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公开(公告)号：US20150050217A1
公开(公告)日：2015-02-19
申请号：US14394004
申请日：2013-04-12
申请人： Universite Claude Bernard Lyon 1 , Nano-H , Centre National de la Recherche Scientifique-CNRS , Universite Joseph Fourier
发明人： Yannick Cremillieux , Andrea Bianchi , Sandrine Dufort , Jean-Luc Coll , Francois Lux , Olivier Tillement
摘要： The invention relates to a novel use of ultrafine nanoparticles, of use as a diagnostic, therapeutic or theranostic agent, characterized by their mode of administration via the airways. The invention is also directed toward the applications which follow from this novel mode of administration, in particular for imaging the lungs, and the diagnosis or prognosis of pathological pulmonary conditions. In the therapeutic field, the applications envisioned are those of radiosensitizing or radioactive agents for radiotherapy (and optionally curietherapy), or for neutron therapy, or of agents for PDT (photodynamic therapy), in particular for the treatment of lung tumors.
摘要翻译： 本发明涉及超细纳米颗粒的新用途，其用作诊断，治疗或治疗剂，其特征在于其经由气道的给药模式。 本发明还涉及从这种新型施用模式，特别是用于对肺成像，以及病理性肺病的诊断或预后的应用。 在治疗领域中，设想的应用是用于放射增敏剂或放射剂（用于放射疗法）或用于中子治疗或PDT（光动力疗法）的药剂，特别是用于治疗肺肿瘤的应用。
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公开(公告)号：US11857604B2
公开(公告)日：2024-01-02
申请号：US16755866
申请日：2018-10-12
申请人： NH THERAGUIX , Universite Claude Bernard Lyon 1 , Centre National de La Recherche Scientifique—CNRS—
发明人： Olivier Tillement , François Lux , Fabien Rossetti , Vu-Long Tran , Clélia Mathieu , Myleva Dahan
IPC分类号： A61K38/31 , A61K47/69 , A61P35/00 , A61K33/243 , A61K9/14 , A61K31/704 , A61K49/00 , A61K49/12 , A61K49/18 , B82Y5/00 , A61K33/244 , A61K9/00
CPC分类号： A61K38/31 , A61K9/146 , A61K31/704 , A61K33/243 , A61K33/244 , A61K47/6929 , A61K49/0002 , A61K49/128 , A61K49/1881 , A61P35/00 , B82Y5/00 , A61K9/0019
摘要： The present invention relates to the field of nanovectors for the delivery of active substances in the body, in particular for the treatment of tumours. In particular, the use of these nanovectors makes it possible to improve the pharmacokinetics of the active substances with a more selective delivery, for example in the tumour tissues.
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公开(公告)号：US10472556B2
公开(公告)日：2019-11-12
申请号：US15536523
申请日：2014-12-15
申请人： TOTAL SA , UNIVERSITE CLAUDE BERNARD LYON 1 , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE-CNRS-
发明人： Christian Hurtevent , Salima Baraka-Lokmane , John-Richard Ordonez-Varela , Olivier Tillement , Arthur Marais , Albert Moussaron
摘要： Novel hybrid nanoparticles, useful for inhibiting or slowing down the formation of sulfur deposits or minerals in a well during the extraction of gas or oil. Specifically, the nanoparticles each include (i) a polyorganosiloxane (POS) matrix; and, optionally as a coating over a lanthanide oxide core, (iii) at least one polymeric scale inhibitor during the extraction of gas or oil. The invention also relates to the method for obtaining the nano-inhibitors and the application of same.
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公开(公告)号：US11512003B2
公开(公告)日：2022-11-29
申请号：US16620413
申请日：2018-06-08
申请人： NH THERAGUIX , Universite Claude Bernard Lyon 1 , Centre National de La Recherche Scientifique—CNRS
摘要： The invention relates to a method for synthesizing ultrasmall silica nanoparticles, useful in particular for diagnostics and/or therapy. More specifically, a method for synthesizing silica nanoparticles, said method comprising the mixing of at least one silane which is negatively charged at physiological pH with at least one silane which is neutral at physiological pH, and/or at least one silane which is positively charged at physiological pH, wherein: —the molar ratio A of neutral silane(s) to negatively charged silane(s) is defined as follows: 0≤A≤6, —the molar ratio B of positively charged silane(s) to negatively charged silane(s) is defined as follows: 0≤B≤5, —the molar ratio C of neutral and positively charged silanes to negatively charged silane(s) is defined as follows: 0
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5.发明授权公开(公告)号：US10975318B2
公开(公告)日：2021-04-13
申请号：US16068258
申请日：2017-01-12
申请人： INOVENTEAM , UNIVERSITE CLAUDE BERNARD LYON 1 , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
发明人： Arthur Marais , Mahmoud Ould-Metidji , Florian Lepoivre , Anatole Collet , Matteo Martini , Fabien Rossetti , Olivier Tillement , Antoine Vanlaer , François Ghillebaert
摘要： The use, as markers of petroleum products, crude oils, biofuels or lubricants, of rare earth complexes or one of the constituents thereof chosen from rare earth ligands or salts, being capable of forming a rare earth complex after the addition of a developing solution. Preferably, the rare earth complex can be detected by time-resolved fluorescence. Also, a marking method and a method for detecting a rare earth complex as a marker of petroleum products, crude oils, biofuels or lubricants.
