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公开(公告)号：US07688445B2
公开(公告)日：2010-03-30
申请号：US11760337
申请日：2007-06-08
IPC分类号： G01J3/30
CPC分类号： G01J3/20 , G01J3/02 , G01J3/0229 , G01J3/0237 , G01J3/04 , G01J3/18
摘要： A spectroscope of the present invention includes a concave diffraction grating which disperses incident light, an incident light introduction unit which introduces incident light into the concave diffraction grating, and an outgoing light receiving unit which receives outgoing light dispersed for different wavelengths by the concave diffraction grating. The spectroscope further includes an incident aperture which limits an incident angle of light emitted by the incident light introduction unit to the concave diffraction grating, and an outgoing aperture which limits an outgoing angle of outgoing light dispersed for different wavelengths by the concave diffraction grating to the light receiving unit. The spectroscope is constructed so that relatively rotational transfer of at least two out of the concave diffraction grating, the incident aperture and the outgoing apertures can be performed along a Rowland circle which the concave diffraction grating forms.
摘要翻译： 本发明的分光镜包括散射入射光的凹面衍射光栅，将入射光引入到凹面衍射光栅中的入射光导入单元和通过凹面衍射光栅接收不同波长散射的出射光的出射光接收单元 。 分光器还包括将入射光引入单元发射的光的入射角限制到凹面衍射光栅的入射孔径，以及通过凹面衍射光栅将散射的不同波长的出射光的出射角限制在外部的出射孔， 光接收单元。 分光镜被构造成使得可以沿凹面衍射光栅形成的Rowland圆进行至少两个凹入衍射光栅，入射孔和出射孔的相对旋转传递。
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2.发明授权Recognition chip for target substance, and detection method and device for the same 有权目标物质识别芯片及其检测方法及装置公开(公告)号：US08023109B2
公开(公告)日：2011-09-20
申请号：US12895776
申请日：2010-09-30
申请人： Junta Yamamichi , Miki Ogawa , Yoichiro Handa , Takeshi Imamura , Norihiko Utsunomiya , Satoru Nishiuma
发明人： Junta Yamamichi , Miki Ogawa , Yoichiro Handa , Takeshi Imamura , Norihiko Utsunomiya , Satoru Nishiuma
CPC分类号： G01N21/05 , G01N21/554 , G01N21/645 , G01N21/66 , G01N2021/0346
摘要： A detection device comprising a substrate comprising a plurality of objects of which properties are changed due to the contact with a target substance, means for bringing the target substance into contact with the objects, and means for detecting a change in properties of the objects caused when the target substance is brought into contact with the objects, based on light output when the objects are irradiated with light, wherein the plurality of the objects are located in the direction in which the light for irradiation travels, and the detecting means is means for detecting the change in the properties based on the summation of light output from the plurality of the objects upon irradiation with light.
摘要翻译： 一种检测装置，包括：基板，包括由于与目标物质的接触而使特性变化的多个物体;使目标物质与物体接触的装置;以及用于检测物体的特性变化的装置， 当物体被光照射时，目标物质与物体接触，其中多个物体位于照射光的行进方向上，检测装置是检测装置 基于在照射光时来自多个物体的光输出的总和的属性的变化。
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3.发明申请Recognition Chip for Target Substance, and Detection Method and Device for the Same 有权目标物质识别芯片及其检测方法及装置公开(公告)号：US20090009756A1
公开(公告)日：2009-01-08
申请号：US10571906
申请日：2005-03-02
申请人： Junta Yamamichi , Miki Ogawa , Yoichiro Handa , Takeshi Imamura , Norihiko Utsunomiya , Satoru Nishiuma
发明人： Junta Yamamichi , Miki Ogawa , Yoichiro Handa , Takeshi Imamura , Norihiko Utsunomiya , Satoru Nishiuma
IPC分类号： G01N21/01
CPC分类号： G01N21/05 , G01N21/554 , G01N21/645 , G01N21/66 , G01N2021/0346
摘要： A detection device comprising a substrate comprising a plurality of objects of which properties are changed due to the contact with a target substance, means for bringing the target substance into contact with the objects, and means for detecting a change in properties of the objects caused when the target substance is brought into contact with the objects, based on light output when the objects are irradiated with light, wherein the plurality of the objects are located in the direction in which the light for irradiation travels, and the detecting means is means for detecting the change in the properties based on the summation of light output from the plurality of the objects upon irradiation with light.
