公开(公告)号：US20180271502A1

公开(公告)日：2018-09-27

申请号：US15762143

申请日：2016-09-22

Applicant: University Health Network

Inventor： Arash Zarrine-Afsar ,  David A. Jaffray ,  Alessandra Tata ,  Michael Woolman ,  Alexander Vitkin

IPC: A61B10/02 ,  H01J49/00 ,  H01J49/04 ,  A61B34/10 ,  A61B18/12 ,  A61B18/20 ,  A61B5/00 ,  A61B5/055 ,  A61B6/03 ,  A61B8/08

CPC classification number: A61B10/0266 ,  A61B5/0095 ,  A61B5/055 ,  A61B6/032 ,  A61B6/037 ,  A61B8/085 ,  A61B10/0233 ,  A61B18/12 ,  A61B18/20 ,  A61B34/10 ,  A61B2018/00577 ,  A61B2018/00595 ,  A61B2018/00904 ,  A61B2034/107 ,  A61B2034/2072 ,  G01N21/21 ,  H01J49/0004 ,  H01J49/0031 ,  H01J49/04

Abstract: Various embodiments are described herein for a system and a method for obtaining samples of tissue for analysis by mass spectrometry. A region of interest can be identified in tissue using image data from a first imaging modality that is other than mass spectrometry. At least one tissue sample can be acquired using a tissue sampler from a sampling location related to the region of interest. Mass spectrum data can be generated for the acquired tissue samples using a mass spectrometer. In some embodiments. polarimetry may be used on a tissue slice, mass spectrometry may be performed on the same tissue slice and then H&E imaging may be performed on the same tissue slice.

公开(公告)号：US11266383B2

公开(公告)日：2022-03-08

申请号：US15762143

申请日：2016-09-22

Applicant: University Health Network

Inventor： Arash Zarrine-Afsar ,  David A. Jaffray ,  Alessandra Tata ,  Michael Woolman ,  Alexander Vitkin

IPC: G01N21/00 ,  A61B10/02 ,  A61B18/20 ,  H01J49/04 ,  G01N21/21 ,  A61B34/10 ,  A61B5/00 ,  A61B5/055 ,  A61B6/03 ,  A61B8/08 ,  A61B18/12 ,  H01J49/00 ,  A61B34/20 ,  A61B18/00

Abstract: Various embodiments are described herein for a system and a method for obtaining samples of tissue for analysis by mass spectrometry. A region of interest can be identified in tissue using image data from a first imaging modality that is other than mass spectrometry. At least one tissue sample can be acquired using a tissue sampler from a sampling location related to the region of interest. Mass spectrum data can be generated for the acquired tissue samples using a mass spectrometer. In some embodiments, polarimetry may be used on a tissue slice, mass spectrometry may be performed on the same tissue slice and then H&E imaging may be performed on the same tissue slice.