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    METHOD AND APPARATUS FOR DETECTION OF NERVOUS SYSTEM DISORDERS
    2.
    发明申请
    METHOD AND APPARATUS FOR DETECTION OF NERVOUS SYSTEM DISORDERS 审中-公开
    用于检测神经系统疾病的方法和装置

    公开(公告)号：US20070249953A1

    公开(公告)日：2007-10-25

    申请号：US11609388

    申请日：2006-12-12

    申请人： Mark Frei ,  Ivan Osorio ,  David Carlson ,  Eric Panken ,  Touby Drew

    发明人： Mark Frei ,  Ivan Osorio ,  David Carlson ,  Eric Panken ,  Touby Drew

    IPC分类号： A61B5/04 ,  A61N1/00

    CPC分类号： A61N1/36082

    摘要： Systems and methods for detecting and/or treating nervous system disorders, such as seizures, are disclosed. Certain embodiments of the invention relate generally to implantable medical devices (IMDs) adapted to detect and treat nervous system disorders in patients with an IMD. Certain embodiments of the invention include detection of seizures based upon comparisons of long-term and short-term representations of physiological signals. Other embodiments include prediction of seizure activity based upon analysis of physiological signal levels. A further embodiment of the invention includes detection of seizure activity following the delivery of therapy.

    摘要翻译： 公开了用于检测和/或治疗诸如癫痫发作的神经系统疾病的系统和方法。 本发明的某些实施方案一般涉及适于检测和治疗患有IMD的患者的神经系统疾病的可植入医疗装置（IMD）。 本发明的某些实施方案包括基于生理信号的长期和短期表示的比较来检测癫痫发作。 其他实施方案包括基于生理信号水平的分析预测癫痫发作活动。 本发明的另一个实施方案包括在递送治疗后检测发作活动。

    FLEXIBLE MEMORY MANAGEMENT SCHEME FOR LOOP RECORDING IN AN IMPLANTABLE DEVICE
    4.
    发明申请
    FLEXIBLE MEMORY MANAGEMENT SCHEME FOR LOOP RECORDING IN AN IMPLANTABLE DEVICE 有权
    用于在可移植设备中进行环路记录的灵活存储器管理方案

    公开(公告)号：US20070255147A1

    公开(公告)日：2007-11-01

    申请号：US11380590

    申请日：2006-04-27

    申请人： Touby Drew ,  David Carlson

    发明人： Touby Drew ,  David Carlson

    IPC分类号： A61B5/04

    CPC分类号： A61B5/0476 ,  A61B5/4094 ,  A61B5/7232

    摘要： A method and apparatus is provided for handling multiple recordings that result from events in a limited memory device. The events may include various automatic and manual triggers. The method provides a mechanism for storing different configurations of data, associated with different events.

    摘要翻译： 提供一种用于处理由有限存储器件中的事件引起的多个记录的方法和装置。 事件可能包括各种自动和手动触发。 该方法提供用于存储与不同事件相关联的数据的不同配置的机制。

    Event-based lead impedance monitoring
    6.
    发明申请
    Event-based lead impedance monitoring 有权
    基于事件的导线阻抗监测

    公开(公告)号：US20060264777A1

    公开(公告)日：2006-11-23

    申请号：US11413072

    申请日：2006-04-27

    申请人： Touby Drew

    发明人： Touby Drew

    IPC分类号： A61B5/05

    CPC分类号： A61B5/4094 ,  A61B5/048 ,  A61B5/053 ,  A61N1/0529 ,  A61N1/36082

    摘要： A medical device senses electrical activity within a patient and, in some embodiments, delivers stimulation to the patient via a plurality electrical paths, which include electrodes and associated conductors of one or more leads. The medical device determines whether a symptomatic event, such as a seizure, is detected based on the sensed electrical activity, and measures the impedance of one or more of the paths in response to the determination. If the medical device identifies a dysfunctional electrical path based on the measured impedance, the device may, as examples, disable the dysfunctional electrical path, or modify a stimulation or sensing program to not use the dysfunctional electrical path. In this manner, the medical device may identify inaccurate symptomatic event detection and, where the device delivers a therapy in response to such detection, such as stimulation via the electrical paths, avoid inappropriate therapy delivery.

