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公开(公告)号：US07072700B2
公开(公告)日：2006-07-04
申请号：US10148991
申请日：2000-11-29
申请人： Tsuyoshi Yamamoto , Atsushi Maki , Hideaki Koizumi , Fumio Kawaguchi , Michiyuki Fujiwara , Mikihiro Kaga
发明人： Tsuyoshi Yamamoto , Atsushi Maki , Hideaki Koizumi , Fumio Kawaguchi , Michiyuki Fujiwara , Mikihiro Kaga
IPC分类号： A61B5/00
CPC分类号： A61B5/14546 , A61B5/0059 , A61B5/0261 , A61B5/14553 , A61B2562/0233 , A61B2562/046
摘要： The invention provides a biological photometric device characterized by a method of disposing a light source and a light detector, capable of measuring a distribution of concentrations at different depths and changes in the concentration in the case of measuring and forming an image of the concentration of metabolites in an organ and changes in the concentration. The light sources and light detectors are disposed on the subject so that, in the case of measuring a concentration of metabolites in an organ and changes in the concentration in a shallow portion in the subject by using an about midpoint position between each of the light sources and each of the light detectors as a sampling point, measurement is performed by using a sampling point of a pair of the light source and said light detector which are disposed at a small interval. In the case of measurement in a deep portion in the subject, a sampling point of a pair of the light source and the light detector which are disposed at a large interval is used.
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2.发明授权公开(公告)号：US07974671B2
公开(公告)日：2011-07-05
申请号：US10572357
申请日：2004-09-03
申请人： Michiyuki Fujiwara , Tsuneaki Kawaguchi , Fumio Kawaguchi , Shingo Kawasaki , Atsushi Maki , Yukiko Hirabayashi , Yukari Yamamoto , Masashi Kiguchi , Hiroki Sato , Tsuyoshi Yamamoto , Takushige Katsura , Hideo Kawaguchi
发明人： Michiyuki Fujiwara , Tsuneaki Kawaguchi , Fumio Kawaguchi , Shingo Kawasaki , Atsushi Maki , Yukiko Hirabayashi , Yukari Yamamoto , Masashi Kiguchi , Hiroki Sato , Tsuyoshi Yamamoto , Takushige Katsura , Hideo Kawaguchi
IPC分类号： A61B5/00
CPC分类号： A61B5/14553 , A61B5/0042 , A61B5/0059 , A61B5/0261 , A61B5/0476 , A61B5/0478 , A61B5/0482 , A61B5/0484 , A61B5/0488 , A61B5/11 , A61B5/6822 , A61B5/742 , A61B2562/0209 , A61B2562/0233 , A61B2562/046
摘要： A living body information signal processing system (100) combining organically a living body optical measurement apparatus and a brain wave measurement apparatus, the living body optical measurement apparatus (300) in which inspection light of from visible to near infrared is irradiated on a head portion of a subject (140) and the penetration light is received and which measures an optical characteristic variation induced by a brain activity inside the head portion as a living body optical signal and the brain wave measurement apparatus (400) which measures an electrical characteristic variation induced by a brain activity inside the head portion of the subject as a brain wave signal, is provided with a probe device (50) used for both apparatus; and a living body information signal processing and displaying device (200) which displays the living body optical signal corresponding to respective measurement positions from the living body optical measurement apparatus and the brain wave signal corresponding to respective measurement positions from the brain wave measurement apparatus on a common display device while correlating the respective measurement positions each other, thereby, with the system comprehensive observation of both data can be achieved.