摘要翻译： 一种检测装置，包括：基板，包括由于与目标物质的接触而使特性变化的多个物体;使目标物质与物体接触的装置;以及用于检测物体的特性变化的装置， 当物体被光照射时，目标物质与物体接触，其中多个物体位于照射光的行进方向上，检测装置是检测装置 基于在照射光时来自多个物体的光输出的总和的属性的变化。
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公开(公告)号：US20070291266A1
公开(公告)日：2007-12-20
申请号：US11760337
申请日：2007-06-08
IPC分类号： G01J3/28
CPC分类号： G01J3/20 , G01J3/02 , G01J3/0229 , G01J3/0237 , G01J3/04 , G01J3/18
摘要： A spectroscope of the present invention includes a concave diffraction grating which disperses incident light, an incident light introduction unit which introduces incident light into the concave diffraction grating, and an outgoing light receiving unit which receives outgoing light dispersed for different wavelengths by the concave diffraction grating. The spectroscope further includes an incident aperture which limits an incident angle of light emitted by the incident light introduction unit to the concave diffraction grating, and an outgoing aperture which limits an outgoing angle of outgoing light dispersed for different wavelengths by the concave diffraction grating to the light receiving unit. The spectroscope is constructed so that relatively rotational transfer of at least two out of the concave diffraction grating, the incident aperture and the outgoing apertures can be performed along a Rowland circle which the concave diffraction grating forms.
摘要翻译： 本发明的分光镜包括散射入射光的凹面衍射光栅，将入射光引入到凹面衍射光栅中的入射光导入单元和通过凹面衍射光栅接收不同波长散射的出射光的出射光接收单元 。 分光器还包括将入射光引入单元发射的光的入射角限制到凹面衍射光栅的入射孔径，以及通过凹面衍射光栅将散射的不同波长的出射光的出射角限制在外部的出射孔， 光接收单元。 分光镜被构造成使得可以沿凹面衍射光栅形成的Rowland圆进行至少两个凹入衍射光栅，入射孔和出射孔的相对旋转传递。
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5.发明申请RECOGNITION CHIP FOR TARGET SUBSTANCE, AND DETECTION METHOD AND DEVICE FOR THE SAME 有权目标物质的识别芯片及其相关的检测方法和装置公开(公告)号：US20110019195A1
公开(公告)日：2011-01-27
申请号：US12895776
申请日：2010-09-30
申请人： Junta Yamamichi , Miki Ogawa , Yoichiro Handa , Takeshi Imamura , Norihiko Utsunomiya , Satoru Nishiuma
发明人： Junta Yamamichi , Miki Ogawa , Yoichiro Handa , Takeshi Imamura , Norihiko Utsunomiya , Satoru Nishiuma
IPC分类号： G01N21/59
CPC分类号： G01N21/05 , G01N21/554 , G01N21/645 , G01N21/66 , G01N2021/0346
摘要： A detection device comprising a substrate comprising a plurality of objects of which properties are changed due to the contact with a target substance, means for bringing the target substance into contact with the objects, and means for detecting a change in properties of the objects caused when the target substance is brought into contact with the objects, based on light output when the objects are irradiated with light, wherein the plurality of the objects are located in the direction in which the light for irradiation travels, and the detecting means is means for detecting the change in the properties based on the summation of light output from the plurality of the objects upon irradiation with light.
