摘要:
The present invention is to provide a piperidine compound represented by the formula [I]: wherein Ring A is an optionally substituted benzene ring, Ring B is an optionally substituted benzene ring, R1 is hydrogen atom or a substituent for amino group, R2 is hydrogen atom, an optionally substituted hydroxyl group, an optionally substituted amino group, an optionally substituted alkyl group, a substituted carbonyl group or a halogen atom, Z is oxygen atom or —N(R3)—, R3 is hydrogen atom or an optionally substituted alkyl group, R4a and R4b may be the same or different, and each is hydrogen atom or an optionally substituted alkyl group, or may be bonded to each other at the both ends to form an alkylene group, or a pharmaceutically acceptable salt thereof, which has an excellent tachykinin receptor antagonistic action.
摘要:
The present invention relates to a piperidine compound represented by the formula [I]: wherein Ring A represents an optionally substituted benzene ring, Ring B represents an optionally substituted benzene ring, R1 represents an optionally substituted hydoxyl group, a substituted thiol group, a substituted sulfonyl group, etc., or a group represented by the formula: R11 represents a substituted carbonyl group or a substituted sulfonyl group, R12 represents hydrogen atom or an optionally substituted alkyl group, R2 represents hydrogen atom, etc., Z represent oxygen atom or a group represented by —N(R3)—, R3 represents an optionally substituted alkyl group, etc., R4a represents an optionally substituted alkyl group, R4b represents an optionally substituted alkyl group, or a pharmaceutically acceptable salt thereof, having an excellent tachykinin receptor antagonistic action.
摘要翻译:本发明涉及由式[I]表示的哌啶化合物:其中环A表示任选取代的苯环,环B表示任选取代的苯环,R 1表示任选取代的羟基 取代的硫醇基,取代的磺酰基等,或由下式表示的基团:R 11表示取代的羰基或取代的磺酰基,R 12 >表示氢原子或任选取代的烷基,R 2表示氢原子等,Z表示氧原子或由-N(R 3 O 3) - 表示的基团, R 3表示任选取代的烷基等,R 4a表示任选取代的烷基,R 4b表示任选取代的烷基 基团或其药学上可接受的盐,具有优异的速激肽受体拮抗作用。
摘要:
Disclosed are a novel piperidine compound represented by the general formula [I] below which has an excellent tachykinin receptor antagonizing activity and pharmacologically acceptable salts thereof. [I] In the formula, ring A represents an optionally substituted benzene ring; ring B represents an optionally substituted benzene ring; R1 represents an optionally substituted hydroxyl group, a thiol group having a substituent, a sulfonyl group having a substituent, or a group represented by the following formula [II]: wherein R11 represents a carbonyl group having a substituent or a sulfonyl group having a substituent and R12 represents a hydrogen atom or an optionally substituted alkyl group; R2 represents a hydrogen atom or the like; Z represents an oxygen atom or a group represented by —N(R3)— wherein R3 represents an optionally substituted alkyl group or the like; R4a represents an optionally substituted alkyl group; and R4b represents an optionally substituted alkyl group.
摘要翻译:公开了由下述通式[I]表示的新型哌啶化合物,其具有优异的速激肽受体拮抗活性及其药理学上可接受的盐。 式中,环A表示任选取代的苯环; 环B表示任选取代的苯环; R 1表示任选取代的羟基,具有取代基的硫醇基,具有取代基的磺酰基或由下式[II]表示的基团:其中R 11, SUP>表示具有取代基的羰基或具有取代基的磺酰基,R 12表示氢原子或任选取代的烷基; R 2表示氢原子等; Z表示氧原子或由-N(R 3 O 3)表示的基团,其中R 3表示任选取代的烷基等; R 4a表示任选取代的烷基; R 4b表示任选取代的烷基。
摘要:
The present invention is to provide a piperidine compound represented by the formula [I]: wherein Ring A is an optionally substituted benzene ring, Ring B is an optionally substituted benzene ring, R1 is hydrogen atom or a substituent for amino group, R2 is hydrogen atom, an optionally substituted hydroxyl group, an optionally substituted amino group, an optionally substituted alkyl group, a substituted carbonyl group or a halogen atom, Z is oxygen atom or —N(R3)—, R3 is hydrogen atom or an optionally substituted alkyl group, R4a and R4b may be the same or different, and each is hydrogen atom or an optionally substituted alkyl group, or may be bonded to each other at the both ends to form an alkylene group, or a pharmaceutically acceptable salt thereof, which has an excellent tachykinin receptor antagonistic action.