摘要翻译： 一种生物体信息信号处理系统（100），其组织有机地生物体光学测量装置和脑电波测定装置，所述生物体光学测量装置（300）将从所述可见光到近红外线的检查光照射在头部 并且测量由头部内部的脑活动引起的作为生物体光信号的光学特性变化和测量电特性变化的脑波测量装置（400）的穿透光， 通过作为脑波信号的被检体头部内的脑活动，设置有用于两个装置的探针装置（50）; 以及生物体信息信号处理和显示装置（200），其从来自所述生物体光学测量装置的对应于各测量位置的生物体光信号和对应于来自所述脑波测量装置的各测量位置的脑波信号 共同显示装置，同时将各个测量位置相互关联，从而可以实现对两个数据的系统综合观察。
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公开(公告)号：US07778694B2
公开(公告)日：2010-08-17
申请号：US11355017
申请日：2006-02-16
IPC分类号： A61B6/00
CPC分类号： A61B5/6814 , A61B5/1455 , A61B2562/0233 , A61B2562/046 , G01N21/4795
摘要： A biological optical measurement instrument including: a measurement probe positionable to a surface of a subject, which irradiates light beams having a plurality of wavelengths from a light beam source through optical fibers onto the subject, and collects the light beams passed inside the subject from a plurality of positions to facilitate production of diagnostics from collected light beams of the subject, wherein the measurement probe is provided with probe casings which hold the optical fibers, fixing members where each respective fixing member is mateable with a respective probe casing to position the probe casings in a predetermined interval, and a support member which supports the fixing members, and wherein at least one of the respective probe casing or the respective fixing member is provided with a stopper claw to permit fixed engagement of the respective probe casing with the respective fixing member upon mating thereof.
摘要翻译： 一种生物学光学测量仪器，包括：测量探针，其可定位到被检体的表面，其将来自光束源的多个波长的光束通过光纤照射到所述被检体上，并且从所述被检体的内部收集通过所述被检体内的光束 多个位置以便于从被检体的收集的光束产生诊断，其中测量探针设置有保持光纤的探针壳体，固定构件，其中每个相应的固定构件可与相应的探针壳体配合，以将探针壳体 以及支撑固定构件的支撑构件，并且其中各个探针壳体或相应的固定构件中的至少一个设置有止动爪，以允许各个探针壳体与相应的固定构件的固定接合 在交配时。
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公开(公告)号：US20060184044A1
公开(公告)日：2006-08-17
申请号：US11355017
申请日：2006-02-16
IPC分类号： A61B6/00
CPC分类号： A61B5/6814 , A61B5/1455 , A61B2562/0233 , A61B2562/046 , G01N21/4795
摘要： A biological optical measurement instrument including: a measurement probe positionable to a surface of a subject, which irradiates light beams having a plurality of wavelengths from a light beam source through optical fibers onto the subject, and collects the light beams passed inside the subject from a plurality of positions to facilitate production of diagnostics from collected light beams of the subject, wherein the measurement probe is provided with probe casings which hold the optical fibers, fixing members where each respective fixing member is mateable with a respective probe casing to position the probe casings in a predetermined interval, and a support member which supports the fixing members, and wherein at least one of the respective probe casing or the respective fixing member is provided with a stopper claw to permit fixed engagement of the respective probe casing with the respective fixing member upon mating thereof.
摘要翻译： 一种生物学光学测量仪器，包括：测量探针，其可定位到被检体的表面，其将来自光束源的多个波长的光束通过光纤照射到所述被检体上，并且从所述被检体的内部收集通过所述被检体内的光束 多个位置以便于从被检体的收集的光束产生诊断，其中测量探针设置有保持光纤的探针壳体，固定构件，其中每个相应的固定构件可与相应的探针壳体配合，以将探针壳体 以及支撑固定构件的支撑构件，并且其中各个探针壳体或相应的固定构件中的至少一个设置有止动爪，以允许各个探针壳体与相应的固定构件的固定接合 在交配时。
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公开(公告)号：US07039454B1
公开(公告)日：2006-05-02
申请号：US09937842
申请日：2000-03-24
IPC分类号： A61B6/00
CPC分类号： A61B5/6814 , A61B5/1455 , A61B2562/0233 , A61B2562/046 , G01N21/4795
摘要： A biological optical measuring instrument comprising a measuring probe (101) for collecting light from a plurality of portions of a subject (214) transmitted through the subject (214) by means of an optical fiber (108) by guiding light emitted from a light source (102) by an optical fiber (107), and irradiating the light to the subject (214) so as to create a living body transmitted light intensity image of the subject (214) from the transmitted and collected light. The measuring probe (101) further comprises optical fiber fixing members (201, 210, 211) for fixing the optical fibers (107, 108) at a predetermined interval and support members (202, 204, 205) for rockably supporting the optical fiber fixing members. Thus, it is possible to provide a technique of performing living body optical measurement while the living body lies in lateral decubitus.
