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公开(公告)号：US08945868B2
公开(公告)日：2015-02-03
申请号：US13188417
申请日：2011-07-21
申请人： Trevor Collingwood , Laurence J. N. Cooper , Philip D. Gregory , Michael C. Holmes , Jeffrey C. Miller , Edward J. Rebar , Andreas Reik , Fyodor Urnov
发明人： Trevor Collingwood , Laurence J. N. Cooper , Philip D. Gregory , Michael C. Holmes , Jeffrey C. Miller , Edward J. Rebar , Andreas Reik , Fyodor Urnov
CPC分类号： C07K14/70539 , A61K35/17 , C07K2319/81 , C12N15/907 , C12N2800/80
摘要： Disclosed herein are methods and compositions for modulating the expression of a HLA locus or for selectively deleting or manipulating a HLA locus or HLA regulator.
摘要翻译： 本文公开了用于调节HLA基因座表达或选择性删除或操纵HLA基因座或HLA调节剂的方法和组合物。
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公开(公告)号：US20120060230A1
公开(公告)日：2012-03-08
申请号：US13188417
申请日：2011-07-21
申请人： Trevor Collingwood , Laurence J.N. Cooper , Philip D. Gregory , Michael C. Holmes , Jeffrey C. Miller , Edward J. Rebar , Andreas Reik , Fyodor Urnov
发明人： Trevor Collingwood , Laurence J.N. Cooper , Philip D. Gregory , Michael C. Holmes , Jeffrey C. Miller , Edward J. Rebar , Andreas Reik , Fyodor Urnov
IPC分类号： A61K48/00 , C12N15/11 , A61P5/38 , A61P19/00 , A61P37/00 , A61P7/02 , A61P3/00 , A61P31/14 , A61P5/14 , A61P29/00 , A61P17/06 , A61P19/02 , A61P17/00 , A61P19/04 , C12N9/96 , C12N15/63 , C12N1/19 , C12N5/10 , C12N5/071 , C12N5/0775 , C12N5/0735 , C12N5/0797 , A01K67/027 , C07K7/06
CPC分类号： C07K14/70539 , A61K35/17 , C07K2319/81 , C12N15/907 , C12N2800/80
摘要： Disclosed herein are methods and compositions for modulating the expression of a HLA locus or for selectively deleting or manipulating a HLA locus or HLA regulator.
摘要翻译： 本文公开了用于调节HLA基因座表达或选择性删除或操纵HLA基因座或HLA调节子的方法和组合物。
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公开(公告)号：US08586526B2
公开(公告)日：2013-11-19
申请号：US13068735
申请日：2011-05-17
申请人： Philip D. Gregory , Jeffrey C. Miller , David Paschon , Edward J. Rebar , Siyuan Tan , Fyodor Urnov , Lei Zhang
发明人： Philip D. Gregory , Jeffrey C. Miller , David Paschon , Edward J. Rebar , Siyuan Tan , Fyodor Urnov , Lei Zhang
CPC分类号： C12N15/907 , A61K38/00 , C07K14/195 , C07K2319/80 , C12N9/22 , C12N15/52 , C12N15/62 , C12N15/8213 , C12N15/85 , C12Y301/21004
摘要： Disclosed herein are polypeptides, polynucleotides encoding, cells and organisms comprising novel DNA-binding domains, including TALE DNA-binding domains. Also disclosed are methods of using these novel DNA-binding domains for modulation of gene expression and/or genomic editing of endogenous cellular sequences.
摘要翻译： 本文公开了编码包含新的DNA结合结构域（包括TALE DNA结合结构域）的多肽，多核苷酸，细胞和生物体。 还公开了使用这些新的DNA结合结构域来调节内源细胞序列的基因表达和/或基因组编辑的方法。
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公开(公告)号：US20110301073A1
公开(公告)日：2011-12-08
申请号：US13068735
申请日：2011-05-17
申请人： Philip D. Gregory , Jeffrey C. Miller , David Paschon , Edward J. Rebar , Siyuan Tan , Fyodor Urnov , Lei Zhang
发明人： Philip D. Gregory , Jeffrey C. Miller , David Paschon , Edward J. Rebar , Siyuan Tan , Fyodor Urnov , Lei Zhang
IPC分类号： A61K38/02 , C07K19/00 , C12N9/16 , C12N5/071 , C12N5/04 , C12N1/21 , C07H21/00 , C12N1/19 , C12N5/10 , C12N1/15 , C12N1/13 , C12N1/11 , C07K14/00 , C12N1/16
CPC分类号： C12N15/907 , A61K38/00 , C07K14/195 , C07K2319/80 , C12N9/22 , C12N15/52 , C12N15/62 , C12N15/8213 , C12N15/85 , C12Y301/21004
摘要： Disclosed herein are polypeptides, polynucleotides encoding, cells and organisms comprising novel DNA-binding domains, including TALE DNA-binding domains. Also disclosed are methods of using these novel DNA-binding domains for modulation of gene expression and/or genomic editing of endogenous cellular sequences.
