公开(公告)号：US20100233825A1

公开(公告)日：2010-09-16

申请号：US12738228

申请日：2008-10-29

申请人： Tomohiro Yamada ,  Yoichiro Handa

发明人： Tomohiro Yamada ,  Yoichiro Handa

IPC分类号： G01N33/553 ,  G01N21/00

CPC分类号： G01N21/554 ,  G01N21/27 ,  Y10S436/805

摘要： A chemical sensor element contains a resonator having a first reflector in which particles of a fine metal structure are arranged two-dimensionally and periodically is counterposed with interposition of a dielectric layer to a second reflector, wherein the resonance wavelength of a resonator in which the entire of the first reflector is replaced by a metal thin film having the same thickness as the metal fine structure is different from the surface plasmon resonance wavelength induced in the metal fine structure; and the mode of the surface plasmon resonance excited in the metal fine structure is coupled with the mode of the resonator in which the entire of the first reflector is replaced by the metal thin film.

摘要翻译： 化学传感器元件包括具有第一反射器的谐振器，其中精细金属结构的颗粒被二维地周期性布置，并且与第二反射器插入介质层相反，其中谐振器的谐振波长整体 由具有与金属精细结构相同的厚度的金属薄膜替换为与金属精细结构中诱发的表面等离子体共振波长不同的金属薄膜; 并且在金属精细结构中激发的表面等离子体激元谐振的模式与谐振器的模式耦合，其中整个第一反射器被金属薄膜代替。

公开(公告)号：US20110164252A1

公开(公告)日：2011-07-07

申请号：US12672067

申请日：2008-09-25

申请人： Yoichiro Handa ,  Tomohiro Yamada

发明人： Yoichiro Handa ,  Tomohiro Yamada

IPC分类号： G01N21/55

CPC分类号： G01N21/554 ,  B82Y15/00 ,  B82Y20/00

摘要： A target substance-detecting apparatus for detecting a target substance in an analyte comprises a detecting device having a substrate and metal structures capable of causing a plasmon resonance arranged thereon, an illumination optical system for illuminating an incident light containing a polarization component polarized in a first direction onto the detecting device to cross the arranged metal structures, a light-receiving device for receiving light containing the polarization component polarized in the first direction and transmitted through or reflected by the detecting device, and an arithmetic unit for calculating on signals from the light-receiving device to analyze a characteristic of the analyte; the metal structures arranged at first intervals not more than 1/10 of a plasmon resonance wavelength in lines in the first direction and at second intervals not less than ¼ of the plasmon resonance wavelength and not more than the wavelength in lines parallel in a second direction.

摘要翻译： 用于检测分析物中的目标物质的目标物质检测装置包括具有基板的检测装置和能够引起其上排列的等离子体共振的金属结构，照明光学系统，用于照射包含第一 方向移动到检测装置上以穿过排列的金属结构;光接收装置，用于接收包含在第一方向上偏振并被检测装置透射或反射的偏振分量的光，以及用于计算来自光的信号的运算单元 接收装置分析分析物的特征; 金属结构以第一方向排列的等离子体共振波长的1/10不等于等离子体共振波长的1/4以上的第一方向的第二间隔，并且不大于沿第二方向平行的波长的波长 。

公开(公告)号：US07859672B2

公开(公告)日：2010-12-28

申请号：US12045335

申请日：2008-03-10

申请人： Tomohiro Yamada ,  Yoichiro Handa ,  Satoru Nishiuma ,  Ryo Kuroda

发明人： Tomohiro Yamada ,  Yoichiro Handa ,  Satoru Nishiuma ,  Ryo Kuroda

IPC分类号： G01N21/00

CPC分类号： B29D11/00365 ,  B29D11/00807 ,  G01N21/554

摘要： An optical element of the present invention includes a conductive microstructure having a conductive property, and detects an optical spectrum signal varied by the binding of measured molecules on the surface of the conductive microstructure. The optical element has a distribution in the binding capacity of the measured molecules on the surface of the conductive microstructure in the direction of the electric displacement vector generated inside the conductive microstructure. As a result, it is possible to provide an optical element capable of measuring the density at high accuracy without depending on the binding position of the measured molecules.

摘要翻译： 本发明的光学元件包括具有导电特性的导电微结构，并且检测由导电微结构的表面上测量分子的结合而变化的光谱信号。 光学元件在导电微结构内部产生的电位移矢量的方向上具有导电微结构表面上测量分子的结合能力分布。 结果，可以提供能够高精度地测量密度的光学元件，而不依赖于所测量的分子的结合位置。

公开(公告)号：US20070206194A1

公开(公告)日：2007-09-06

申请号：US11677890

申请日：2007-02-22

申请人： Tomohiro Yamada ,  Yoichiro Handa

发明人： Tomohiro Yamada ,  Yoichiro Handa

IPC分类号： G01N21/55 ,  B32B27/04

CPC分类号： G01N21/554 ,  G01N2021/258

摘要： Even when only a few antigens exist in a specimen, a change in a dielectric constant and a change in an optical spectrum accompanied thereto in the periphery of a conductive member are made larger, so that sensing at high sensitivity can be performed. A structure including a protrusion including a dielectric material protruded on a substrate and a conductive member provided on a first surface of the protrusion, in which the maximum value of the cross-sectional area in the cross-section in parallel with a first surface of the conductive member is larger than the area of the first surface.

