公开(公告)号：US08229531B2

公开(公告)日：2012-07-24

申请号：US11914701

申请日：2006-02-13

申请人： Hirokazu Atsumori ,  Masashi Kiguchi ,  Atsushi Maki ,  Michiyuki Fujiwara

发明人： Hirokazu Atsumori ,  Masashi Kiguchi ,  Atsushi Maki ,  Michiyuki Fujiwara

IPC分类号： A61B5/1455

CPC分类号： A61B5/0059 ,  A61B5/6814 ,  A61B2562/0233 ,  A61B2562/046

摘要： There is provided an optical bioinstrumentation device, with which measurement data reflect more correctly the information inside the living body with less noise even the subject moves when the information inside the living body is measured by using the light.In the present invention, the means for fixing the part other than the tips of the optical fibers for irradiation and detection on the fixing member which is to fix the tips of the optical fiber for irradiation and detection on the subject, or, the means for fixing the optical fiber is fixed on the fixing member which is to fix the end of the optical fiber on the subject, or the means for fixing the optical fiber at two or more positions on the subject.

摘要翻译： 提供了一种光学生物仪器装置，通过使用光来测量生物体内部的信息，即使被检体移动，测量数据也能更准确地反映生物体内部的信息，噪音较小。 在本发明中，将用于照射和检测的光纤的末端以外的部分固定在固定部件上的装置，该固定部件用于将用于照射和检测的光纤的前端固定在被检体上， 固定光纤被固定在将光纤端部固定在被摄体上的固定部件上，或将光纤固定在被检体上的两个以上位置的装置。

公开(公告)号：US20090088616A1

公开(公告)日：2009-04-02

申请号：US11914701

申请日：2006-02-13

申请人： Hirokazu Atsumori ,  Masashi Kiguchi ,  Atsushi Maki ,  Michiyuki Fujiwara

发明人： Hirokazu Atsumori ,  Masashi Kiguchi ,  Atsushi Maki ,  Michiyuki Fujiwara

IPC分类号： A61B5/00

CPC分类号： A61B5/0059 ,  A61B5/6814 ,  A61B2562/0233 ,  A61B2562/046

摘要： There is provided an optical bioinstrumentation device, with which measurement data reflect more correctly the information inside the living body with less noise even the subject moves when the information inside the living body is measured by using the light.In the present invention, the means for fixing the part other than the tips of the optical fibers for irradiation and detection on the fixing member which is to fix the tips of the optical fiber for irradiation and detection on the subject, or, the means for fixing the optical fiber is fixed on the fixing member which is to fix the end of the optical fiber on the subject, or the means for fixing the optical fiber at two or more positions on the subject.

摘要翻译： 提供了一种光学生物仪器装置，通过使用光来测量生物体内部的信息，即使被检体移动，测量数据也能更准确地反映生物体内部的信息，噪音较小。 在本发明中，将用于照射和检测的光纤的末端以外的部分固定在固定部件上的装置，该固定部件用于将用于照射和检测的光纤的前端固定在被检体上， 固定光纤被固定在将光纤端部固定在被摄体上的固定部件上，或将光纤固定在被检体上的两个以上位置的装置。

公开(公告)号：US07974671B2

公开(公告)日：2011-07-05

申请号：US10572357

申请日：2004-09-03

申请人： Michiyuki Fujiwara ,  Tsuneaki Kawaguchi ,  Fumio Kawaguchi ,  Shingo Kawasaki ,  Atsushi Maki ,  Yukiko Hirabayashi ,  Yukari Yamamoto ,  Masashi Kiguchi ,  Hiroki Sato ,  Tsuyoshi Yamamoto ,  Takushige Katsura ,  Hideo Kawaguchi

发明人： Michiyuki Fujiwara ,  Tsuneaki Kawaguchi ,  Fumio Kawaguchi ,  Shingo Kawasaki ,  Atsushi Maki ,  Yukiko Hirabayashi ,  Yukari Yamamoto ,  Masashi Kiguchi ,  Hiroki Sato ,  Tsuyoshi Yamamoto ,  Takushige Katsura ,  Hideo Kawaguchi

