公开(公告)号：US10073082B2

公开(公告)日：2018-09-11

申请号：US15028846

申请日：2014-10-03

Applicant: UNIVERSITY HEALTH NETWORK ,  BECKMAN COULTER, INC.

Inventor： T. Vincent Shankey ,  Sergei Gulnik ,  Lidice L. Lopez ,  David W. Hedley ,  Sue Chow

IPC: G01N33/49 ,  G01N33/53 ,  G01N33/50 ,  C12Q1/37 ,  G01N33/58 ,  G01N15/14 ,  C07K14/47 ,  C07K16/18 ,  G01N15/00 ,  G01N15/10

CPC classification number: G01N33/5041 ,  C07K14/47 ,  C07K16/18 ,  C12Q1/37 ,  G01N15/14 ,  G01N33/4915 ,  G01N33/5011 ,  G01N33/5047 ,  G01N33/53 ,  G01N33/582 ,  G01N2015/008 ,  G01N2015/1006 ,  G01N2015/149 ,  G01N2333/4704 ,  G01N2440/14

Abstract: Assays that can measure the effect of proteasome inhibitors on target cells in a biological sample are provided. The assays include evaluation of the effects of proteasome inhibitors on proteasome activity in cells in a biological sample.

公开(公告)号：US09642856B2

公开(公告)日：2017-05-09

申请号：US15029269

申请日：2014-10-03

Applicant: University Health Network

Inventor： David W. Hedley ,  Ines Lohse ,  Jacqueline M. Mason ,  Mark R. Bray

IPC: A61K31/5377 ,  A61K31/416 ,  A61P35/00 ,  C07D413/14 ,  A61K45/06 ,  A61K31/7068 ,  A61K33/24

CPC classification number: A61K31/5377 ,  A61K31/7068 ,  A61K33/24 ,  A61K45/06 ,  C07D403/08 ,  C07D413/14 ,  A61K2300/00

Abstract: The invention is related to a method of treating a subject with pancreatic cancer with administration of a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof.

公开(公告)号：US20160250220A1

公开(公告)日：2016-09-01

申请号：US15029269

申请日：2014-10-03

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： David W. Hedley ,  Ines Lohse ,  Jacqueline M. Mason ,  Mark R. Bray

IPC: A61K31/5377 ,  A61K33/24 ,  A61K31/7068

CPC classification number: A61K31/5377 ,  A61K31/7068 ,  A61K33/24 ,  A61K45/06 ,  C07D403/08 ,  C07D413/14 ,  A61K2300/00

Abstract: The invention is related to a method of treating a subject with pancreatic cancer with administration of a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof.

Abstract translation: 本发明涉及通过施用结构式（I）表示的化合物或其药学上可接受的盐来治疗患有胰腺癌的受试者的方法。

公开(公告)号：US09555042B2

公开(公告)日：2017-01-31

申请号：US15029269

申请日：2014-10-03

Applicant: University Health Network

Inventor： David W. Hedley ,  Ines Lohse ,  Jacqueline M. Mason ,  Mark R. Bray

IPC: A61K31/5377 ,  A61K31/416 ,  A61P35/00 ,  C07D413/14 ,  A61K45/06 ,  A61K31/7068 ,  A61K33/24

Abstract: The invention is related to a method of treating a subject with pancreatic cancer with administration of a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof.

Abstract translation: 本发明涉及通过施用结构式（I）表示的化合物或其药学上可接受的盐来治疗患有胰腺癌的受试者的方法。