公开(公告)号：US12037324B2

公开(公告)日：2024-07-16

申请号：US17861809

申请日：2022-07-11

申请人： Université de Montréal ,  Bristol-Myers Squibb Company

发明人： Eldon Scott Priestley ,  Samuel Kaye Reznik ,  Edward H. Ruediger ,  James R. Gillard ,  Oz Scott Halpern ,  Wen Jiang ,  Jeremy Richter ,  Rejean Ruel ,  Sasmita Tripathy ,  Wu Yang ,  Xiaojun Zhang

IPC分类号： C07D401/14 ,  A61K31/41 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/4709 ,  A61K31/497 ,  A61K31/501 ,  A61P9/04 ,  C07D233/90 ,  C07D235/26 ,  C07D239/20 ,  C07D257/04 ,  C07D271/07 ,  C07D401/10 ,  C07D403/10 ,  C07D403/14 ,  C07D405/14 ,  C07D413/10 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D498/10

CPC分类号： C07D401/14 ,  A61K31/41 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/4709 ,  A61K31/497 ,  A61K31/501 ,  A61P9/04 ,  C07D233/90 ,  C07D235/26 ,  C07D239/20 ,  C07D257/04 ,  C07D271/07 ,  C07D401/10 ,  C07D403/10 ,  C07D403/14 ,  C07D405/14 ,  C07D413/10 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D498/10

摘要： The present invention provides compounds of Formula (I):




wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are biased agonists, or β-Arrestin agonists of the angiotensin II receptor, which may be used as medicaments.

公开(公告)号：US10508104B2

公开(公告)日：2019-12-17

申请号：US16309161

申请日：2017-06-14

申请人： Bristol-Myers Squibb Company

发明人： George O. Tora ,  Heather Finlay ,  Wen Jiang ,  Wei Meng ,  Xiaojun Zhang

IPC分类号： C07D405/04 ,  C07D403/12 ,  C07D401/14 ,  C07D405/14 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D405/06 ,  C07D405/12 ,  C07D409/12 ,  C07D239/60 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  A61P9/10 ,  A61P9/04

摘要： The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments.

公开(公告)号：US20190194173A1

公开(公告)日：2019-06-27

申请号：US16309161

申请日：2017-06-14

申请人： BRISTOL-MYERS SQUIBB COMPANY

发明人： George O. Tora ,  Heather Finlay ,  Wen Jiang ,  Wei Meng ,  Xiaojun Zhang

IPC分类号： C07D405/04 ,  A61P9/04 ,  A61P9/10 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/06 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04

CPC分类号： C07D405/04 ,  A61P9/04 ,  A61P9/10 ,  C07D239/60 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/06 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04

摘要： The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments.

公开(公告)号：US20170275272A1

公开(公告)日：2017-09-28

申请号：US15468230

申请日：2017-03-24

申请人： BRISTOL-MYERS SQUIBB COMPANY

发明人： Zulan Pi ,  Donna M. Bilder ,  Robert Paul Brigance ,  Heather Finlay ,  Wen Jiang ,  James A. Johnson ,  R. Michael Lawrence ,  Wei Meng ,  Michael C. Myers ,  Monique Phillips ,  George O. Tora ,  Xiaojun Zhang

IPC分类号： C07D403/06 ,  C07D471/04 ,  C07D417/14 ,  C07D401/14

CPC分类号： C07D403/06 ,  A61K31/505 ,  C07D239/54 ,  C07D239/545 ,  C07D239/557 ,  C07D401/06 ,  C07D401/14 ,  C07D403/02 ,  C07D403/14 ,  C07D417/14 ,  C07D471/04

摘要： The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments.

公开(公告)号：US12060347B2

公开(公告)日：2024-08-13

申请号：US17123265

申请日：2020-12-16

申请人： BRISTOL-MYERS SQUIBB COMPANY

发明人： Xiaojun Zhang ,  Eldon Scott Priestley ,  J. Alex Bates ,  Oz Scott Halpern ,  Samuel Kaye Reznik ,  Jeremy M. Richter

IPC分类号： C07D417/04 ,  A61P7/04 ,  A61P9/10 ,  C07D403/04 ,  C07D405/04 ,  C07D405/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D513/04 ,  C07D519/00

CPC分类号： C07D417/04 ,  A61P7/04 ,  A61P9/10 ,  C07D403/04 ,  C07D405/04 ,  C07D405/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D513/04 ,  C07D519/00

摘要： Disclosed are compounds of Formula (I) to (VIII):




or a stereoisomer, tautomer, pharmaceutically acceptable salt, solvate or prodrug thereof, wherein R3 is a bicyclic heteroaryl group substituted with zero to 3 R3a; and R1, R2, R3a, R4, and n are defined herein. Also disclosed are methods of using such compounds as PAR4 inhibitors, and pharmaceutical compositions comprising such compounds. These compounds are useful in inhibiting or preventing platelet aggregation, and are useful for the treatment of a thromboembolic disorder or the primary prophylaxis of a thromboembolic disorder.