IPC分类号： A61B5/00

CPC分类号： A61B5/14553 ,  A61B5/0042 ,  A61B5/0059 ,  A61B5/0261 ,  A61B5/0476 ,  A61B5/0478 ,  A61B5/0482 ,  A61B5/0484 ,  A61B5/0488 ,  A61B5/11 ,  A61B5/6822 ,  A61B5/742 ,  A61B2562/0209 ,  A61B2562/0233 ,  A61B2562/046

摘要： A living body information signal processing system (100) combining organically a living body optical measurement apparatus and a brain wave measurement apparatus, the living body optical measurement apparatus (300) in which inspection light of from visible to near infrared is irradiated on a head portion of a subject (140) and the penetration light is received and which measures an optical characteristic variation induced by a brain activity inside the head portion as a living body optical signal and the brain wave measurement apparatus (400) which measures an electrical characteristic variation induced by a brain activity inside the head portion of the subject as a brain wave signal, is provided with a probe device (50) used for both apparatus; and a living body information signal processing and displaying device (200) which displays the living body optical signal corresponding to respective measurement positions from the living body optical measurement apparatus and the brain wave signal corresponding to respective measurement positions from the brain wave measurement apparatus on a common display device while correlating the respective measurement positions each other, thereby, with the system comprehensive observation of both data can be achieved.

摘要翻译： 一种生物体信息信号处理系统（100），其组织有机地生物体光学测量装置和脑电波测定装置，所述生物体光学测量装置（300）将从所述可见光到近红外线的检查光照射在头部 并且测量由头部内部的脑活动引起的作为生物体光信号的光学特性变化和测量电特性变化的脑波测量装置（400）的穿透光， 通过作为脑波信号的被检体头部内的脑活动，设置有用于两个装置的探针装置（50）; 以及生物体信息信号处理和显示装置（200），其从来自所述生物体光学测量装置的对应于各测量位置的生物体光信号和对应于来自所述脑波测量装置的各测量位置的脑波信号 共同显示装置，同时将各个测量位置相互关联，从而可以实现对两个数据的系统综合观察。

公开(公告)号：US07280859B2

公开(公告)日：2007-10-09

申请号：US10484258

申请日：2002-05-24

申请人： Atsushi Maki ,  Michiyuki Fujiwara

发明人： Atsushi Maki ,  Michiyuki Fujiwara

IPC分类号： A61B5/00

CPC分类号： A61B5/6814 ,  A61B5/0261 ,  A61B5/0476 ,  A61B5/14553 ,  A61B5/702 ,  A61B2562/0233 ,  A61B2562/046

摘要： The present invention provides a biological measurement probe readily wearable on a biological surface having a large curvature and a measurement technique of simultaneously measuring the blood circulation dynamic change accompanying the auditory/language/visual function activities of a subject (especially baby) and brain waves. A biological measurement probe having illuminating means for illuminating a subject through a first optical waveguide and light collecting means for collecting light illuminated from the illuminating means and propagated through the subject through a second optical waveguide, has first and second guide members having passages through which the first and second optical waveguides are passed and fixing the first and second optical waveguides, and a base member connecting the first guide member to the second one, holding them, and forming a portion brought into contact with the subject.

摘要翻译： 本发明提供一种在具有大曲率的生物学表面上易于佩戴的生物测量探针和同时测量伴随对象（特别是婴儿）和脑波的听觉/语言/视觉功能活动的血液循环动态变化的测量技术。 一种具有用于通过第一光波导照射被摄体的照明装置的生物测量探针和用于收集从照明装置照射并通过第二光波导传播通过被摄体的光的聚光装置，具有第一和第二引导构件， 第一和第二光波导通过并固定第一和第二光波导，以及将第一引导构件连接到第二导波构件的基座，保持它们，并形成与被摄体接触的部分。

公开(公告)号：US07072700B2

公开(公告)日：2006-07-04

申请号：US10148991

申请日：2000-11-29

申请人： Tsuyoshi Yamamoto ,  Atsushi Maki ,  Hideaki Koizumi ,  Fumio Kawaguchi ,  Michiyuki Fujiwara ,  Mikihiro Kaga

