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公开(公告)号：US20050054675A1
公开(公告)日：2005-03-10
申请号：US10494298
申请日：2002-10-17
IPC分类号： C12P21/02 , A61K31/427 , A61K31/47 , A61K31/4709 , A61P1/02 , A61P1/16 , A61P17/00 , A61P17/02 , A61P19/00 , A61P19/02 , A61P31/04 , A61P31/06 , A61P31/10 , A61P31/12 , A61P31/18 , A61P31/22 , A61P35/00 , A61P35/02 , A61P37/02 , A61P37/08 , A61P39/06 , A61P43/00 , C07D215/10 , C07D215/12 , C07D277/28 , C07D277/30 , C12R1/91
CPC分类号： A61K31/4709 , A61K31/427 , C07D215/10 , C07D215/12 , C07D277/30 , Y02A50/411
摘要： The object of the present invention is to provide an agent for promoting IFN-γ production, which can be safely applied to living bodies; the present invention solves the problem by providing an agent for promoting IFN-γ production, which comprises a tri-heterocyclic polymethine cyanine dye(s), and a method for producing IFN-γ, which comprises a step of allowing the agent to act on immunocompetent cells.
摘要翻译： 本发明的目的在于提供可以安全地应用于生物体的IFN-γ生成促进剂。 本发明通过提供用于促进IFN-γ产生的试剂来解决该问题，其包括三杂环多甲基花青染料和用于产生IFN-γ的方法，其包括使试剂作用的步骤 免疫活性细胞。
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2.发明授权Interferon-γ inducing polypeptide, pharmaceutical composition thereof, monoclonal antibody thereto, and methods of use 有权干扰素-γ诱导多肽，其药物组合物，其单克隆抗体及其使用方法公开(公告)号：US07355014B2
公开(公告)日：2008-04-08
申请号：US11580922
申请日：2006-10-16
申请人： Shimpei Ushio , Kakuji Torigoe , Todao Tanimoto , Haruki Okamura , Masashi Kurimoto , Shigeharu Fukuda , Toshio Kunikata , Mutsuko Taniguchi , Keizo Kohno
发明人： Shimpei Ushio , Kakuji Torigoe , Todao Tanimoto , Haruki Okamura , Masashi Kurimoto , Shigeharu Fukuda , Toshio Kunikata , Mutsuko Taniguchi , Keizo Kohno
IPC分类号： C07K16/00 , C07K16/18 , C07K16/24 , C12P21/08 , A61K38/00 , A61K38/19 , C07K14/00 , C07K14/54
CPC分类号： A61K38/2013 , A61K38/1709 , A61K38/208 , C07K16/18 , A61K2300/00
摘要： A human IFN-γ inducing polypeptide and its nucleotide sequence was isolated, purified and characterized. Pharmaceutical compositions containing this novel INF-γ inducing polypeptide or active fragments thereof are formulated and monoclonal antibodies are raised against this polypeptide or antigenic fragments thereof. The polypeptide can be used in a method for treating diseases susceptive to treatment with INF-γ, and methods for enhancing the cytotoxicity of NK cells or for inducing the formation of LAK cells, such as to treat tumors and malignant pathologies.
摘要翻译： 分离，纯化和表征人IFN-γ诱导多肽及其核苷酸序列。 配制含有该新型INF-γ诱导多肽或其活性片段的药物组合物，并针对该多肽或其抗原性片段产生单克隆抗体。 该多肽可以用于治疗对用INF-γ进行治疗的疾病的方法，以及用于增强NK细胞的细胞毒性或诱导LAK细胞形成的方法，例如治疗肿瘤和恶性病变。
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3.发明授权Interferon-gamma (IFN-&ggr;) inducing factor (IGIF, IL-18) and peptide fragment thereof 有权干扰素-γ（IFN-γ）诱导因子（IGIF，IL-18）及其肽片段公开(公告)号：US06274709B1
公开(公告)日：2001-08-14
申请号：US09253523
申请日：1999-02-19
申请人： Haruki Okamura , Tadao Tanimoto , Kakuji Torigoe , Toshio Kunikata , Mutsuko Taniguchi , Keizo Kohno , Masashi Kurimoto
发明人： Haruki Okamura , Tadao Tanimoto , Kakuji Torigoe , Toshio Kunikata , Mutsuko Taniguchi , Keizo Kohno , Masashi Kurimoto
IPC分类号： C07K100
CPC分类号： C07K16/244 , A61K2039/505 , C07K14/52 , C07K16/24 , C07K2316/96 , C07K2317/76 , G01N33/6863 , G01N33/6866 , G01N33/6869 , G01N33/6872
摘要： A protein which induces the IFN-&ggr; production by immunocompetent cells and has a molecular weight of 19,000±5,000 daltons on SDS-PAGE or gel filtration method and a pI of 4.8±1.0 on chromatofocusing. The protein is isolated from mouse liver and can be purified by a monoclonal antibody specific to it. The monoclonal antibody can be also used for assaying the protein.
