，R 8，R 9和R 10各自为氢，烷基，烷氧基，酰氧基，芳基，芳烷基，羟基，羟烷基，卤素，腈，硝基，氨基， 氨基甲酰基或烷氧基羰基; 并且m和n分别为0-3的整数（m + n不超过3）; k是1-4的整数; p和i中的每一个是2-13的整数; 并且q和j中的每一个是4-7的整数。