发明人： Tsuyoshi Yamamoto ,  Atsushi Maki ,  Hideaki Koizumi ,  Fumio Kawaguchi ,  Michiyuki Fujiwara ,  Mikihiro Kaga

IPC分类号： A61B5/00

CPC分类号： A61B5/14546 ,  A61B5/0059 ,  A61B5/0261 ,  A61B5/14553 ,  A61B2562/0233 ,  A61B2562/046

摘要： The invention provides a biological photometric device characterized by a method of disposing a light source and a light detector, capable of measuring a distribution of concentrations at different depths and changes in the concentration in the case of measuring and forming an image of the concentration of metabolites in an organ and changes in the concentration. The light sources and light detectors are disposed on the subject so that, in the case of measuring a concentration of metabolites in an organ and changes in the concentration in a shallow portion in the subject by using an about midpoint position between each of the light sources and each of the light detectors as a sampling point, measurement is performed by using a sampling point of a pair of the light source and said light detector which are disposed at a small interval. In the case of measurement in a deep portion in the subject, a sampling point of a pair of the light source and the light detector which are disposed at a large interval is used.

公开(公告)号：US07139600B2

公开(公告)日：2006-11-21

申请号：US10450895

申请日：2002-01-18

申请人： Atsushi Maki ,  Michiyuki Fujiwara ,  Jacques Mehler ,  Ghislaine Dehaene-Lambertz ,  Marcela Pena

发明人： Atsushi Maki ,  Michiyuki Fujiwara ,  Jacques Mehler ,  Ghislaine Dehaene-Lambertz ,  Marcela Pena

IPC分类号： A61B5/00

CPC分类号： A61B5/6814 ,  A61B5/0059 ,  A61B5/14552 ,  A61B5/14553 ,  A61B2562/0233 ,  A61B2562/046

摘要： The present invention provides an optical measurement device of biological tissue having a probe attachable to a moving part of a living body with a high curvature in biophotometry. A member having a high flexibility and a high friction coefficient is disposed on a surface for contact with the living body. In addition, a device for light irradiation and a device for collection of light are fixed with an elastic material for uniform pressure application. The resulting double structure or double layer has solved a problem.

摘要翻译： 本发明提供一种生物组织的光学测量装置，其具有可附接到生物光度测量中高曲率的活体的运动部分的探针。 具有高柔性和高摩擦系数的构件设置在与生物体接触的表面上。 此外，用于光照射的装置和用于收集光的装置用弹性材料固定以均匀地施加压力。 所得到的双层结构或双层解决了一个问题。

公开(公告)号：US07285790B2

公开(公告)日：2007-10-23

申请号：US11044040

申请日：2005-01-28

申请人： Naoki Tanaka ,  Takusige Katura ,  Masashi Kiguchi ,  Hiroki Sato ,  Atsushi Maki

发明人： Naoki Tanaka ,  Takusige Katura ,  Masashi Kiguchi ,  Hiroki Sato ,  Atsushi Maki

IPC分类号： A61B5/00

CPC分类号： A61B5/16 ,  A61B5/14553 ,  A61B5/6814

摘要： A response period is determined arbitrarily. A satisfactory detecting ability may not be provided because of an artifact or the like contained in a signal. Therefore, an effective detection method and an effective display method of presenting results of detection must be developed. A series of tasks (stimuli) or a selected measurement signal is used as a reference signal, and a phase difference of any other measurement signal from the reference signal is calculated. The synchronousness of the phase of the measurement signal with the phase of the reference signal is numerically expressed. The thus obtained numerical value is statistically processed in order to numerically express a degree of reliability. Thus, a brain activity or a functional connectivity is visualized.

