公开(公告)号：US12037324B2

公开(公告)日：2024-07-16

申请号：US17861809

申请日：2022-07-11

Applicant: Université de Montréal ,  Bristol-Myers Squibb Company

Inventor： Eldon Scott Priestley ,  Samuel Kaye Reznik ,  Edward H. Ruediger ,  James R. Gillard ,  Oz Scott Halpern ,  Wen Jiang ,  Jeremy Richter ,  Rejean Ruel ,  Sasmita Tripathy ,  Wu Yang ,  Xiaojun Zhang

IPC: C07D401/14 ,  A61K31/41 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/4709 ,  A61K31/497 ,  A61K31/501 ,  A61P9/04 ,  C07D233/90 ,  C07D235/26 ,  C07D239/20 ,  C07D257/04 ,  C07D271/07 ,  C07D401/10 ,  C07D403/10 ,  C07D403/14 ,  C07D405/14 ,  C07D413/10 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D498/10

CPC classification number: C07D401/14 ,  A61K31/41 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/4709 ,  A61K31/497 ,  A61K31/501 ,  A61P9/04 ,  C07D233/90 ,  C07D235/26 ,  C07D239/20 ,  C07D257/04 ,  C07D271/07 ,  C07D401/10 ,  C07D403/10 ,  C07D403/14 ,  C07D405/14 ,  C07D413/10 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D498/10

Abstract: The present invention provides compounds of Formula (I):




wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are biased agonists, or β-Arrestin agonists of the angiotensin II receptor, which may be used as medicaments.

公开(公告)号：US11932658B2

公开(公告)日：2024-03-19

申请号：US17142288

申请日：2021-01-06

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Xiaojun Zhang ,  Eldon Scott Priestley ,  Oz Scott Halpern ,  Wen Jiang ,  Samuel Kaye Reznik ,  Jeremy M. Richter

IPC: C07D491/04 ,  A61K31/498 ,  A61P7/02 ,  C07D493/04 ,  C07D495/04 ,  C07D498/04 ,  C07D513/04 ,  C07D515/14 ,  C07D519/00

CPC classification number: C07D519/00 ,  A61P7/02 ,  C07D515/14

Abstract: Disclosed are compounds of Formula (I) to (VIII):




or a stereoisomer, tautomer, pharmaceutically acceptable salt, solvate or prodrug thereof, wherein R3 is a tricyclic heteroaryl group substituted with R3a and zero to 2 R3b; and Ri, R2, R3a, R3b, R4, and n are defined herein. Also disclosed are methods of using such compounds as PAR4 inhibitors, and pharmaceutical compositions comprising such compounds. These compounds are useful in inhibiting or preventing platelet aggregation, and are useful for the treatment of a thromboembolic disorder or the primary prophylaxis of a thromboembolic disorder.

公开(公告)号：US20190315774A1

公开(公告)日：2019-10-17

申请号：US16317258

申请日：2017-07-13

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： XIAOJUN Zhang ,  Eldon Scott Priestley ,  Oz Scott Halpern ,  Wen Jiang ,  Samuel Kaye Reznik ,  Jeremy M. Richter

IPC: C07D519/00 ,  A61P7/02 ,  C07D515/14

Abstract: Disclosed are compounds of Formula (I) to (VIII): (I) (II) (III) (IV) (V) (VI) (VII) (VIII) or a stereoisomer, tautomer, pharmaceutically acceptable salt, solvate or prodrug thereof, wherein R3 is a tricyclic heteroaryl group substituted with R3a and zero to 2 R3b; and R1, R2, R3a, R3b, R4, and n are defined herein. Also disclosed are methods of using such compounds as PAR4 inhibitors, and pharmaceutical compositions comprising such compounds. These compounds are useful in inhibiting or preventing platelet aggregation, and are useful for the treatment of a thromboembolic disorder or the primary prophylaxis of a thromboembolic disorder.

公开(公告)号：US20240309019A1

公开(公告)日：2024-09-19

申请号：US18530405

申请日：2023-12-06

Applicant: Bristol-Myers Squibb Company

Inventor： Xiaojun Zhang ,  Eldon Scott Priestley ,  Oz Scott Halpern ,  Wen Jiang ,  Samuel Kaye Reznik ,  Jeremy M. Richter

IPC: C07D519/00 ,  A61P7/02 ,  C07D515/14

CPC classification number: C07D519/00 ,  A61P7/02 ,  C07D515/14

Abstract: Disclosed are compounds of Formula (I) to (VIII):




or a stereoisomer, tautomer, pharmaceutically acceptable salt, solvate or prodrug thereof, wherein R3 is a tricyclic heteroaryl group substituted with R3a and zero to 2 R3b; and R1, R2, R3a, R3b, R4, and n are defined herein. Also disclosed are methods of using such compounds as PAR4 inhibitors, and pharmaceutical compositions comprising such compounds. These compounds are useful in inhibiting or preventing platelet aggregation, and are useful for the treatment of a thromboembolic disorder or the primary prophylaxis of a thromboembolic disorder.

