公开(公告)号：US20050152973A1

公开(公告)日：2005-07-14

申请号：US10992120

申请日：2004-11-19

申请人： Toshio Murakami ,  Noritaka Ii ,  Hiroyuki Sakurai

发明人： Toshio Murakami ,  Noritaka Ii ,  Hiroyuki Sakurai

IPC分类号： A61K9/00 ,  A61K9/20 ,  A61K31/7012

CPC分类号： A61K9/2004 ,  A61K9/0056 ,  A61K9/2018

摘要： The present invention relates to a disintegrant comprising a substance which is solid at room temperature and has a water solubility of 30 wt. % or more, a saturated aqueous solution of the substance having a viscosity of 50 mpa.s.

摘要翻译： 本发明涉及一种崩解剂，其包括在室温下为固体且水溶性为30重量％的物质。 ％以上，该物质的饱和水溶液的粘度为50mpa.s。

公开(公告)号：US08932414B2

公开(公告)日：2015-01-13

申请号：US13634614

申请日：2011-03-22

申请人： Hideo Hata ,  Toshio Murakami ,  Yukihiro Utsumi

发明人： Hideo Hata ,  Toshio Murakami ,  Yukihiro Utsumi

IPC分类号： C22C38/02 ,  C22C38/04 ,  C22C38/06 ,  C21D8/02 ,  C22C38/12 ,  C22C38/14 ,  C22C38/16 ,  C21D8/04 ,  C21D1/20

CPC分类号： C21D8/0226 ,  C21D1/20 ,  C21D8/0447 ,  C21D8/0463 ,  C21D8/0473 ,  C21D2211/001 ,  C21D2211/002 ,  C21D2211/005 ,  C21D2211/008 ,  C22C38/002 ,  C22C38/005 ,  C22C38/02 ,  C22C38/04 ,  C22C38/06 ,  C22C38/08 ,  C22C38/12 ,  C22C38/14 ,  C22C38/16 ,  C22C38/38

摘要： Disclosed is a high-strength steel plate with excellent warm workability that has a component composition comprising, in mass %, 0.05 to 0.4% C, 0.5 to 3% Si+Al, 0.5 to 3% Mn, no more than 0.15% P (not including 0%), and no more than 0.02% S (including 0%), with the remainder comprising iron and impurities, and a composition that includes a total of 45 to 80% martensite and/or bainitic ferrite in terms of the area ratio relative to the entire composition, 5 to 40% polygonal ferrite in terms of the area ratio relative to the entire composition, and 5 to 20% retained austenite in terms of the area ratio relative to the entire composition, wherein the C concentration (CγR) within said residual austenite is in the range of 0.6 mass % to less than 1.0 mass %, and that furthermore may include bainite. In the high-strength steel plate, TRIP effects are achieved to the fullest extent in warm working, and increased ductility over prior steel plates is reliably achieved.

摘要翻译： 公开了一种具有优异的温加工性的高强度钢板，其具有以质量％计含有0.05〜0.4％的C，0.5〜3％的Si + Al，0.5〜3％的Mn，0.15％以下的P（ 不包括0％）和不超过0.02％的S（包括0％），剩余部分包括铁和杂质，以及包括总共45-80％的马氏体和/或贝氏体铁素体的组合物的面积 相对于整个组合物的比率，相对于组合物的面积比为5〜40％的多边形铁素体，相对于组合物的面积比为5〜20％的残留奥氏体，其中C浓度 ）在0.6质量％以下且小于1.0质量％的范围内，并且还可以包括贝氏体。 在高强度钢板中，TRIP效果在温暖加工中达到最大程度，并且可靠地实现了比现有钢板更高的延展性。

公开(公告)号：US20140271331A1

公开(公告)日：2014-09-18

申请号：US14238599

申请日：2012-08-15

申请人： Toshio Murakami ,  Elijah Kakiuchi ,  Hideo Hata ,  Naoki Mizuta ,  Tatsuya Asai

发明人： Toshio Murakami ,  Elijah Kakiuchi ,  Hideo Hata ,  Naoki Mizuta ,  Tatsuya Asai

IPC分类号： C22C38/38 ,  C22C38/14 ,  C22C38/12 ,  C22C38/00 ,  C22C38/06 ,  C22C38/04 ,  C22C38/02 ,  C22C38/16 ,  C22C38/08