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6.发明授权公开(公告)号：US11313800B2
公开(公告)日：2022-04-26
申请号：US16088232
申请日：2016-04-20
申请人： TOTAL SA , UNIVERSITE CLAUDE BERNARD LYON 1 , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS
摘要： A method for the detection and quantification, in a complex aqueous fluid, of additives and water-soluble polymers used in the enhanced recovery of oil and shale gas.
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公开(公告)号：US10517962B2
公开(公告)日：2019-12-31
申请号：US14394004
申请日：2013-04-12
申请人： Universite Claude Bernard Lyon I , Nano-H , Centre National de la Recherche Scientifique—CNRS , Universite Joseph Fourier
发明人： Yannick Cremillieux , Andrea Bianchi , Sandrine Dufort , Jean-Luc Coll , Francois Lux , Olivier Tillement
IPC分类号： A61K47/69 , A61K49/00 , A61K41/00 , A61K49/10 , A61K49/18 , A61K51/12 , A61K9/51 , A61K49/04
摘要： The invention relates to a novel use of ultrafine nanoparticles, of use as a diagnostic, therapeutic or theranostic agent, characterized by their mode of administration via the airways. The invention is also directed toward the applications which follow from this novel mode of administration, in particular for imaging the lungs, and the diagnosis or prognosis of pathological pulmonary conditions. In the therapeutic field, the applications envisioned are those of radiosensitizing or radioactive agents for radiotherapy (and optionally curietherapy), or for neutron therapy, or of agents for PDT (photodynamic therapy), in particular for the treatment of lung tumors.
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公开(公告)号：US11529316B2
公开(公告)日：2022-12-20
申请号：US16705305
申请日：2019-12-06
申请人： Universite Claude Bernard Lyon I , Nano-H , Centre National de la Recherche Scientifique—CNRS , Universite Grenoble Alpes , Universite de Bordeaux
发明人： Yannick Cremillieux , Andrea Bianchi , Sandrine Dufort , Jean-Luc Coll , Francois Lux , Olivier Tillement
IPC分类号： A61K9/51 , A61K49/10 , A61K49/00 , A61K49/18 , A61K51/12 , A61K49/04 , A61K47/69 , A61K41/00
摘要： The invention relates to a novel use of ultrafine nanoparticles, of use as a diagnostic, therapeutic or theranostic agent, characterized by their mode of administration via the airways. The invention is also directed toward the applications which follow from this novel mode of administration, in particular for imaging the lungs, and the diagnosis or prognosis of pathological pulmonary conditions. In the therapeutic field, the applications envisioned are those of radiosensitizing or radioactive agents for radiotherapy (and optionally curietherapy), or for neutron therapy, or of agents for PDT (photodynamic therapy), in particular for the treatment of lung tumors.
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公开(公告)号：US10106722B2
公开(公告)日：2018-10-23
申请号：US15106610
申请日：2014-12-19
发明人： Christian Hurtevent , Salima Baraka-Lokmane , John-Richard Ordonez-Varela , Olivier Tillement , Fabien Rossetti , Mahmoud Ould Metidji
摘要： A copolymer containing a unit including an optionally neutralized styrene sulphonic acid unit and a unit containing at least one optionally neutralized (poly)carboxylic acid unit or a (poly)amido-amine unit, to inhibit or slow the formation of sulphide deposits during the extraction of gas or oil. It also relates to a method to inhibit or slow the formation of sulphide deposits during the extraction of gas or oil, including the injection of a fluid containing the abovementioned copolymer into a wellbore, a subterranean formation or a gas or oil well.
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公开(公告)号：US10329879B2
公开(公告)日：2019-06-25
申请号：US15105328
申请日：2014-12-19
发明人： Christian Hurtevent , Salima Baraka-Lokmane , John-Richard Ordonez-Varela , Olivier Tillement , Thomas Brichart , Matteo Martini
摘要： A method for adjusting, to a pre-determined value, the level of a mineral deposition or corrosion inhibitor injected into a gas or oil well. Using of the time-resolved fluorescence method for detecting and quantifying a mineral deposition or corrosion inhibitor in a fluid from an oil or gas production well.
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