公开(公告)号：US20210188877A1

公开(公告)日：2021-06-24

申请号：US17142288

申请日：2021-01-06

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Xiaojun Zhang ,  Eldon Scott Priestley ,  Oz Scott Halpern ,  Wen Jiang ,  Samuel Kaye Reznik ,  Jeremy M. Richter

IPC: C07D519/00 ,  A61P7/02 ,  C07D515/14

Abstract: Disclosed are compounds of Formula (I) to (VIII): or a stereoisomer, tautomer, pharmaceutically acceptable salt, solvate or prodrug thereof, wherein R3 is a tricyclic heteroaryl group substituted with R3a and zero to 2 R3b; and R1, R2, R3a, R3b, R4, and n are defined herein. Also disclosed are methods of using such compounds as PAR4 inhibitors, and pharmaceutical compositions comprising such compounds. These compounds are useful in inhibiting or preventing platelet aggregation, and are useful for the treatment of a thromboembolic disorder or the primary prophylaxis of a thromboembolic disorder.

公开(公告)号：US20190002441A1

公开(公告)日：2019-01-03

申请号：US16122975

申请日：2018-09-06

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Zulan Pi ,  Donna M. Bilder ,  Robert Paul Brigance ,  Heather Finlay ,  Wen Jiang ,  James A. Johnson ,  R. Michael Lawrence ,  Wei Meng ,  Michael C. Myers ,  Monique Phillips ,  George O. Tora ,  Xiaojun Zhang

IPC: C07D403/06 ,  C07D403/02 ,  C07D417/14 ,  A61K31/505 ,  C07D239/557 ,  C07D401/14 ,  C07D401/06 ,  C07D471/04 ,  C07D239/54 ,  C07D239/545 ,  C07D403/14

Abstract: The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments.

公开(公告)号：US10106528B2

公开(公告)日：2018-10-23

申请号：US15468230

申请日：2017-03-24

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Zulan Pi ,  Donna M. Bilder ,  Robert Paul Brigance ,  Heather Finlay ,  Wen Jiang ,  James A. Johnson ,  R. Michael Lawrence ,  Wei Meng ,  Michael C. Myers ,  Monique Phillips ,  George O. Tora ,  Xiaojun Zhang

IPC: C07D403/06 ,  A61K31/505 ,  C07D239/54 ,  C07D239/545 ,  C07D401/14 ,  C07D403/02 ,  C07D417/14 ,  C07D471/04 ,  C07D401/06 ,  C07D403/14 ,  C07D239/557

Abstract: The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments.

公开(公告)号：US11407733B2

公开(公告)日：2022-08-09

申请号：US16311835

申请日：2017-06-28

Applicant: Universite de Montreal ,  Bristol-Myers Squibb Company

Inventor： Eldon Scott Priestley ,  Samuel Kaye Reznik ,  Edward H. Ruediger ,  James R. Gillard ,  Oz Scott Halpern ,  Wen Jiang ,  Jeremy Richter ,  Rejean Ruel ,  Sasmita Tripathy ,  Wu Yang ,  Xiaojun Zhang

IPC: C07D401/14 ,  C07D403/10 ,  C07D403/12 ,  C07D403/14 ,  C07D409/14 ,  C07D417/14 ,  C07D491/107 ,  C07D401/10 ,  C07D235/26 ,  C07D413/10 ,  C07D471/04 ,  C07D257/04 ,  C07D405/14 ,  C07D233/90 ,  C07D498/10 ,  C07D413/14 ,  A61P9/04 ,  A61K31/41 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/4709 ,  A61K31/497 ,  A61K31/501 ,  C07D239/20 ,  C07D271/07

Abstract: The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are biased agonists, or β-Arrestin agonists of the angiotensin II receptor, which may be used as medicaments.

公开(公告)号：US10508104B2

公开(公告)日：2019-12-17

申请号：US16309161

申请日：2017-06-14

Applicant: Bristol-Myers Squibb Company

Inventor： George O. Tora ,  Heather Finlay ,  Wen Jiang ,  Wei Meng ,  Xiaojun Zhang

IPC: C07D405/04 ,  C07D403/12 ,  C07D401/14 ,  C07D405/14 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D405/06 ,  C07D405/12 ,  C07D409/12 ,  C07D239/60 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  A61P9/10 ,  A61P9/04

Abstract: The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments.

公开(公告)号：US20190194173A1

公开(公告)日：2019-06-27

申请号：US16309161

申请日：2017-06-14

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： George O. Tora ,  Heather Finlay ,  Wen Jiang ,  Wei Meng ,  Xiaojun Zhang

IPC: C07D405/04 ,  A61P9/04 ,  A61P9/10 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/06 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04

CPC classification number: C07D405/04 ,  A61P9/04 ,  A61P9/10 ,  C07D239/60 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/06 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04

Abstract: The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments.