公开(公告)号：US20180325377A1

公开(公告)日：2018-11-15

申请号：US16027775

申请日：2018-07-05

申请人： UNIVERSITY HEALTH NETWORK

发明人： Ralph S. DACOSTA ,  Brian C. WILSON ,  Kai ZHANG

IPC分类号： A61B5/00 ,  A61B5/01 ,  G01N21/64 ,  A61B10/00

CPC分类号： A61B5/0071 ,  A61B5/0042 ,  A61B5/0059 ,  A61B5/01 ,  A61B5/445 ,  A61B5/4519 ,  A61B5/72 ,  A61B5/742 ,  A61B10/00 ,  G01N21/6408 ,  G01N21/6456 ,  G01N21/6486 ,  G01N2021/6421 ,  G01N2021/6471 ,  G01N2201/0221 ,  Y02A90/26

摘要： A system for fluorescence-based imaging of a target includes at least one excitation light source configured to emit a homogeneous field of excitation light and positioned to uniformly illuminate a target surface with the homogeneous field of excitation light during fluorescent imaging, a power source, and a portable housing configured to be held in a user's hand during imaging. The housing contains a lens, a filter, an image sensor, and a processor. The filter is configured to permit optical signals responsive to illumination of the target surface and having a wavelength corresponding to at least one of bacterial autofluorescence and tissue autofluorescence to pass through the filter to the image sensor. The at least one excitation light is adjacent to the housing so as to be positioned between the target surface and the image sensor during fluorescent imaging.

公开(公告)号：US20180242848A1

公开(公告)日：2018-08-30

申请号：US15965462

申请日：2018-04-27

申请人： University Health Network

发明人： Ralph DACOSTA ,  Brian C. WILSON ,  Kai ZHANG

IPC分类号： A61B5/00 ,  A61B5/01 ,  G01N21/64 ,  A61B10/00

摘要： A portable, handheld device for fluorescence-based imaging is provided. The device comprises a wireless communication device having a sensor configured to detect optical signals. The device further comprises an assembly configured to receive and secure the wireless communication device therein. The assembly includes a housing, at least one light source coupled to the housing, a power supply, and an optical filter holder coupled to the housing and configured to receive one or more optical filters. An endoscope portion of the device is positioned relative to the sensor to visualize at least a portion of a confined anatomical space and to receive optical signals from a visualized, illuminated portion of a target positioned within the confined anatomical space. A processor of the device includes image analysis software and is configured to produce a composite representation of the illuminated portion of the target positioned within the confined anatomical space.

公开(公告)号：US20170100606A1

公开(公告)日：2017-04-13

申请号：US15289574

申请日：2016-10-10

申请人： Theralase Technologies, Inc. ,  University Health Network

发明人： Lothar LILGE ,  Arkady MANDEL ,  Wayne EMBREE ,  Kai ZHANG ,  Don LEM ,  Jenny WU ,  Roger DUMOULIN-WHITE

IPC分类号： A61N5/06 ,  A61M25/00 ,  A61B5/00

CPC分类号： A61N5/062 ,  A61B5/0084 ,  A61B5/202 ,  A61B5/4839 ,  A61B5/6858 ,  A61B90/30 ,  A61B2090/306 ,  A61M25/0074 ,  A61M2205/3306 ,  A61M2210/1085 ,  A61N2005/061 ,  A61N2005/063

摘要： Apparatus for illuminating comprises one or more fibers, the one or more fibers including fiber portions meeting at an apex and a bottom location to form a three dimensional cage; a detector attached to each of the fiber portions for receiving light and transmitting light along each of the fiber portions, respectively; and an illumination member situated within the cage. A method for illuminating a hollow member includes the steps of inserting one or more fibers into the hollow member, wherein one or more fibers include fiber portions that meet at a location to form a three-dimensional cage; permitting light to emit from within the three-dimensional cage and towards the fiber portions; receiving light at distinct locations on each of said fibers; and allowing each of the fibers to transmit the light received on each of the fiber portions out of the hollow member.