    摘要翻译： 医疗装置感测患者内的电活动，并且在一些实施例中，经由包括一个或多个引线的电极和相关导体的多个电路径向患者传递刺激。 医疗设备基于感测到的电活动来确定是否检测到诸如癫痫发作的症状事件，并且响应于该确定测量一个或多个路径的阻抗。 如果医疗设备基于测量的阻抗来识别功能不良的电路径，则该设备可以例如禁用功能不良的电路径，或者修改刺激或感测程序以不使用功能不良的电路径。 以这种方式，医疗设备可以识别不准确的症状事件检测，并且在设备响应于诸如经由电路径的刺激的这种检测进行治疗时，避免不适当的治疗递送。

    Techniques for user-activated data retention in an implantable medical device
    7.
    发明申请
    Techniques for user-activated data retention in an implantable medical device 有权
    在可植入医疗设备中用户激活的数据保留技术

    公开(公告)号：US20060094972A1

    公开(公告)日：2006-05-04

    申请号：US11264915

    申请日：2005-11-02

    申请人： Touby Drew

    发明人： Touby Drew

    IPC分类号： A61N1/36 ,  A61B5/04

    CPC分类号： A61B5/0031 ,  A61B5/04325 ,  A61B5/0476 ,  A61B5/113 ,  A61B5/4094 ,  A61B5/7232 ,  A61N1/36082 ,  A61N1/3702 ,  A61N1/37252 ,  G06F19/00 ,  G06F19/3481 ,  G16H40/63

    摘要： Apparatus for storing data records associated with a medical monitoring event in a data structure. Upon indication by a patient of a possible manifestation of a neurological event, the implanted device obtains and stores data in the data record in a first data structure that is age-based. Before an oldest data record is lost, the oldest data record may be stored in a second data structure that is priority index-based. The priority index may be determined by a severity level and may be further determined by associated factors. The implanted device may organize, off-load, report, and/or display a plurality of data records based on an associated priority index. Additionally, the implanted device may select a subset or composite of physiologic channels from the available physiologic channels based on a selection criterion.

    摘要翻译： 用于存储与数据结构中的医疗监视事件相关联的数据记录的装置。 在由患者指示神经系统事件的可能表现的情况下，植入装置以数据记录的形式获取并存储数据为基于年龄的第一数据结构。 在最旧的数据记录丢失之前，最早的数据记录可以存储在基于优先级索引的第二数据结构中。 优先权索引可以由严重性级别确定，并且可以由相关因素进一步确定。 植入的装置可以基于相关联的优先级索引来组织，卸载，报告和/或显示多个数据记录。 另外，植入装置可以基于选择标准从可用生理通道中选择生理通道的子集或复合物。

    Techniques for data retention upon detection of an event in an implantable medical device
    8.
    发明申请
    Techniques for data retention upon detection of an event in an implantable medical device 有权
    检测植入式医疗设备中的事件时的数据保留技术

    公开(公告)号：US20060094971A1

    公开(公告)日：2006-05-04

    申请号：US11264974

    申请日：2005-11-02

    申请人： Touby Drew

    发明人： Touby Drew

    IPC分类号： A61B5/04

    CPC分类号： A61B5/4094 ,  A61B5/0006 ,  A61B5/0031 ,  A61B5/02055 ,  A61B5/021 ,  A61B5/024 ,  A61B5/031 ,  A61B5/04001 ,  A61B5/04012 ,  A61B5/0402 ,  A61B5/0476 ,  A61B5/0816 ,  A61B5/1118 ,  A61B5/165 ,  A61B5/4082 ,  A61B5/686 ,  A61B5/7232 ,  A61B5/7282 ,  A61N1/36132 ,  A61N1/36135 ,  A61N1/36521 ,  A61N1/36585 ,  A61N1/3702 ,  A61N1/37252 ,  A61N1/37282 ,  G06F17/30336 ,  G06F19/00 ,  G06F19/3418 ,  G16H10/60 ,  G16H40/63

    摘要： Methods and apparatus for storing data records associated with a medical monitoring event in a data structure. Upon detection of a possible occurrence of a physiological event by one group of monitoring elements, an implanted device records data received from another group of monitoring elements. The implanted device obtains and stores the data in the data record in a first data structure that is age-based. Before an oldest data record is lost, the oldest data record may be stored in a second data structure that is priority index-based. The priority index may be determined by a severity level and may be further determined by associated factors. The implanted device may organize, off-load, report, and/or display a plurality of data records based on an associated priority index. Additionally, the implanted device may select a subset or composite of physiologic channels from the available physiologic channels based on a selection criterion.

    摘要翻译： 用于存储与数据结构中的医疗监视事件相关联的数据记录的方法和装置。 在通过一组监测元件检测到生理事件的可能发生时，植入装置记录从另一组监测元件接收的数据。 植入装置以基于年龄的第一数据结构获得并存储在数据记录中的数据。 在最旧的数据记录丢失之前，最早的数据记录可以存储在基于优先级索引的第二数据结构中。 优先权索引可以由严重性级别确定，并且可以由相关因素进一步确定。 植入的装置可以基于相关联的优先级索引来组织，卸载，报告和/或显示多个数据记录。 另外，植入装置可以基于选择标准从可用生理通道中选择生理通道的子集或复合物。

    PEAK DATA RETENTION OF SIGNAL DATA IN AN IMPLANTABLE MEDICAL DEVICE
    9.
    发明申请
    PEAK DATA RETENTION OF SIGNAL DATA IN AN IMPLANTABLE MEDICAL DEVICE 失效
    信号数据在可移植医疗设备中的峰值数据保持

    公开(公告)号：US20070255531A1

    公开(公告)日：2007-11-01

    申请号：US11380586

    申请日：2006-04-27

    申请人： Touby Drew

    发明人： Touby Drew

    IPC分类号： G06F19/00 ,  G06F17/40

    CPC分类号： A61B5/02055 ,  A61B5/4094 ,  A61B5/7232 ,  A61N1/08 ,  A61N1/3601 ,  A61N1/36082

    摘要： Methods and apparatus for storing data records associated with an extreme value are disclosed. Signal data is stored in a first buffer of a set of buffers. If a local extreme value for the first buffer exceeds a global extreme value, signal data is stored in a second buffer of the set of buffers. This process is repeated, wrapping around and overwriting buffers until the signal data in a current buffer does not have a local extreme value that exceeds the global extreme value. When this happens, signal data may be stored in a subsequent buffer and if a local extreme value of the subsequent buffer does not exceed the global extreme value, further signal data may be stored in the subsequent buffer in a circular manner until either an instantaneous extreme value exceeds the global extreme value or the recording period ends. In an embodiment, the extreme value may be a peak value.

    摘要翻译： 公开了存储与极值相关联的数据记录的方法和装置。 信号数据存储在一组缓冲器的第一缓冲器中。 如果第一缓冲区的局部极值超过全局极值，则信号数据被存储在该组缓冲器的第二缓冲器中。 重复此过程，环绕并覆盖缓冲区，直到当前缓冲区中的信号数据不具有超过全局极值的局部极值。 当这种情况发生时，信号数据可以存储在随后的缓冲器中，并且如果后续缓冲器的局部极值不超过全局极限值，则可以以循环方式将另外的信号数据存储在随后的缓冲器中，直到瞬时极限 值超过全局极值或记录周期结束。 在一个实施例中，极值可以是峰值。

    Clustering with combined physiological signals
    10.
    发明申请
    Clustering with combined physiological signals 有权
    组合生理信号

    公开(公告)号：US20060195039A1

    公开(公告)日：2006-08-31

    申请号：US11411712

    申请日：2006-04-26

    申请人： Touby Drew ,  Jonathan Werder ,  Jonathon Giftakis ,  Eric Panken

    发明人： Touby Drew ,  Jonathan Werder ,  Jonathon Giftakis ,  Eric Panken

    IPC分类号： A61B5/04

    CPC分类号： A61B5/04 ,  A61B5/0006 ,  A61B5/0031 ,  A61B5/04001 ,  A61B5/04012 ,  A61B5/4094 ,  A61B5/7232 ,  A61N1/36135 ,  A61N1/36146 ,  A61N1/36521 ,  A61N1/36585 ,  A61N1/3702 ,  A61N1/37252 ,  A61N1/37282 ,  A61N1/3925 ,  G06F19/00 ,  G06F19/3418 ,  G16H10/60 ,  G16H40/63 ,  G16H50/70

    摘要： Methods of generating an extended cluster are disclosed. A first cluster including data representative of a first signal indicative of an abnormal physiological symptom is generated. A second signal is detected as representing a second abnormal physiological symptom and the second abnormal physiological symptom continues after the first abnormal physiological symptom ends. An extended cluster including the data from the first signal and the second signal is generated that extends from the time when the first abnormal physiological symptom occurs to the time when the second abnormal physiological symptom ends. The first and the extended cluster may include data of both the first and second signals the entire period of the clusters. If desired, the first signal or the second signal may be provided from a sensor implanted in a patient's brain tissue.

    摘要翻译： 公开了生成扩展簇的方法。 产生包括表示表示异常生理症状的第一信号的数据的第一群集。 检测到第二信号表示第二异常生理症状，第二异常生理症状在第一异常生理症状终止后继续。 产生包括来自第一信号和第二信号的数据的扩展簇，其从第一异常生理症状发生时到第二异常生理症状结束时延伸。 第一和扩展簇可以包括簇的整个周期的第一和第二信号的数据。 如果需要，可以从植入患者脑组织的传感器提供第一信号或第二信号。