摘要翻译： 通过免疫活性细胞诱导IFN-γ产生的蛋白质，并且在SDS-PAGE或凝胶过滤方法上具有19,000±5,000道尔顿的分子量，在色谱聚焦上的pI为4.8±1.0。 蛋白质从小鼠肝脏中分离出来，可以通过特异性的单克隆抗体纯化。 单克隆抗体也可用于测定蛋白质。
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4.发明授权Recombinant production of murine interferon--.gamma. (IFN-.gamma.) inducing factor (IGIF, IL-18) 失效鼠干扰素-γ（IFN-γ）诱导因子（IGIF，IL-18）的重组产生
公开(公告)号：US5914253A
公开(公告)日：1999-06-22
申请号：US908005
申请日：1997-08-11
申请人： Haruki Okamura , Tadao Tanimoto , Kakuji Torigoe , Toshio Kunikata , Mutsuko Taniguchi , Keizo Kohno , Masashi Kurimoto
发明人： Haruki Okamura , Tadao Tanimoto , Kakuji Torigoe , Toshio Kunikata , Mutsuko Taniguchi , Keizo Kohno , Masashi Kurimoto
CPC分类号： C07K16/244 , C07K14/52 , C07K16/24 , G01N33/6863 , G01N33/6866 , G01N33/6869 , G01N33/6872 , A61K2039/505 , C07K2316/96
摘要： DNA encoding a murine protein capable of inducing the production of interferon-.gamma. by immunocompetent cells is described. The native protein from mouse liver has a molecular weight of 19.+-.5 kDa, a pI of 4.8.+-.1.0, and the amino acid sequence shown in SEQ ID NO: 2. Methods for producing the protein in recombinant expression systems including E. coli are provided.
摘要翻译： 描述了编码能够通过免疫活性细胞诱导干扰素-γ产生的鼠蛋白的DNA。 来自小鼠肝脏的天然蛋白质的分子量为19 +/- 5kDa，pI为4.8 +/- 1.0，氨基酸序列如SEQ ID NO：2所示。在重组表达系统中产生蛋白质的方法包括 提供大肠杆菌。
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5.发明授权公开(公告)号：US07405048B2
公开(公告)日：2008-07-29
申请号：US10327069
申请日：2002-12-24
IPC分类号： G01K33/53
CPC分类号： C07K16/244 , C07K14/52 , C07K14/54 , C07K16/24
摘要： A monoclonal antibody which is specific to a polypeptide having a molecular weight of 18,500±3,000 daltons on SDS-PAGE and a pI of 4.9±1.0 on chromatofocusing. The monoclonal antibody is obtainable from hybridomas and can be used for the purification and detection of the polypeptide. The polypeptide strongly induces the IFN-γ production by immunocompetent cells with only a small amount, and dose not cause serious side effects even when administered to human in a relatively-high dose.
摘要翻译： 对SDS-PAGE上分子量为18,500±3,000道尔顿的多肽具有特异性的单克隆抗体，在色谱聚焦上的pI为4.9±1.0。 单克隆抗体可从杂交瘤获得，可用于纯化和检测多肽。 该多肽强烈诱导免疫活性细胞仅产生少量的IFN-γ产生，即使以较高剂量施用于人，也不会引起严重的副作用。
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公开(公告)号：US06600022B1
公开(公告)日：2003-07-29
申请号：US09649063
申请日：2000-08-29
IPC分类号： C07K1600
CPC分类号： C07K16/2866 , A61K38/00 , C07K14/7155
摘要： Disclosed are a receptor protein which recognize a novel cytokine, i.e., interleukin-18, a monoclonal antibody specific to the protein, and uses thereof. The receptor protein is useful as pharmaceutical to treat and prevent autoimmune and allergic disease because it suppresses and regulates excessive immunoreaction. The monoclonal antibody specifically reacts with interleukin-18 receptor, exhibiting efficacy in purification, detection and inhibition of interleukin-18 receptor.
