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1.发明公开公开(公告)号：US20240230634A9
公开(公告)日：2024-07-11
申请号：US18382849
申请日：2023-10-23
发明人： Leidong Mao , Yang Liu
IPC分类号： G01N33/543 , B01L3/00 , G01N15/14 , G01N15/1404
CPC分类号： G01N33/54366 , B01L3/50273 , B01L3/502753 , B01L3/502761 , G01N15/1404 , G01N15/1484 , B01L2200/0647 , B01L2400/043 , G01N2015/1006
摘要： The present disclosure provides devices, kits, and methods for focusing/enriching and/or separating/sorting submicron size particles, including biological entities such as exosomes and other submicron size extracellular vesicles. Devices, kits, and methods of the present disclosure utilize ferrohydrodynamic manipulation to focus populations of submicron particles into a stream for enrichment and/or further sort various sub-populations of submicron particles based on size differences.
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2.发明授权公开(公告)号：US11841365B2
公开(公告)日：2023-12-12
申请号：US16930664
申请日：2020-07-16
发明人： Leidong Mao , Yang Liu
IPC分类号： G01N33/543 , B01L3/00 , G01N15/14 , G01N15/10
CPC分类号： G01N33/54366 , B01L3/50273 , B01L3/502753 , B01L3/502761 , G01N15/1404 , G01N15/1484 , B01L2200/0647 , B01L2400/043 , G01N2015/1006 , G01N2015/149 , G01N2015/1415 , G01N2015/1486
摘要： The present disclosure provides devices, kits, and methods for focusing/enriching and/or separating/sorting submicron size particles, including biological entities such as exosomes and other submicron size extracellular vesicles. Devices, kits, and methods of the present disclosure utilize ferrohydrodynamic manipulation to focus populations of submicron particles into a stream for enrichment and/or further sort various sub-populations of submicron particles based on size differences.
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3.发明申请公开(公告)号：US20220125731A1
公开(公告)日：2022-04-28
申请号：US17518759
申请日：2021-11-04
发明人： Lohitash Karumbaiah , Leidong Mao , Meghan T. Logun , Wujun Zhao
IPC分类号： A61K9/19 , A61K47/69 , A61K31/726 , C12N5/00
摘要： Disclosed herein are compositions and methods for cellular reconstitution of photopolymerized, lyophilized, bioactive chondroitin sulfate glycosaminoglycan (CS-GAG)-based hydrogel matrices.
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公开(公告)号：US20200238287A1
公开(公告)日：2020-07-30
申请号：US16636517
申请日：2018-08-04
发明人： Leidong Mao
摘要： A variety of devices and methods are provided for separating or enriching circulating tumor cells in a biological sample such as whole blood. In some aspects, the devices are multi-stage devices including at least (i) a filtering stage, (ii) a sheath flow stage for ferrohydrodynamic separation of magnetically labelled white blood cells, and (iii) a focusing stage for markerindependent and size-independent focusing of magnetically labeled particles so as to separate or enrich unlabeled rare cells in the biological sample. The devices and methods are, in some aspects, capable of high throughput in excess of 6 milliliters per hour while achieving high separation (>95%) of the unlabeled rare cells.
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公开(公告)号：US10676719B2
公开(公告)日：2020-06-09
申请号：US15223515
申请日：2016-07-29
发明人： Leidong Mao , Carsten Schroeder , Wujun Zhao
摘要： Devices for non-invasive, label-free separation of particles in liquid, including circulating tumors cells in blood, are provided. Embodiments of the disclosure provide for devices employing magnetic fluids and magnets for separation of circulating tumor cells from blood. Methods for separation of particles including circulating tumor cells are also provided.
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公开(公告)号：US20170072405A1
公开(公告)日：2017-03-16
申请号：US15290700
申请日：2016-10-11
发明人： Leidong Mao , Taotao Zhu , Mark A. Eiteman
CPC分类号： B03C1/288 , B03C1/32 , B03C2201/18 , B03C2201/26 , C12N13/00 , G01N27/74
摘要： Embodiments of the present disclosure provide for devices, methods for separating particles, and the like.
摘要翻译： 本公开的实施例提供了用于分离颗粒的装置，方法等。
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7.发明公开公开(公告)号：US20240026267A1
公开(公告)日：2024-01-25
申请号：US18224717
申请日：2023-07-21
发明人： Leidong Mao , Yang Liu , Wujun Zhao
摘要： The present disclosure provides for microfluidic devices, systems, kits, and methods of using multi-stage microfluidic devices are provided for high throughput sorting, separation/enrichment of target rare cells from a sample, and can additionally provide for characterization/phenotyping of circulating tumor cells (CTCs) and other unlabeled rare cells in a biological sample such as blood, where the rare cells do not need to be labeled.
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公开(公告)号：US11292000B2
公开(公告)日：2022-04-05
申请号：US16406440
申请日：2019-05-08
发明人： Leidong Mao , Yang Liu , Wujun Zhao
摘要： A variety of devices, systems, kits, and methods are provided for separating or enriching circulating tumor cells in a biological sample such as whole blood. In some aspects, the devices are multi-stage devices including at least a filtering stage, and two separation stages for ferrohydrodynamic separation of magnetically labelled white blood cells and for marker-independent and size-independent focusing of magnetically labeled particles so as to separate or enrich unlabeled rare cells in the biological sample. The devices and methods are, in some aspects, capable of high throughput in excess of 6 milliliters per hour while achieving high separation (>97%) of the unlabeled rare cells.
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公开(公告)号：US20130306566A1
公开(公告)日：2013-11-21
申请号：US13873424
申请日：2013-04-30
发明人： Leidong Mao , Taotao Zhu , Mark A. Eiteman
IPC分类号： B03C1/32
CPC分类号： B03C1/288 , B03C1/32 , B03C2201/18 , B03C2201/26 , C12N13/00 , G01N27/74
摘要： Embodiments of the present disclosure provide for devices, methods for separating particles, and the like.
摘要翻译： 本公开的实施例提供了用于分离颗粒的装置，方法等。
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10.发明授权公开(公告)号：US12090229B2
公开(公告)日：2024-09-17
申请号：US17518759
申请日：2021-11-04
发明人： Lohitash Karumbaiah , Leidong Mao , Meghan T. Logun , Wujun Zhao
CPC分类号： A61K9/19 , A61K31/726 , A61K47/6903 , C12M25/02 , C12N5/0012 , G01N33/5029 , C12M23/16
摘要： Disclosed herein are compositions and methods for cellular reconstitution of photopolymerized, lyophilized, bioactive chondroitin sulfate glycosaminoglycan (CS-GAG)-based hydrogel matrices.
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