摘要翻译： 本文公开了编码包含新的DNA结合结构域（包括TALE DNA结合结构域）的多肽，多核苷酸，细胞和生物体。 还公开了使用这些新的DNA结合结构域来调节内源细胞序列的基因表达和/或基因组编辑的方法。
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公开(公告)号：US08012946B1
公开(公告)日：2011-09-06
申请号：US12008245
申请日：2008-01-09
CPC分类号： C07K14/4705 , A61K38/00 , C07K14/4702 , C07K14/811 , C07K2319/71 , C07K2319/81 , C12N2799/022 , C12N2799/025 , C12N2799/028
摘要： Disclosed herein are methods and compositions for treatment of conditions requiring inhibition of angiogenesis. Such conditions include those characterized by neovascularization, such as retinopathies, macular degeneration and various malignancies.
摘要翻译： 本文公开了用于治疗需要抑制血管发生的病症的方法和组合物。 这些病症包括以新生血管形成为特征，如视网膜病变，黄斑变性和各种恶性肿瘤。
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6.发明授权公开(公告)号：US09234016B2
公开(公告)日：2016-01-12
申请号：US12804764
申请日：2010-07-28
CPC分类号： A61K38/1709 , A61K38/00 , A61K48/00 , C07K14/47 , C07K2319/00 , C07K2319/71 , C07K2319/81 , C12N15/907
摘要： Disclosed herein are methods and compositions for treating trinucleotide repeat disorders.
摘要翻译： 本文公开了用于治疗三核苷酸重复障碍的方法和组合物。
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公开(公告)号：US07893022B2
公开(公告)日：2011-02-22
申请号：US11981386
申请日：2007-10-31
CPC分类号： C07K14/4705 , A61K38/00 , C07K14/4702 , C07K14/811 , C07K2319/71 , C07K2319/81 , C12N2799/022 , C12N2799/025 , C12N2799/028
摘要： Disclosed herein are methods and compositions for treatment of conditions requiring inhibition of angiogenesis. Such conditions include those characterized by neovascularization, such as retinopathies, macular degeneration and various malignancies.
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公开(公告)号：US07732196B2
公开(公告)日：2010-06-08
申请号：US11999549
申请日：2007-12-06
CPC分类号： C07K14/4705 , A61K38/00 , C07K14/4702 , C07K14/811 , C07K2319/71 , C07K2319/81 , C12N2799/022 , C12N2799/025 , C12N2799/028
摘要： Disclosed herein are methods and compositions for treatment of conditions requiring inhibition of angiogenesis. Such conditions include those characterized by neovascularization, such as retinopathies, macular degeneration and various malignancies.
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公开(公告)号：US08772453B2
公开(公告)日：2014-07-08
申请号：US13068102
申请日：2011-05-02
申请人： David Paschon , Edward J. Rebar
发明人： David Paschon , Edward J. Rebar
CPC分类号： C12N15/62
摘要： Disclosed herein are compositions for linking DNA binding modules to allow for specific and selective binding to module subsites separated by 1 or more base pairs. Also described are methods of making and using compositions comprising these linkers.
摘要翻译： 本文公开了用于连接DNA结合模块以允许特定和选择性结合由1个或更多个碱基对分开的模块亚型的组合物。 还描述了制备和使用包含这些接头的组合物的方法。
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公开(公告)号：US07943553B2
公开(公告)日：2011-05-17
申请号：US11486254
申请日：2006-07-12
申请人： Casey C. Case , Edward J. Rebar , Andrew Jamieson
发明人： Casey C. Case , Edward J. Rebar , Andrew Jamieson
IPC分类号： C40B40/10
CPC分类号： C12N15/1079
摘要： The present invention relates to methods of using libraries of randomized zinc finger proteins to identify genes associated with selected phenotypes.
摘要翻译： 本发明涉及使用随机锌指蛋白的文库鉴定与选择的表型相关的基因的方法。
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