公开(公告)号：US20210163465A1

公开(公告)日：2021-06-03

申请号：US17123265

申请日：2020-12-16

申请人： Bristol-Myers Squibb Company

发明人： Xiaojun Zhang ,  Eldon Scott Priestley ,  J. Alex Bates ,  Oz Scott Halpern ,  Samuel Kaye Reznik ,  Jeremy M. Richter

IPC分类号： C07D417/04 ,  A61P7/04 ,  A61P9/10 ,  C07D405/04 ,  C07D405/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D513/04 ,  C07D519/00 ,  C07D403/04

摘要： Disclosed are compounds of Formula (I) to (VIII): or a stereoisomer, tautomer, pharmaceutically acceptable salt, solvate or prodrug thereof, wherein R3 is a bicyclic heteroaryl group substituted with zero to 3 R3a; and R1, R2, R3a, R4, and n are defined herein. Also disclosed are methods of using such compounds as PAR4 inhibitors, and pharmaceutical compositions comprising such compounds. These compounds are useful in inhibiting or preventing platelet aggregation, and are useful for the treatment of a thromboembolic disorder or the primary prophylaxis of a thromboembolic disorder.

公开(公告)号：US10590113B2

公开(公告)日：2020-03-17

申请号：US16122975

申请日：2018-09-06

申请人： BRISTOL-MYERS SQUIBB COMPANY

发明人： Zulan Pi ,  Donna M. Bilder ,  Robert Paul Brigance ,  Heather Finlay ,  Wen Jiang ,  James A. Johnson ,  R. Michael Lawrence ,  Wei Meng ,  Michael C. Myers ,  Monique Phillips ,  George O. Tora ,  Xiaojun Zhang

IPC分类号： A61K31/505 ,  C07D403/06 ,  C07D401/06 ,  C07D403/14 ,  C07D239/557 ,  C07D239/54 ,  C07D239/545 ,  C07D401/14 ,  C07D403/02 ,  C07D417/14 ,  C07D471/04

摘要： The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments.

公开(公告)号：US20180214445A1

公开(公告)日：2018-08-02

申请号：US15747218

申请日：2016-07-28

申请人： BRISTOL-MYERS SQUIBB COMPANY

发明人： Xiaojun Zhang ,  Xiaofan Zheng ,  Louis S. Chupak

IPC分类号： A61K31/498 ,  A61P7/02 ,  A61P9/10 ,  A61P31/20

摘要： Disclosed is a compound of Formula (I) or a stereoisomer, tautomer, pharmaceutically acceptable salt, solvate or prodrug thereof, wherein one R3 is H and the other R3 is an aryl group substituted with zero to 3 R3a; and R1, R2, and R3a are defined herein. Also disclosed are methods of using such compounds as PAR4 inhibitors for the inhibition or prevention of platelet aggregation, and the treatment of a thromboembolic disorder or the primary prophylaxis of a thromboembolic disorder. Also disclosed are methods of using such compounds for the treatment of human papillomavirus. Additionally, pharmaceutical compositions comprising at least one compound of Formula (I) are disclosed.

公开(公告)号：US09174974B2

公开(公告)日：2015-11-03

申请号：US14405507

申请日：2013-06-05

申请人： BRISTOL-MYERS SQUIBB COMPANY

发明人： Xiaojun Zhang ,  Peter Glunz ,  Eldon Scott Priestley ,  James A. Johnson ,  Nicholas Ronald Wurtz ,  Vladimir Ladziata

IPC分类号： C07D401/12 ,  C07D401/14 ,  C07D413/12 ,  C07D273/02 ,  C07D413/14 ,  C07D417/14 ,  C07F9/6558

CPC分类号： C07D413/12 ,  C07D273/02 ,  C07D401/12 ,  C07D413/14 ,  C07D417/14 ,  C07F9/65583

摘要： The present invention provides compounds of Formula (I): as defined in the specification and compositions comprising any of such novel compounds. These compounds are Factor VIIa inhibitors which may be used as medicaments.

摘要翻译： 本发明提供式（I）化合物：如说明书中所定义和包含任何这些新化合物的组合物。 这些化合物是可以用作药物的因子VIIa抑制剂。

公开(公告)号：US11932658B2

公开(公告)日：2024-03-19

申请号：US17142288

申请日：2021-01-06

申请人： BRISTOL-MYERS SQUIBB COMPANY

发明人： Xiaojun Zhang ,  Eldon Scott Priestley ,  Oz Scott Halpern ,  Wen Jiang ,  Samuel Kaye Reznik ,  Jeremy M. Richter

IPC分类号： C07D491/04 ,  A61K31/498 ,  A61P7/02 ,  C07D493/04 ,  C07D495/04 ,  C07D498/04 ,  C07D513/04 ,  C07D515/14 ,  C07D519/00

CPC分类号： C07D519/00 ,  A61P7/02 ,  C07D515/14

摘要： Disclosed are compounds of Formula (I) to (VIII):




or a stereoisomer, tautomer, pharmaceutically acceptable salt, solvate or prodrug thereof, wherein R3 is a tricyclic heteroaryl group substituted with R3a and zero to 2 R3b; and Ri, R2, R3a, R3b, R4, and n are defined herein. Also disclosed are methods of using such compounds as PAR4 inhibitors, and pharmaceutical compositions comprising such compounds. These compounds are useful in inhibiting or preventing platelet aggregation, and are useful for the treatment of a thromboembolic disorder or the primary prophylaxis of a thromboembolic disorder.