摘要翻译： 即使在试样中只存在少量抗原，导电性部件的周围的介电常数的变化和伴随其的光谱的变化也变大，可以进行高灵敏度的感测。 一种结构，其特征在于，具有包括突出在基板上的介电材料的突起和设置在所述突起的第一面上的导电性部件，所述突起的横截面积的最大值与所述突起的第一面平行的截面积的最大值 导电构件比第一表面的面积大。

公开(公告)号：US20080297800A1

公开(公告)日：2008-12-04

申请号：US12045335

申请日：2008-03-10

申请人： Tomohiro Yamada ,  Yoichiro Handa ,  Satoru Nishiuma ,  Ryo Kuroda

发明人： Tomohiro Yamada ,  Yoichiro Handa ,  Satoru Nishiuma ,  Ryo Kuroda

IPC分类号： G01N21/59 ,  B29D11/00

CPC分类号： B29D11/00365 ,  B29D11/00807 ,  G01N21/554

摘要： An optical element 4 of the present invention includes a conductive microstructure 6 having a conductive property, and detects an optical spectrum signal varied by the binding of measured molecules on the surface of the conductive microstructure 6. The optical element 4 has a distribution in the direction to the electric displacement vector generated inside the conductive microstructure 6 by the binding capacity of the measured molecules on the surface of the conductive microstructure 6. As a result, it is possible to provide an optical element capable of measuring the density at high accuracy without depending on the binding position of the measured molecules.

摘要翻译： 本发明的光学元件4包括具有导电特性的导电微结构6，并且检测由导电微结构6的表面上测量分子的结合而变化的光谱信号。光学元件4在方向 通过导电微结构6的表面上测量的分子的结合能力，在导电性微结构体6内产生的电位移矢量。结果，可以提供能够以高精度测量密度的光学元件，而不依赖于 在测量分子的结合位置。

公开(公告)号：US08314935B2

公开(公告)日：2012-11-20

申请号：US12672067

申请日：2008-09-25

申请人： Yoichiro Handa ,  Tomohiro Yamada

发明人： Yoichiro Handa ,  Tomohiro Yamada

IPC分类号： G01J3/447 ,  G01N21/55

CPC分类号： G01N21/554 ,  B82Y15/00 ,  B82Y20/00

摘要： A target substance-detecting apparatus for detecting a target substance in an analyte comprises a detecting device having a substrate and metal structures capable of causing a plasmon resonance arranged thereon, an illumination optical system for illuminating an incident light containing a polarization component polarized in a first direction onto the detecting device to cross the arranged metal structures, a light-receiving device for receiving light containing the polarization component polarized in the first direction and transmitted through or reflected by the detecting device, and an arithmetic unit for calculating on signals from the light-receiving device to analyze a characteristic of the analyte; the metal structures arranged at first intervals not more than 1/10 of a plasmon resonance wavelength in lines in the first direction and at second intervals not less than ¼ of the plasmon resonance wavelength and not more than the wavelength in lines parallel in a second direction.

摘要翻译： 用于检测分析物中的目标物质的目标物质检测装置包括具有基板的检测装置和能够引起其上排列的等离子体共振的金属结构，照明光学系统，用于照射包含第一 方向移动到检测装置上以穿过排列的金属结构;光接收装置，用于接收包含在第一方向上偏振并被检测装置透射或反射的偏振分量的光，以及用于计算来自光的信号的运算单元 接收装置分析分析物的特征; 金属结构以第一方向排列的等离子体共振波长的1/10不等于等离子体共振波长的1/4以上的第一方向的第二间隔，并且不大于沿第二方向平行的波长的波长 。

公开(公告)号：US08877519B2

公开(公告)日：2014-11-04

申请号：US12738228

申请日：2008-10-29

申请人： Tomohiro Yamada ,  Yoichiro Handa

发明人： Tomohiro Yamada ,  Yoichiro Handa

IPC分类号： G01N33/553 ,  G01N21/55 ,  G01N21/27

CPC分类号： G01N21/554 ,  G01N21/27 ,  Y10S436/805

摘要： A chemical sensor element contains a resonator having a first reflector in which particles of a fine metal structure are arranged two-dimensionally and periodically is counterposed with interposition of a dielectric layer to a second reflector, wherein the resonance wavelength of a resonator in which the entire of the first reflector is replaced by a metal thin film having the same thickness as the metal fine structure is different from the surface plasmon resonance wavelength induced in the metal fine structure; and the mode of the surface plasmon resonance excited in the metal fine structure is coupled with the mode of the resonator in which the entire of the first reflector is replaced by the metal thin film.