CPC分类号： C22C38/38 ,  B21D22/208 ,  C21D8/0226 ,  C21D8/0236 ,  C21D9/46 ,  C21D2211/001 ,  C21D2211/002 ,  C21D2211/008 ,  C22C38/001 ,  C22C38/002 ,  C22C38/02 ,  C22C38/04 ,  C22C38/06 ,  C22C38/08 ,  C22C38/12 ,  C22C38/14 ,  C22C38/16

摘要： This high-strength steel plate has a component composition including, by mass %, C: 0.02-0.3%, Si: 1-3%, Mn: 1.8-3%, P: 0.1% or less, S: 0.01% or less, Al: 0.001-0.1%, N: 0.002-0.03%, the rest consisting of iron and impurities. Said steel plate has a microstructure including, in terms of area ratio relative to the entire microstructure, each of the following phases: bainitic ferrite: 50-85%; retained γ; 3% or greater; martensite+the aforementioned retained γ; 10-45%; and ferrite: 5-40%. The C concentration (CγR) in the aforementioned retained austenite is 0.3-1.2 mass %, part or all of the N in the aforementioned component composition is solid solution N, and the amount of said solid solution N is 30-100 ppm.

摘要翻译： 该高强度钢板的组成成分按质量％计含有C：0.02-0.3％，Si：1-3％，Mn：1.8-3％，P：0.1％以下，S：0.01％以下 ，Al：0.001-0.1％，N：0.002-0.03％，其余由铁和杂质组成。 所述钢板具有包括相对于整个微观结构的面积比的以下各相的微结构：贝氏体铁素体：50-85％; 保留γ; 3％以上; 马氏体+上述保留的γ; 10-45％; 铁素体：5-40％。 上述残留奥氏体中的C浓度（CγR）为0.3〜1.2质量％，上述成分组成中的N的一部分或全部为固溶N，所述固溶N的量为30〜100ppm。

公开(公告)号：US20140161659A1

公开(公告)日：2014-06-12

申请号：US14237286

申请日：2012-08-15

申请人： Toshio Murakami ,  Masao Kinefuchi ,  Hideo Hata

发明人： Toshio Murakami ,  Masao Kinefuchi ,  Hideo Hata

IPC分类号： C22C38/28 ,  C22C38/16 ,  C22C38/14 ,  C22C38/00 ,  C22C38/08 ,  C22C38/06 ,  C22C38/04 ,  C22C38/02 ,  C22C38/24 ,  C22C38/12

CPC分类号： C22C38/28 ,  C21D8/0226 ,  C21D9/46 ,  C21D2211/002 ,  C21D2211/004 ,  C21D2211/005 ,  C22C38/001 ,  C22C38/02 ,  C22C38/04 ,  C22C38/06 ,  C22C38/08 ,  C22C38/12 ,  C22C38/14 ,  C22C38/16 ,  C22C38/24

摘要： This high-strength hot-rolled steel plate contains specific amounts of C, Si, Mn, Al, V and also Ti and/or Nb so as to fulfill C−12(V/51+Ti/48+Nb/93)>0.03, and the rest consists of iron and unavoidable impurities. Ferrite is the main microstructure, the remaining microstructure is one or more selected from the group consisting of bainite, martensite and retained austenite, wherein the average particle diameter of precipitated carbides (the total content of V, Ti and Nb is 0.02% or greater) in the ferrite is less than 6 nm.

摘要翻译： 该高强度热轧钢板含有特定量的C，Si，Mn，Al，V以及Ti和/或Nb，以满足C-12（V / 51 + Ti / 48 + Nb / 93）> 0.03，其余由铁和不可避免的杂质组成。 铁素体是主要的微结构，剩余的微结构是选自贝氏体，马氏体和残余奥氏体中的一种或多种，​​其中沉淀碳化物的平均粒径（V，Ti和Nb的总含量为0.02％以上） 在铁素体中小于6nm。

公开(公告)号：US20130236350A1

公开(公告)日：2013-09-12

申请号：US13988382

申请日：2011-11-16

申请人： Elijah Kakiuchi ,  Toshio Murakami ,  Hideo Hata ,  Tatsuya Asai ,  Naoki Mizuta

发明人： Elijah Kakiuchi ,  Toshio Murakami ,  Hideo Hata ,  Tatsuya Asai ,  Naoki Mizuta

