摘要:
A polymer compound including: the repeating unit shown in the following formula (I) (wherein: Ar1 represents an arylene group, a divalent heterocyclic group, or a divalent aromatic amine; J1 and J2 each represent a direct bond, an alkylene group, or a phenylene group, and X1 represents an oxygen atom or a sulfur atom; i is an integer from 0 to 3; j is 0 or 1; m is 1 or 2; and R1 represents a hydrogen atom, an alkyl group, an alkoxy group, or the like) and the repeating unit shown in the following formula (II) (wherein: Ar2 represents a fluorene-diyl group; J3 and J4 each represent a direct bond, an alkylene group, or a phenylene group; X2 represents an oxygen atom or a sulfur atom; k is an integer from 0 to 3; l is 0 or 1; and n is 1 or 2).
摘要:
A polymer compound including: the repeating unit shown in the following formula (I) (wherein: Ar1 represents an arylene group, a divalent heterocyclic group, or a divalent aromatic amine; J1 and J2 each represent a direct bond, an alkylene group, or a phenylene group, and X1 represents an oxygen atom or a sulfur atom; i is an integer from 0 to 3; j is 0 or 1; m is 1 or 2; and R1 represents a hydrogen atom, an alkyl group, an alkoxy group, or the like) and the repeating unit shown in the following formula (II) (wherein: Ar2 represents a fluorene-diyl group; J3 and J4 each represent a direct bond, an alkylene group, or a phenylene group; X2 represents an oxygen atom or a sulfur atom; k is an integer from 0 to 3; l is 0 or 1; and n is 1 or 2).
摘要:
A polymer light emitting material which contains a polymer compound comprising a repeating unit of the following formula (1) or (2) and having a polystyrene-reduced number-average molecular weight of 103 to 108, and which exhibits light emission from the triplet excited state. [wherein Ar1 and Ar2 each independently represent a trivalent aromatic hydrocarbon group or a trivalent heterocyclic group. X1 and X2 each independently represent O, S, C(═O), S(═O), SO2, C(R1)(R2), Si(R3)(R4), N(R5), B(R6), P(R7) or P(═O)(R8). X1 and Ar2 bond to adjacent carbon atoms in the aromatic ring of Ar1; and X2 and Ar1 bond to adjacent carbon atoms in the aromatic ring of Ar2]; [wherein Ar3 and Ar4 each independently represent a trivalent aromatic hydrocarbon group or a trivalent heterocyclic group. X3 and X4 each independently represent N, B, P, C(R9) or Si(R10). X3 and Ar4 bond to adjacent carbon atoms in the aromatic ring of Ar3; and X4 and Ar3 bond to adjacent carbon atoms in the aromatic ring of Ar4].
摘要:
The present invention is a probe, a primer, and an antibody, for detecting a dopaminergic neuron proliferative progenitor cell. According to the present invention, there is provided a polynucleotide probe and a polynucleotide primer for use in the detection or selection of a dopaminergic neuron proliferative progenitor cell, which can hybridize with a polynucleotide consisting of a nucleotide sequence of a Nato3 gene, or a complementary sequence thereto, and an antibody against a Nato3 protein, or a part thereof for use in the detection or selection of a dopaminergic neuron proliferative progenitor cell.
摘要:
A novel gene 65B13 expressed specifically and transiently in dopaminergic neuron precursor cells immediately after cell cycle exit was obtained by the present invention. The cellular expression of 65B13 can be used as an index to select cells that are suitable in terms of their safety, survival rate, and network formation ability, for transplant therapy of neurodegenerative diseases such as Parkinson's disease.
摘要:
A novel gene 65B13 expressed specifically and transiently in dopaminergic neuron precursor cells immediately after cell cycle exit was obtained by the present invention. The cellular expression of 65B13 can be used as an index to select cells that are suitable in terms of their safety, survival rate, and network formation ability, for transplant therapy of neurodegenerative diseases such as Parkinson's disease.
摘要:
Disclosed is a luminescent or charge-transporting polymer compound having a main chain containing a divalent heterocyclic group, a divalent condensed polycyclic hydrocarbon group including no five-membered ring, a group represented by the formula (1) below or a divalent aromatic amine group as a repeating unit, and a functional side chain containing at least one functional group selected from the group consisting of hole injecting/transporting groups, electron injecting/transporting groups, and light-emitting groups. This polymer compound is characterized in that the functional group is directly bonded to a saturated carbon atom in the repeating unit or bonded to the repeating unit via X is an —RJ—X— group (wherein RJ represents an optionally substituted alkylene group, X represents a direct bond, an oxygen atom, a sulfur atom, C═O, C(═O)—O, S═O, SiR8R9, NR10, BR11, PR12 or P(═O)R13. (In the formula, the ring A and the ring B independently represent an optionally substituted aromatic hydrocarbon ring, and the aromatic hydrocarbon ring in the ring A and the aromatic hydrocarbon ring in the ring B have different ring structures from each other; two bonding hands are respectively present on the ring A and/or the ring B; Bw and Rx independently represent a hydrogen atom or a substituent, and Rw and Rx may combine together to form a ring.)
摘要:
Total RNAs were prepared from the ventral and dorsal regions of embryonic day 12.5 mouse mesencephalon, and a cDNA fragment was obtained by the subtraction method (N-RDA). The full-length cDNA was cloned and the nucleotide sequence was determined. The gene was named Corl2. The result of homology search showed that about 850 residues of Corl2 exhibited homology to the XM_355050 sequence deposited in GenBank; however, the remaining ˜150 residues showed no homology. Thus, Corl2 was demonstrated to be a novel gene. The Corl2 expression in various mouse organs was analyzed by RT-PCR, and the result showed that Corl2 expression was specific to brain. The result of immunostaining day 12.5 embryos and postnatal day 12 brains demonstrated that Corl2 is useful as a Purkinje cell marker at any differentiation stages.
摘要:
The present invention identified Lmx1a genes, which are expressed in dopaminergic neurons at all differentiation stages, from proliferating dopaminergic neuron progenitor cells before cell cycle exit to cells after cell cycle exit. Lmx1a expression in cells can be used as an indicator when selecting cells suitable for transplantation therapy for neurodegenerative diseases such as Parkinson's disease, and is useful as a marker for screening agents involved in the induction of dopaminergic neuron differentiation.
摘要:
Disclosed is a compound containing a divalent group represented by formula (I). (In formula (I), Ar1 represents an arylene group, a divalent heterocyclic group or a divalent aromatic amine group; J1 represents a phenylene group; J2 represents an alkylene group; X represents an oxygen atom or a sulfur atom; j represents 0 or 1, k represents an integer of 0-3, and l represents 0 or 1, while satisfying 1≦j+k+l≦5; m represents 1 or 2; R1 represents a hydrogen atom, an alkyl group, an alkoxy group, an alkylthio group, an aryl group, an aryloxy group, an arylthio group, an arylalkyl group, an arylalkoxy group, an arylalkylthio group, an arylalkenyl group, an arylalkynyl group, an amino group, a substituted amino group, a silyl group, a substituted silyl group, a halogen atom, an acyl group, an acyloxy group, an imine residue, a carbamoyl group, an acid imide group, a monovalent heterocyclic group, a carboxyl group, a substituted carboxyl group, a cyano group or a nitro group; the plurality of R1's may be the same as or different from each other; and when there are a plurality of J1's, J2's, X's, j's, k's or l's, the J1's, J2's, X's, j's, k's or l's may be the same as or different from each other, respectively).