摘要:
The present invention discloses a thiomorpholine compound represented by the formula [I]: wherein Ring A represents an optionally substituted benzene ring; Ring B represents an optionally substituted benzene ring; R1 represents hydrogen atom, an optionally substituted hydroxyl group, an optionally substituted amino group, an optionally substituted alkyl group, a substituted carbonyl group or a halogen atom; R2 represents hydrogen atom or an optionally substituted alkyl group; and R3a and R3b may be the same or different from each other, and each represent hydrogen atom or an optionally substituted alkyl group, or combined to each other at the both ends thereof to form an alkylene group, and n is an integer of 1 or 2, or a pharmaceutically acceptable salt thereof.
摘要:
Provided is a protective film for an automotive wheel having excellent performances, which can sufficiently prevent scratching of the wheel surface and staining, and also the generation of rust at a disc brake inside the wheel during a period until delivery of an automobile; and can be easily peeled. The protective film for an automotive wheel of the present invention is a protective film for an automotive wheel, including a base layer and a pressure-sensitive adhesive layer, wherein the pressure-sensitive adhesive layer of the protective film is bonded onto the back surface of the base layer of the protective film, and an adhesive force to the back surface after storage at 50° C. for 24 hours in an state of being bonded is from 0.1 to 2 N/20 mm at any peeling speed of 0.3 m/minute, 10 m/minute and 30 m/minute.
摘要:
An object of the present invention is to provide a surface protecting film which dramatically improves an efficiency of transporting and storing a mother glass, has better peelability from an adherend when peeled without polluting a mother glass surface, and gives reinforcing effect by adopting a pressure-sensitive adhesive protecting film, and use thereof. This invention relates to a film for protecting a mother glass for a flat panel display having a pressure-sensitive adhesive layer on one side of a film substrate, wherein a surface roughness Ra of the pressure-sensitive adhesive layer is 0.2 μm or smaller, and a surface roughness Rz is 1.0 μm or smaller, and wherein the pressure-sensitive adhesive layer comprises a crosslinked copolymer containing a (meth)acrylic acid ester monomer and a vinyl-based monomer having a functional group as a component, and a glass transition temperature of the copolymer obtained by a Fox's equation is −25 to −10° C.
摘要:
A foam substrate-attached adhesive sheet or tape comprising a substrate having formed thereon a layer of a pressure-sensitive adhesive, wherein the substrate is a foam elastomer having a breaking elongation of at least 800% and an apparent 800% modulus of from 1.0 to 15 kg/cm.sup.2 in a tensile test of 23.degree. C., and a breaking elongation of at least 400% and an apparent 400% modulus of from 2.0 to 60 kg/cm.sup.2 in a tensile test of -30.degree. C.
摘要翻译:一种带泡沫基片的粘合片或带,其包括在其上形成有压敏粘合剂层的基底,其中基底是断裂伸长率至少为800%,表观800%模量为1.0至 在23℃的拉伸试验中,在23℃的拉伸试验中为15kg / cm 2,在-30℃的拉伸试验中断裂伸长率为至少400%,表观400%模量为2.0〜60kg / cm 2。
摘要:
Tape apparatus in which a length of pliant material is fed between supply and take-up rolls in edge driven relationship with a capstan. A static force provided, for example, by friction or a spring is utilized to maintain the take-up roll against the capstan with a greater force than the supply roll, and in the event of a reversal of tape direction, this force is immediately and automatically applied to the new take-up roll and removed from the new supply roll.
摘要:
An object of the present invention is to provide a surface protecting film which dramatically improves an efficiency of transporting and storing a mother glass, has better peelability from an adherend when peeled without polluting a mother glass surface, and gives reinforcing effect, and use thereof, by using a pressure-sensitive adhesive protecting film. There is provided a film for protecting a mother glass for a flat panel display, characterized in that a rear side is unevenly-processed, and a pressure-sensitive adhesive side is smoother than a rear side.