IPC分类号： C22C38/38 ,  C22C38/14 ,  C22C38/12 ,  B21D11/22 ,  C22C38/06 ,  C22C38/04 ,  C22C38/02 ,  C22C38/00 ,  C22C38/16 ,  C22C38/08

摘要： A high-strength steel sheet has a chemical composition including 0.05% to 0.3% of C, 1% to 3% of Si, 0.5% to 3% of Mn, 0% to 0.1% of P, 0.001% to 0.1% of Al, and 0.002% to 0.03% of N, in mass percent; further includes iron and impurities; and has a structure including 50% to 90% of bainitic ferrite, 5% to 20% of retained austenite (γR), a total of 10% to 50% of martensite and the retained austenite, and 0% to 40% of polygonal ferrite, in area percent based on the entire structure. The retained austenite has a carbon content (CγR) of 0.5% to 1.2% by mass, an average equivalent circle diameter of 0.2 to 2 μm, and an average aspect ratio (maximum diameter/minimum diameter) of less than 3.0. The high-strength steel sheet excels both in elongation and deep drawability while having a strength of 980 MPa or more.

摘要翻译： 高强度钢板具有C：0.05〜0.3％，Si：1〜3％，Mn：0.5〜3％，P：0〜0.1％，Al：0.001〜0.1％ ，以质量％计，N：0.002〜0.03％ 进一步包括铁和杂质; 并且具有包括50％至90％的贝氏体铁素体，5％至20％的残留奥氏体（γR），总共10％至5​​0％的马氏体和残余奥氏体以及0％至40％的多边形铁素体 ，占整个结构的面积百分比。 残留奥氏体的碳含量（CgammaR）为0.5〜1.2质量％，平均当量圆直径为0.2〜2μm，平均纵横比（最大直径/最小直径）小于3.0。 高强度钢板的强度为980MPa以上，伸长率和深冲性均优异。

公开(公告)号：US08343288B2

公开(公告)日：2013-01-01

申请号：US12919159

申请日：2009-03-06

申请人： Toshio Murakami ,  Akira Ibano

发明人： Toshio Murakami ,  Akira Ibano

IPC分类号： C22C38/44

CPC分类号： C22C38/04 ,  C21D1/25 ,  C21D8/0236 ,  C21D2211/004 ,  C21D2211/005 ,  C21D2211/008 ,  C22C38/06

摘要： Provided are the following cold-rolled steel sheets: 1) a cold-rolled steel sheet having higher stretch flangeability than conventional steels; 2) a cold-rolled steel sheet having a higher balance between elongation and stretch flangeability than conventional steels; and 3) a cold-rolled steel sheet heightened in all of yield stress, elongation, and stretch flangeability. The cold-rolled steel sheets are characterized by containing 0.03-0.30 mass % carbon, up to 3.0 mass % (including 0 mass %) silicon, 0.1-5.0 mass % manganese, up to 0.1 mass % phosphorus, less than 0.01 mass % sulfur, up to 0.01 mass % nitrogen, and 0.01-1.00 mass % aluminum and having a structure which comprises tempered martensite in an amount of 50% or more (including 100%) in terms of areal proportion and in which the remainder is ferrite. The steel sheets are further characterized in that at least one of the following structural factors has been regulated: the proportions of cementite particles and of the ferrite grains in the tempered martensite and the dislocation density in all structures.

摘要翻译： 提供以下冷轧钢板：1）具有比常规钢更高的拉伸凸缘性的冷轧钢板; 2）与常规钢相比，延伸率和拉伸凸缘性之间的平衡比较高的冷轧钢板; 和3）在所有屈服应力，伸长率和拉伸凸缘性方面提高的冷轧钢板。 冷轧钢板的特征在于，含有0.03-0.30质量％的碳，至多3.0质量％（包括0质量％）的硅，0.1-5.0质量％的锰，至多0.1质量％的磷，小于0.01质量％的硫 ，至多0.01质量％的氮和0.01〜1.00质量％的铝，并且具有以面积比例计为50％以上（包括100％）量的回火马氏体，其余为铁素体的结构。 钢板的特征还在于，以下结构因素中的至少一个已被调节：回火马氏体中的渗碳体颗粒和铁素体晶粒的比例以及所有结构中的位错密度。