摘要翻译： 一种生物光学测量仪器，包括测量探针（101），用于通过引导从光源发出的光来收集来自通过对象（214）的被摄体（214）的多个部分的光 （102），并且将光照射到被摄体（214），以从所发射和收集的光中产生对象（214）的活体透射光强度图像。 测量探针（101）还包括用于以预定间隔固定光纤（107,108）的光纤固定构件（201,210,211）和支撑构件（202,204,205），用于可摆动地支撑光纤固定 会员 因此，可以提供一种在活体位于侧卧位时进行生物体光学测量的技术。
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6.发明申请公开(公告)号：US20070083097A1
公开(公告)日：2007-04-12
申请号：US10572357
申请日：2004-09-03
CPC分类号： A61B5/14553 , A61B5/0042 , A61B5/0059 , A61B5/0261 , A61B5/0476 , A61B5/0478 , A61B5/0482 , A61B5/0484 , A61B5/0488 , A61B5/11 , A61B5/6822 , A61B5/742 , A61B2562/0209 , A61B2562/0233 , A61B2562/046
摘要： A living body information signal processing system (100) combining organically a living body optical measurement apparatus and a brain wave measurement apparatus, the living body optical measurement apparatus (300) in which inspection light of from visible to near infrared is irradiated on a head portion of a subject (140) and the penetration light is received and which measures an optical characteristic variation induced by a brain activity inside the head portion as a living body optical signal and the brain wave measurement apparatus (400) which measures an electrical characteristic variation induced by a brain activity inside the head portion of the subject as a brain wave signal, is provided with a probe device (50) used for both apparatus; and a living body information signal processing and displaying device (200) which displays the living body optical signal corresponding to respective measurement positions from the living body optical measurement apparatus and the brain wave signal corresponding to respective measurement positions from the brain wave measurement apparatus on a common display device while correlating the respective measurement positions each other, thereby, with the system comprehensive observation of both data can be achieved.
摘要翻译： 一种生物体信息信号处理系统（100），其组织有机地生物体光学测量装置和脑电波测定装置，所述生物体光学测量装置（300）将从所述可见光到近红外线的检查光照射在头部 并且测量由头部内部的脑活动引起的作为生物体光信号的光学特性变化和测量电特性变化的脑波测量装置（400）的穿透光， 通过作为脑波信号的被检体头部内的脑活动，设置有用于两个装置的探针装置（50）; 以及生物体信息信号处理和显示装置（200），其从来自所述生物体光学测量装置的对应于各测量位置的生物体光信号和对应于来自所述脑波测量装置的各测量位置的脑波信号 共同显示装置，同时将各个测量位置相互关联，从而可以实现对两个数据的系统综合观察。
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公开(公告)号：US08229531B2
公开(公告)日：2012-07-24
申请号：US11914701
申请日：2006-02-13
IPC分类号： A61B5/1455
CPC分类号： A61B5/0059 , A61B5/6814 , A61B2562/0233 , A61B2562/046
摘要： There is provided an optical bioinstrumentation device, with which measurement data reflect more correctly the information inside the living body with less noise even the subject moves when the information inside the living body is measured by using the light.In the present invention, the means for fixing the part other than the tips of the optical fibers for irradiation and detection on the fixing member which is to fix the tips of the optical fiber for irradiation and detection on the subject, or, the means for fixing the optical fiber is fixed on the fixing member which is to fix the end of the optical fiber on the subject, or the means for fixing the optical fiber at two or more positions on the subject.