摘要翻译： 一种检测装置，包括：基板，包括由于与目标物质的接触而使特性变化的多个物体;使目标物质与物体接触的装置;以及用于检测物体的特性变化的装置， 当物体被光照射时，目标物质与物体接触，其中多个物体位于照射光的行进方向上，检测装置是检测装置 基于在照射光时来自多个物体的光输出的总和的属性的变化。
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6.发明授权Biological tissue processing substrate for fixing proteins or protein degradation products in tissue for analysis 有权用于将蛋白质或蛋白质降解产物固定在组织中用于分析的生物组织处理底物公开(公告)号：US08962302B2
公开(公告)日：2015-02-24
申请号：US11592313
申请日：2006-11-03
申请人： Kazuhiro Ban , Miki Ogawa , Norihiko Utsunomiya , Hiroyuki Hashimoto , Manabu Komatsu , Yohei Murayama
发明人： Kazuhiro Ban , Miki Ogawa , Norihiko Utsunomiya , Hiroyuki Hashimoto , Manabu Komatsu , Yohei Murayama
IPC分类号： C12M1/00 , C12M1/34 , C12Q1/00 , C12Q1/34 , C12Q1/37 , C12Q1/02 , C12N11/14 , C12N11/02 , C12N11/04 , G01N33/68 , G01N33/50
CPC分类号： G01N33/6848 , G01N33/5082
摘要： A biological tissue processing substrate for fixing proteins in a biological tissue or degradation products of the proteins, the substrate comprising: a porous body that forms a contact surface with the biological tissue, the porous body holding in pores an enzyme for obtaining the proteins or the degradation products of the proteins from the biological tissue, wherein the proteins or the degradation products obtained by the action of the enzyme are brought into contact with a member consisting of a metal.
摘要翻译： 一种用于将蛋白质固定在生物组织中的生物组织处理底物或蛋白质的降解产物，所述底物包括：与生物组织形成接触表面的多孔体，多孔体在孔中保留用于获得蛋白质的酶或 使来自生物组织的蛋白质的降解产物与由金属构成的构件接触，其中通过酶的作用获得的蛋白质或降解产物与金属接触。
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7.发明授权公开(公告)号：US08634600B2
公开(公告)日：2014-01-21
申请号：US12874939
申请日：2010-09-02
IPC分类号： G06K9/00
CPC分类号： G06T7/13 , G06T7/33 , G06T2207/20164 , G06T2207/30041 , G06T2207/30101
摘要： It is an object of the invention to provide a method of extracting a crossing/branching portion of a blood vessel from a fundus image of the eye at a high probability. The crossing/branching portion of the blood vessel is extracted from the fundus image under such conditions that three or more blood vessels run on an outer circumferential portion of an extraction candidate region and that a coordinate average of a plurality of blood vessels in the outer circumferential portion exists in a center portion of the extraction candidate region.
摘要翻译： 本发明的一个目的是提供一种以高概率从眼底的图像中提取血管的交叉/分支部分的方法。 在三个或更多个血管在提取候选区域的外周部分上行进，并且在外周的多个血管的坐标平均值的条件下，从眼底图像中提取血管的交叉/分支部分 部分存在于提取候选区域的中心部分。
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8.发明申请IMAGE PICKUP APPARATUS AND IMAGE PICKUP METHOD USING OPTICAL COHERENCE TOMOGRAPHY 有权使用光学相干图像的图像拾取装置和图像拾取方法公开(公告)号：US20120092677A1
公开(公告)日：2012-04-19
申请号：US13377369
申请日：2010-06-15
申请人： Nobuhito Suehira , Kazuro Yamada , Norihiko Utsunomiya , Takashi Naba , Ryoji Kurosaka , Kei Suzuki
发明人： Nobuhito Suehira , Kazuro Yamada , Norihiko Utsunomiya , Takashi Naba , Ryoji Kurosaka , Kei Suzuki
IPC分类号： G01B9/02
CPC分类号： G01B9/02058 , A61B3/102 , G01B9/02012 , G01B9/02072 , G01B9/02091
摘要： The present invention relates to an apparatus having a simple configuration capable of correctly detecting malfunction of an OCT apparatus by detecting the states of a light source and a sensor.An image pickup apparatus includes a switching unit that switches between a first mode in which a combined light beam of a return light beam from a specimen and a reference light beam is detectable by a detecting unit and a second mode in which the reference light beam is detectable by the detecting unit.The image pickup apparatus is switchable to the first mode on the basis of an intensity of the reference light beam detected by the detecting unit in the second mode.