公开(公告)号：US08332159B2

公开(公告)日：2012-12-11

申请号：US10546293

申请日：2004-02-18

申请人： Toshio Murakami ,  Hirofumi Higuchi ,  Keiichi Makizumi ,  Toshihiro Maeda ,  Hiroshi Mizokami

发明人： Toshio Murakami ,  Hirofumi Higuchi ,  Keiichi Makizumi ,  Toshihiro Maeda ,  Hiroshi Mizokami

IPC分类号： G06F7/00

CPC分类号： C07K16/00 ,  A61K2039/505 ,  C07K16/1063 ,  C07K2317/34

摘要： A method of enhancing the efficacy of a monoclonal antibody preparation wherein antigens from patients are tested for their reactivity with the antibody. An amino acid sequence of an expressed protein is deuced from a nucleotide sequence determined by isolation and analysis of a target molecule gene in a biopsy from a patient. This is compared with the previously determined amino acid sequence recognized by the monoclonal antibody preparation in order to assess the fitness of patients for administration of the monoclonal antibody preparation.

摘要翻译： 一种提高单克隆抗体制剂的功效的方法，其中测试来自患者的抗原与抗体的反应性。 通过从患者的活组织检查中分离和分析靶分子基因而确定的核苷酸序列，从表达的蛋白质的氨基酸序列中去除。 将其与由单克隆抗体制剂识别的先前确定的氨基酸序列进行比较，以评估患者施用单克隆抗体制剂的适合性。

公开(公告)号：US08075836B2

公开(公告)日：2011-12-13

申请号：US12710021

申请日：2010-02-22

申请人： Rie Okada ,  Shinobu Nakayama ,  Toshio Murakami

发明人： Rie Okada ,  Shinobu Nakayama ,  Toshio Murakami

IPC分类号： C21D6/00

CPC分类号： C21D11/00 ,  C21D8/0463 ,  C21D9/48 ,  C21D9/573 ,  C21D9/60 ,  C21D11/005 ,  Y02P10/253

摘要： Steel-sheet continuous annealing equipment includes, in sequence, a pre-heating zone, a heating zone, a soaking zone, a cooling zone, a reheating zone, an overaging zone, and a final cooling zone, and further includes a rapid heating region and a rapid cooling region that are provided within a range from the reheating zone to the final cooling zone (including the reheating zone and the final cooling zone), the rapid heating region allowing rapid heating of a steel sheet at a heating rate of 15° C./s or more and the rapid cooling region allowing rapid cooling, at a cooling rate of 10° C./s or more, of the steel sheet that has been rapidly heated in the rapid heating region. Various steel-sheet products ranging from mild steel sheets to ultrahigh-tensile steel sheets can be produced by performing a heat treatment with such steel-sheet continuous annealing equipment.

摘要翻译： 钢板连续退火设备依次包括预热区，加热区，均热区，冷却区，再加热区，过碱化区和最终冷却区，并且还包括快速加热区域 以及设置在从再加热区域到最终冷却区域（包括再加热区域和最终冷却区域）的范围内的快速冷却区域，快速加热区域能够以15°的加热速度快速加热钢板 在快速加热区域中快速加热的钢板以10℃/ s以上的冷却速度快速冷却的快速冷却区域。 通过对这种钢板连续退火设备进行热处理，可以制造从低碳钢板到超高强度钢板的各种钢板制品。

公开(公告)号：US20110005643A1

公开(公告)日：2011-01-13

申请号：US12919159

申请日：2009-03-06

申请人： Toshio Murakami ,  Akira Ibano

发明人： Toshio Murakami ,  Akira Ibano

IPC分类号： C22C38/16 ,  C22C38/00 ,  C22C38/04 ,  C22C38/08 ,  C22C38/12 ,  C22C38/06 ,  C22C38/18

CPC分类号： C22C38/04 ,  C21D1/25 ,  C21D8/0236 ,  C21D2211/004 ,  C21D2211/005 ,  C21D2211/008 ,  C22C38/06

摘要： Provided are the following cold-rolled steel sheets: 1) a cold-rolled steel sheet having higher stretch flangeability than conventional steels; 2) a cold-rolled steel sheet having a higher balance between elongation and stretch flangeability than conventional steels; and 3) a cold-rolled steel sheet heightened in all of yield stress, elongation, and stretch flangeability. The cold-rolled steel sheets are characterized by containing 0.03-0.30 mass % carbon, up to 3.0 mass % (including 0 mass %) silicon, 0.1-5.0 mass % manganese, up to 0.1 mass % phosphorus, less than 0.01 mass % sulfur, up to 0.01 mass % nitrogen, and 0.01-1.00 mass % aluminum and having a structure which comprises tempered martensite in an amount of 50% or more (including 100%) in terms of areal proportion and in which the remainder is ferrite. The steel sheets are further characterized in that at least one of the following structural factors has been regulated: the proportions of cementite particles and of the ferrite grains in the tempered martensite and the dislocation density in all structures.