摘要翻译： 提供了一种光学生物仪器装置，通过使用光来测量生物体内部的信息，即使被检体移动，测量数据也能更准确地反映生物体内部的信息，噪音较小。 在本发明中，将用于照射和检测的光纤的末端以外的部分固定在固定部件上的装置，该固定部件用于将用于照射和检测的光纤的前端固定在被检体上， 固定光纤被固定在将光纤端部固定在被摄体上的固定部件上，或将光纤固定在被检体上的两个以上位置的装置。
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8.发明授权公开(公告)号：US07280859B2
公开(公告)日：2007-10-09
申请号：US10484258
申请日：2002-05-24
申请人： Atsushi Maki , Michiyuki Fujiwara
发明人： Atsushi Maki , Michiyuki Fujiwara
IPC分类号： A61B5/00
CPC分类号： A61B5/6814 , A61B5/0261 , A61B5/0476 , A61B5/14553 , A61B5/702 , A61B2562/0233 , A61B2562/046
摘要： The present invention provides a biological measurement probe readily wearable on a biological surface having a large curvature and a measurement technique of simultaneously measuring the blood circulation dynamic change accompanying the auditory/language/visual function activities of a subject (especially baby) and brain waves. A biological measurement probe having illuminating means for illuminating a subject through a first optical waveguide and light collecting means for collecting light illuminated from the illuminating means and propagated through the subject through a second optical waveguide, has first and second guide members having passages through which the first and second optical waveguides are passed and fixing the first and second optical waveguides, and a base member connecting the first guide member to the second one, holding them, and forming a portion brought into contact with the subject.
摘要翻译： 本发明提供一种在具有大曲率的生物学表面上易于佩戴的生物测量探针和同时测量伴随对象（特别是婴儿）和脑波的听觉/语言/视觉功能活动的血液循环动态变化的测量技术。 一种具有用于通过第一光波导照射被摄体的照明装置的生物测量探针和用于收集从照明装置照射并通过第二光波导传播通过被摄体的光的聚光装置，具有第一和第二引导构件， 第一和第二光波导通过并固定第一和第二光波导，以及将第一引导构件连接到第二导波构件的基座，保持它们，并形成与被摄体接触的部分。
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公开(公告)号：US20090088616A1
公开(公告)日：2009-04-02
申请号：US11914701
申请日：2006-02-13
IPC分类号： A61B5/00
CPC分类号： A61B5/0059 , A61B5/6814 , A61B2562/0233 , A61B2562/046
摘要： There is provided an optical bioinstrumentation device, with which measurement data reflect more correctly the information inside the living body with less noise even the subject moves when the information inside the living body is measured by using the light.In the present invention, the means for fixing the part other than the tips of the optical fibers for irradiation and detection on the fixing member which is to fix the tips of the optical fiber for irradiation and detection on the subject, or, the means for fixing the optical fiber is fixed on the fixing member which is to fix the end of the optical fiber on the subject, or the means for fixing the optical fiber at two or more positions on the subject.
摘要翻译： 提供了一种光学生物仪器装置，通过使用光来测量生物体内部的信息，即使被检体移动，测量数据也能更准确地反映生物体内部的信息，噪音较小。 在本发明中，将用于照射和检测的光纤的末端以外的部分固定在固定部件上的装置，该固定部件用于将用于照射和检测的光纤的前端固定在被检体上， 固定光纤被固定在将光纤端部固定在被摄体上的固定部件上，或将光纤固定在被检体上的两个以上位置的装置。
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公开(公告)号：US07139600B2
公开(公告)日：2006-11-21
申请号：US10450895
申请日：2002-01-18
IPC分类号： A61B5/00
CPC分类号： A61B5/6814 , A61B5/0059 , A61B5/14552 , A61B5/14553 , A61B2562/0233 , A61B2562/046
摘要： The present invention provides an optical measurement device of biological tissue having a probe attachable to a moving part of a living body with a high curvature in biophotometry. A member having a high flexibility and a high friction coefficient is disposed on a surface for contact with the living body. In addition, a device for light irradiation and a device for collection of light are fixed with an elastic material for uniform pressure application. The resulting double structure or double layer has solved a problem.
摘要翻译： 本发明提供一种生物组织的光学测量装置，其具有可附接到生物光度测量中高曲率的活体的运动部分的探针。 具有高柔性和高摩擦系数的构件设置在与生物体接触的表面上。 此外，用于光照射的装置和用于收集光的装置用弹性材料固定以均匀地施加压力。 所得到的双层结构或双层解决了一个问题。
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