摘要翻译： 本发明涉及具有能够通过检测光源和传感器的状态来正确检测OCT装置的故障的简单结构的装置。 一种图像拾取装置，包括：切换单元，其在第一模式和第二模式之间进行切换，在第一模式中，通过检测单元检测来自样本的返回光束的组合光和参考光束;以及第二模式，其中参考光束为 可由检测单元检测。 基于在第二模式中由检测单元检测到的参考光束的强度，图像拾取装置可切换到第一模式。
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9.发明授权Device and method for acquiring information on objective substance to be detected by detecting a change of wavelength characteristics on the optical transmittance 失效通过检测光透射率上的波长特性的变化来获取关于要检测的物质的信息的装置和方法公开(公告)号：US07659987B2
公开(公告)日：2010-02-09
申请号：US11659717
申请日：2005-09-14
IPC分类号： G01N21/00
CPC分类号： G01N21/554 , G01N21/648 , G01N2021/258 , G01N2201/0635 , G01N2201/0636
摘要： An information-acquiring device for acquiring information on an objective substance to be detected, which is provided with a sensing element that has a surface capable of fixing the objective substance to be detected thereon, and makes applied light change its wavelength characteristics in response to the fixed state of the objective substance to be detected onto the surface, a light source, and light-receiving means for receiving light emitted from the light source through the sensing element, has the light-receiving means and the light source arranged on the same substrate so that the light which has been emitted from the light source and has been transmitted through the sensing element can be led to the light-receiving means, and has means for varying the wavelength regions of each light incident on each of a plurality of the light-receiving means installed in an optical path from the light source to the light-receiving means.
摘要翻译： 一种信息获取装置，用于获取关于待检测的物质的信息，该信息获取装置设置有具有能够固定待检测的物体的表面的感测元件，并且使得施加的光响应于该检测元件的波长特性而改变其 要检测的目标物质的固定状态，光源和用于接收通过感测元件从光源发射的光的光接收装置，其中光接收装置和光源布置在同一基板上 使得已经从光源发射并已经透射通过感测元件的光可以被引导到光接收装置，并且具有用于改变入射到多个光中的每一个的每个光的波长区域的装置 - 接收装置安装在从光源到光接收装置的光路中。
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10.发明申请TARGET SUBSTANCE DETECTING ELEMENT, TARGET SUBSTANCE DETECTION APPARATUS AND TARGET SUBSTANCE DETECTION METHOD 失效目标物质检测元件，目标物质检测装置和目标物质检测方法公开(公告)号：US20080225292A1
公开(公告)日：2008-09-18
申请号：US12123167
申请日：2008-05-19
CPC分类号： G01N33/54326 , G01N33/54373 , Y10S435/808 , Y10S436/805
摘要： Magnetic particles with a metal coat holding target substance captors are made to react with a target substance contained in a specimen in a solution where the magnetic particles are dispersed in a liquid medium. Subsequently, the dispersion of the magnetic particles is applied to a surface having a periodic structure that is adapted to generate plasmon resonance and a change in the plasmon resonance attributable to the concentration of the target substance held on the magnetic particles fixed magnetically to the surface is optically detected to determine the concentration of the target substance in the specimen.
摘要翻译： 使具有保持目标物质俘获物的金属涂层的磁性颗粒与磁性颗粒分散在液体介质中的溶液中的样品中包含的目标物质反应。 随后，将磁性颗粒的分散体施加到具有适于产生等离子体共振的周期性结构的表面，并且由于保持在磁性颗粒上的目标物质的浓度与表面固定的等离子体共振的变化是 光学检测以确定样品中目标物质的浓度。
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