摘要翻译： 提供以下冷轧钢板：1）具有比常规钢更高的拉伸凸缘性的冷轧钢板; 2）与常规钢相比，延伸率和拉伸凸缘性之间的平衡比较高的冷轧钢板; 和3）在所有屈服应力，伸长率和拉伸凸缘性方面提高的冷轧钢板。 冷轧钢板的特征在于，含有0.03-0.30质量％的碳，至多3.0质量％（包括0质量％）的硅，0.1-5.0质量％的锰，至多0.1质量％的磷，小于0.01质量％的硫 ，至多0.01质量％的氮和0.01〜1.00质量％的铝，并且具有以面积比例计为50％以上（包括100％）量的回火马氏体，其余为铁素体的结构。 钢板的特征还在于，以下结构因素中的至少一个已被调节：回火马氏体中的渗碳体颗粒和铁素体晶粒的比例以及所有结构中的位错密度。

公开(公告)号：US20050131182A1

公开(公告)日：2005-06-16

申请号：US10980283

申请日：2004-11-04

申请人： Toshio Murakami ,  Hidetatsu Murakami ,  Yasuhiro Takano ,  Kenji Doi ,  Akira Kumagae ,  Yasuhiro Hasada ,  Toshizi Nishimura

发明人： Toshio Murakami ,  Hidetatsu Murakami ,  Yasuhiro Takano ,  Kenji Doi ,  Akira Kumagae ,  Yasuhiro Hasada ,  Toshizi Nishimura

IPC分类号： C08F32/06 ,  C08F4/44

CPC分类号： C08F32/06

摘要： It is an object of the present invention to provide a non-conjugated cyclic diene and a non-conjugated cyclic diene composition which enable the production of a polymer based on non-conjugated cyclic diene which makes it possible to produce a (co)polymer at a high degree of polymerization activity, and a method of producing a polymer based on non-conjugated cyclic diene which makes it possible to produce a (co)polymer at a high degree of polymerization activity. A non-conjugated cyclic diene is used which meets at least one of the following requirements: (1) it contains a compound having a seven-membered cyclic triene hydrocarbon structure in a specific amount or less and (2) it contains a conjugated polyene compound having an eight-membered bicyclic hydrocarbon structure in a specific amount. Also, in a method of producing a non-conjugated cyclic diene polymer, the aforementioned non-conjugated cyclic diene is supplied to the polymerization or copolymerization using an olefin polymerization catalyst containing an organic aluminum oxy compound and/or an ionizing ionic compound. Also, in another method of producing a non-conjugated cyclic diene polymer, a non-conjugated cyclic diene which is obtained by bringing a crude non-conjugated cyclic diene into contact with an alkali and then removing at least a part of a low-boiling point fraction and at least a part of a high-boiling point fraction is used for the polymerization.

摘要翻译： 本发明的目的是提供一种非共轭环状二烯和非共轭环状二烯组合物，其可以制备基于非共轭环状二烯的聚合物，这使得可以在 高聚合活性的方法，以及制备基于非共轭环状二烯的聚合物的方法，其可以以高聚合活性制备（共）聚合物。 使用满足以下要求中的至少一个的非共轭环状二烯：（1）含有特定量以下的七元环状三烯烃结构的化合物和（2）含有共轭多烯化合物 具有特定量的八元双环烃结构。 另外，在非共轭环状二烯系聚合物的制造方法中，使用含有有机铝氧化合物和/或离子化离子化合物的烯烃聚合催化剂将上述非共轭环状二烯供给到聚合或共聚中。 此外，在另一种制备非共轭环状二烯聚合物的方法中，通过使粗非共轭环状二烯与碱接触，然后除去至少一部分低沸点而得到的非共轭环状二烯 点馏分和至少一部分高沸点馏分用于聚合。