摘要翻译： 响应时间是任意确定的。 由于信号中包含的伪影等，不能提供令人满意的检测能力。 因此，必须开发一种提供检测结果的有效检测方法和有效的显示方法。 使用一系列任务（刺激）或所选择的测量信号作为参考信号，并且计算来自参考信号的任何其它测量信号的相位差。 测量信号的相位与参考信号的相位的同步性被数字表示。 对这样得到的数值进行统计处理，以便数值地表达可靠度。 因此，大脑活动或功能连接可视化。

公开(公告)号：US07022083B2

公开(公告)日：2006-04-04

申请号：US10457478

申请日：2003-06-10

申请人： Naoki Tanaka ,  Atsushi Maki ,  Masashi Kiguchi

发明人： Naoki Tanaka ,  Atsushi Maki ,  Masashi Kiguchi

IPC分类号： A61B5/02 ,  A61B5/00

CPC分类号： A61B5/486 ,  A61B5/0086 ,  A61B5/1455

摘要： A satisfactory averaged signal can be obtained with only a small number of repetitions of measurement in the measurement of responses to a stimulus given to a living body. A low-frequency biological fluctuation is extracted and a stimulus is presented to the living body in synchronism with the phase of the extracted fluctuation.

摘要翻译： 在对给予生物体的刺激的响应的测量的测量中，可以仅获得少量的测量重复来获得满意的平均信号。 提取低频生物波动，并且与提取的波动的相位同步地向生物体提供刺激。

公开(公告)号：US07516021B2

公开(公告)日：2009-04-07

申请号：US11570558

申请日：2005-06-08

申请人： Hiroki Sato ,  Atsushi Maki ,  Tsuyoshi Yamamoto ,  Masashi Kiguchi

发明人： Hiroki Sato ,  Atsushi Maki ,  Tsuyoshi Yamamoto ,  Masashi Kiguchi

IPC分类号： G01N31/00

CPC分类号： A61B5/7264 ,  A61B5/0059 ,  A61B5/7425 ,  A61B5/743 ,  G06F19/00 ,  G16H40/63

摘要： Apparatus and method for hemoglobin measurement including irradiating light to a living body, detecting light that has propagated through the living body, and acquiring measured data that represents a change in the concentration of oxidized hemoglobin in the living body and a change in the concentration of deoxidized hemoglobin; irradiating light to the living body, detecting light that has propagated through the living body, and acquiring measured data that represents a change in the concentration of oxidized hemoglobin in the living body and a change in the concentration of deoxidized hemoglobin; classifying the data measured at the first step and the data measured at the second step according to each of an increase or a decrease in the concentration of oxidized hemoglobin and an increase or a decrease in the concentration of deoxidized hemoglobin; and displaying the classifications determined at the third step.

摘要翻译： 用于血红蛋白测量的装置和方法，包括向生物体照射光，检测通过活体传播的光，并获取表示生物体中氧化血红蛋白浓度变化的测量数据和脱氧浓度变化 血红蛋白 对生物体照射光，检测通过生物体传播的光，获取表示生物体中氧化血红蛋白浓度变化的测定数据和脱氧血红蛋白浓度的变化; 根据氧化血红蛋白浓度的增加或减少以及脱氧血红蛋白浓度的增加或减少，分别在第一步骤测量的数据和在第二步骤测量的数据; 并显示在第三步确定的分类。

公开(公告)号：US07150717B2

公开(公告)日：2006-12-19

申请号：US10764561

申请日：2004-01-27

申请人： Takusige Katura ,  Atsushi Maki ,  Masashi Kiguchi

发明人： Takusige Katura ,  Atsushi Maki ,  Masashi Kiguchi

IPC分类号： A61B5/00

CPC分类号： A61B5/4884 ,  A61B5/02055 ,  A61B5/021 ,  A61B5/0261 ,  A61B5/0816 ,  A61B5/14553

摘要： Disclosed is an optical measurement apparatus for a living body to provide a means for measuring blood flow activity within a short time inside the body, even if the test subject cannot distinguish between the active task period and the rest period. An optical measurement apparatus for a living body comprises a light irradiating section, and a light detecting section for detecting light transmitting through or reflected from the interior of the body. The concentration of carbon dioxide gas taken into the body is controlled by the respiration of the test subject and the resulting change in output from the light detecting section is then evaluated.

摘要翻译： 公开了一种生物体的光学测量装置，即使被检体不能区分活动任务期间和休止期间，也能够在体内短时间内测定血液流动活动的手段。 用于生物体的光学测量装置包括光照射部分和用于检测透射到身体内部或从身体内部反射的光的光检测部分。 进入身体的二氧化碳气体的浓度由受检对象的呼吸控制，然后评估所得到的光检测部分的输出变化。