摘要翻译： 化学传感器元件包括具有第一反射器的谐振器，其中精细金属结构的颗粒被二维地周期性布置，并且与第二反射器插入电介质层，其中整个谐振器的谐振波长 由具有与金属精细结构相同的厚度的金属薄膜替换为与金属精细结构中诱发的表面等离子体共振波长不同的金属薄膜; 并且在金属精细结构中激发的表面等离子体激元谐振的模式与谐振器的模式耦合，其中整个第一反射器被金属薄膜代替。

公开(公告)号：US08154722B2

公开(公告)日：2012-04-10

申请号：US11677890

申请日：2007-02-22

申请人： Tomohiro Yamada ,  Yoichiro Handa

发明人： Tomohiro Yamada ,  Yoichiro Handa

IPC分类号： G01J3/44

CPC分类号： G01N21/554 ,  G01N2021/258

摘要： Even when only a few antigens exist in a specimen, a change in a dielectric constant and a change in an optical spectrum accompanied thereto in the periphery of a conductive member are made larger, so that sensing at high sensitivity can be performed. A structure including a protrusion including a dielectric material protruded on a substrate and a conductive member provided on a first surface of the protrusion, in which the maximum value of the cross-sectional area in the cross-section in parallel with a first surface of the conductive member is larger than the area of the first surface.

摘要翻译： 即使在试样中只存在少量抗原，导电性部件的周围的介电常数的变化和伴随其的光谱的变化也变大，可以进行高灵敏度的感测。 一种结构，其特征在于，具有包括突出在基板上的介电材料的突起和设置在所述突起的第一面上的导电性部件，所述突起的横截面积的最大值与所述突起的第一面平行的截面积的最大值 导电构件比第一表面的面积大。

公开(公告)号：US08023109B2

公开(公告)日：2011-09-20

申请号：US12895776

申请日：2010-09-30

申请人： Junta Yamamichi ,  Miki Ogawa ,  Yoichiro Handa ,  Takeshi Imamura ,  Norihiko Utsunomiya ,  Satoru Nishiuma

发明人： Junta Yamamichi ,  Miki Ogawa ,  Yoichiro Handa ,  Takeshi Imamura ,  Norihiko Utsunomiya ,  Satoru Nishiuma

IPC分类号： G01N21/27 ,  G01N21/64

CPC分类号： G01N21/05 ,  G01N21/554 ,  G01N21/645 ,  G01N21/66 ,  G01N2021/0346

摘要： A detection device comprising a substrate comprising a plurality of objects of which properties are changed due to the contact with a target substance, means for bringing the target substance into contact with the objects, and means for detecting a change in properties of the objects caused when the target substance is brought into contact with the objects, based on light output when the objects are irradiated with light, wherein the plurality of the objects are located in the direction in which the light for irradiation travels, and the detecting means is means for detecting the change in the properties based on the summation of light output from the plurality of the objects upon irradiation with light.

摘要翻译： 一种检测装置，包括：基板，包括由于与目标物质的接触而使特性变化的多个物体;使目标物质与物体接触的装置;以及用于检测物体的特性变化的装置， 当物体被光照射时，目标物质与物体接触，其中多个物体位于照射光的行进方向上，检测装置是检测装置 基于在照射光时来自多个物体的光输出的总和的属性的变化。

公开(公告)号：US07688445B2

公开(公告)日：2010-03-30

申请号：US11760337

申请日：2007-06-08

申请人： Yoichiro Handa ,  Norihiko Utsunomiya

发明人： Yoichiro Handa ,  Norihiko Utsunomiya

IPC分类号： G01J3/30

CPC分类号： G01J3/20 ,  G01J3/02 ,  G01J3/0229 ,  G01J3/0237 ,  G01J3/04 ,  G01J3/18

摘要： A spectroscope of the present invention includes a concave diffraction grating which disperses incident light, an incident light introduction unit which introduces incident light into the concave diffraction grating, and an outgoing light receiving unit which receives outgoing light dispersed for different wavelengths by the concave diffraction grating. The spectroscope further includes an incident aperture which limits an incident angle of light emitted by the incident light introduction unit to the concave diffraction grating, and an outgoing aperture which limits an outgoing angle of outgoing light dispersed for different wavelengths by the concave diffraction grating to the light receiving unit. The spectroscope is constructed so that relatively rotational transfer of at least two out of the concave diffraction grating, the incident aperture and the outgoing apertures can be performed along a Rowland circle which the concave diffraction grating forms.

摘要翻译： 本发明的分光镜包括散射入射光的凹面衍射光栅，将入射光引入到凹面衍射光栅中的入射光导入单元和通过凹面衍射光栅接收不同波长散射的出射光的出射光接收单元 。 分光器还包括将入射光引入单元发射的光的入射角限制到凹面衍射光栅的入射孔径，以及通过凹面衍射光栅将散射的不同波长的出射光的出射角限制在外部的出射孔， 光接收单元。 分光镜被构造成使得可以沿凹面衍射光栅形成的Rowland圆进行至少两个凹入衍射光栅，入射孔和出射孔的相对旋转传递。