摘要翻译： 公开了一种识别新型细胞因子即白细胞介素-18的受体蛋白，该蛋白质特异性的单克隆抗体及其用途。 受体蛋白质可用作药物以治疗和预防自身免疫性和过敏性疾病，因为它抑制和调节过度的免疫反应。 单克隆抗体与白细胞介素-18受体特异性反应，表现出纯化，检测和抑制白细胞介素-18受体的功效。
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7.发明授权Physiologically active extract obtained from indigo plant polygonum tinctorium 失效从靛蓝植物um子得到的生理活性提取物公开(公告)号：US06524625B2
公开(公告)日：2003-02-25
申请号：US09339928
申请日：1999-06-25
IPC分类号： A65K3578
CPC分类号： A61K36/48
摘要： A physiologically active extract comprising an ethyl acetate-soluble ingredient of an indigo plant, which is obtainable by soaking a raw indigo plant in an organic solvent used for extraction. The ethyl acetate-soluble ingredient includes tryptanthrin, 3,5,4′-trihydroxy-6,7-methylenedioxy-flavone, kaempferol, 3,5,7,4′-tetrahydroxy-6-methoxy-flavone, gallic acid, caffeic acid, indirubin, pheophorbide a, and methylpheophorbide a.
摘要翻译： 一种生理活性提取物，其包含靛蓝植物的乙酸乙酯可溶成分，其可通过将生靛蓝植物浸泡在用于萃取的有机溶剂中获得。 乙酸乙酯可溶成分包括色胺，3,5,4'-三羟基-6,7-亚甲二氧基黄酮，山奈酚，3,5,7,4'-四羟基-6-甲氧基黄酮，没食子酸，咖啡酸 ，靛玉红，偏硼酸a和甲基偏硼酸a。
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8.发明授权Monoclonal antibody specific to polypeptide which induces interferon-G&ggr; production 有权诱导干扰素-Ggamma生产的多肽特异性单克隆抗体公开(公告)号：US06509449B1
公开(公告)日：2003-01-21
申请号：US09711899
申请日：2000-11-15
IPC分类号： C07K1624
CPC分类号： C07K16/244 , C07K14/52 , C07K14/54 , C07K16/24
摘要： A monoclonal antibody which is specific to a polypeptide having a molecular weight of 18,500±3,000 daltons on SDS-PAGE and a pI of 4.9±1.0 on chromatofocusing. The monoclonal antibody is obtainable from hybridomas and can be used for the purification and detection of the polypeptide. The polypeptide strongly induces the IFN-&ggr; production by immunocompetent cells with only a small amount, and dose not cause serious side effects even when administered to human in a relatively-high dose.
摘要翻译： 对SDS-PAGE上分子量为18,500 3,000道尔顿的多肽具有特异性的单克隆抗体，在色谱聚焦上的pI为4.9 1.0。 单克隆抗体可从杂交瘤获得，可用于纯化和检测多肽。 该多肽强烈诱导免疫活性细胞仅产生少量的IFN-γ产生，即使以较高剂量施用于人，也不会引起严重的副作用
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公开(公告)号：US06268486B1
公开(公告)日：2001-07-31
申请号：US08832177
申请日：1997-04-08
IPC分类号： A23J100
CPC分类号： C07K16/244 , C07K14/52 , C07K14/54 , C07K16/24
摘要： A monoclonal antibody which is specific to a polypeptide having a molecular weight of 18,500±3,000 daltons on SDS-PAGE and a pI of 4.9±1.0 on chromatofocusing. The monoclonal antibody is obtainable from hybridomas and can be used for the purification and detection of the polypeptide. The polypeptide strongly induces the IFN-&ggr; production by immunocompetent cells with only a small amount, and dose not cause serious side effects even when administered to human in a relatively-high dose.
摘要翻译： 对SDS-PAGE上分子量为18,500 3,000道尔顿的多肽具有特异性的单克隆抗体，在色谱聚焦上的pI为4.9 1.0。 单克隆抗体可从杂交瘤获得，可用于纯化和检测多肽。 该多肽强烈诱导免疫活性细胞仅产生少量的IFN-γ产生，即使以较高剂量施用于人，也不会引起严重的副作用
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公开(公告)号：US07141393B2
公开(公告)日：2006-11-28
申请号：US08996140
申请日：1997-12-22
IPC分类号： C12P21/04
CPC分类号： C07K16/2866 , A61K38/00 , C07K14/7155
摘要： Disclosed are a receptor protein which recognize a novel cytokine, i.e., interleukin-18, a monoclonal antibody specific to the protein, and uses thereof. The receptor protein is useful as pharmaceutical to treat and prevent autoimmune and allergic disease because it suppresses and regulates excessive immunoreaction. The monoclonal antibody specifically reacts with interleukin-18, exhibiting efficacy in purification, detection and inhibition of interleukin-18.
摘要翻译： 公开了一种识别新型细胞因子即白细胞介素-18的受体蛋白，该蛋白质特异性的单克隆抗体及其用途。 受体蛋白质可用作药物以治疗和预防自身免疫性和过敏性疾病，因为它抑制和调节过度的免疫反应。 单克隆抗体与白细胞介素-18特异性反应，表现出在纯化，检测和抑制白细胞介素-18中的功效。
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